Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction von Simonetta, Kyle R., Taygerly, Joshua, Boyle, Kathleen, Basham, Stephen E., Padovani, Chris, Lou, Yan, Cummins, Thomas J., Yung, Stephanie L., von Soly, Szerenke Kiss, Kayser, Frank, Kuriyan, John, Rape, Michael, Cardozo, Mario, Gallop, Mark A., Bence, Neil F., Barsanti, Paul A., Saha, Anjanabha

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Global Impairment of the Ubiquitin-Proteasome System by Nuclear or Cytoplasmic Protein Aggregates Precedes Inclusion Body Formation von Bennett, Eric J., Bence, Neil F., Jayakumar, Rajadas, Kopito, Ron R.

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Impairment of the Ubiquitin-Proteasome System by Protein Aggregation von Bence, Neil F., Sampat, Roopal M., Kopito, Ron R.

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Treatment-Emergent Mutations in NAEβ Confer Resistance to the NEDD8-Activating Enzyme Inhibitor MLN4924 von Milhollen, Michael A., Thomas, Michael P., Narayanan, Usha, Traore, Tary, Riceberg, Jessica, Amidon, Benjamin S., Bence, Neil F., Bolen, Joseph B., Brownell, James, Dick, Lawrence R., Loke, Huay-Keng, McDonald, Alice A., Ma, Jingya, Manfredi, Mark G., Sells, Todd B., Sintchak, Mike D., Yang, Xiaofeng, Xu, Qing, Koenig, Erik M., Gavin, James M., Smith, Peter G.

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Intersecting pathways to neurodegeneration in Parkinson's disease: Effects of the pesticide rotenone on DJ-1, α-synuclein, and the ubiquitin–proteasome system von Betarbet, Ranjita, Canet-Aviles, Rosa M., Sherer, Todd B., Mastroberardino, Pier G., McLendon, Chris, Kim, Jin-Ho, Lund, Serena, Na, Hye-Mee, Taylor, Georgia, Bence, Neil F., Kopito, Ron, Seo, Byoung Boo, Yagi, Takao, Yagi, Akemi, Klinefelter, Gary, Cookson, Mark R., Greenamyre, J. Timothy

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A Rhodopsin Mutant Linked to Autosomal Dominant Retinitis Pigmentosa Is Prone to Aggregate and Interacts with the Ubiquitin Proteasome System von Illing, Michelle E., Rajan, Rahul S., Bence, Neil F., Kopito, Ron R.

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Mechanistic Study of Uba5 Enzyme and the Ufm1 Conjugation Pathway von Gavin, James M., Hoar, Kara, Xu, Qing, Ma, Jingya, Lin, Yafang, Chen, Jiejin, Chen, Wei, Bruzzese, Frank J., Harrison, Sean, Mallender, William D., Bump, Nancy J., Sintchak, Michael D., Bence, Neil F., Li, Ping, Dick, Lawrence R., Gould, Alexandra E., Chen, Jesse J.

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A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment von Hyer, Marc L, Milhollen, Michael A, Ciavarri, Jeff, Fleming, Paul, Traore, Tary, Sappal, Darshan, Huck, Jessica, Shi, Judy, Gavin, James, Brownell, Jim, Yang, Yu, Stringer, Bradley, Griffin, Robert, Bruzzese, Frank, Soucy, Teresa, Duffy, Jennifer, Rabino, Claudia, Riceberg, Jessica, Hoar, Kara, Lublinsky, Anya, Menon, Saurabh, Sintchak, Michael, Bump, Nancy, Pulukuri, Sai M, Langston, Steve, Tirrell, Stephen, Kuranda, Mike, Veiby, Petter, Newcomb, John, Li, Ping, Wu, Jing Tao, Powe, Josh, Dick, Lawrence R, Greenspan, Paul, Galvin, Katherine, Manfredi, Mark, Claiborne, Chris, Amidon, Benjamin S, Bence, Neil F

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Formation of Morphologically Similar Globular Aggregates from Diverse Aggregation-Prone Proteins in Mammalian Cells von Mukai, Hideyuki, Isagawa, Takayuki, Goyama, Emiko, Tanaka, Shuhei, Bence, Neil F., Tamura, Atsuo, Ono, Yoshitaka, Kopito, Ron R., Ingram, Vernon Martin

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Mechanistic Studies of Substrate-assisted Inhibition of Ubiquitin-activating Enzyme by Adenosine Sulfamate Analogues von Chen, Jesse J., Tsu, Christopher A., Gavin, James M., Milhollen, Michael A., Bruzzese, Frank J., Mallender, William D., Sintchak, Michael D., Bump, Nancy J., Yang, Xiaofeng, Ma, Jingya, Loke, Huay-Keng, Xu, Qing, Li, Ping, Bence, Neil F., Brownell, James E., Dick, Lawrence R.

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Specificity in Intracellular Protein Aggregation and Inclusion Body Formation von Rajan, Rahul S., Illing, Michelle E., Bence, Neil F., Kopito, Ron R.

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Abstract 2696: Genetic and pharmacologic evaluation of the ubiquitin ligase CBL-B as a small-molecule, tumor immunotherapy target von Gosling, Jennifa, Rountree, Ryan, Taherbhoy, Asad, Wang, Chenbo, Cummins, Thomas, Cohen, Frederick, Tanaka, Hiroko, Weiss, Dahlia, Cardozo, Mario, Karim, Christopher, Tan, May, Juan, Joseph, Tenn-McClellan, Austin, Soly, Szerenke Kiss von, Sheung, Julie, Boyle, Kathleen, Dhamnaskar, Ketki, Kurylo, Katherine, Bruffey, Jilliane, McKinnell, Jennifer, Karr, Dane, Christianson, Andria, Vries, Anne-Renee Van Der Vuurst de, Sivakumar, Pallavur, Gallop, Mark, Barsanti, Paul A., Saha, Anjanabha, Bence, Neil F., Zapf, Christoph W.

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Redundant Control of the Caenorhabditis elegans Sperm/Oocyte Switch by PUF-8 and FBF-1, Two Distinct PUF RNA-Binding Proteins von Bachorik, Jennifer L., Kimble, Judith

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Application and analysis of the GFPu family of ubiquitin-proteasome system reporters von Bence, Neil F, Bennett, Eric J, Kopito, Ron R

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Application and Analysis of the GFPu Family of Ubiquitin‐Proteasome System Reporters von Bence, Neil F., Bennett, Eric J., Kopito, Ron R.

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Cyano cyclobutyl compounds for Cbl-b inhibition and uses thereof von ZAPF, Chistoph W, GOSLING, Jennifa, CUMMINS, Thomas, SHUNATONA, Hunter, COHEN, Frederick, SANDS, Arthur, WEISS, Dahlia, CARDOZO, Mario, BENCE, Neil F, WANG, Chenbo, TANAKA, Hiroko

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3-substituted piperidine compounds for Cbl-b inhibition, and use of a Cbl-b inhibitor in combination with a cancer vaccine and/or oncolytic virus von GOSLING, Jennifa, CUMMINS, Thomas, SANDS, Arthur T, SHUNATONA, Hunter, COHEN, Frederick, ZAPF, Christoph W, WEISS, Dahlia, CARDOZO, Mario, BENCE, Neil F, WANG, Chenbo, TANAKA, Hiroko

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3-SUBSTITUTED PIPERIDINE COMPOUNDS FOR CBL-B INHIBITION, AND USE THEREOF von Wang, Chenbo, Cummins, Thomas, SANDS, Arthur T, Cohen, Frederick, Tanaka, Hiroko, Weiss, Dahlia, Shunatona, Hunter, Gosling, Jennifa, Bence, Neil F, Cardozo, Mario, Zapf, Christoph W

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3-substituted piperidine compounds for cbl-b inhibition, and use of a cbl-b inhibitor in combination with a cancer vaccine and/or oncolytic virus von BENCE Neil F, SANDS Arthur T, ZAPF Christoph W, CARDOZO Mario, WEISS Dahlia, SHUNATONA Hunter Paul, WANG Chenbo, TANAKA Hiroko, GOSLING Jennifa, CUMMINS Thomas, COHEN Frederick

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Cyano cyclobutyl compounds for Cbl-b inhibition and uses thereof von Wang, Chenbo, Cummins, Thomas, Sands, Arthur T, Cohen, Frederick, Tanaka, Hiroko, Weiss, Dahlia, Shunatona, Hunter, Gosling, Jennifa, Bence, Neil F, Cardozo, Mario, Zapf, Christoph W

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