Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C von Weiss, Andreas, Lorthiois, Edwige, Barys, Louise, Beyer, Kim S, Bomio-Confaglia, Claudio, Burks, Heather, Chen, Xueying, Cui, Xiaoming, de Kanter, Ruben, Dharmarajan, Lekshmi, Fedele, Carmine, Gerspacher, Marc, Guthy, Daniel Alexander, Head, Victoria, Jaeger, Ashley, Núñez, Eloísa Jiménez, Kearns, Jeffrey D, Leblanc, Catherine, Maira, Sauveur-Michel, Murphy, Jason, Oakman, Helen, Ostermann, Nils, Ottl, Johannes, Rigollier, Pascal, Roman, Danielle, Schnell, Christian, Sedrani, Richard, Shimizu, Toshio, Stringer, Rowan, Vaupel, Andrea, Voshol, Hans, Wessels, Peter, Widmer, Toni, Wilcken, Rainer, Xu, Kun, Zecri, Frederic, Farago, Anna F, Cotesta, Simona, Brachmann, Saskia M

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JDQ443, a Structurally Novel, Pyrazole-Based, Covalent Inhibitor of KRASG12C for the Treatment of Solid Tumors von Lorthiois, Edwige, Gerspacher, Marc, Beyer, Kim S., Vaupel, Andrea, Leblanc, Catherine, Stringer, Rowan, Weiss, Andreas, Wilcken, Rainer, Guthy, Daniel A., Lingel, Andreas, Bomio-Confaglia, Claudio, Machauer, Rainer, Rigollier, Pascal, Ottl, Johannes, Arz, Dorothee, Bernet, Pascal, Desjonqueres, Gaëlle, Dussauge, Solene, Kazic-Legueux, Malika, Lozac’h, Marie-Anne, Mura, Christophe, Sorge, Mickaël, Todorov, Milen, Warin, Nicolas, Zink, Florence, Voshol, Hans, Zecri, Frederic J., Sedrani, Richard C., Ostermann, Nils, Brachmann, Saskia M., Cotesta, Simona

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Structure of the MRAS–SHOC2–PP1C phosphatase complex von Hauseman, Zachary J., Fodor, Michelle, Dhembi, Anxhela, Viscomi, Jessica, Egli, David, Bleu, Melusine, Katz, Stephanie, Park, Eunyoung, Jang, Dong Man, Porter, Kathryn A., Meili, Fabian, Guo, Hongqiu, Kerr, Grainne, Mollé, Sandra, Velez-Vega, Camilo, Beyer, Kim S., Galli, Giorgio G., Maira, Saveur-Michel, Stams, Travis, Clark, Kirk, Eck, Michael J., Tordella, Luca, Thoma, Claudio R., King, Daniel A.

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Discovery of Novel Dot1L Inhibitors through a Structure-Based Fragmentation Approach von Chen, Chao, Zhu, Hugh, Stauffer, Frédéric, Caravatti, Giorgio, Vollmer, Susanne, Machauer, Rainer, Holzer, Philipp, Möbitz, Henrik, Scheufler, Clemens, Klumpp, Martin, Tiedt, Ralph, Beyer, Kim S, Calkins, Keith, Guthy, Daniel, Kiffe, Michael, Zhang, Jeff, Gaul, Christoph

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Optimization of a Fragment-Based Screening Hit toward Potent DOT1L Inhibitors Interacting in an Induced Binding Pocket von Scheufler, Clemens, Möbitz, Henrik, Gaul, Christoph, Ragot, Christian, Be, Céline, Fernández, César, Beyer, Kim S, Tiedt, Ralph, Stauffer, Frédéric

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Discovery of Potent, Selective, and Structurally Novel Dot1L Inhibitors by a Fragment Linking Approach von Möbitz, Henrik, Machauer, Rainer, Holzer, Philipp, Vaupel, Andrea, Stauffer, Frédéric, Ragot, Christian, Caravatti, Giorgio, Scheufler, Clemens, Fernandez, Cesar, Hommel, Ulrich, Tiedt, Ralph, Beyer, Kim S, Chen, Chao, Zhu, Hugh, Gaul, Christoph

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JDQ443, a Structurally Novel, Pyrazole-Based, Covalent Inhibitor of KRAS G12C for the Treatment of Solid Tumors von Lorthiois, Edwige, Gerspacher, Marc, Beyer, Kim S, Vaupel, Andrea, Leblanc, Catherine, Stringer, Rowan, Weiss, Andreas, Wilcken, Rainer, Guthy, Daniel A, Lingel, Andreas, Bomio-Confaglia, Claudio, Machauer, Rainer, Rigollier, Pascal, Ottl, Johannes, Arz, Dorothee, Bernet, Pascal, Desjonqueres, Gaëlle, Dussauge, Solene, Kazic-Legueux, Malika, Lozac'h, Marie-Anne, Mura, Christophe, Sorge, Mickaël, Todorov, Milen, Warin, Nicolas, Zink, Florence, Voshol, Hans, Zecri, Frederic J, Sedrani, Richard C, Ostermann, Nils, Brachmann, Saskia M, Cotesta, Simona

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New Potent DOT1L Inhibitors for in Vivo Evaluation in Mouse von Stauffer, Frédéric, Weiss, Andreas, Scheufler, Clemens, Möbitz, Henrik, Ragot, Christian, Beyer, Kim S, Calkins, Keith, Guthy, Daniel, Kiffe, Michael, Van Eerdenbrugh, Bernard, Tiedt, Ralph, Gaul, Christoph

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Influence of Biodentine® - A Dentine Substitute - On Collagen Type I Synthesis in Pulp Fibroblasts In Vitro von Nikfarjam, Frangis, Beyer, Kim, König, Anke, Hofmann, Matthias, Butting, Manuel, Valesky, Eva, Kippenberger, Stefan, Kaufmann, Roland, Heidemann, Detlef, Bernd, August, Zöller, Nadja Nicole

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A Mutation Hot Spot for Nonspecific X-Linked Mental Retardation in the MECP2 Gene Causes the PPM-X Syndrome von Klauck, Sabine M., Lindsay, Susan, Beyer, Kim S., Splitt, Miranda, Burn, John, Poustka, Annemarie

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A comparative study of fragment screening methods on the p38α kinase: new methods, new insights von Pollack, Scott J., Beyer, Kim S., Lock, Christopher, Müller, Ilka, Sheppard, David, Lipkin, Mike, Hardick, David, Blurton, Peter, Leonard, Philip M., Hubbard, Paul A., Todd, Daniel, Richardson, Christine M., Ahrens, Thomas, Baader, Manuel, Hafenbradl, Doris O., Hilyard, Kate, Bürli, Roland W.

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Mediator Subunit MED28 (Magicin) Is a Repressor of Smooth Muscle Cell Differentiation von Beyer, Kim S., Beauchamp, Roberta L., Lee, Ming-Fen, Gusella, James F., Näär, Anders M., Ramesh, Vijaya

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Mutation analysis of the coding sequence of the MECP2 gene in infantile autism von BEYER, Kim S, BLASI, Francesca, BACCHELLI, Elena, KLAUCK, Sabine M, MAESTRINI, Elena, POUSTKA, Annemarie

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FARP2, HDLBP and PASK are downregulated in a patient with autism and 2q37.3 deletion syndrome von Felder, Bärbel, Radlwimmer, Bernhard, Benner, Axel, Mincheva, Antoaneta, Tödt, Grischa, Beyer, Kim S., Schuster, Claudia, Bölte, Sven, Schmötzer, Gabriele, Klauck, Sabine M., Poustka, Fritz, Lichter, Peter, Poustka, Annemarie

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Magicin associates with the Src-family kinases and is phosphorylated upon CD3 stimulation von Lee, Ming-Fen, Beauchamp, Roberta L., Beyer, Kim S., Gusella, James F., Ramesh, Vijaya

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Abstract 1770: A new DOT1L inhibitor with in vivo activity in mouse models of MLL-translocated leukemia von Weiss, Andreas, Stauffer, Frederic, Clemens, Clemens, Möbitz, Henrik, Ragot, Christian, Beyer, Kim S., Calkins, Keith, Thoma, Claudio, Guthy, Daniel, Kiffe, Michael, Van Eerdenbrugh, Bernard, Sellers, William R., Hofmann, Francesco, Tiedt, Ralph, Gaul, Christoph

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Abstract P124: JDQ443, a covalent irreversible inhibitor of KRAS G12C, exhibits a novel binding mode and demonstrates potent anti-tumor activity and favorable pharmacokinetic prope... von Brachmann, Saskia M., Weiss, Andreas, Guthy, Daniel A., Beyer, Kim, Voshol, Johannes, Maira, Michel, Prahallad, Anirudh, Porta, Diana Graus, Schnell, Christian, Ostermann, Nils, Vaupel, Andrea, Gerspacher, Marc, Leblanc, Catherine, Erdmann, Dirk, Sterker, Dario, Kerr, Grainne, Jerome, Giovannoni, Head, Victoria, Stringer, Rowan, De Kanter, Ruben, Jeff, Kearns, Roman, Danielle, Widmer, Toni, Wessels, Peter, Nunez, Eloisa Jimenez, Sedrani, Richard, Zecri, Frederic, Hofmann, Francesco, Engleman, Jeff, Lorthiois, Edwige, Cotesta, Simona

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Influence of Biodentine.sup.® - A Dentine Substitute - On Collagen Type I Synthesis in Pulp Fibroblasts In Vitro von Nikfarjam, Frangis, Beyer, Kim, König, Anke, Hofmann, Matthias, Butting, Manuel, Valesky, Eva, Kippenberger, Stefan, Kaufmann, Roland, Heidemann, Detlef, Bernd, August, Zöller, Nadja Nicole

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Dynamic conformational equilibria in the active states of KRAS and NRAS von Rennella, Enrico, Georgescauld, Florian, Wales, Thomas E., Erdmann, Dirk, Maira, Michel, Sedrani, Richard, Brachmann, Saskia M., Ostermann, Nils, Engen, John R., Beyer, Kim Stefanie, Wilcken, Rainer, Jahnke, Wolfgang, Henry, Christelle, Dickson, Callum J., Cotesta, Simona, Kay, Lewis E.

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Association studies of the HOPA dodecamer duplication variant in different subtypes of autism von Beyer, Kim S., Klauck, Sabine M., Benner, Axel, Poustka, Fritz, Poustka, Annemarie

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