Chimeric antigen receptors enable superior control of HIV replication by rapidly killing infected cells von Zhou, Yuqi, Jadlowsky, Julie, Baiduc, Caitlin, Klattenhoff, Alex W, Chen, Zhilin, Bennett, Alan D, Pumphrey, Nicholas J, Jakobsen, Bent K, Riley, James L

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An approved in vitro approach to preclinical safety and efficacy evaluation of engineered T cell receptor anti-CD3 bispecific (ImmTAC) molecules von Harper, Jane, Adams, Katherine J, Bossi, Giovanna, Wright, Debbie E, Stacey, Andrea R, Bedke, Nicole, Martinez-Hague, Ruth, Blat, Dan, Humbert, Laure, Buchanan, Hazel, Le Provost, Gabrielle S, Donnellan, Zoe, Carreira, Ricardo J, Paston, Samantha J, Weigand, Luise U, Canestraro, Martina, Sanderson, Joseph P, Botta Gordon-Smith, Sophie, Lowe, Kate L, Rygiel, Karolina A, Powlesland, Alex S, Vuidepot, Annelise, Hassan, Namir J, Cameron, Brian J, Jakobsen, Bent K, Dukes, Joseph

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Germ Line-governed Recognition of a Cancer Epitope by an Immunodominant Human T-cell Receptor von Cole, David K., Yuan, Fang, Rizkallah, Pierre J., Miles, John J., Gostick, Emma, Price, David A., Gao, George F., Jakobsen, Bent K., Sewell, Andrew K.

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Human TCR-Binding Affinity is Governed by MHC Class Restriction von Cole, David K, Pumphrey, Nicholas J, Boulter, Jonathan M, Sami, Malkit, Bell, John I, Gostick, Emma, Price, David A, Gao, George F, Sewell, Andrew K, Jakobsen, Bent K

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Cholesteryl esters stabilize human CD1c conformations for recognition by self-reactive T cells von Mansour, Salah, Tocheva, Anna S., Cave-Ayland, Chris, Machelett, Moritz M., Sander, Barbara, Lissin, Nikolai M., Molloy, Peter E., Baird, Mark S., Stübs, Gunthard, Schröder, Nicolas W. J., Schumann, Ralf R., Rademann, Jörg, Postle, Anthony D., Jakobsen, Bent K., Marshall, Ben G., Gosain, Rajendra, Elkington, Paul T., Elliott, Tim, Skylaris, Chris-Kriton, Essex, Jonathan W., Tews, Ivo, Gadola, Stephan D.

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Novel TCR-based biologics: mobilising T cells to warm ‘cold’ tumours von Lowe, Kate L., Cole, David, Kenefeck, Rupert, OKelly, Ita, Lepore, Marco, Jakobsen, Bent K.

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The tumor targeted superantigen ABR-217620 selectively engages TRBV7-9 and exploits TCR-pMHC affinity mimicry in mediating T cell cytotoxicity von Hedlund, Gunnar, Eriksson, Helena, Sundstedt, Anette, Forsberg, Göran, Jakobsen, Bent K, Pumphrey, Nicholas, Rödström, Karin, Lindkvist-Petersson, Karin, Björk, Per

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NY-ESO-1–specific TCR–engineered T cells mediate sustained antigen-specific antitumor effects in myeloma von Rapoport, Aaron P, Stadtmauer, Edward A, Binder-Scholl, Gwendolyn K, Goloubeva, Olga, Vogl, Dan T, Lacey, Simon F, Badros, Ashraf Z, Garfall, Alfred, Weiss, Brendan, Finklestein, Jeffrey, Kulikovskaya, Irina, Sinha, Sanjoy K, Kronsberg, Shari, Gupta, Minnal, Bond, Sarah, Melchiori, Luca, Brewer, Joanna E, Bennett, Alan D, Gerry, Andrew B, Pumphrey, Nicholas J, Williams, Daniel, Tayton- Martin, Helen K, Ribeiro, Lilliam, Holdich, Tom, Yanovich, Saul, Hardy, Nancy, Yared, Jean, Kerr, Naseem, Philip, Sunita, Westphal, Sandra, Siegel, Don L, Levine, Bruce L, Jakobsen, Bent K, Kalos, Michael, June, Carl H

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ImmTACs for targeted cancer therapy: Why, what, how, and which von Oates, Joanne, Hassan, Namir J., Jakobsen, Bent K.

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Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma von Linette, Gerald P., Stadtmauer, Edward A., Maus, Marcela V., Rapoport, Aaron P., Levine, Bruce L., Emery, Lyndsey, Litzky, Leslie, Bagg, Adam, Carreno, Beatriz M., Cimino, Patrick J., Binder-Scholl, Gwendolyn K., Smethurst, Dominic P., Gerry, Andrew B., Pumphrey, Nick J., Bennett, Alan D., Brewer, Joanna E., Dukes, Joseph, Harper, Jane, Tayton-Martin, Helen K., Jakobsen, Bent K., Hassan, Namir J., Kalos, Michael, June, Carl H.

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Examining the presentation of tumor-associated antigens on peptide-pulsed T2 cells von Bossi, Giovanna, Gerry, Andrew B, Paston, Samantha J, Sutton, Deborah H, Hassan, Namir J, Jakobsen, Bent K

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Fludarabine and neurotoxicity in engineered T-cell therapy von Lowe, Kate L., Mackall, Crystal L., Norry, Elliot, Amado, Rafael, Jakobsen, Bent K., Binder, Gwendolyn

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Polyfunctional response by ImmTAC (IMCgp100) redirected CD8+ and CD4+ T cells von Boudousquie, Caroline, Bossi, Giovanna, Hurst, Jacob M., Rygiel, Karolina A., Jakobsen, Bent K., Hassan, Namir J.

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Different affinity windows for virus and cancer‐specific T‐cell receptors: Implications for therapeutic strategies von Aleksic, Milos, Liddy, Nathaniel, Molloy, Peter E., Pumphrey, Nick, Vuidepot, Annelise, Chang, Kyong‐Mi, Jakobsen, Bent K.

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TCR Binding to Peptide-MHC Stabilizes a Flexible Recognition Interface von Willcox, Benjamin E, Gao, George F, Wyer, Jessica R, Ladbury, John E, Bell, John I, Jakobsen, Bent K, van der Merwe, P.Anton

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ImmTAC-redirected tumour cell killing induces and potentiates antigen cross-presentation by dendritic cells von Bossi, Giovanna, Buisson, Sandrine, Oates, Joanne, Jakobsen, Bent K., Hassan, Namir J.

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Specificity of bispecific T cell receptors and antibodies targeting peptide-HLA von Holland, Christopher J, Crean, Rory M, Pentier, Johanne M, de Wet, Ben, Lloyd, Angharad, Srikannathasan, Velupillai, Lissin, Nikolai, Lloyd, Katy A, Blicher, Thomas H, Conroy, Paul J, Hock, Miriam, Pengelly, Robert J, Spinner, Thomas E, Cameron, Brian, Potter, Elizabeth A, Jeyanthan, Anitha, Molloy, Peter E, Sami, Malkit, Aleksic, Milos, Liddy, Nathaniel, Robinson, Ross A, Harper, Stephen, Lepore, Marco, Pudney, Chris R, van der Kamp, Marc W, Rizkallah, Pierre J, Jakobsen, Bent K, Vuidepot, Annelise, Cole, David K

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Monoclonal TCR-redirected tumor cell killing von Liddy, Nathaniel, Bossi, Giovanna, Adams, Katherine J, Lissina, Anna, Mahon, Tara M, Hassan, Namir J, Gavarret, Jessie, Bianchi, Frayne C, Pumphrey, Nicholas J, Ladell, Kristin, Gostick, Emma, Sewell, Andrew K, Lissin, Nikolai M, Harwood, Naomi E, Molloy, Peter E, Li, Yi, Cameron, Brian J, Sami, Malkit, Baston, Emma E, Todorov, Penio T, Paston, Samantha J, Dennis, Rebecca E, Harper, Jane V, Dunn, Steve M, Ashfield, Rebecca, Johnson, Andy, McGrath, Yvonne, Plesa, Gabriela, June, Carl H, Kalos, Michael, Price, David A, Vuidepot, Annelise, Williams, Daniel D, Sutton, Deborah H, Jakobsen, Bent K

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Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy von Raman, Marine C C, Rizkallah, Pierre J, Simmons, Ruth, Donnellan, Zoe, Dukes, Joseph, Bossi, Giovanna, Le Provost, Gabrielle S, Todorov, Penio, Baston, Emma, Hickman, Emma, Mahon, Tara, Hassan, Namir, Vuidepot, Annelise, Sami, Malkit, Cole, David K, Jakobsen, Bent K.

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TCRs with Distinct Specificity Profiles Use Different Binding Modes to Engage an Identical Peptide-HLA Complex von Coles, Charlotte H, Mulvaney, Rachel M, Malla, Sunir, Walker, Andrew, Smith, Kathrine J, Lloyd, Angharad, Lowe, Kate L, McCully, Michelle L, Martinez Hague, Ruth, Aleksic, Milos, Harper, Jane, Paston, Samantha J, Donnellan, Zoe, Chester, Fiona, Wiederhold, Katrin, Robinson, Ross A, Knox, Andrew, Stacey, Andrea R, Dukes, Joseph, Baston, Emma, Griffin, Sue, Jakobsen, Bent K, Vuidepot, Annelise, Harper, Stephen

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