Targets for Ibrutinib Beyond B Cell Malignancies von Berglöf, A., Hamasy, A., Meinke, S., Palma, M., Krstic, A., Månsson, R., Kimby, E., Österborg, A., Smith, C. I. E.

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Bruton's tyrosine kinase: cell biology, sequence conservation, mutation spectrum, siRNA modifications, and expression profiling von Lindvall, Jessica M., Blomberg, K. Emelie M., Väliaho, Jouni, Vargas, Leonardo, Heinonen, Juhana E., Berglöf, Anna, Mohamed, Abdalla J., Nore, Beston F., Vihinen, Mauno, Smith, C. I. Edvard

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Substitution scanning identifies a novel, catalytically active ibrutinib-resistant BTK cysteine 481 to threonine (C481T) variant von Hamasy, A, Wang, Q, Blomberg, K E M, Mohammad, D K, Yu, L, Vihinen, M, Berglöf, A, Smith, C I E

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Treatment of Epstein Barr virus‐induced haemophagocytic lymphohistiocytosis with rituximab‐containing chemo‐immunotherapeutic regimens von Chellapandian, DeepakBabu, Das, Rupali, Zelley, Kristin, Wiener, Susan J., Zhao, Huaqing, Teachey, David T., Nichols, Kim E., Hale, Gregory, Minkov, Milen, Karlhuber, Susanne, Weinstein, Joanna L., Weitzman, Sheila, Moshous, Despina, Fischer, Alain, Jeng, Michael, Henry, Michael, Haupt, Riccardo, Svahn, Joanna, Zapotocka, Ester, Wolfson, Julie, Yacobovich, Joanne, Van Laar, Jan A.M., Talano, Julie, Astigarraga, Itziar, Beutel, Karin, Berglöf, Elisabet, Henter, Jan‐Inge, Imashuku, Shinsaku, Ho, Marco Hok‐kung, Fraser, Chris, Greene Welch, Jennifer, Kitchen, Brenda, Jasty, Rama, Degar, Barbara A., Gunnes, Maria Winther, McMahon, Corrina, Garrington, Timothy, Filipovich, Alexandra H., Jordan, Michael B., Bleesing, Jacob J., Marsh, Rebecca A.

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Gene expression profile of B cells from Xid mice and Btk knockout mice von Lindvall, Jessica M., Blomberg, K. Emelie M., Berglöf, Anna, Yang, Qian, Smith, C. I. Edvard, Islam, Tahmina C.

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Functional Interaction of Caveolin-1 with Bruton's Tyrosine Kinase and Bmx von Vargas, Leonardo, Nore, Beston F., Berglöf, Anna, Heinonen, Juhana E., Mattsson, Pekka T., Smith, C. I. Edvard, Mohamed, Abdalla J.

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BTK gatekeeper residue variation combined with cysteine 481 substitution causes super-resistance to irreversible inhibitors acalabrutinib, ibrutinib and zanubrutinib von Estupiñán, H. Yesid, Wang, Qing, Berglöf, Anna, Schaafsma, Gerard C. P., Shi, Yuye, Zhou, Litao, Mohammad, Dara K., Yu, Liang, Vihinen, Mauno, Zain, Rula, Smith, C. I. Edvard

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Comparative Analysis of BTK Inhibitors and Mechanisms Underlying Adverse Effects von Estupiñán, H Yesid, Berglöf, Anna, Zain, Rula, Smith, C I Edvard

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Substitution scanning identifies a novel, catalytically active ibrutinib-resistant BTK cysteine 481 to threonine von Vihinen, M, Berglöf, A, Yu, L, Smith, C I E, Mohammad, D K, Wang, Q, Hamasy, A, Blomberg, K E M

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Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain von Mohamed, Abdalla J, Yu, Liang, Bäckesjö, Carl-Magnus, Vargas, Leonardo, Faryal, Rani, Aints, Alar, Christensson, Birger, Berglöf, Anna, Vihinen, Mauno, Nore, Beston F, Edvard Smith, C.I

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Experimental autoimmune myasthenia gravis induction in B cell-deficient mice von Li, H, Shi, F D, He, B, Bakheit, M, Wahren, B, Berglöf, A, Sandstedt, K, Link, H

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Ibrutinib Has Time‐dependent On‐ and Off‐target Effects on Plasma Biomarkers and Immune Cells in Chronic Lymphocytic Leukemia von Mulder, Tom A., Peña‐Pérez, Lucía, Berglöf, Anna, Meinke, Stephan, Estupiñán, H. Yesid, Heimersson, Kia, Zain, Rula, Månsson, Robert, Smith, C. I. Edvard, Palma, Marzia

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The role of B-cells in experimental myasthenia gravis in mice von Wang, H.B., Li, H., He, B., Bakheit, M., Levi, M., Wahren, B., Berglöf, A., Sandstedt, K., Link, H., Shi, F.D.

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transcriptional regulator PLZF induces the development of CD44 high memory phenotype T cells von Raberger, Julia, Schebesta, Alexandra, Sakaguchi, Shinya, Boucheron, Nicole, Blomberg, K. Emelie M, Berglöf, Anna, Kolbe, Thomas, Smith, C.I. Edvard, Rülicke, Thomas, Ellmeier, Wilfried

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Very Early Effects of Ibrutinib on Tumor and Immune Cells in Blood and Lymph Nodes in Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) Patients von Palma, Marzia, Krstic, Aleksandra, Berglöf, Anna, Wang, Qing, Blomberg, Emelie, Meinke, Stephan, Kamali-Moghaddam, Masood, Shen, Qiujin, Jaremko, Georg, Lundin, Jeanette, Kimby, Eva, Höglund, Petter, Månsson, Robert, Österborg, Anders, Smith, Edvard

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Novel mouse model resistant to irreversible BTK inhibitors: a tool identifying new therapeutic targets and side effects von Estupiñán, H. Yesid, Bouderlique, Thibault, He, Chenfei, Berglöf, Anna, Gupta, Dhanu, Saher, Osama, Daza Cruz, Miguel Ángel, Peña-Perez, Lucia, Yu, Liang, Zain, Rula, Karlsson, Mikael C.I., Månsson, Robert, Smith, C. I. Edvard

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In BTK, phosphorylated Y223 in the SH3 domain mirrors catalytic activity, but does not in fl uence biological function von Estupinan, HY, Bouderlique, T, He, C, Berglof, A, Cappelleri, A, Frengen, N, Zain, R, Karlsson, MCI, Mansson, R, Smith, CIE

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Splice-Correction Strategies for Treatment of X-Linked Agammaglobulinemia von Bestas, Burcu, Turunen, Janne J., Blomberg, K. Emelie M., Wang, Qing, Månsson, Robert, EL Andaloussi, Samir, Berglöf, Anna, Smith, C. I. Edvard

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Defective Toll-like receptor 9-mediated cytokine production in B cells from Bruton's tyrosine kinase-deficient mice von Hasan, Maroof, Lopez-Herrera, Gabriela, Blomberg, K. Emelie M, Lindvall, Jessica M, Berglöf, Anna, Smith, C.I. Edvard, Vargas, Leonardo

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Transcriptional signatures of Itk-deficient CD3+, CD4+ and CD8+ T-cells von Blomberg, K Emelie M, Boucheron, Nicole, Lindvall, Jessica M, Yu, Liang, Raberger, Julia, Berglöf, Anna, Ellmeier, Wilfried, Smith, Ci Edvard

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