Modulators of the Nuclear Receptor Retinoic Acid Receptor-Related Orphan Receptor-γ (RORγ or RORc) von Fauber, Benjamin P, Magnuson, Steven

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Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity von Maurer, Till, Garrenton, Lindsay S, Oh, Angela, Pitts, Keith, Anderson, Daniel J, Skelton, Nicholas J, Fauber, Benjamin P, Pan, Borlan, Malek, Shiva, Stokoe, David, Ludlam, Mary J. C, Bowman, Krista K, Wu, Jiansheng, Giannetti, Anthony M, Starovasnik, Melissa A, Mellman, Ira, Jackson, Peter K, Rudolph, Joachim, Wang, Weiru, Fang, Guowei

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Concise Syntheses of (−)-Galanthamine and (±)-Codeine via Intramolecular Alkylation of a Phenol Derivative von Magnus, Philip, Sane, Neeraj, Fauber, Benjamin P., Lynch, Vince

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Structure-based design of substituted hexafluoroisopropanol-arylsulfonamides as modulators of RORc von Fauber, Benjamin P., de Leon Boenig, Gladys, Burton, Brenda, Eidenschenk, Céline, Everett, Christine, Gobbi, Alberto, Hymowitz, Sarah G., Johnson, Adam R., Liimatta, Marya, Lockey, Peter, Norman, Maxine, Ouyang, Wenjun, René, Olivier, Wong, Harvey

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Identification of 2-amino-5-aryl-pyrazines as inhibitors of human lactate dehydrogenase von Fauber, Benjamin P., Dragovich, Peter S., Chen, Jinhua, Corson, Laura B., Ding, Charles Z., Eigenbrot, Charles, Giannetti, Anthony M., Hunsaker, Thomas, Labadie, Sharada, Liu, Yichin, Liu, Yingchun, Malek, Shiva, Peterson, David, Pitts, Keith, Sideris, Steve, Ultsch, Mark, VanderPorten, Erica, Wang, Jing, Wei, BinQing, Yen, Ivana, Yue, Qin

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Discovery of imidazo[1,5-a]pyridines and -pyrimidines as potent and selective RORc inverse agonists von Fauber, Benjamin P., Gobbi, Alberto, Robarge, Kirk, Zhou, Aihe, Barnard, Adrian, Cao, Jianhua, Deng, Yuzhong, Eidenschenk, Céline, Everett, Christine, Ganguli, Arunima, Hawkins, Julie, Johnson, Adam R., La, Hank, Norman, Maxine, Salmon, Gary, Summerhill, Susan, Ouyang, Wenjun, Tang, Wei, Wong, Harvey

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Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells von Rutz, Sascha, Kayagaki, Nobuhiko, Phung, Qui T., Eidenschenk, Celine, Noubade, Rajkumar, Wang, Xiaoting, Lesch, Justin, Lu, Rongze, Newton, Kim, Huang, Oscar W., Cochran, Andrea G., Vasser, Mark, Fauber, Benjamin P., DeVoss, Jason, Webster, Joshua, Diehl, Lauri, Modrusan, Zora, Kirkpatrick, Donald S., Lill, Jennie R., Ouyang, Wenjun, Dixit, Vishva M.

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Syntheses of 4-, 5-, 6-, and 7-substituted tryptamine derivatives and the use of a bromine atom as a protecting group von René, Olivier, Fauber, Benjamin P.

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Discovery of 1‑{4-[3-Fluoro-4-((3S,6R)‑3-methyl-1,1-dioxo-6-phenyl-[1,2]thiazinan-2-ylmethyl)-phenyl]-piperazin-1-yl}-ethanone (GNE-3500): a Potent, Selective, and Orally Bioavaila... von Fauber, Benjamin P, René, Olivier, Deng, Yuzhong, DeVoss, Jason, Eidenschenk, Céline, Everett, Christine, Ganguli, Arunima, Gobbi, Alberto, Hawkins, Julie, Johnson, Adam R, La, Hank, Lesch, Justin, Lockey, Peter, Norman, Maxine, Ouyang, Wenjun, Summerhill, Susan, Wong, Harvey

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Palladium-Catalyzed α‑Arylation of Sultams with Aryl and Heteroaryl Iodides von René, Olivier, Fauber, Benjamin P, Malhotra, Sushant, Yajima, Herbert

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Palladium-Catalyzed Ring Expansion of Spirocyclopropanes to Form Caprolactams and Azepanes von René, Olivier, Stepek, Iain A, Gobbi, Alberto, Fauber, Benjamin P, Gaines, Simon

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Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase von Dragovich, Peter S., Fauber, Benjamin P., Corson, Laura B., Ding, Charles Z., Eigenbrot, Charles, Ge, HongXiu, Giannetti, Anthony M., Hunsaker, Thomas, Labadie, Sharada, Liu, Yichin, Malek, Shiva, Pan, Borlan, Peterson, David, Pitts, Keith, Purkey, Hans E., Sideris, Steve, Ultsch, Mark, VanderPorten, Erica, Wei, BinQing, Xu, Qing, Yen, Ivana, Yue, Qin, Zhang, Huihui, Zhang, Xuying

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Discovery of oxa-sultams as RORc inverse agonists showing reduced lipophilicity, improved selectivity and favorable ADME properties von René, Olivier, Fauber, Benjamin P., Barnard, Adrian, Chapman, Kerry, Deng, Yuzhong, Eidenschenk, Céline, Everett, Christine, Gobbi, Alberto, Johnson, Adam R., La, Hank, Norman, Maxine, Salmon, Gary, Summerhill, Susan, Wong, Harvey

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Structure-based optimization of hydroxylactam as potent, cell-active inhibitors of lactate dehydrogenase von Wei, BinQing, Robarge, Kirk, Labadie, Sharada S., Chen, Jinhua, Corson, Laura B., DiPasquale, Antonio, Dragovich, Peter S., Eigenbrot, Charles, Evangelista, Marie, Fauber, Benjamin P., Hitz, Anna, Hong, Rebecca, Lai, Kwong Wah, Liu, Wenfeng, Ma, Shuguang, Malek, Shiva, O'Brien, Thomas, Pang, Jodie, Peterson, David, Salphati, Laurent, Sampath, Deepak, Sideris, Steven, Ultsch, Mark, Xu, Zijin, Yen, Ivana, Yu, Dong, Yue, Qin, Zhou, Aihe, Purkey, Hans E.

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Experimental and Computational Studies of the Diastereoselective Alkylations of 3‑Substituted γ‑Sultams von Fauber, Benjamin P, Clagg, Kyle, Gibbons, Paul, René, Olivier

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Reduction in lipophilicity improved the solubility, plasma–protein binding, and permeability of tertiary sulfonamide RORc inverse agonists von Fauber, Benjamin P., René, Olivier, de Leon Boenig, Gladys, Burton, Brenda, Deng, Yuzhong, Eidenschenk, Céline, Everett, Christine, Gobbi, Alberto, Hymowitz, Sarah G., Johnson, Adam R., La, Hank, Liimatta, Marya, Lockey, Peter, Norman, Maxine, Ouyang, Wenjun, Wang, Weiru, Wong, Harvey

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Minor Structural Change to Tertiary Sulfonamide RORc Ligands Led to Opposite Mechanisms of Action von René, Olivier, Fauber, Benjamin P, Boenig, Gladys de Leon, Burton, Brenda, Eidenschenk, Céline, Everett, Christine, Gobbi, Alberto, Hymowitz, Sarah G, Johnson, Adam R, Kiefer, James R, Liimatta, Marya, Lockey, Peter, Norman, Maxine, Ouyang, Wenjun, Wallweber, Heidi A, Wong, Harvey

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Identification of tertiary sulfonamides as RORc inverse agonists von Fauber, Benjamin P., René, Olivier, Burton, Brenda, Everett, Christine, Gobbi, Alberto, Hawkins, Julie, Johnson, Adam R., Liimatta, Marya, Lockey, Peter, Norman, Maxine, Wong, Harvey

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Identification of N-sulfonyl-tetrahydroquinolines as RORc inverse agonists von Fauber, Benjamin P., Gobbi, Alberto, Savy, Pascal, Burton, Brenda, Deng, Yuzhong, Everett, Christine, La, Hank, Johnson, Adam R., Lockey, Peter, Norman, Maxine, Wong, Harvey

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Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice von Purkey, Hans E, Robarge, Kirk, Chen, Jinhua, Chen, Zhongguo, Corson, Laura B, Ding, Charles Z, DiPasquale, Antonio G, Dragovich, Peter S, Eigenbrot, Charles, Evangelista, Marie, Fauber, Benjamin P, Gao, Zhenting, Ge, Hongxiu, Hitz, Anna, Ho, Qunh, Labadie, Sharada S, Lai, Kwong Wah, Liu, Wenfeng, Liu, Yajing, Li, Chiho, Ma, Shuguang, Malek, Shiva, O’Brien, Thomas, Pang, Jodie, Peterson, David, Salphati, Laurent, Sideris, Steve, Ultsch, Mark, Wei, BinQing, Yen, Ivana, Yue, Qin, Zhang, Huihui, Zhou, Aihe

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