CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer von Sanij, Elaine, Hannan, Katherine M., Xuan, Jiachen, Yan, Shunfei, Ahern, Jessica E., Trigos, Anna S., Brajanovski, Natalie, Son, Jinbae, Chan, Keefe T., Kondrashova, Olga, Lieschke, Elizabeth, Wakefield, Matthew J., Frank, Daniel, Ellis, Sarah, Cullinane, Carleen, Kang, Jian, Poortinga, Gretchen, Nag, Purba, Deans, Andrew J., Khanna, Kum Kum, Mileshkin, Linda, McArthur, Grant A., Soong, John, Berns, Els M. J. J., Hannan, Ross D., Scott, Clare L., Sheppard, Karen E., Pearson, Richard B.

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The Changing View of High-Grade Serous Ovarian Cancer von BERNS, Els M. J. J, BOWTELL, David D

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miR-634 restores drug sensitivity in resistant ovarian cancer cells by targeting the Ras-MAPK pathway von van Jaarsveld, Marijn T M, van Kuijk, Patricia F, Boersma, Antonius W M, Helleman, Jozien, van IJcken, Wilfred F, Mathijssen, Ron H J, Pothof, Joris, Berns, Els M J J, Verweij, Jaap, Wiemer, Erik A C

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Hallmarks of Aromatase Inhibitor Drug Resistance Revealed by Epigenetic Profiling in Breast Cancer von JANSEN, Maurice P. H. M, KNIJNENBURG, Theo, FOEKENS, John A, WESSELS, Lodewyk, LINN, Sabine C, BERNS, Els M. J. J, ZWART, Wilbert, REIJM, Esther A, SIMON, Iris, KERKHOVEN, Ron, DROOG, Marjolein, VELDS, Arno, VAN LAERE, Steven, DIRIX, Luc, ALEXI, Xanthippi

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Ovarian cancer cell line panel (OCCP): clinical importance of in vitro morphological subtypes von Beaufort, Corine M, Helmijr, Jean C A, Piskorz, Anna M, Hoogstraat, Marlous, Ruigrok-Ritstier, Kirsten, Besselink, Nicolle, Murtaza, Muhammed, van IJcken, Wilfred F J, Heine, Anouk A J, Smid, Marcel, Koudijs, Marco J, Brenton, James D, Berns, Els M J J, Helleman, Jozien

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Correlation of breast cancer susceptibility loci with patient characteristics, metastasis-free survival, and mRNA expression of the nearest genes von Riaz, Muhammad, Berns, Els M. J. J., Sieuwerts, Anieta M., Ruigrok-Ritstier, Kirsten, de Weerd, Vanja, Groenewoud, Arwin, Uitterlinden, Andrè G., Look, Maxime P., Klijn, Jan G. M., Sleijfer, Stefan, Foekens, John A., Martens, John W. M.

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Intra-Gene DNA Methylation Variability Is a Clinically Independent Prognostic Marker in Women's Cancers von Bartlett, Thomas E, Jones, Allison, Goode, Ellen L, Fridley, Brooke L, Cunningham, Julie M, Berns, Els M J J, Wik, Elisabeth, Salvesen, Helga B, Davidson, Ben, Trope, Claes G, Lambrechts, Sandrina, Vergote, Ignace, Widschwendter, Martin

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TP53 Mutations in Serum Circulating Cell-Free Tumor DNA As Longitudinal Biomarker for High-Grade Serous Ovarian Cancer von Vitale, Silvia R., Groenendijk, Floris H., van Marion, Ronald, Beaufort, Corine M., Helmijr, Jean C., Dubbink, Hendrikus Jan, Dinjens, Winand N. M., Ewing-Graham, Patricia C., Smolders, Ramon, van Doorn, Helena C., Boere, Ingrid A., Berns, Els M. J. J., Helleman, Jozien, Jansen, Maurice P. H. M.

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Hotspot mutations in PIK3CA associate with first-line treatment outcome for aromatase inhibitors but not for tamoxifen von Ramirez-Ardila, Diana E., Helmijr, Jean C., Look, Maxime P., Lurkin, Irene, Ruigrok-Ritstier, Kirsten, van Laere, Steven, Dirix, Luc, Sweep, Fred C., Span, Paul N., Linn, Sabine C., Foekens, John A., Sleijfer, Stefan, Berns, Els M. J. J., Jansen, Maurice P. H. M.

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IGF1R signaling drives antiestrogen resistance through PAK2/PIX activation in luminal breast cancer von Zhang, Yinghui, Wester, Lynn, He, Jichao, Geiger, Tamar, Moerkens, Marja, Siddappa, Ram, Helmijr, Jean A., Timmermans, Mieke M., Look, Maxime P., van Deurzen, Caroline H. M., Martens, John W. M., Pont, Chantal, de Graauw, Marjo, Danen, Erik H. J., Berns, Els M. J. J., Meerman, John H. N., Jansen, Maurice P. H. M., van de Water, Bob

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An 8-gene mRNA expression profile in circulating tumor cells predicts response to aromatase inhibitors in metastatic breast cancer patients von Reijm, Esther A, Sieuwerts, Anieta M, Smid, Marcel, Vries, Joan Bolt-de, Mostert, Bianca, Onstenk, Wendy, Peeters, Dieter, Dirix, Luc Y, Seynaeve, Caroline M, Jager, Agnes, de Jongh, Felix E, Hamberg, Paul, van Galen, Anne, Kraan, Jaco, Jansen, Maurice P H M, Gratama, Jan W, Foekens, John A, Martens, John W M, Berns, Els M J J, Sleijfer, Stefan

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HOXB13-to-IL17BR Expression Ratio Is Related With Tumor Aggressiveness and Response to Tamoxifen of Recurrent Breast Cancer: A Retrospective Study von JANSEN, Maurice P. H. M, SIEUWERTS, Anieta M, LOOK, Maxime P, RITSTIER, Kirsten, MEIJER-VAN GELDER, Marion E, VAN STAVEREN, Iris L, KLIJN, Jan G. M, FOEKENS, John A, BERNS, Els M. J. J

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Thirteen new p53 gene mutants identified among 41 human breast cancer cell lines von WASIELEWSKI, Marijke, ELSTRODT, Fons, KLIJN, Jan G. M, BERNS, Els M. J. J, SCHUTTE, Mieke

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Comparison of gene expression profiles predicting progression in breast cancer patients treated with tamoxifen von Kok, Marleen, Linn, Sabine C., Van Laar, Ryan K., Jansen, Maurice P. H. M., van den Berg, Teun M., Delahaye, Leonie J. M. J., Glas, Annuska M., Peterse, Johannes L., Hauptmann, Michael, Foekens, John A., Klijn, Jan G. M., Wessels, Lodewyk F. A., Van’t Veer, Laura J., Berns, Els M. J. J.

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Sensitivity to systemic therapy for metastatic breast cancer in CHEK2 1100delC mutation carriers von Kriege, Mieke, Jager, Agnes, Hollestelle, Antoinette, Berns, Els M. J. J., Blom, Jannet, Meijer-van Gelder, Marion E., Sieuwerts, Anieta M., van den Ouweland, Ans, Collée, J. Margriet, Kroep, Judith R., Martens, John W. M., Hooning, Maartje J., Seynaeve, Caroline

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Circulating HPV DNA as a Marker for Early Detection of Relapse in Patients with Cervical Cancer von Jeannot, Emmanuelle, Latouche, Aurelien, Bonneau, Claire, Calmejane, Marie-Ange, Beaufort, Corine, Ruigrok-Ritstier, Kirsten, Bataillon, Guillaume, Cherif, Linda Larbi, Dupain, Celia, Lecerf, Charlotte, Popovic, Marina, de la Rochefordiere, Anne, Lecuru, Fabrice, Fourchotte, Virginie, Jordanova, Ekaterina S., von der Leyen, Heiko, Tran-Perennou, Carine, Legrier, Marie-Emmanuelle, Dureau, Sylvain, Raizonville, Laurence, Roufai, Diana Bello, Le Tourneau, Christophe, Bieche, Ivan, Rouzier, Roman, Berns, Els M. J. J., Kamal, Maud, Scholl, Suzy

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Epidermal Growth Factor Receptor (EGFR) Pathway Biomarkers in the Randomized Phase III Trial of Erlotinib Versus Observation in Ovarian Cancer Patients with No Evidence of Disease... von Despierre, Evelyn, Vergote, Ignace, Anderson, Ryan, Coens, Corneel, Katsaros, Dionyssios, Hirsch, Fred R., Boeckx, Bram, Varella-Garcia, Marileila, Ferrero, Annamaria, Ray-Coquard, Isabelle, Berns, Els M. J. J., Casado, Antonio, Lambrechts, Diether, Jimeno, Antonio

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Human papilloma virus (HPV) integration signature in Cervical Cancer: identification of MACROD2 gene as HPV hot spot integration site von Kamal, Maud, Lameiras, Sonia, Deloger, Marc, Morel, Adeline, Vacher, Sophie, Lecerf, Charlotte, Dupain, Célia, Jeannot, Emmanuelle, Girard, Elodie, Baulande, Sylvain, Dubot, Coraline, Kenter, Gemma, Jordanova, Ekaterina S., Berns, Els M. J. J., Bataillon, Guillaume, Popovic, Marina, Rouzier, Roman, Cacheux, Wulfran, Le Tourneau, Christophe, Nicolas, Alain, Servant, Nicolas, Scholl, Suzy M., Bièche, Ivan

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Downregulation of SIAH2, an ubiquitin E3 ligase, is associated with resistance to endocrine therapy in breast cancer von Jansen, Maurice P. H. M, Ruigrok-Ritstier, Kirsten, Dorssers, Lambert C. J, van Staveren, Iris L, Look, Maxime P, Meijer-van Gelder, Marion E, Sieuwerts, Anieta M, Helleman, Jozien, Sleijfer, Stefan, Klijn, Jan G. M, Foekens, John A, Berns, Els M. J. J

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Microarray-based oncogenic pathway profiling in advanced serous papillary ovarian carcinoma von Trinh, Xuan Bich, Tjalma, Wiebren A A, Dirix, Luc Y, Vermeulen, Peter B, Peeters, Dieter J, Bachvarov, Dimcho, Plante, Marie, Berns, Els M, Helleman, Jozien, Van Laere, Steven J, van Dam, Peter A

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