A Highly Durable RNAi Therapeutic Inhibitor of PCSK9 von Fitzgerald, Kevin, White, Suellen, Borodovsky, Anna, Bettencourt, Brian R, Strahs, Andrew, Clausen, Valerie, Wijngaard, Peter, Horton, Jay D, Taubel, Jorg, Brooks, Ashley, Fernando, Chamikara, Kauffman, Robert S, Kallend, David, Vaishnaw, Akshay, Simon, Amy

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An Investigational RNAi Therapeutic Targeting Glycolate Oxidase Reduces Oxalate Production in Models of Primary Hyperoxaluria von Liebow, Abigail, Li, Xingsheng, Racie, Timothy, Hettinger, Julia, Bettencourt, Brian R, Najafian, Nader, Haslett, Patrick, Fitzgerald, Kevin, Holmes, Ross P, Erbe, David, Querbes, William, Knight, John

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Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a... von Fitzgerald, Kevin, Dr, Frank-Kamenetsky, Maria, PhD, Shulga-Morskaya, Svetlana, MSc, Liebow, Abigail, BS, Bettencourt, Brian R, PhD, Sutherland, Jessica E, PhD, Hutabarat, Renta M, PhD, Clausen, Valerie A, PhD, Karsten, Verena, PhD, Cehelsky, Jeffrey, MBA, Nochur, Saraswathy V, PhD, Kotelianski, Victor, MD, Horton, Jay, MD, Mant, Timothy, MD, Chiesa, Joseph, MD, Ritter, James, MD, Munisamy, Malathy, MD, Vaishnaw, Akshay K, MD, Gollob, Jared A, MD, Simon, Amy, MD

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Clinical Proof of Concept for a Novel Hepatocyte-Targeting GalNAc-siRNA Conjugate von Zimmermann, Tracy S., Karsten, Verena, Chan, Amy, Chiesa, Joseph, Boyce, Malcolm, Bettencourt, Brian R., Hutabarat, Renta, Nochur, Saraswathy, Vaishnaw, Akshay, Gollob, Jared

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Efficacy and safety of patisiran for familial amyloidotic polyneuropathy: a phase II multi-dose study von Suhr, Ole B, Coelho, Teresa, Buades, Juan, Pouget, Jean, Conceicao, Isabel, Berk, John, Schmidt, Hartmut, Waddington-Cruz, Márcia, Campistol, Josep M, Bettencourt, Brian R, Vaishnaw, Akshay, Gollob, Jared, Adams, David

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ALN-RSV01 for prevention of bronchiolitis obliterans syndrome after respiratory syncytial virus infection in lung transplant recipients von Gottlieb, Jens, MD, Zamora, Martin R., MD, Hodges, Tony, MD, Musk, A.W., MD, Sommerwerk, Urte, MD, Dilling, Daniel, MD, FACP, Arcasoy, Selim, MD, DeVincenzo, John, MD, Karsten, Verena, PhD, Shah, Shaily, Bettencourt, Brian R., PhD, Cehelsky, Jeffrey, MBA, Nochur, Sara, PhD, Gollob, Jared, MD, Vaishnaw, Akshay, MD, Simon, Amy R., MD, Glanville, Allan R., MD, MBBS

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An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe−/− mice and ameliorates anemia and iron overload in murine β-thalassemia intermedia von Schmidt, Paul J., Toudjarska, Iva, Sendamarai, Anoop K., Racie, Tim, Milstein, Stuart, Bettencourt, Brian R., Hettinger, Julia, Bumcrot, David, Fleming, Mark D.

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Spider phylosymbiosis: divergence of widow spider species and their tissues' microbiomes von Dunaj, Sara J, Bettencourt, Brian R, Garb, Jessica E, Brucker, Robert M

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Rapid progression of familial amyloidotic polyneuropathy: A multinational natural history study von Adams, David, Coelho, Teresa, Obici, Laura, Merlini, Giampaolo, Mincheva, Zoia, Suanprasert, Narupat, Bettencourt, Brian R, Gollob, Jared A, Gandhi, Pritesh J, Litchy, William J, Dyck, Peter J

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Inducible and constitutive heat shock gene expression responds to modification of Hsp70 copy number in Drosophila melanogaster but does not compensate for loss of thermotolerance i... von Bettencourt, Brian R, Hogan, Catherine C, Nimali, Mario, Drohan, Brian W

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Safety and Efficacy of RNAi Therapy for Transthyretin Amyloidosis von Coelho, Teresa, Adams, David, Silva, Ana, Lozeron, Pierre, Hawkins, Philip N, Mant, Timothy, Perez, Javier, Chiesa, Joseph, Warrington, Steve, Tranter, Elizabeth, Munisamy, Malathy, Falzone, Rick, Harrop, Jamie, Cehelsky, Jeffrey, Bettencourt, Brian R, Geissler, Mary, Butler, James S, Sehgal, Alfica, Meyers, Rachel E, Chen, Qingmin, Borland, Todd, Hutabarat, Renta M, Clausen, Valerie A, Alvarez, Rene, Fitzgerald, Kevin, Gamba-Vitalo, Christina, Nochur, Saraswathy V, Vaishnaw, Akshay K, Sah, Dinah W.Y, Gollob, Jared A, Suhr, Ole B

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Evolution of proteins and gene expression levels are coupled in Drosophila and are independently associated with mRNA abundance, protein length, and number of protein-protein inter... von Lemos, Bernardo, Bettencourt, Brian R, Meiklejohn, Colin D, Hartl, Daniel L

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Organization and evolution of hsp70 clusters strikingly differ in two species of Stratiomyidae (Diptera) inhabiting thermally contrasting environments von Garbuz, David G, Yushenova, Irina A, Zatsepina, Olga G, Przhiboro, Andrey A, Bettencourt, Brian R, Evgen'ev, Michael B

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Natural variation of the amino-terminal glutamine-rich domain in Drosophila argonaute2 is not associated with developmental defects von Hain, Daniel, Bettencourt, Brian R, Okamura, Katsutomo, Csorba, Tibor, Meyer, Wibke, Jin, Zhigang, Biggerstaff, Jason, Siomi, Haruhiko, Hutvagner, Gyorgy, Lai, Eric C, Welte, Michael, Müller, H-Arno J

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Compensated deleterious mutations in insect genomes von Kulathinal, R.J, Bettencourt, B.R, Hartl, D.L

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In vivo quantification of formulated and chemically modified small interfering RNA by heating-in-Triton quantitative reverse transcription polymerase chain reaction (HIT qRT-PCR) von Landesman, Yosef, Svrzikapa, Nenad, Cognetta, 3rd, Armand, Zhang, Xuemei, Bettencourt, Brian R, Kuchimanchi, Satya, Dufault, Keri, Shaikh, Sarfraz, Gioia, Maple, Akinc, Akin, Hutabarat, Renta, Meyers, Rachel

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Annotation of the Drosophila melanogastereuchromatic genome: a systematic review von Misra, Sima, Crosby, Madeline A, Mungall, Christopher J, Matthews, Beverley B, Campbell, Kathryn S, Hradecky, Pavel, Huang, Yanmei, Kaminker, Joshua S, Millburn, Gillian H, Prochnik, Simon E, Smith, Christopher D, Tupy, Jonathan L, Whitfield, Eleanor J, Bayraktaroglu, Leyla, Berman, Benjamin P, Bettencourt, Brian R, Celniker, Susan E, de Grey, Aubrey DNJ, Drysdale, Rachel A, Harris, Nomi L, Richter, John, Russo, Susan, Schroeder, Andrew J, Shu, ShengQiang, Stapleton, Mark, Yamada, Chihiro, Ashburner, Michael, Gelbart, William M, Rubin, Gerald M, Lewis, Suzanna E

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Rotationally Constrained 2,4-Diamino-5,6-disubstituted Pyrimidines: A New Class of Histamine H4 Receptor Antagonists with Improved Druglikeness and in Vivo Efficacy in Pain and Inf... von Cowart, Marlon D, Altenbach, Robert J, Liu, Huaqing, Hsieh, Gin C, Drizin, Irene, Milicic, Ivan, Miller, Thomas R, Witte, David G, Wishart, Neil, Fix-Stenzel, Shannon R, McPherson, Michael J, Adair, Ronald M, Wetter, Jill M, Bettencourt, Brian M, Marsh, Kennan C, Sullivan, James P, Honore, Prisca, Esbenshade, Timothy A, Brioni, Jorge D

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Mapping Genotype Distributions in the Unisexual Ambystoma Complex von Charney, Noah D, Ireland, Andrea T, Bettencourt, Brian R

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Rapid concerted evolution via gene conversion at the Drosophila hsp70 genes von Bettencourt, Brian R, Feder, Martin E

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