Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy von Huber, Kilian V. M., Salah, Eidarus, Radic, Branka, Gridling, Manuela, Elkins, Jonathan M., Stukalov, Alexey, Jemth, Ann-Sofie, Göktürk, Camilla, Sanjiv, Kumar, Strömberg, Kia, Pham, Therese, Berglund, Ulrika Warpman, Colinge, Jacques, Bennett, Keiryn L., Loizou, Joanna I., Helleday, Thomas, Knapp, Stefan, Superti-Furga, Giulio

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A patient-derived xenograft pre-clinical trial reveals treatment responses and a resistance mechanism to karonudib in metastatic melanoma von Einarsdottir, Berglind O., Karlsson, Joakim, Söderberg, Elin M. V., Lindberg, Mattias F., Funck-Brentano, Elisa, Jespersen, Henrik, Brynjolfsson, Siggeir F., Olofsson Bagge, Roger, Carstam, Louise, Scobie, Martin, Koolmeister, Tobias, Wallner, Olof, Stierner, Ulrika, Berglund, Ulrika Warpman, Ny, Lars, Nilsson, Lisa M., Larsson, Erik, Helleday, Thomas, Nilsson, Jonas A.

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Validation and development of MTH1 inhibitors for treatment of cancer von Warpman Berglund, U., Sanjiv, K., Gad, H., Kalderén, C., Koolmeister, T., Pham, T., Gokturk, C., Jafari, R., Maddalo, G., Seashore-Ludlow, B., Chernobrovkin, A., Manoilov, A., Pateras, I.S., Rasti, A., Jemth, A.-S., Almlöf, I., Loseva, O., Visnes, T., Einarsdottir, B.O., Gaugaz, F.Z., Saleh, A., Platzack, B., Wallner, O.A., Vallin, K.S.A., Henriksson, M., Wakchaure, P., Borhade, S., Herr, P., Kallberg, Y., Baranczewski, P., Homan, E.J., Wiita, E., Nagpal, V., Meijer, T., Schipper, N., Rudd, S.G., Bräutigam, L., Lindqvist, A., Filppula, A., Lee, T.-C., Artursson, P., Nilsson, J.A., Gorgoulis, V.G., Lehtiö, J., Zubarev, R.A., Scobie, M., Helleday, T.

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Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function von Michel, Maurice, Benítez-Buelga, Carlos, Calvo, Patricia A., Hanna, Bishoy M. F., Mortusewicz, Oliver, Masuyer, Geoffrey, Davies, Jonathan, Wallner, Olov, Sanjiv, Kumar, Albers, Julian J., Castañeda-Zegarra, Sergio, Jemth, Ann-Sofie, Visnes, Torkild, Sastre-Perona, Ana, Danda, Akhilesh N., Homan, Evert J., Marimuthu, Karthick, Zhenjun, Zhao, Chi, Celestine N., Sarno, Antonio, Wiita, Elisée, von Nicolai, Catharina, Komor, Anna J., Rajagopal, Varshni, Müller, Sarah, Hank, Emily C., Varga, Marek, Scaletti, Emma R., Pandey, Monica, Karsten, Stella, Haslene-Hox, Hanne, Loevenich, Simon, Marttila, Petra, Rasti, Azita, Mamonov, Kirill, Ortis, Florian, Schömberg, Fritz, Loseva, Olga, Stewart, Josephine, D’Arcy-Evans, Nicholas, Koolmeister, Tobias, Henriksson, Martin, Michel, Dana, de Ory, Ana, Acero, Lucia, Calvete, Oriol, Scobie, Martin, Hertweck, Christian, Vilotijevic, Ivan, Kalderén, Christina, Osorio, Ana, Perona, Rosario, Stolz, Alexandra, Stenmark, Pål, Berglund, Ulrika Warpman, de Vega, Miguel, Helleday, Thomas

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24PTherapeutic implications of MTH1 inhibitor TH1579 in cutaneous malignant melanoma von Das, I, Gad, H, Bräutigam, L, Pudelko, L, Tuominen, R, Höiom, V, Almlöf, I, Hansson, J, Helleday, T, Brage, S E, Berglund, U W

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Coexpression of MTH1 and PMS2 Is Associated with Advanced Disease and Disease Progression after Therapy in Melanoma von Das, Ishani, Tuominen, Rainer, Helleday, Thomas, Hansson, Johan, Warpman Berglund, Ulrika, Egyházi Brage, Suzanne

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AXL and CAV-1 play a role for MTH1 inhibitor TH1579 sensitivity in cutaneous malignant melanoma von Das, Ishani, Gad, Helge, Bräutigam, Lars, Pudelko, Linda, Tuominen, Rainer, Höiom, Veronica, Almlöf, Ingrid, Rajagopal, Varshni, Hansson, Johan, Helleday, Thomas, Egyházi Brage, Suzanne, Warpman Berglund, Ulrika

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Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2 von Carter, Megan, Jemth, Ann-Sofie, Hagenkort, Anna, Page, Brent D. G., Gustafsson, Robert, Griese, Julia J., Gad, Helge, Valerie, Nicholas C. K., Desroses, Matthieu, Boström, Johan, Warpman Berglund, Ulrika, Helleday, Thomas, Stenmark, Pål

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MTH1 Inhibitors for the Treatment of Psoriasis von Bivik Eding, Cecilia, Köhler, Ines, Verma, Deepti, Sjögren, Florence, Bamberg, Claudia, Karsten, Stella, Pham, Therese, Scobie, Martin, Helleday, Thomas, Warpman Berglund, Ulrika, Enerbäck, Charlotta

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MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP von Jemth, Ann-Sofie, Gustafsson, Robert, Bräutigam, Lars, Henriksson, Linda, Vallin, Karl S A, Sarno, Antonio, Almlöf, Ingrid, Homan, Evert, Rasti, Azita, Warpman Berglund, Ulrika, Stenmark, Pål, Helleday, Thomas

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NEIL3 Prevents Senescence in Hepatocellular Carcinoma by Repairing Oxidative Lesions at Telomeres during Mitosis von Zhao, Zhenjun, Gad, Helge, Benitez-Buelga, Carlos, Sanjiv, Kumar, Hua Xiangwei, Kang, He, Feng, Mingxuan, Zhao, Zhicong, Berglund, Ulrika Warpman, Xia, Qiang, Helleday, Thomas

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MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool von Scaletti, Emma Rose, Vallin, Karl S., Bräutigam, Lars, Sarno, Antonio, Warpman Berglund, Ulrika, Helleday, Thomas, Stenmark, Pål, Jemth, Ann-Sofie

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Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities von Sanjiv, Kumar, Hagenkort, Anna, Calderón-Montaño, José Manuel, Koolmeister, Tobias, Reaper, Philip M., Mortusewicz, Oliver, Jacques, Sylvain A., Kuiper, Raoul V., Schultz, Niklas, Scobie, Martin, Charlton, Peter A., Pollard, John R., Berglund, Ulrika Warpman, Altun, Mikael, Helleday, Thomas

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Inhibition of Oxidized Nucleotide Sanitation By TH1579 and Conventional Chemotherapy Cooperatively Enhance Oxidative DNA Damage and Survival in AML von Centio, Anders, Estruch, Montserrat, Reckzeh, Kristian, Sanjiv, Kumar, Vittori, Camilla, Engelhard, Sophia, Warpman Berglund, Ulrika, Helleday, Thomas, Theilgaard-Mönch, Kim

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Broadly Active Antiviral Compounds Disturb Zika Virus Progeny Release Rescuing Virus-Induced Toxicity in Brain Organoids von Pettke, Aleksandra, Tampere, Marianna, Pronk, Robin, Wallner, Olov, Falk, Anna, Warpman Berglund, Ulrika, Helleday, Thomas, Mirazimi, Ali, Puumalainen, Marjo-Riitta

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Fragment-Based Discovery and Optimization of Enzyme Inhibitors by Docking of Commercial Chemical Space von Rudling, Axel, Gustafsson, Robert, Almlöf, Ingrid, Homan, Evert, Scobie, Martin, Warpman Berglund, Ulrika, Helleday, Thomas, Stenmark, Pål, Carlsson, Jens

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Global survey of the immunomodulatory potential of common drugs von Vladimer, Gregory I, Snijder, Berend, Krall, Nikolaus, Bigenzahn, Johannes W, Huber, Kilian V M, Lardeau, Charles-Hugues, Sanjiv, Kumar, Ringler, Anna, Berglund, Ulrika Warpman, Sabler, Monika, de la Fuente, Oscar Lopez, Knöbl, Paul, Kubicek, Stefan, Helleday, Thomas, Jäger, Ulrich, Superti-Furga, Giulio

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Erratum: Glioblastoma and glioblastoma stem cells are dependent on functional MTH1 (Oncotarget (2017) 8 (84671-84684) DOI: 10.18632/oncotarget.19404) von Pudelko, L., Rouhi, P., Sanjiv, K., Gad, H., Kalderén, C., Höglund, A., Squatrito, M., Schuhmacher, A. J., Edwards, Steven, Hägerstrand, D., Berglund, U. W., Helleday, T., Bräutigam, L.

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MTH1 Inhibitor TH588 Disturbs Mitotic Progression and Induces Mitosis-Dependent Accumulation of Genomic 8-oxodG von Rudd, Sean G., Gad, Helge, Sanjiv, Kumar, Amaral, Nuno, Hagenkort, Anna, Groth, Petra, Strom, Cecilia E., Mortusewicz, Oliver, Berglund, Ulrika Warpman, Helleday, Thomas

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Short term starvation potentiates the efficacy of chemotherapy in triple negative breast cancer via metabolic reprogramming von Pateras, Ioannis S, Williams, Chloe, Gianniou, Despoina D, Margetis, Aggelos T, Avgeris, Margaritis, Rousakis, Pantelis, Legaki, Aigli-Ioanna, Mirtschink, Peter, Zhang, Wei, Panoutsopoulou, Konstantina, Delis, Anastasios D, Pagakis, Stamatis N, Tang, Wei, Ambs, Stefan, Warpman Berglund, Ulrika, Helleday, Thomas, Varvarigou, Anastasia, Chatzigeorgiou, Antonios, Nordström, Anders, Tsitsilonis, Ourania E, Trougakos, Ioannis P, Gilthorpe, Jonathan D, Frisan, Teresa

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