Structural basis of substrate discrimination and integrin binding by autotaxin von Hausmann, Jens, Kamtekar, Satwik, Christodoulou, Evangelos, Day, Jacqueline E, Wu, Tao, Fulkerson, Zachary, Albers, Harald M H G, van Meeteren, Laurens A, Houben, Anna J S, van Zeijl, Leonie, Jansen, Silvia, Andries, Maria, Hall, Troii, Pegg, Lyle E, Benson, Timothy E, Kasiem, Mobien, Harlos, Karl, Kooi, Craig W Vander, Smyth, Susan S, Ovaa, Huib, Bollen, Mathieu, Morris, Andrew J, Moolenaar, Wouter H, Perrakis, Anastassis

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Identifying Initiation and Elongation Inhibitors of Dengue Virus RNA Polymerase in a High-Throughput Lead-Finding Campaign von Smith, Thomas M., Lim, Siew Pheng, Yue, Kimberley, Busby, Scott A., Arora, Rishi, Seh, Cheah Chen, Wright, S. Kirk, Nutiu, Razvan, Niyomrattanakit, Pornwaratt, Wan, Kah Fei, Beer, David, Shi, Pei-Yong, Benson, Timothy E.

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High Resolution Crystal Structure of the Catalytic Domain of ADAMTS-5 (Aggrecanase-2) von Shieh, Huey-Sheng, Mathis, Karl J., Williams, Jennifer M., Hills, Robert L., Wiese, Joe F., Benson, Timothy E., Kiefer, James R., Marino, Margaret H., Carroll, Jeffery N., Leone, Joseph W., Malfait, Anne-Marie, Arner, Elizabeth C., Tortorella, Micky D., Tomasselli, Alfredo

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Structure of lipoprotein lipase in complex with GPIHBP1 von Arora, Rishi, Nimonkar, Amitabh V., Baird, Daniel, Wang, Chunhua, Chiu, Chun-Hao, Horton, Patricia A., Hanrahan, Susan, Cubbon, Rose, Weldon, Stephen, Tschantz, William R., Mueller, Sascha, Brunner, Reto, Lehr, Philipp, Meier, Peter, Ottl, Johannes, Voznesensky, Andrei, Pandey, Pramod, Smith, Thomas M., Stojanovic, Aleksandar, Flyer, Alec, Benson, Timothy E., Romanowski, Michael J., Trauger, John W.

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Two RNA Tunnel Inhibitors Bind in Highly Conserved Sites in Dengue Virus NS5 Polymerase: Structural and Functional Studies von Arora, Rishi, Liew, Chong Wai, Soh, Tingjin Sherryl, Otoo, Dorcas Adobea, Seh, Cheah Chen, Yue, Kimberley, Nilar, Shahul, Wang, Gang, Yokokawa, Fumiaki, Noble, Christian G, Chen, Yen Liang, Shi, Pei-Yong, Lescar, Julien, Smith, Thomas M, Benson, Timothy E, Lim, Siew Pheng

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Crystal Structure of Fatty Acid Amide Hydrolase Bound to the Carbamate Inhibitor URB597: Discovery of a Deacylating Water Molecule and Insight into Enzyme Inactivation von Mileni, Mauro, Kamtekar, Satwik, Wood, David C., Benson, Timothy E., Cravatt, Benjamin F., Stevens, Raymond C.

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Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with CP-690550 and CMP-6 von Chrencik, Jill E., Patny, Akshay, Leung, Iris K., Korniski, Brian, Emmons, Thomas L., Hall, Troii, Weinberg, Robin A., Gormley, Jennifer A., Williams, Jennifer M., Day, Jacqueline E., Hirsch, Jeffrey L., Kiefer, James R., Leone, Joseph W., Fischer, H. David, Sommers, Cynthia D., Huang, Horng-Chih, Jacobsen, E.J., Tenbrink, Ruth E., Tomasselli, Alfredo G., Benson, Timothy E.

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High-resolution structures of variant Zif268–DNA complexes: implications for understanding zinc finger–DNA recognition von Elrod-Erickson, Monicia, Benson, Timothy E, Pabo, Carl O

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Potent and selective isophthalamide S2 hydroxyethylamine inhibitors of BACE1 von KORTUM, Steven W, BENSON, Timothy E, BIENKOWSKI, Michael J, EMMONS, Thomas L, PRINCE, D. Bryan, PADDOCK, Donna J, TOMASSELLI, Alfredo G, MOON, Joseph B, LABORDE, Alice, TENBRINK, Ruth E

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X-Ray Crystal Structure of Staphylococcus aureus FemA von Benson, Timothy E., Prince, D.Bryan, Mutchler, Veronica T., Curry, Kimberly A., Ho, Andrea M., Sarver, Ronald W., Hagadorn, Jeanne C., Choi, Gil H., Garlick, Robert L.

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A Conserved Pocket in the Dengue Virus Polymerase Identified through Fragment-based Screening von Noble, Christian G., Lim, Siew Pheng, Arora, Rishi, Yokokawa, Fumiaki, Nilar, Shahul, Seh, Cheah Chen, Wright, S.Kirk, Benson, Timothy E., Smith, Paul W., Shi, Pei-Yong

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Design, Synthesis, and Crystal Structure of Hydroxyethyl Secondary Amine-Based Peptidomimetic Inhibitors of Human β-Secretase von Maillard, Michel C, Hom, Roy K, Benson, Timothy E, Moon, Joseph B, Mamo, Shumeye, Bienkowski, Michael, Tomasselli, Alfredo G, Woods, Danielle D, Prince, D. Bryan, Paddock, Donna J, Emmons, Thomas L, Tucker, John A, Dappen, Michael S, Brogley, Louis, Thorsett, Eugene D, Jewett, Nancy, Sinha, Sukanto, John, Varghese

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A Structural Variation for MurB:  X-ray Crystal Structure of Staphylococcus aureus UDP-N-Acetylenolpyruvylglucosamine Reductase (MurB) von Benson, Timothy E, Harris, Melissa S, Choi, Gil H, Cialdella, Joyce I, Herberg, John T, Martin, Joseph P, Baldwin, Eric T

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Overexpression, purification, and mechanistic study of UDP-N-acetylenolpyruvylglucosamine reductase von Benson, Timothy E, Marquardt, John L, Marquardt, Anne C, Etzkorn, Felicia A, Walsh, Christopher T

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Design of potent inhibitors of human β-secretase. Part 1 von Freskos, John N., Fobian, Yvette M., Benson, Timothy E., Bienkowski, Michael J., Brown, David L., Emmons, Thomas L., Heintz, Robert, Laborde, Alice, McDonald, Joseph J., Mischke, Brent V., Molyneaux, John M., Moon, Joseph B., Mullins, Patrick B., Bryan Prince, D., Paddock, Donna J., Tomasselli, Alfredo G., Winterrowd, Gregory

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Design of potent inhibitors of human β-secretase. Part 2 von Freskos, John N., Fobian, Yvette M., Benson, Timothy E., Moon, Joseph B., Bienkowski, Michael J., Brown, David L., Emmons, Thomas L., Heintz, Robert, Laborde, Alice, McDonald, Joseph J., Mischke, Brent V., Molyneaux, John M., Mullins, Patrick B., Bryan Prince, D., Paddock, Donna J., Tomasselli, Alfredo G., Winterrowd, Greg

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Crystallization and preliminary X-ray diffraction analysis of rat autotaxin von Day, Jacqueline E., Hall, Troii, Pegg, Lyle E., Benson, Timothy E., Hausmann, Jens, Kamtekar, Satwik

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The structure of the substrate-free form of MurB, an essential enzyme for the synthesis of bacterial cell walls von Benson, Timothy E, Walsh, Christopher T, Hogle, James M

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Kinetic Characterization of Wild-Type and S229A Mutant MurB:  Evidence for the Role of Ser 229 as a General Acid von Benson, Timothy E, Walsh, Christopher T, Massey, Vincent

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X-ray Crystal Structures of the S229A Mutant and Wild-Type MurB in the Presence of the Substrate Enolpyruvyl-UDP-N-Acetylglucosamine at 1.8-Å Resolution von Benson, Timothy E, Walsh, Christopher T, Hogle, James M

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