Homing in on a Moving Target: Androgen Receptor Cistromic Plasticity in Prostate Cancer von Eickhoff, Nils, Bergman, Andries M, Zwart, Wilbert

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Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): a multic... von Kwon, Eugene D, Prof, Drake, Charles G, MD, Scher, Howard I, Prof, Fizazi, Karim, Prof, Bossi, Alberto, MD, van den Eertwegh, Alfons J M, MD, Krainer, Michael, MD, Houede, Nadine, MD, Santos, Ricardo, MD, Mahammedi, Hakim, MD, Ng, Siobhan, MD, Maio, Michele, MD, Franke, Fabio A, MD, Sundar, Santhanam, MBBS, Agarwal, Neeraj, MD, Bergman, Andries M, MD, Ciuleanu, Tudor E, Prof, Korbenfeld, Ernesto, MD, Sengeløv, Lisa, MD, Hansen, Steinbjorn, MD, Logothetis, Christopher, Prof, Beer, Tomasz M, Prof, McHenry, M Brent, PhD, Gagnier, Paul, MD, Liu, David, MD, Gerritsen, Winald R, Prof

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Prostate cancer reactivates developmental epigenomic programs during metastatic progression von Pomerantz, Mark M., Qiu, Xintao, Zhu, Yanyun, Takeda, David Y., Pan, Wenting, Baca, Sylvan C., Gusev, Alexander, Korthauer, Keegan D., Severson, Tesa M., Ha, Gavin, Viswanathan, Srinivas R., Seo, Ji-Heui, Nguyen, Holly M., Zhang, Baohui, Pasaniuc, Bogdan, Giambartolomei, Claudia, Alaiwi, Sarah A., Bell, Connor A., O’Connor, Edward P., Chabot, Matthew S., Stillman, David R., Lis, Rosina, Font-Tello, Alba, Li, Lewyn, Cejas, Paloma, Bergman, Andries M., Sanders, Joyce, van der Poel, Henk G., Gayther, Simon A., Lawrenson, Kate, Fonseca, Marcos A. S., Reddy, Jessica, Corona, Rosario I., Martovetsky, Gleb, Egan, Brian, Choueiri, Toni, Ellis, Leigh, Garraway, Isla P., Lee, Gwo-Shu Mary, Corey, Eva, Long, Henry W., Zwart, Wilbert, Freedman, Matthew L.

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Androgen receptor enhancer usage and the chromatin regulatory landscape in human prostate cancers von Stelloo, Suzan, Bergman, Andries M, Zwart, Wilbert

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The genomic landscape of metastatic castration-resistant prostate cancers reveals multiple distinct genotypes with potential clinical impact von van Dessel, Lisanne F., van Riet, Job, Smits, Minke, Zhu, Yanyun, Hamberg, Paul, van der Heijden, Michiel S., Bergman, Andries M., van Oort, Inge M., de Wit, Ronald, Voest, Emile E., Steeghs, Neeltje, Yamaguchi, Takafumi N., Livingstone, Julie, Boutros, Paul C., Martens, John W. M., Sleijfer, Stefan, Cuppen, Edwin, Zwart, Wilbert, van de Werken, Harmen J. G., Mehra, Niven, Lolkema, Martijn P.

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Androgen receptor signalling in macrophages promotes TREM-1-mediated prostate cancer cell line migration and invasion von Cioni, Bianca, Zaalberg, Anniek, van Beijnum, Judy R., Melis, Monique H. M., van Burgsteden, Johan, Muraro, Mauro J., Hooijberg, Erik, Peters, Dennis, Hofland, Ingrid, Lubeck, Yoni, de Jong, Jeroen, Sanders, Joyce, Vivié, Judith, van der Poel, Henk G., de Boer, Jan Paul, Griffioen, Arjan W., Zwart, Wilbert, Bergman, Andries M.

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CHD1 Loss Alters AR Binding at Lineage-Specific Enhancers and Modulates Distinct Transcriptional Programs to Drive Prostate Tumorigenesis von Augello, Michael A., Liu, Deli, Deonarine, Lesa D., Robinson, Brian D., Huang, Dennis, Stelloo, Suzan, Blattner, Mirjam, Doane, Ashley S., Wong, Elissa W.P., Chen, Yu, Rubin, Mark A., Beltran, Himisha, Elemento, Olivier, Bergman, Andries M., Zwart, Wilbert, Sboner, Andrea, Dephoure, Noah, Barbieri, Christopher E.

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Cistrome Partitioning Reveals Convergence of Somatic Mutations and Risk Variants on Master Transcription Regulators in Primary Prostate Tumors von Mazrooei, Parisa, Kron, Ken J., Zhu, Yanyun, Zhou, Stanley, Grillo, Giacomo, Mehdi, Tahmid, Ahmed, Musaddeque, Severson, Tesa M., Guilhamon, Paul, Armstrong, Nicholas Sinnott, Huang, Vincent, Yamaguchi, Takafumi N., Fraser, Michael, van der Kwast, Theodorus, Boutros, Paul C., He, Housheng Hansen, Bergman, Andries M., Bristow, Robert G., Zwart, Wilbert, Lupien, Mathieu

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Enzalutamide therapy for advanced prostate cancer: efficacy, resistance and beyond von Linder, Simon, van der Poel, Henk G, Bergman, Andries M, Zwart, Wilbert, Prekovic, Stefan

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Custirsen in combination with docetaxel and prednisone for patients with metastatic castration-resistant prostate cancer (SYNERGY trial): a phase 3, multicentre, open-label, random... von Chi, Kim N, Prof, Higano, Celestia S, MD, Blumenstein, Brent, PhD, Ferrero, Jean-Marc, Prof, Reeves, James, MD, Feyerabend, Susan, MD, Gravis, Gwenaelle, MD, Merseburger, Axel S, Prof, Stenzl, Arnulf, Prof, Bergman, Andries M, MD, Mukherjee, Som D, MD, Zalewski, Pawel, MD, Saad, Fred, Prof, Jacobs, Cindy, MD, Gleave, Martin, Prof, de Bono, Johann S, Prof

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An androgen receptor switch underlies lineage infidelity in treatment-resistant prostate cancer von Davies, Alastair, Nouruzi, Shaghayegh, Ganguli, Dwaipayan, Namekawa, Takeshi, Thaper, Daksh, Linder, Simon, Karaoğlanoğlu, Fatih, Omur, Meltem E., Kim, Soojin, Kobelev, Maxim, Kumar, Sahil, Sivak, Olena, Bostock, Chiara, Bishop, Jennifer, Hoogstraat, Marlous, Talal, Amina, Stelloo, Suzan, van der Poel, Henk, Bergman, Andries M., Ahmed, Musaddeque, Fazli, Ladan, Huang, Haojie, Tilley, Wayne, Goodrich, David, Feng, Felix Y., Gleave, Martin, He, Housheng Hansen, Hach, Faraz, Zwart, Wilbert, Beltran, Himisha, Selth, Luke, Zoubeidi, Amina

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It Takes Two to Tango: The Interplay between Prostate Cancer and Its Microenvironment from an Epigenetic Perspective von Zaalberg, Anniek, Pottendorfer, Elisabeth, Zwart, Wilbert, Bergman, Andries M

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Phase III Study of Cabozantinib in Previously Treated Metastatic Castration-Resistant Prostate Cancer: COMET-1 von Smith, Matthew, De Bono, Johann, Sternberg, Cora, Le Moulec, Sylvestre, Oudard, Stéphane, De Giorgi, Ugo, Krainer, Michael, Bergman, Andries, Hoelzer, Wolfgang, De Wit, Ronald, Bögemann, Martin, Saad, Fred, Cruciani, Giorgio, Thiery-Vuillemin, Antoine, Feyerabend, Susan, Miller, Kurt, Houédé, Nadine, Hussain, Syed, Lam, Elaine, Polikoff, Jonathan, Stenzl, Arnulf, Mainwaring, Paul, Ramies, David, Hessel, Colin, Weitzman, Aaron, Fizazi, Karim

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A kinome-centered CRISPR-Cas9 screen identifies activated BRAF to modulate enzalutamide resistance with potential therapeutic implications in BRAF-mutated prostate cancer von Palit, Sander A. L., van Dorp, Jeroen, Vis, Daniel, Lieftink, Cor, Linder, Simon, Beijersbergen, Roderick, Bergman, Andries M., Zwart, Wilbert, van der Heijden, Michiel S.

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Loss of androgen receptor signaling in prostate cancer‐associated fibroblasts (CAFs) promotes CCL2‐ and CXCL8‐mediated cancer cell migration von Cioni, Bianca, Nevedomskaya, Ekaterina, Melis, Monique H. M., Burgsteden, Johan, Stelloo, Suzan, Hodel, Emma, Spinozzi, Daniele, Jong, Jeroen, der Poel, Henk, Boer, Jan Paul, Wessels, Lodewyk F. A., Zwart, Wilbert, Bergman, Andries M.

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Functional mapping of androgen receptor enhancer activity von Huang, Chia-Chi Flora, Lingadahalli, Shreyas, Morova, Tunc, Ozturan, Dogancan, Hu, Eugene, Yu, Ivan Pak Lok, Linder, Simon, Hoogstraat, Marlous, Stelloo, Suzan, Sar, Funda, van der Poel, Henk, Altintas, Umut Berkay, Saffarzadeh, Mohammadali, Le Bihan, Stephane, McConeghy, Brian, Gokbayrak, Bengul, Feng, Felix Y., Gleave, Martin E., Bergman, Andries M., Collins, Colin, Hach, Faraz, Zwart, Wilbert, Emberly, Eldon, Lack, Nathan A.

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Grade Group 1 Prostate Cancers Exhibit Tumor-defining Androgen Receptor–driven Programs von Linder, Simon, Severson, Tesa M., van der Mijn, Koen J.C., Nevedomskaya, Ekaterina, Siefert, Joseph C., Stelloo, Suzan, Pomerantz, Mark M., Freedman, Matthew L., van der Poel, Henk, Jerónimo, Carmen, Henrique, Rui, Bergman, Andries M., Zwart, Wilbert

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Clinical activity and tolerability of enzalutamide (MDV3100) in patients with metastatic, castration‐resistant prostate cancer who progress after docetaxel and abiraterone treatmen... von Badrising, Sushil, van der Noort, Vincent, van Oort, Inge M., van den Berg, H. Pieter, Los, Maartje, Hamberg, Paul, Coenen, Jules L., van den Eertwegh, Alfons J. M., de Jong, Igle J., Kerver, Emile D., van Tinteren, Harm, Bergman, Andries M.

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Opposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer von Che, Meixia, Chaturvedi, Aashi, Munro, Sarah A., Pitzen, Samuel P., Ling, Alex, Zhang, Weijie, Mentzer, Josh, Ku, Sheng-Yu, Puca, Loredana, Zhu, Yanyun, Bergman, Andries M., Severson, Tesa M., Forster, Colleen, Liu, Yuzhen, Hildebrand, Jacob, Daniel, Mark, Wang, Ting-You, Selth, Luke A., Hickey, Theresa, Zoubeidi, Amina, Gleave, Martin, Bareja, Rohan, Sboner, Andrea, Tilley, Wayne, Carroll, Jason S., Tan, Winston, Kohli, Manish, Yang, Rendong, Hsieh, Andrew C., Murugan, Paari, Zwart, Wilbert, Beltran, Himisha, Huang, R. Stephanie, Dehm, Scott M.

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Extensive androgen receptor enhancer heterogeneity in primary prostate cancers underlies transcriptional diversity and metastatic potential von Kneppers, Jeroen, Severson, Tesa M., Siefert, Joseph C., Schol, Pieter, Joosten, Stacey E. P., Yu, Ivan Pak Lok, Huang, Chia-Chi Flora, Morova, Tunç, Altıntaş, Umut Berkay, Giambartolomei, Claudia, Seo, Ji-Heui, Baca, Sylvan C., Carneiro, Isa, Emberly, Eldon, Pasaniuc, Bogdan, Jerónimo, Carmen, Henrique, Rui, Freedman, Matthew L., Wessels, Lodewyk F. A., Lack, Nathan A., Bergman, Andries M., Zwart, Wilbert

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