A selective nonpeptide somatostatin receptor 5 agonist effectively decreases insulin secretion in hyperinsulinism von Juliana, Christine A., Chai, Jinghua, Arroyo, Pablo, Rico-Bautista, Elizabeth, Betz, Stephen F., De León, Diva D.

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Somatostatin receptors in congenital hyperinsulinism: Biology to bedside von van Albada, Mirjam E, Mohnike, Klaus, Dunne, Mark J, Banerjee, Indi, Betz, Stephen F

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In Vitro Pharmacological Characterization of CRN04894: The First Reported Oral, Selective Nonpeptide Melanocortin 2 Receptor Antagonist Evaluated in Phase 1 First‐in‐Human Clinical... von Nguyen, Julie B., Kusnetzow, Ana K., Reinhart, Greg, Kim, Sun Hee, Struthers, R. S., Zhu, Yun Fei, Betz, Stephen F.

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Discovery of substituted 3H-pyrido[2,3-d]pyrimidin-4-ones as potent, biased, and orally bioavailable sst2 agonist von Zhao, Jian, Chen, Zhiyong, Kusnetzow, Ana Karin, Nguyen, Julie, Rico-Bautista, Elizabeth, Tan, Hannah, Betz, Stephen F., Struthers, R. Scott, Zhu, Yunfei

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Paltusotine, a novel oral once-daily nonpeptide SST2 receptor agonist, suppresses GH and IGF-1 in healthy volunteers von Madan, Ajay, Markison, Stacy, Betz, Stephen F., Krasner, Alan, Luo, Rosa, Jochelson, Theresa, Lickliter, Jason, Struthers, R. Scott

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Discovery of CRN04894: A Novel Potent Selective MC2R Antagonist von Kim, Sun Hee, Han, Sangdon, Zhao, Jian, Wang, Shimiao, Kusnetzow, Ana Karin, Reinhart, Greg, Fowler, Melissa A., Markison, Stacy, Johns, Michael, Luo, Rosa, Struthers, R. Scott, Zhu, Yunfei, Betz, Stephen F.

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Discovery of Paltusotine (CRN00808), a Potent, Selective, and Orally Bioavailable Non-peptide SST2 Agonist von Zhao, Jian, Wang, Shimiao, Markison, Stacy, Kim, Sun Hee, Han, Sangdon, Chen, Mi, Kusnetzow, Ana Karin, Rico-Bautista, Elizabeth, Johns, Michael, Luo, Rosa, Struthers, R. Scott, Madan, Ajay, Zhu, Yunfei, Betz, Stephen F.

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Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain von Fesik, Stephen W, Liu, Zhihong, Sun, Chaohong, Olejniczak, Edward T, Meadows, Robert P, Betz, Stephen F, Oost, Thorsten, Herrmann, Julia, Wu, Joe C

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Discovery of nonpeptide 3,4-dihydroquinazoline-4-carboxamides as potent and selective sst2 agonists von Zhao, Jian, Wang, Shimiao, Han, Sangdon, Kim, Sun Hee, Kusnetzow, Ana Karin, Nguyen, Julie, Rico-Bautista, Elizabeth, Tan, Hannah, Betz, Stephen F., Scott Struthers, R., Zhu, Yunfei

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Discovery of 4-(3-aminopyrrolidinyl)-3-aryl-5-(benzimidazol-2-yl)-pyridines as potent and selective SST5 agonists for the treatment of congenital hyperinsulinism von Zhao, Jian, Wang, Shimiao, Hee Kim, Sun, Han, Sangdon, Rico-Bautista, Elizabeth, Sturchler, Emmanuel, Nguyen, Julie, Tan, Hannah, Staley, Christine, Karin Kusnetzow, Ana, Betz, Stephen F., Johns, Michael, Goulet, Lance, Luo, Rosa, Fowler, Melissa, Athanacio, Jon, Markison, Stacy, Scott Struthers, R., Zhu, Yunfei

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1182-P: A Selective Nonpeptide Somatostatin Receptor 5 (sst5) Agonist Effectively Decreases Insulin Secretion in the KATPHI Mouse Model von JULIANA, CHRISTINE, CHAI, JINGHUA, RICO-BAUTISTA, ELIZABETH F., BETZ, STEPHEN F., DE LEON, DIVA D.

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Discovery of Potent Antagonists of the Antiapoptotic Protein XIAP for the Treatment of Cancer von Oost, Thorsten K, Sun, Chaohong, Armstrong, Robert C, Al-Assaad, Ali-Samer, Betz, Stephen F, Deckwerth, Thomas L, Ding, Hong, Elmore, Steven W, Meadows, Robert P, Olejniczak, Edward T, Oleksijew, Andrew, Oltersdorf, Tilman, Rosenberg, Saul H, Shoemaker, Alexander R, Tomaselli, Kevin J, Zou, Hua, Fesik, Stephen W

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The Crystal Structure of a Quercetin 2,3-Dioxygenase from Bacillus subtilis Suggests Modulation of Enzyme Activity by a Change in the Metal Ion at the Active Site(s) von Gopal, B, Madan, Lalima L, Betz, Stephen F, Kossiakoff, Anthony A

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Non-Peptide Gonadotropin-Releasing Hormone Receptor Antagonists von Betz, Stephen F, Zhu, Yun-Fei, Chen, Chen, Struthers, R. Scott

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Protein Design: A Hierarchic Approach von Bryson, James W., Betz, Stephen F., Lu, Helen S., Suich, Daniel J., Zhou, Hongxing X., O'Neil, Karyn T., DeGrado, William F.

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Disulfide bonds and the stability of globular proteins von Betz, Stephen F.

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Single amino acid residue determinants of non-peptide antagonist binding to the corticotropin-releasing factor1 (CRF1) receptor von HOARE, Sam R. J, BROWN, Brock T, SANTOS, Mark A, MALANY, Siobhan, BETZ, Stephen F, GRIGORIADIS, Dimitri E

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Overlapping, Nonidentical Binding Sites of Different Classes of Nonpeptide Antagonists for the Human Gonadotropin-Releasing Hormone Receptor von Betz, Stephen F, Reinhart, Greg J, Lio, Francisco M, Chen, Struthers, R. Scott

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Non-peptidic small molecule inhibitors of XIAP von Park, Cheol-Min, Sun, Chaohong, Olejniczak, Edward T., Wilson, Alan E., Meadows, Robert P., Betz, Stephen F., Elmore, Steven W., Fesik, Stephen W.

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Discovery of Potent Inhibitors of Dihydroneopterin Aldolase Using CrystaLEAD High-Throughput X-ray Crystallographic Screening and Structure-Directed Lead Optimization von Sanders, William J, Nienaber, Vicki L, Lerner, Claude G, McCall, J. Owen, Merrick, Sean M, Swanson, Susan J, Harlan, John E, Stoll, Vincent S, Stamper, Geoffrey F, Betz, Stephen F, Condroski, Kevin R, Meadows, Robert P, Severin, Jean M, Walter, Karl A, Magdalinos, Peter, Jakob, Clarissa G, Wagner, Rolf, Beutel, Bruce A

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