Linking permafrost thaw to shifting biogeochemistry and food web resources in an arctic river von Kendrick, Michael R., Huryn, Alexander D., Bowden, William B., Deegan, Linda A., Findlay, Robert H., Hershey, Anne E., Peterson, Bruce J., Beneš, Joshua P., Schuett, Elissa B.

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Biogeochemical responses over 37 years to manipulation of phosphorus concentrations in an Arctic river: The Upper Kuparuk River Experiment von Iannucci, Frances M., Beneš, Joshua, Medvedeff, Alexander, Bowden, William B.

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Effect of particle size and heterogeneity on sediment biofilm metabolism and nutrient uptake scaled using two approaches von Parker, Samuel P., Bowden, William B., Flinn, Michael B., Giles, Courtney D., Arndt, Kyle A., Beneš, Joshua P., Jent, Derrick G.

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Microbial iron oxidation in the Arctic tundra and its implications for biogeochemical cycling von Emerson, David, Scott, Jarrod J, Benes, Joshua, Bowden, William B

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Targeting FGFR overcomes EMT-mediated resistance in EGFR mutant non-small cell lung cancer von Raoof, Sana, Mulford, Iain J., Frisco-Cabanos, Heidie, Nangia, Varuna, Timonina, Daria, Labrot, Emma, Hafeez, Nafeeza, Bilton, Samantha J., Drier, Yotam, Ji, Fei, Greenberg, Max, Williams, August, Kattermann, Krystina, Damon, Leah, Sovath, Sosathya, Rakiec, Daniel P., Korn, Joshua M., Ruddy, David A., Benes, Cyril H., Hammerman, Peter S., Piotrowska, Zofia, Sequist, Lecia V., Niederst, Matthew J., Barretina, Jordi, Engelman, Jeffrey A., Hata, Aaron N.

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Harnessing synthetic lethality to predict the response to cancer treatment von Lee, Joo Sang, Das, Avinash, Jerby-Arnon, Livnat, Arafeh, Rand, Auslander, Noam, Davidson, Matthew, McGarry, Lynn, James, Daniel, Amzallag, Arnaud, Park, Seung Gu, Cheng, Kuoyuan, Robinson, Welles, Atias, Dikla, Stossel, Chani, Buzhor, Ella, Stein, Gidi, Waterfall, Joshua J., Meltzer, Paul S., Golan, Talia, Hannenhalli, Sridhar, Gottlieb, Eyal, Benes, Cyril H., Samuels, Yardena, Shanks, Emma, Ruppin, Eytan

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Imipridone ONC212 activates orphan G protein-coupled receptor GPR132 and integrated stress response in acute myeloid leukemia von Nii, Takenobu, Prabhu, Varun V., Ruvolo, Vivian, Madhukar, Neel, Zhao, Ran, Mu, Hong, Heese, Lauren, Nishida, Yuki, Kojima, Kensuke, Garnett, Mathew J., McDermott, Ultan, Benes, Cyril H., Charter, Neil, Deacon, Sean, Elemento, Olivier, Allen, Joshua E., Oster, Wolfgang, Stogniew, Martin, Ishizawa, Jo, Andreeff, Michael

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Cancer stem cell-related gene expression as a potential biomarker of response for first-in-class imipridone ONC201 in solid tumors von Prabhu, Varun V, Lulla, Amriti R, Madhukar, Neel S, Ralff, Marie D, Zhao, Dan, Kline, Christina Leah B, Van den Heuvel, A Pieter J, Lev, Avital, Garnett, Mathew J, McDermott, Ultan, Benes, Cyril H, Batchelor, Tracy T, Chi, Andrew S, Elemento, Olivier, Allen, Joshua E, El-Deiry, Wafik S

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AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies von Caenepeel, Sean, Brown, Sean P, Belmontes, Brian, Moody, Gordon, Keegan, Kathleen S, Chui, Danny, Whittington, Douglas A, Huang, Xin, Poppe, Leszek, Cheng, Alan C, Cardozo, Mario, Houze, Jonathan, Li, Yunxiao, Lucas, Brian, Paras, Nick A, Wang, Xianghong, Taygerly, Joshua P, Vimolratana, Marc, Zancanella, Manuel, Zhu, Liusheng, Cajulis, Elaina, Osgood, Tao, Sun, Jan, Damon, Leah, Egan, Regina K, Greninger, Patricia, McClanaghan, Joseph D, Gong, Jianan, Moujalled, Donia, Pomilio, Giovanna, Beltran, Pedro, Benes, Cyril H, Roberts, Andrew W, Huang, David C, Wei, Andrew, Canon, Jude, Coxon, Angela, Hughes, Paul E

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EGFR Inhibition Potentiates FGFR Inhibitor Therapy and Overcomes Resistance in FGFR2 Fusion-Positive Cholangiocarcinoma von Wu, Qibiao, Zhen, Yuanli, Shi, Lei, Vu, Phuong, Greninger, Patricia, Adil, Ramzi, Merritt, Joshua, Egan, Regina, Wu, Meng-Ju, Yin, Xunqin, Ferrone, Cristina R, Deshpande, Vikram, Baiev, Islam, Pinto, Christopher J, McLoughlin, Daniel E, Walmsley, Charlotte S, Stone, James R, Gordan, John D, Zhu, Andrew X, Juric, Dejan, Goyal, Lipika, Benes, Cyril H, Bardeesy, Nabeel

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Preclinical evaluation of the imipridone family, analogs of clinical stage anti-cancer small molecule ONC201, reveals potent anti-cancer effects of ONC212 von Wagner, Jessica, Kline, Christina Leah, Ralff, Marie D, Lev, Avital, Lulla, Amriti, Zhou, Lanlan, Olson, Gary L, Nallaganchu, Bhaskara Rao, Benes, Cyril H, Allen, Joshua E, Prabhu, Varun V, Stogniew, Martin, Oster, Wolfgang, El-Deiry, Wafik S

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Discovery and clinical introduction of first-in-class imipridone ONC201 von Allen, Joshua E, Kline, C Leah B, Prabhu, Varun V, Wagner, Jessica, Ishizawa, Jo, Madhukar, Neel, Lev, Avital, Baumeister, Marie, Zhou, Lanlan, Lulla, Amriti, Stogniew, Martin, Schalop, Lee, Benes, Cyril, Kaufman, Howard L, Pottorf, Richard S, Nallaganchu, B Rao, Olson, Gary L, Al-Mulla, Fahd, Duvic, Madeleine, Wu, Gen Sheng, Dicker, David T, Talekar, Mala K, Lim, Bora, Elemento, Olivier, Oster, Wolfgang, Bertino, Joseph, Flaherty, Keith, Wang, Michael L, Borthakur, Gautam, Andreeff, Michael, Stein, Mark, El-Deiry, Wafik S

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Anti-pancreatic cancer activity of ONC212 involves the unfolded protein response (UPR) and is reduced by IGF1-R and GRP78/BIP von Lev, Avital, Lulla, Amriti R, Wagner, Jessica, Ralff, Marie D, Kiehl, Joshua B, Zhou, Yan, Benes, Cyril H, Prabhu, Varun V, Oster, Wolfgang, Astsaturov, Igor, Dicker, David T, El-Deiry, Wafik S

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Targeting Aberrant Glutathione Metabolism to Eradicate Human Acute Myelogenous Leukemia Cells von Pei, Shanshan, Minhajuddin, Mohammad, Callahan, Kevin P., Balys, Marlene, Ashton, John M., Neering, Sarah J., Lagadinou, Eleni D., Corbett, Cheryl, Ye, Haobin, Liesveld, Jane L., O'Dwyer, Kristen M., Li, Zheng, Shi, Lei, Greninger, Patricia, Settleman, Jeffrey, Benes, Cyril, Hagen, Fred K., Munger, Joshua, Crooks, Peter A., Becker, Michael W., Jordan, Craig T.

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Lysine demethylase KDM4A associates with translation machinery and regulates protein synthesis von Van Rechem, Capucine, Black, Joshua C, Boukhali, Myriam, Aryee, Martin J, Gräslund, Susanne, Haas, Wilhelm, Benes, Cyril H, Whetstine, Johnathan R

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Single agent and synergistic combinatorial efficacy of first-in-class small molecule imipridone ONC201 in hematological malignancies von Prabhu, Varun V, Talekar, Mala K, Lulla, Amriti R, Kline, C Leah B, Zhou, Lanlan, Hall, Junior, Van den Heuvel, A Pieter J, Dicker, David T, Babar, Jawad, Grupp, Stephan A, Garnett, Mathew J, McDermott, Ultan, Benes, Cyril H, Pu, Jeffrey J, Claxton, David F, Khan, Nadia, Oster, Wolfgang, Allen, Joshua E, El-Deiry, Wafik S

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LD Score regression distinguishes confounding from polygenicity in genome-wide association studies von Bulik-Sullivan, Brendan K, Loh, Po-Ru, Finucane, Hilary K, Ripke, Stephan, Yang, Jian, Patterson, Nick, Daly, Mark J, Price, Alkes L, Neale, Benjamin M

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Biological insights from 108 schizophrenia-associated genetic loci von Neale, Benjamin M, Pers, Tune H, Agartz, Ingrid, Agerbo, Esben, Amin, Farooq, Bergen, Sarah E, Bigdeli, Tim B, Buckner, Randy L, Cai, Guiqing, Catts, Stanley V, Chan, Raymond C. K, Chen, Eric Y. H, Cheng, Wei, Cheung, Eric F. C, Ann Chong, Siow, Robert Cloninger, C, Cohen, Nadine, Crowley, James J, Davidson, Michael, Davis, Kenneth L, Del Favero, Jurgen, Demontis, Ditte, Dinan, Timothy, Djurovic, Srdjan, Drapeau, Elodie, Eriksson, Johan, Escott-Price, Valentina, Friedl, Marion, Fromer, Menachem, Genovese, Giulio, Georgieva, Lyudmila, Giusti-Rodriguez, Paola, Gopal, Srihari, Gratten, Jacob, Hammer, Christian, Hofman, Andrea, Hougaard, David M, Julia, Antonio, Klovins, Janis, Ausrele Kucinskiene, Zita, Hong Lee, S, Lerer, Bernard, Limborska, Svetlana, Lubinski, Jan, Macek Jr, Milan, Magnusson, Patrik K. E, Mattheisen, Manuel, McDonald, Colm, Michie, Patricia T, Milanova, Vihra, Mokrab, Younes, Muller-Myhsok, Bertram, Nenadic, Igor, Nordin, Annelie, Van Os, Jim, Endophenotypes International Consortium, Psychosis, Parkhomenko, Elena, Pejovic-Milovancevic, Milica, Pimm, Jonathan, Price, Alkes, Purcell, Shaun M, Quested, Digby, Rasmussen, Henrik B, Roffman, Joshua L, Schubert, Christian R, Schwab, Sibylle G, Scott, Rodney J, Seidman, Larry J, Silverman, Jeremy M, Smoller, Jordan W, Steinberg, Stacy, Strengman, Eric, Strohmaier, Jana, Svrakic, Dragan M, Soderman, Erik, Thirumalai, Srinivas, Toncheva, Draga, Tosato, Sarah, Veijola, Juha, Walsh, Dermot, Weiser, Mark, Wolen, Aaron R, Zheng, Xuebin, Wray, Naomi R, Visscher, Peter M, Trust Case-Control Consortium, Wellcome, Andreassen, Ole A, Blackwood, Douglas H. R, Esko, Tonu, Gill, Michael, Jablensky, Assen V, McCarroll, Steven A, Mowry, Bryan J, Owen, Michael J, Pato, Carlos N, Posthuma, Danielle, Rujescu, Dan, Sham, Pak C, Sklar, Pamela, St Clair, David

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BIOM-60. BIOMARKER EVALUATION FOR IMIPRIDONE ONC206 REVEALS ClpP, ATF4, MYC, EGFR and HIF1 AS KEY PREDICTORS OF ANTI-CANCER EFFICACY von Morrow, Sara, Garnett, Mathew, McDermott, Ultan, Benes, Cyril, Allen, Joshua, Prabhu, Varun

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A coding single-nucleotide polymorphism in lysine demethylase KDM4A associates with increased sensitivity to mTOR inhibitors von Van Rechem, Capucine, Black, Joshua C, Greninger, Patricia, Zhao, Yang, Donado, Carlos, Burrowes, Paul D, Ladd, Brendon, Christiani, David C, Benes, Cyril H, Whetstine, Johnathan R

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