Deploying whole genome sequencing in clinical practice and public health: Meeting the challenge one bin at a time von Berg, Jonathan S., Khoury, Muin J., Evans, James P.

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Points to Consider: Ethical, Legal, and Psychosocial Implications of Genetic Testing in Children and Adolescents von Botkin, Jeffrey R., Belmont, John W., Berg, Jonathan S., Berkman, Benjamin E., Bombard, Yvonne, Holm, Ingrid A., Levy, Howard P., Ormond, Kelly E., Saal, Howard M., Spinner, Nancy B., Wilfond, Benjamin S., McInerney, Joseph D.

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Increasing the diagnostic yield of exome sequencing by copy number variant analysis von Marchuk, Daniel S, Crooks, Kristy, Strande, Natasha, Kaiser-Rogers, Kathleen, Milko, Laura V, Brandt, Alicia, Arreola, Alexandra, Tilley, Christian R, Bizon, Chris, Vora, Neeta L, Wilhelmsen, Kirk C, Evans, James P, Berg, Jonathan S

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Evaluating the Clinical Validity of Gene-Disease Associations: An Evidence-Based Framework Developed by the Clinical Genome Resource von Strande, Natasha T., Riggs, Erin Rooney, Buchanan, Adam H., Ceyhan-Birsoy, Ozge, DiStefano, Marina, Dwight, Selina S., Goldstein, Jenny, Ghosh, Rajarshi, Seifert, Bryce A., Sneddon, Tam P., Wright, Matt W., Milko, Laura V., Cherry, J. Michael, Giovanni, Monica A., Murray, Michael F., O’Daniel, Julianne M., Ramos, Erin M., Santani, Avni B., Scott, Alan F., Plon, Sharon E., Rehm, Heidi L., Martin, Christa L., Berg, Jonathan S.

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ACMG clinical laboratory standards for next-generation sequencing von Rehm, Heidi L., Bale, Sherri J., Bayrak-Toydemir, Pinar, Berg, Jonathan S., Brown, Kerry K., Deignan, Joshua L., Friez, Michael J., Funke, Birgit H., Hegde, Madhuri R., Lyon, Elaine

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ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing von Green, Robert C., Berg, Jonathan S., Grody, Wayne W., Kalia, Sarah S., Korf, Bruce R., Martin, Christa L., McGuire, Amy L., Nussbaum, Robert L., O’Daniel, Julianne M., Ormond, Kelly E., Rehm, Heidi L., Watson, Michael S., Williams, Marc S., Biesecker, Leslie G.

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Recommendations for application of the functional evidence PS3/BS3 criterion using the ACMG/AMP sequence variant interpretation framework von Brnich, Sarah E, Abou Tayoun, Ahmad N, Couch, Fergus J, Cutting, Garry R, Greenblatt, Marc S, Heinen, Christopher D, Kanavy, Dona M, Luo, Xi, McNulty, Shannon M, Starita, Lea M, Tavtigian, Sean V, Wright, Matt W, Harrison, Steven M, Biesecker, Leslie G, Berg, Jonathan S

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ClinGen Variant Curation Expert Panel experiences and standardized processes for disease and gene‐level specification of the ACMG/AMP guidelines for sequence variant interpretation... von Rivera‐Muñoz, Edgar A., Milko, Laura V., Harrison, Steven M., Azzariti, Danielle R., Kurtz, C. Lisa, Lee, Kristy, Mester, Jessica L., Weaver, Meredith A., Currey, Erin, Craigen, William, Eng, Charis, Funke, Birgit, Hegde, Madhuri, Hershberger, Ray E., Mao, Rong, Steiner, Robert D., Vincent, Lisa M., Martin, Christa L., Plon, Sharon E., Ramos, Erin, Rehm, Heidi L., Watson, Michael, Berg, Jonathan S.

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Navigating the nuances of clinical sequence variant interpretation in Mendelian disease von Strande, Natasha T., Brnich, Sarah E., Roman, Tamara S., Berg, Jonathan S.

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Quantifying the potential of functional evidence to reclassify variants of uncertain significance in the categorical and Bayesian interpretation frameworks von Brnich, Sarah E., Rivera‐Muñoz, Edgar A., Berg, Jonathan S.

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Parent-Reported Clinical Utility of Pediatric Genomic Sequencing von Smith, Hadley Stevens, Ferket, Bart S, Gelb, Bruce D, Hindorff, Lucia, Ferar, Kathleen D, Norton, Mary E, Sahin-Hodoglugil, Nuriye, Slavotinek, Anne, Lich, Kristen Hasmiller, Berg, Jonathan S, Russell, Heidi V

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ClinGen and ClinVar – Enabling Genomics in Precision Medicine von Rehm, Heidi L., Berg, Jonathan S., Plon, Sharon E.

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Germline Analysis from Tumor-Germline Sequencing Dyads to Identify Clinically Actionable Secondary Findings von Seifert, Bryce A, O'Daniel, Julianne M, Amin, Krunal, Marchuk, Daniel S, Patel, Nirali M, Parker, Joel S, Hoyle, Alan P, Mose, Lisle E, Marron, Andrew, Hayward, Michele C, Bizon, Christopher, Wilhelmsen, Kirk C, Evans, James P, Earp, 3rd, H Shelton, Sharpless, Norman E, Hayes, D Neil, Berg, Jonathan S

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The Path to Genomic Screening—Far From Simple, but the Journey Has Begun von Berg, Jonathan S

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Comparative analysis of functional assay evidence use by ClinGen Variant Curation Expert Panels von Kanavy, Dona M, McNulty, Shannon M, Jairath, Meera K, Brnich, Sarah E, Bizon, Chris, Powell, Bradford C, Berg, Jonathan S

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Age-Based Genomic Screening during Childhood: Ethical and Practical Considerations in Public Health Genomics Implementation von Milko, Laura V, Berg, Jonathan S

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Exome Sequencing Identifies Mutations in CCDC114 as a Cause of Primary Ciliary Dyskinesia von Knowles, Michael R., Leigh, Margaret W., Ostrowski, Lawrence E., Huang, Lu, Carson, Johnny L., Hazucha, Milan J., Yin, Weining, Berg, Jonathan S., Davis, Stephanie D., Dell, Sharon D., Ferkol, Thomas W., Rosenfeld, Margaret, Sagel, Scott D., Milla, Carlos E., Olivier, Kenneth N., Turner, Emily H., Lewis, Alexandra P., Bamshad, Michael J., Nickerson, Deborah A., Shendure, Jay, Zariwala, Maimoona A.

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We screen newborns, don’t we?: realizing the promise of public health genomics von Evans, James P., Berg, Jonathan S., Olshan, Andrew F., Magnuson, Terry, Rimer, Barbara K.

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Actionability of commercial laboratory sequencing panels for newborn screening and the importance of transparency for parental decision-making von DeCristo, Daniela M., Milko, Laura V., O'Daniel, Julianne M., Foreman, Ann Katherine M., Mollison, Lonna F., Powell, Bradford C., Powell, Cynthia M., Berg, Jonathan S.

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The progression of the ClinGen gene clinical validity classification over time von McGlaughon, Jennifer L., Goldstein, Jennifer L., Thaxton, Courtney, Hemphill, Sarah E., Berg, Jonathan S.

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