Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): a multic... von Kwon, Eugene D, Prof, Drake, Charles G, MD, Scher, Howard I, Prof, Fizazi, Karim, Prof, Bossi, Alberto, MD, van den Eertwegh, Alfons J M, MD, Krainer, Michael, MD, Houede, Nadine, MD, Santos, Ricardo, MD, Mahammedi, Hakim, MD, Ng, Siobhan, MD, Maio, Michele, MD, Franke, Fabio A, MD, Sundar, Santhanam, MBBS, Agarwal, Neeraj, MD, Bergman, Andries M, MD, Ciuleanu, Tudor E, Prof, Korbenfeld, Ernesto, MD, Sengeløv, Lisa, MD, Hansen, Steinbjorn, MD, Logothetis, Christopher, Prof, Beer, Tomasz M, Prof, McHenry, M Brent, PhD, Gagnier, Paul, MD, Liu, David, MD, Gerritsen, Winald R, Prof

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Prostate cancer reactivates developmental epigenomic programs during metastatic progression von Pomerantz, Mark M., Qiu, Xintao, Zhu, Yanyun, Takeda, David Y., Pan, Wenting, Baca, Sylvan C., Gusev, Alexander, Korthauer, Keegan D., Severson, Tesa M., Ha, Gavin, Viswanathan, Srinivas R., Seo, Ji-Heui, Nguyen, Holly M., Zhang, Baohui, Pasaniuc, Bogdan, Giambartolomei, Claudia, Alaiwi, Sarah A., Bell, Connor A., O’Connor, Edward P., Chabot, Matthew S., Stillman, David R., Lis, Rosina, Font-Tello, Alba, Li, Lewyn, Cejas, Paloma, Bergman, Andries M., Sanders, Joyce, van der Poel, Henk G., Gayther, Simon A., Lawrenson, Kate, Fonseca, Marcos A. S., Reddy, Jessica, Corona, Rosario I., Martovetsky, Gleb, Egan, Brian, Choueiri, Toni, Ellis, Leigh, Garraway, Isla P., Lee, Gwo-Shu Mary, Corey, Eva, Long, Henry W., Zwart, Wilbert, Freedman, Matthew L.

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The genomic landscape of metastatic castration-resistant prostate cancers reveals multiple distinct genotypes with potential clinical impact von van Dessel, Lisanne F., van Riet, Job, Smits, Minke, Zhu, Yanyun, Hamberg, Paul, van der Heijden, Michiel S., Bergman, Andries M., van Oort, Inge M., de Wit, Ronald, Voest, Emile E., Steeghs, Neeltje, Yamaguchi, Takafumi N., Livingstone, Julie, Boutros, Paul C., Martens, John W. M., Sleijfer, Stefan, Cuppen, Edwin, Zwart, Wilbert, van de Werken, Harmen J. G., Mehra, Niven, Lolkema, Martijn P.

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Androgen receptor enhancer usage and the chromatin regulatory landscape in human prostate cancers von Stelloo, Suzan, Bergman, Andries M, Zwart, Wilbert

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Androgen receptor signalling in macrophages promotes TREM-1-mediated prostate cancer cell line migration and invasion von Cioni, Bianca, Zaalberg, Anniek, van Beijnum, Judy R., Melis, Monique H. M., van Burgsteden, Johan, Muraro, Mauro J., Hooijberg, Erik, Peters, Dennis, Hofland, Ingrid, Lubeck, Yoni, de Jong, Jeroen, Sanders, Joyce, Vivié, Judith, van der Poel, Henk G., de Boer, Jan Paul, Griffioen, Arjan W., Zwart, Wilbert, Bergman, Andries M.

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CHD1 Loss Alters AR Binding at Lineage-Specific Enhancers and Modulates Distinct Transcriptional Programs to Drive Prostate Tumorigenesis von Augello, Michael A., Liu, Deli, Deonarine, Lesa D., Robinson, Brian D., Huang, Dennis, Stelloo, Suzan, Blattner, Mirjam, Doane, Ashley S., Wong, Elissa W.P., Chen, Yu, Rubin, Mark A., Beltran, Himisha, Elemento, Olivier, Bergman, Andries M., Zwart, Wilbert, Sboner, Andrea, Dephoure, Noah, Barbieri, Christopher E.

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Cistrome Partitioning Reveals Convergence of Somatic Mutations and Risk Variants on Master Transcription Regulators in Primary Prostate Tumors von Mazrooei, Parisa, Kron, Ken J., Zhu, Yanyun, Zhou, Stanley, Grillo, Giacomo, Mehdi, Tahmid, Ahmed, Musaddeque, Severson, Tesa M., Guilhamon, Paul, Armstrong, Nicholas Sinnott, Huang, Vincent, Yamaguchi, Takafumi N., Fraser, Michael, van der Kwast, Theodorus, Boutros, Paul C., He, Housheng Hansen, Bergman, Andries M., Bristow, Robert G., Zwart, Wilbert, Lupien, Mathieu

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Custirsen in combination with docetaxel and prednisone for patients with metastatic castration-resistant prostate cancer (SYNERGY trial): a phase 3, multicentre, open-label, random... von Chi, Kim N, Prof, Higano, Celestia S, MD, Blumenstein, Brent, PhD, Ferrero, Jean-Marc, Prof, Reeves, James, MD, Feyerabend, Susan, MD, Gravis, Gwenaelle, MD, Merseburger, Axel S, Prof, Stenzl, Arnulf, Prof, Bergman, Andries M, MD, Mukherjee, Som D, MD, Zalewski, Pawel, MD, Saad, Fred, Prof, Jacobs, Cindy, MD, Gleave, Martin, Prof, de Bono, Johann S, Prof

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A kinome-centered CRISPR-Cas9 screen identifies activated BRAF to modulate enzalutamide resistance with potential therapeutic implications in BRAF-mutated prostate cancer von Palit, Sander A. L., van Dorp, Jeroen, Vis, Daniel, Lieftink, Cor, Linder, Simon, Beijersbergen, Roderick, Bergman, Andries M., Zwart, Wilbert, van der Heijden, Michiel S.

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Loss of androgen receptor signaling in prostate cancer‐associated fibroblasts (CAFs) promotes CCL2‐ and CXCL8‐mediated cancer cell migration von Cioni, Bianca, Nevedomskaya, Ekaterina, Melis, Monique H. M., Burgsteden, Johan, Stelloo, Suzan, Hodel, Emma, Spinozzi, Daniele, Jong, Jeroen, der Poel, Henk, Boer, Jan Paul, Wessels, Lodewyk F. A., Zwart, Wilbert, Bergman, Andries M.

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Functional mapping of androgen receptor enhancer activity von Huang, Chia-Chi Flora, Lingadahalli, Shreyas, Morova, Tunc, Ozturan, Dogancan, Hu, Eugene, Yu, Ivan Pak Lok, Linder, Simon, Hoogstraat, Marlous, Stelloo, Suzan, Sar, Funda, van der Poel, Henk, Altintas, Umut Berkay, Saffarzadeh, Mohammadali, Le Bihan, Stephane, McConeghy, Brian, Gokbayrak, Bengul, Feng, Felix Y., Gleave, Martin E., Bergman, Andries M., Collins, Colin, Hach, Faraz, Zwart, Wilbert, Emberly, Eldon, Lack, Nathan A.

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Opposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer von Che, Meixia, Chaturvedi, Aashi, Munro, Sarah A., Pitzen, Samuel P., Ling, Alex, Zhang, Weijie, Mentzer, Josh, Ku, Sheng-Yu, Puca, Loredana, Zhu, Yanyun, Bergman, Andries M., Severson, Tesa M., Forster, Colleen, Liu, Yuzhen, Hildebrand, Jacob, Daniel, Mark, Wang, Ting-You, Selth, Luke A., Hickey, Theresa, Zoubeidi, Amina, Gleave, Martin, Bareja, Rohan, Sboner, Andrea, Tilley, Wayne, Carroll, Jason S., Tan, Winston, Kohli, Manish, Yang, Rendong, Hsieh, Andrew C., Murugan, Paari, Zwart, Wilbert, Beltran, Himisha, Huang, R. Stephanie, Dehm, Scott M.

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Extensive androgen receptor enhancer heterogeneity in primary prostate cancers underlies transcriptional diversity and metastatic potential von Kneppers, Jeroen, Severson, Tesa M., Siefert, Joseph C., Schol, Pieter, Joosten, Stacey E. P., Yu, Ivan Pak Lok, Huang, Chia-Chi Flora, Morova, Tunç, Altıntaş, Umut Berkay, Giambartolomei, Claudia, Seo, Ji-Heui, Baca, Sylvan C., Carneiro, Isa, Emberly, Eldon, Pasaniuc, Bogdan, Jerónimo, Carmen, Henrique, Rui, Freedman, Matthew L., Wessels, Lodewyk F. A., Lack, Nathan A., Bergman, Andries M., Zwart, Wilbert

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Androgen receptor profiling predicts prostate cancer outcome von Stelloo, Suzan, Nevedomskaya, Ekaterina, van der Poel, Henk G, de Jong, Jeroen, van Leenders, Geert JLH, Jenster, Guido, Wessels, Lodewyk FA, Bergman, Andries M, Zwart, Wilbert

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A common germline variant in CYP11B1 is associated with adverse clinical outcome of treatment with abiraterone or enzalutamide von Buck, Stefan A.J., Meertens, Marinda, van Ooijen, Frederiek M.F., Oomen-de Hoop, Esther, de Jonge, Evert, Coenen, Marieke J.H., Bergman, Andries M., Koolen, Stijn L.W., de Wit, Ronald, Huitema, Alwin D.R., van Schaik, Ron H.N., Mathijssen, Ron H.J.

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Homing in on a Moving Target: Androgen Receptor Cistromic Plasticity in Prostate Cancer von Eickhoff, Nils, Bergman, Andries M, Zwart, Wilbert

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Real-world outcomes of radium-223 dichloride for metastatic castration resistant prostate cancer von Kuppen, Malou C. P., Westgeest, Hans M., van der Doelen, Maarten J., van den Eertwegh, Alphonsus J. M., Coenen, Jules L. L. M., Aben, Katja K. H., van den Bergh, Alphons C. M., Bergman, Andries M., van den Bosch, Joan, Celik, Filiz, Hendriks, Mathijs P., Lavalaye, Jules, van der Meer, Saskia, Polee, Marco B., Somford, Diederik M., van Oort, Inge M., Uyl-de Groot, Carin A., Gerritsen, Winald R.

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TLE3 loss confers AR inhibitor resistance by facilitating GR-mediated human prostate cancer cell growth von Palit, Sander Al, Vis, Daniel, Stelloo, Suzan, Lieftink, Cor, Prekovic, Stefan, Bekers, Elise, Hofland, Ingrid, Šuštić, Tonći, Wolters, Liesanne, Beijersbergen, Roderick, Bergman, Andries M, Győrffy, Balázs, Wessels, Lodewyk Fa, Zwart, Wilbert, van der Heijden, Michiel S

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Epigenetic and transcriptional analysis reveals a core transcriptional program conserved in clonal prostate cancer metastases von Severson, Tesa M., Zhu, Yanyun, De Marzo, Angelo M., Jones, Tracy, Simons, Jonathan W., Nelson, William G., Yegnasubramanian, Srinivasan, Freedman, Matthew L., Wessels, Lodewyk, Bergman, Andries M., Haffner, Michael C., Zwart, Wilbert

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Agent-based modeling of the prostate tumor microenvironment uncovers spatial tumor growth constraints and immunomodulatory properties von van Genderen, Maisa N. G., Kneppers, Jeroen, Zaalberg, Anniek, Bekers, Elise M., Bergman, Andries M., Zwart, Wilbert, Eduati, Federica

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