Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses von Anastasiou, Dimitrios, Poulogiannis, George, Asara, John M., Boxer, Matthew B., Jiang, Jian-kang, Shen, Min, Bellinger, Gary, Sasaki, Atsuo T., Locasale, Jason W., Auld, Douglas S., Thomas, Craig J., Heiden, Matthew G. Vander, Cantley, Lewis C.

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PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells von Israelsen, William J., Dayton, Talya L., Davidson, Shawn M., Fiske, Brian P., Hosios, Aaron M., Bellinger, Gary, Li, Jie, Yu, Yimin, Sasaki, Mika, Horner, James W., Burga, Laura N., Xie, Jianxin, Jurczak, Michael J., DePinho, Ronald A., Clish, Clary B., Jacks, Tyler, Kibbey, Richard G., Wulf, Gerburg M., Di Vizio, Dolores, Mills, Gordon B., Cantley, Lewis C., Vander Heiden, Matthew G.

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Demethylation Therapy as a Targeted Treatment for Human Papillomavirus-Associated Head and Neck Cancer von Biktasova, Asel, Hajek, Michael, Sewell, Andrew, Gary, Cyril, Bellinger, Gary, Deshpande, Hari A, Bhatia, Aarti, Burtness, Barbara, Judson, Benjamin, Mehra, Saral, Yarbrough, Wendell G, Issaeva, Natalia

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Pyruvate Kinase Isoform Expression Alters Nucleotide Synthesis to Impact Cell Proliferation von Lunt, Sophia Y., Muralidhar, Vinayak, Hosios, Aaron M., Israelsen, William J., Gui, Dan Y., Newhouse, Lauren, Ogrodzinski, Martin, Hecht, Vivian, Xu, Kali, Acevedo, Paula N. Marín, Hollern, Daniel P., Bellinger, Gary, Dayton, Talya L., Christen, Stefan, Elia, Ilaria, Dinh, Anh T., Stephanopoulos, Gregory, Manalis, Scott R., Yaffe, Michael B., Andrechek, Eran R., Fendt, Sarah-Maria, Vander Heiden, Matthew G.

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Metformin Decreases Glucose Oxidation and Increases the Dependency of Prostate Cancer Cells on Reductive Glutamine Metabolism von FENDT, Sarah-Maria, BELL, Eric L, PATNAIK, Akash, BLOUIN, Marie Jose, CANTLEY, Lewis C, GUARENTE, Leonard, BLENIS, John, POLLAK, Michael N, OLUMI, Aria F, VANDER HEIDEN, Matthew G, STEPHANOPOULOS, Gregory, KEIBLER, Mark A, DAVIDSON, Shawn M, WIRTH, Gregory J, FISKE, Brian, MAYERS, Jared R, SCHWAB, Matthias, BELLINGER, Gary, CSIBI, Alfredo

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Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion von Juvekar, Ashish, Hu, Hai, Yadegarynia, Sina, Lyssiotis, Costas A., Ullas, Soumya, Lien, Evan C., Bellinger, Gary, Son, Jaekyoung, Hok, Rosanna C., Seth, Pankaj, Daly, Michele B., Kim, Baek, Scully, Ralph, Asara, John M., Cantley, Lewis C., Wulf, Gerburg M.

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Depletion of a Putatively Druggable Class of Phosphatidylinositol Kinases Inhibits Growth of p53-Null Tumors von Emerling, Brooke M., Hurov, Jonathan B., Poulogiannis, George, Tsukazawa, Kazumi S., Choo-Wing, Rayman, Wulf, Gerburg M., Bell, Eric L., Shim, Hye-Seok, Lamia, Katja A., Rameh, Lucia E., Bellinger, Gary, Sasaki, Atsuo T., Asara, John M., Yuan, Xin, Bullock, Andrea, DeNicola, Gina M., Song, Jiaxi, Brown, Victoria, Signoretti, Sabina, Cantley, Lewis C.

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Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma von Davidson, Shawn M, Schmidt, Daniel R, Heyman, Julia E, O'Brien, James P, Liu, Amy C, Israelsen, William J, Dayton, Talya L, Sehgal, Raghav, Bronson, Roderick T, Freinkman, Elizaveta, Mak, Howard H, Fanelli, Giuseppe Nicolò, Malstrom, Scott, Bellinger, Gary, Carracedo, Arkaitz, Pandolfi, Pier Paolo, Courtney, Kevin D, Jha, Abhishek, DePinho, Ronald A, Horner, James W, Thomas, Craig J, Cantley, Lewis C, Loda, Massimo, Vander Heiden, Matthew G

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Identification of CDCP1 as a hypoxia-inducible factor 2α (HIF-2α) target gene that is associated with survival in clear cell renal cell carcinoma patients von Emerling, Brooke M., Benes, Cyril H., Poulogiannis, George, Bell, Eric L., Courtney, Kevin, Liu, Hui, Choo-Wing, Rayman, Bellinger, Gary, Tsukazawa, Kazumi S., Brown, Victoria, Signoretti, Sabina, Soltoff, Stephen P., Cantley, Lewis C.

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ErbB2 Is Required for Ductal Morphogenesis of the Mammary Gland von Jackson-Fisher, Amy J., Bellinger, Gary, Ramabhadran, Rajani, Morris, Jacqueline K., Lee, Kuo-Fen, Stern, David F., Brugge, Joan S.

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AMPK-Dependent Degradation of TXNIP upon Energy Stress Leads to Enhanced Glucose Uptake via GLUT1 von Wu, Ning, Zheng, Bin, Shaywitz, Adam, Dagon, Yossi, Tower, Christine, Bellinger, Gary, Shen, Che-Hung, Wen, Jennifer, Asara, John, McGraw, Timothy E., Kahn, Barbara B., Cantley, Lewis C.

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Abstract LB-333: PARP-1 supports HPV infection and HPV-associated head and neck cancer von Pan, Cassie, Biktasova, Asel, Hajek, Michael, Sewell, Andrew, Sathe, Tejas, Bellinger, Gary, Yarbrough, Wendell, Issaeva, Natalia

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Identification of CDCP1 as a hypoxia-inducible factor 2 alpha (HIF-2 alpha) target gene that is associated with survival in clear cell renal cell carcinoma patients (vol 110, pg 34... von Emerling, Brooke M., Benes, Cyril H., Poulogiannis, George, Bell, Eric L., Courtney, Kevin, Liu, Hui, Choo-Wing, Rayman, Bellinger, Gary, Tsukazawa, Kazumi S., Brown, Victoria, Signoretti, Sabina, Soltoff, Stephen P., Cantley, Lewis C.

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Selective antitumor activity of roscovitine in head and neck cancer von Gary, Cyril, Hajek, Michael, Biktasova, Asel, Bellinger, Gary, Yarbrough, Wendell G, Issaeva, Natalia

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Abstract 4588: Identification of CDCP1 as a HIF-2α target gene involved in the regulation of cancer cell migration and metastasis von Emerling, Brooke M., Benes, Cyril, Bell, Eric, Poulogiannis, George, Courtney, Kevin, Lui, Hui, Choo-Wing, Rayman, Bellinger, Gary, Soltoff, Stephen, Cantley, Lewis

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Abstract LB-365: Effective use of PI3K/MTOR and MEK inhibitors prior to hormone ablative therapy in PTEN-loss driven murine prostate cancer von Patnaik, Akash, Courtney, Kevin, Robichaud, Kyle, Bellinger, Gary, Nardella, Caterina, Signoretti, Sabina, Wooster, Richard, Pandolfi, Pier Paolo, Cantley, Lewis

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Pyruvate Kinase Isoform Expression Alters Nucleotide Synthesis to Impact Cell Proliferation von Lunt, Sophia Y, Muralidhar, Vinayak, Hosios, Aaron M, Israelsen, William J, Gui, Dan Y, Newhouse, Lauren, Ogrodzinski, Martin, Hecht, Vivian, Xu, Kali, Acevedo, Paula N. Marín, Hollern, Daniel P, Bellinger, Gary, Dayton, Talya L, Christen, Stefan, Elia, Ilaria, Dinh, Anh T, Stephanopoulos, Gregory, Manalis, Scott R, Yaffe, Michael B, Andrechek, Eran R, Fendt, Sarah-Maria, Vander Heiden, Matthew G

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Identification of CDCP1 as a hypoxia-inducible factor 2[alpha] (HIF-2[alpha]) target gene that is associated with survival in clear cell renal cell carcinoma patients von Emerling, Brooke M, Benes, Cyril H, Poulogiannis, George, Bell, Eric L, Courtney, Kevin, Liu, Hui, Choo-Wing, Rayman, Bellinger, Gary, Tsukazawa, Kazumi S, Brown, Victoria, Signoretti, Sabina, Soltoff, Stephen P, Cantley, Lewis C

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Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism von Fendt, Sarah-Maria, Bell, Eric L, Keibler, Mark A, Davidson, Shawn M, Wirth, Gregory J, Fiske, Brian, Mayers, Jared R, Schwab, Matthias, Bellinger, Gary, Csibi, Alfredo, Patnaik, Akash, Blouin, Marie Jose, Cantley, Lewis C, Guarente, Leonard, Blenis, John, Pollak, Michael N, Olumi, Aria F, Vander Heiden, Matthew G, Stephanopoulos, Gregory

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Abstract LB-418: Targeting the PI3K/mTOR pathway in genetically engineered mouse models of prostate cancer von Patnaik, Akash, Courtney, Kevin, Bellinger, Gary, Lunsford, Elaine, Robichaud, Kyle, Grant, Aaron, Lenkinski, Robert, Pedrosa, Ivan, Signoretti, Sabina, Wooster, Richard, Cantley, Lewis

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