Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins von Schaer, Dominik J., Buehler, Paul W., Alayash, Abdu I., Belcher, John D., Vercellotti, Gregory M.

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Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease von Belcher, John D., Chen, Chunsheng, Nguyen, Julia, Milbauer, Liming, Abdulla, Fuad, Alayash, Abdu I., Smith, Ann, Nath, Karl A., Hebbel, Robert P., Vercellotti, Gregory M.

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Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction von Belcher, John D, Chen, Chunsheng, Nguyen, Julia, Abdulla, Fuad, Zhang, Ping, Nguyen, Hao, Nguyen, Phong, Killeen, Trevor, Miescher, Sylvia M, Brinkman, Nathan, Nath, Karl A, Steer, Clifford J, Vercellotti, Gregory M

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Oral carbon monoxide therapy in murine sickle cell disease: Beneficial effects on vaso-occlusion, inflammation and anemia von Belcher, John D, Gomperts, Edward, Nguyen, Julia, Chen, Chunsheng, Abdulla, Fuad, Kiser, Zachary M, Gallo, David, Levy, Howard, Otterbein, Leo E, Vercellotti, Gregory M

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A novel, highly potent and selective phosphodiesterase-9 inhibitor for the treatment of sickle cell disease von McArthur, James G, Svenstrup, Niels, Chen, Chunsheng, Fricot, Aurelie, Carvalho, Caroline, Nguyen, Julia, Nguyen, Phong, Parachikova, Anna, Abdulla, Fuad, Vercellotti, Gregory M, Hermine, Olivier, Edwards, Dave, Ribeil, Jean-Antoine, Belcher, John D, Maciel, Thiago T

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Missing the mark(ers): circulating endothelial cells and endothelial-derived extracellular vesicles are elevated in sickle cell disease plasma von Beckman, Joan D, Zhang, Ping, Nguyen, Julia, Hebbel, Robert P, Vercellotti, Gregory M, Belcher, John D

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Identification of a Heme Activation Site on the MD-2/TLR4 Complex von Belcher, John D, Zhang, Ping, Nguyen, Julia, Kiser, Zachary M, Nath, Karl A, Hu, Jianjun, Trent, John O, Vercellotti, Gregory M

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Role of TLR4 signaling in the nephrotoxicity of heme and heme proteins von Nath, Karl A, Belcher, John D, Nath, Meryl C, Grande, Joseph P, Croatt, Anthony J, Ackerman, Allan W, Katusic, Zvonimir S, Vercellotti, Gregory M

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Endothelial TLR4 Expression Mediates Vaso-Occlusive Crisis in Sickle Cell Disease von Beckman, Joan D, Abdullah, Fuad, Chen, Chunsheng, Kirchner, Rachel, Rivera-Rodriguez, Dormarie, Kiser, Zachary M, Nguyen, Aithanh, Zhang, Ping, Nguyen, Julia, Hebbel, Robert P, Belcher, John D, Vercellotti, Gregory M

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Liver‐targeted gene therapy: Approaches and challenges von Aravalli, Rajagopal N., Belcher, John D., Steer, Clifford J.

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Soluble MD-2 and Heme in Sickle Cell Disease Plasma Promote Pro-Inflammatory Signaling in Endothelial Cells von Zhang, Ping, Nguyen, Julia, Abdulla, Fuad, Nelson, Alexander T, Beckman, Joan D, Vercellotti, Gregory M, Belcher, John D

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Hepatic Overexpression of Hemopexin Inhibits Inflammation and Vascular Stasis in Murine Models of Sickle Cell Disease von Vercellotti, Gregory M, Zhang, Ping, Nguyen, Julia, Abdulla, Fuad, Chen, Chunsheng, Nguyen, Phong, Nowotny, Carlos, Steer, Clifford J, Smith, Ann, Belcher, John D

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The multifaceted role of ischemia/reperfusion in sickle cell anemia von Hebbel, Robert P, Belcher, John D, Vercellotti, Gregory M

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The BACH1 inhibitor ASP8731 inhibits inflammation and vaso-occlusion and induces fetal hemoglobin in sickle cell disease von Belcher, John D, Nataraja, Selvaraj, Abdulla, Fuad, Zhang, Ping, Chen, Chunsheng, Nguyen, Julia, Ruan, Conglin, Singh, Maneet, Demes, Shilpa, Olson, Lyndsay, Stickens, Domi, Stanwix, Jeff, Clarke, Emer, Huang, Yongzhao, Biddle, Margaret, Vercellotti, Gregory M

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The HDAC inhibitors trichostatin A and suberoylanilide hydroxamic acid exhibit multiple modalities of benefit for the vascular pathobiology of sickle transgenic mice von Hebbel, Robert P., Vercellotti, Gregory M., Pace, Betty S., Solovey, Anna N., Kollander, Rahn, Abanonu, Chine F., Nguyen, Julia, Vineyard, Julie V., Belcher, John D., Abdulla, Fuad, Osifuye, Shadé, Eaton, John W., Kelm, Robert J., Slungaard, Arne

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The fucosylation inhibitor, 2-fluorofucose, inhibits vaso-occlusion, leukocyte-endothelium interactions and NF-ĸB activation in transgenic sickle mice von Belcher, John D, Chen, Chunsheng, Nguyen, Julia, Abdulla, Fuad, Nguyen, Phong, Nguyen, Minh, Okeley, Nicole M, Benjamin, Dennis R, Senter, Peter D, Vercellotti, Gregory M

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β-Globin sleeping beauty transposon reduces red blood cell sickling in a patient-derived CD34(+)-based in vitro model von Sjeklocha, Lucas M, Wong, Phillip Y-P, Belcher, John D, Vercellotti, Gregory M, Steer, Clifford J

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Critical role of endothelial cell activation in hypoxia-induced vasoocclusion in transgenic sickle mice von Belcher, John D, Mahaseth, Hemchandra, Welch, Thomas E, Vilback, Asa E, Sonbol, Khalid M, Kalambur, Venkatasubramaniam S, Bowlin, Paul R, Bischof, John C, Hebbel, Robert P, Vercellotti, Gregory M

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Control of Oxidative Stress and Inflammation in Sickle Cell Disease with the Nrf2 Activator Dimethyl Fumarate von Belcher, John D, Chen, Chunsheng, Nguyen, Julia, Zhang, Ping, Abdulla, Fuad, Nguyen, Phong, Killeen, Trevor, Xu, Pauline, O'Sullivan, Gerry, Nath, Karl A, Vercellotti, Gregory M

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Thrombin activation of PAR-1 contributes to microvascular stasis in mouse models of sickle cell disease von Sparkenbaugh, Erica M., Chen, Chunsheng, Brzoska, Tomasz, Nguyen, Julia, Wang, Shaobin, Vercellotti, Gregory M., Key, Nigel S., Sundd, Prithu, Belcher, John D., Pawlinski, Rafal

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