Discovery of the HCV NS3/4A Protease Inhibitor (1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl... von Prongay, Andrew J, Guo, Zhuyan, Yao, Nanhua, Pichardo, John, Fischmann, Thierry, Strickland, Corey, Myers, Joseph, Weber, Patricia C, Beyer, Brian M, Ingram, Richard, Hong, Zhi, Prosise, Winifred W, Ramanathan, Lata, Taremi, S. Shane, Yarosh-Tomaine, Taisa, Zhang, Rumin, Senior, Mary, Yang, Rong-Sheng, Malcolm, Bruce, Arasappan, Ashok, Bennett, Frank, Bogen, Stephane L, Chen, Kevin, Jao, Edwin, Liu, Yi-Tsung, Lovey, Raymond G, Saksena, Anil K, Venkatraman, Srikanth, Girijavallabhan, Viyyoor, Njoroge, F. George, Madison, Vincent

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Application of Fragment-Based NMR Screening, X-ray Crystallography, Structure-Based Design, and Focused Chemical Library Design to Identify Novel μM Leads for the Development of nM... von Wang, Yu-Sen, Strickland, Corey, Voigt, Johannes H, Kennedy, Matthew E, Beyer, Brian M, Senior, Mary M, Smith, Elizabeth M, Nechuta, Terry L, Madison, Vincent S, Czarniecki, Michael, McKittrick, Brian A, Stamford, Andrew W, Parker, Eric M, Hunter, John C, Greenlee, William J, Wyss, Daniel F

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Stabilization of the autoproteolysis of TNF-alpha converting enzyme (TACE) results in a novel crystal form suitable for structure-based drug design studies von Ingram, Richard N., Orth, Peter, Strickland, Corey L., Le, Hung V., Madison, Vincent, Beyer, Brian M.

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Crystal Structures of the Pro-Inflammatory Cytokine Interleukin-23 and Its Complex with a High-Affinity Neutralizing Antibody von Beyer, Brian M., Ingram, Richard, Ramanathan, Lata, Reichert, Paul, Le, Hung V., Madison, Vincent, Orth, Peter

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IK682, a tight binding inhibitor of TACE von Niu, Xiaoda, Umland, Shelby, Ingram, Richard, Beyer, Brian M., Liu, Yan-Hui, Sun, Jing, Lundell, Daniel, Orth, Peter

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Discovery of Novel Hydroxamates as Highly Potent Tumor Necrosis Factor-α Converting Enzyme Inhibitors: Part IDiscovery of Two Binding Modes von Zhu, Zhaoning, Mazzola, Robert, Sinning, Lisa, McKittrick, Brian, Niu, Xiaoda, Lundell, Daniel, Sun, Jing, Orth, Peter, Guo, Zhuyan, Madison, Vincent, Ingram, Richard, Beyer, Brian M

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Non-Peptidic Small-Molecule Inhibitors of the Single-Chain Hepatitis C Virus NS3 Protease/NS4A Cofactor Complex Discovered by Structure-Based NMR Screening von Wyss, Daniel F, Arasappan, Ashok, Senior, Mary M, Wang, Yu-Sen, Beyer, Brian M, Njoroge, F. George, McCoy, Mark A

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Characterization of Autocatalytic Conversion of Precursor BACE1 by Heteronuclear NMR Spectroscopy von Wang, Yu-Sen, Beyer, Brian M, Senior, Mary M, Wyss, Daniel F

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Letter to the Editor: Backbone Resonance Assignments of the 45.3 kDa Catalytic Domain of Human BACE1 von Liu, Dingjiang, Wang, Yu-Sen, Gesell, Jennifer J., Wilson, Eileen, Beyer, Brian M., Wyss, Daniel F.

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Key steps in the structure-based optimization of the hepatitis C virus NS3/4A protease inhibitor SCH503034 von Madison, Vincent, Prongay, Andrew J., Guo, Zhuyan, Yao, Nanhua, Pichardo, John, Fischmann, Thierry, Strickland, Corey, Myers Jr, Joseph, Weber, Patricia C., Beyer, Brian M., Ingram, Richard, Hong, Zhi, Prosise, Winifred W., Ramanathan, Lata, Taremi, S. Shane, Yarosh-Tomaine, Taisa, Zhang, Rumin, Senior, Mary, Yang, Rong-Sheng, Malcolm, Bruce, Arasappan, Ashok, Bennett, Frank, Bogen, Stephane L., Chen, Kevin, Jao, Edwin, Liu, Yi-Tsung, Lovey, Raymond G., Saksena, Anil K., Venkatraman, Srikanth, Girijavallabhan, Viyyoor, Njoroge, F. George

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Crystallization of glycosylated human BACE protease domain expressed in Trichoplusia ni von Wang, Wenyan, Reichert, Paul, Beyer, Brian M, Liu, JianJun, Lee, Julie, Zhang, Lili, Liu, Yan-Hui, Taremi, S.Shane, Le, Hung V, Strickland, Corey

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Crystallization and preliminary X-ray analysis of the acyl carrier protein synthase (AcpS) from Staphylococcus aureus von Daubaras, Dayna L., Wilson, Eileen M., Black, Todd, Strickland, Corey, Beyer, Brian M., Orth, Peter

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Application of Fragment-Based NMR Screening, X-ray Crystallography, Structure-Based Design, and Focused Chemical Library Design to Identify Novel [mu]M Leads for the Development of... von Wang, Yu-Sen, Strickland, Corey, Voigt, Johannes H., Kennedy, Matthew E., Beyer, Brian M., Senior, Mary M., Smith, Elizabeth M., Nechuta, Terry L., Madison, Vincent S., Czarniecki, Michael, McKittrick, Brian A., Stamford, Andrew W., Parker, Eric M., Hunter, John C., Greenlee, William J., Wyss, Daniel F.

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A Continuous Spectrophotometric Assay for the Hepatitis C Virus Serine Protease von Zhang, Rumin, Beyer, Brian M., Durkin, James, Ingram, Richard, Njoroge, F.George, Windsor, William T., Malcolm, Bruce A.

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Self-activation of recombinant human lysosomal procathepsin D at a newly engineered cleavage junction, "short" pseudocathepsin D von Beyer, B M, Dunn, B M

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Effect of naturally occurring active site mutations on hepatitis C virus NS3 protease specificity von Beyer, Brian M., Zhang, Rumin, Hong, Zhi, Madison, Vincent, Malcolm, Bruce A.

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Backbone resonance assignments of the 45.3 kDa catalytic domain of human BACE1 von Liu, Dingjiang, Wang, Yu-Sen, Gesell, Jennifer J, Wilson, Eileen, Beyer, Brian M, Wyss, Daniel F

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Prime region subsite specificity characterization of human cathepsin D: The dominant role of position 128 von Beyer, Brian M., Dunn, Ben M.

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Application of fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design to identify novel microM leads for the development o... von Wang, Yu-Sen, Strickland, Corey, Voigt, Johannes H, Kennedy, Matthew E, Beyer, Brian M, Senior, Mary M, Smith, Elizabeth M, Nechuta, Terry L, Madison, Vincent S, Czarniecki, Michael, McKittrick, Brian A, Stamford, Andrew W, Parker, Eric M, Hunter, John C, Greenlee, William J, Wyss, Daniel F

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Self-activation of Recombinant Human Lysosomal Procathepsin D at a Newly Engineered Cleavage Junction, “Short” Pseudocathepsin D von Brian M. Beyer, Ben M. Dunn

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