Monoclonal antibodies to the myeloid stem cells : therapeutic implications of CMA-676, a humanized anti-CD33 antibody calicheamicin conjugate von BERNSTEIN, I. D

Volltext

Dose-dependent effects of the Notch ligand Delta1 on ex vivo differentiation and in vivo marrow repopulating ability of cord blood cells von Delaney, Colleen, Varnum-Finney, Barbara, Aoyama, Keisuke, Brashem-Stein, Carolyn, Bernstein, Irwin D.

Volltext

Combined effects of Notch signaling and cytokines induce a multiple log increase in precursors with lymphoid and myeloid reconstituting ability von Varnum-Finney, Barbara, Brashem-Stein, Carolyn, Bernstein, Irwin D.

Volltext

Final report of the efficacy and safety of gemtuzumab ozogamicin (Mylotarg) in patients with CD33‐positive acute myeloid leukemia in first recurrence von Larson, Richard A., Sievers, Eric L., Stadtmauer, Edward A., Löwenberg, Bob, Estey, Elihu H., Dombret, Hervé, Theobald, Matthias, Voliotis, Dimitris, Bennett, John M., Richie, Maria, Leopold, Lance H., Berger, Mark S., Sherman, Matthew L., Loken, Michael R., van Dongen, Jacques J. M., Bernstein, Irwin D., Appelbaum, Frederick R.

Volltext

The SmoA1 mouse model reveals that Notch signaling is critical for the growth and survival of Sonic hedgehog-induced medulloblastomas von HALLAHAN, Andrew R, PRITCHARD, Joel I, OLSON, James M, HANSEN, Stacey, BENSON, Mark, STOECK, Jennifer, HATTON, Beryl A, RUSSELL, Thomas L, ELLENBOGEN, Richard G, BERNSTEIN, Irwin D, BEACHY, Phillip A

Volltext

Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling von Varnum-Finney, Barbara, Xu, Lanwei, Brashem-Stein, Carolyn, Nourigat, Cynthia, Flowers, David, Bakkour, Sonia, Pear, Warren S, Bernstein, Irwin D

Volltext

Prevalence and prognostic significance of Flt3 internal tandem duplication in pediatric acute myeloid leukemia von Meshinchi, Soheil, Woods, William G., Stirewalt, Derek L., Sweetser, David A., Buckley, Jonathan D., Tjoa, Thomas K., Bernstein, Irwin D., Radich, Jerald P.

Volltext

Influence of CD33 expression levels and ITIM-dependent internalization on gemtuzumab ozogamicin–induced cytotoxicity von Walter, Roland B., Raden, Brian W., Kamikura, Darren M., Cooper, Jonathan A., Bernstein, Irwin D.

Volltext

Notch signalling in hematopoiesis von Ohishi, K., Katayama, N., Shiku, H., Varnum-Finney, B., Bernstein, I.D.

Volltext

Density of the Notch ligand Delta1 determines generation of B and T cell precursors from hematopoietic stem cells von Dallas, Mari H, Varnum-Finney, Barbara, Delaney, Colleen, Kato, Keizo, Bernstein, Irwin D

Volltext

Targeting of the CD33-calicheamicin immunoconjugate Mylotarg (CMA-676) in acute myeloid leukemia: in vivo and in vitro saturation and internalization by leukemic and normal myeloid... von van der Velden, Vincent H.J., te Marvelde, Jeroen G., Hoogeveen, Patricia G., Bernstein, Irwin D., Houtsmuller, Adriaan B., Berger, Mark S., van Dongen, Jacques J.M.

Volltext

Immobilization of Notch ligand, Delta-1, is required for induction of notch signaling von Varnum-Finney, B, Wu, L, Yu, M, Brashem-Stein, C, Staats, S, Flowers, D, Griffin, J D, Bernstein, I D

Volltext

High-dose radioimmunotherapy versus conventional high-dose therapy and autologous hematopoietic stem cell transplantation for relapsed follicular non-Hodgkin lymphoma: a multivaria... von Gopal, Ajay K., Gooley, Theodore A., Maloney, David G., Petersdorf, Stephen H., Eary, Janet F., Rajendran, Joseph G., Bush, Sharon A., Durack, Lawrence D., Golden, Jane, Martin, Paul J., Matthews, Dana C., Appelbaum, Frederick R., Bernstein, Irwin D., Press, Oliver W.

Volltext

Selective Ablation of Acute Myeloid Leukemia Using Antibody-Targeted Chemotherapy: A Phase I Study of an Anti-CD33 Calicheamicin Immunoconjugate von Sievers, E.L., Appelbaum, F.R., Spielberger, R.T., Forman, S.J., Flowers, D., Smith, F.O., Shannon-Dorcy, K., Berger, M.S., Bernstein, I.D.

Volltext

Immunophenotypic evidence of leukemia after induction therapy predicts relapse: results from a prospective Children's Cancer Group study of 252 patients with acute myeloid leukemia von Sievers, Eric L., Lange, Beverly J., Alonzo, Todd A., Gerbing, Robert B., Bernstein, Irwin D., Smith, Franklin O., Arceci, Robert J., Woods, William G., Loken, Michael R.

Volltext

Activating mutations of RTK/ras signal transduction pathway in pediatric acute myeloid leukemia von Meshinchi, Soheil, Stirewalt, Derek L., Alonzo, Todd A., Zhang, Quangeng, Sweetser, David A., Woods, William G., Bernstein, Irwin D., Arceci, Robert J., Radich, Jerald P.

Volltext

Multidrug resistance protein attenuates gemtuzumab ozogamicin–induced cytotoxicity in acute myeloid leukemia cells von Walter, Roland B., Raden, Brian W., Hong, Tom C., Flowers, David A., Bernstein, Irwin D., Linenberger, Michael L.

Volltext

Multidrug-resistance phenotype and clinical responses to gemtuzumab ozogamicin von Linenberger, Michael L., Hong, Tom, Flowers, David, Sievers, Eric L., Gooley, Ted A., Bennett, John M., Berger, Mark S., Leopold, Lance H., Appelbaum, Frederick R., Bernstein, Irwin D.

Volltext

High-dose chemo-radioimmunotherapy with autologous stem cell support for relapsed mantle cell lymphoma von Gopal, Ajay K., Rajendran, Joseph G., Petersdorf, Stephen H., Maloney, David G., Eary, Janet F., Wood, Brent L., Gooley, Theodore A., Bush, Sharon A., Durack, Lawrence D., Martin, Paul J., Matthews, Dana C., Appelbaum, Frederick R., Bernstein, Irwin D., Press, Oliver W.

Volltext

Monoclonal Antibody-Based Therapies of Leukemia and Lymphoma von Grossbard, Michael L., Press, Oliver W., Appelbaum, Frederick R., Bernstein, Irwin D., Nadler, Lee M.

Volltext