Mutational Spectrum, Copy Number Changes, and Outcome: Results of a Sequencing Study of Patients With Newly Diagnosed Myeloma von Walker, Brian A, Boyle, Eileen M, Wardell, Christopher P, Murison, Alex, Begum, Dil B, Dahir, Nasrin M, Proszek, Paula Z, Johnson, David C, Kaiser, Martin F, Melchor, Lorenzo, Aronson, Lauren I, Scales, Matthew, Pawlyn, Charlotte, Mirabella, Fabio, Jones, John R, Brioli, Annamaria, Mikulasova, Aneta, Cairns, David A, Gregory, Walter M, Quartilho, Ana, Drayson, Mark T, Russell, Nigel, Cook, Gordon, Jackson, Graham H, Leleu, Xavier, Davies, Faith E, Morgan, Gareth J

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Clonal evolution in myeloma: the impact of maintenance lenalidomide and depth of response on the genetics and sub-clonal structure of relapsed disease in uniformly treated newly di... von Jones, John R, Weinhold, Niels, Ashby, Cody, Walker, Brian A, Wardell, Chris, Pawlyn, Charlotte, Rasche, Leo, Melchor, Lorenzo, Cairns, David A, Gregory, Walter M, Johnson, David, Begum, Dil B, Ellis, Sidra, Sherborne, Amy L, Cook, Gordon, Kaiser, Martin F, Drayson, Mark T, Owen, Roger G, Jackson, Graham H, Davies, Faith E, Greaves, Mel, Morgan, Gareth J

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APOBEC family mutational signatures are associated with poor prognosis translocations in multiple myeloma von Walker, Brian A., Wardell, Christopher P., Murison, Alex, Boyle, Eileen M., Begum, Dil B., Dahir, Nasrin M., Proszek, Paula Z., Melchor, Lorenzo, Pawlyn, Charlotte, Kaiser, Martin F., Johnson, David C., Qiang, Ya-Wei, Jones, John R., Cairns, David A., Gregory, Walter M., Owen, Roger G., Cook, Gordon, Drayson, Mark T., Jackson, Graham H., Davies, Faith E., Morgan, Gareth J.

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The Spectrum and Clinical Impact of Epigenetic Modifier Mutations in Myeloma von Pawlyn, Charlotte, Kaiser, Martin F, Heuck, Christoph, Melchor, Lorenzo, Wardell, Christopher P, Murison, Alex, Chavan, Shweta S, Johnson, David C, Begum, Dil B, Dahir, Nasrin M, Proszek, Paula Z, Cairns, David A, Boyle, Eileen M, Jones, John R, Cook, Gordon, Drayson, Mark T, Owen, Roger G, Gregory, Walter M, Jackson, Graham H, Barlogie, Bart, Davies, Faith E, Walker, Brian A, Morgan, Gareth J

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Characterization of IGH locus breakpoints in multiple myeloma indicates a subset of translocations appear to occur in pregerminal center B cells von Walker, Brian A., Wardell, Christopher P., Johnson, David C., Kaiser, Martin F., Begum, Dil B., Dahir, Nasrin B., Ross, Fiona M., Davies, Faith E., Gonzalez, David, Morgan, Gareth J.

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Coexistent hyperdiploidy does not abrogate poor prognosis in myeloma with adverse cytogenetics and may precede IGH translocations von Pawlyn, Charlotte, Melchor, Lorenzo, Murison, Alex, Wardell, Christopher P., Brioli, Annamaria, Boyle, Eileen M., Kaiser, Martin F., Walker, Brian A., Begum, Dil B., Dahir, Nasrin B., Proszek, Paula, Gregory, Walter M., Drayson, Mark T., Jackson, Graham H., Ross, Fiona M., Davies, Faith E., Morgan, Gareth J.

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Genome-wide association study identifies variation at 6q25.1 associated with survival in multiple myeloma von Johnson, David C., Weinhold, Niels, Mitchell, Jonathan S., Chen, Bowang, Kaiser, Martin, Begum, Dil B., Hillengass, Jens, Bertsch, Uta, Gregory, Walter A., Cairns, David, Jackson, Graham H., Försti, Asta, Nickel, Jolanta, Hoffmann, Per, Nöethen, Markus M., Stephens, Owen W., Barlogie, Bart, Davis, Faith E., Hemminki, Kari, Goldschmidt, Hartmut, Houlston, Richard S., Morgan, Gareth J.

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Ovarian Hyperstimulation Syndrome Post-dilation and Evacuation of a Hydatidiform Mole: A Case Report von Begum, Dil Anziz, Fatema, Fouzia, Yesmin, Farzana

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Inherited genetic susceptibility to monoclonal gammopathy of unknown significance von Weinhold, Niels, Johnson, David C., Rawstron, Andrew C., Försti, Asta, Doughty, Chi, Vijayakrishnan, Jayaram, Broderick, Peter, Dahir, Nasrin B., Begum, Dil B., Hosking, Fay J., Yong, Kwee, Walker, Brian A., Hoffmann, Per, Mühleisen, Thomas W., Langer, Christian, Dörner, Elisabeth, Jöckel, Karl-Heinz, Eisele, Lewin, Nöthen, Markus M., Hose, Dirk, Davies, Faith E., Goldschmidt, Hartmut, Morgan, Gareth J., Hemminki, Kari, Houlston, Richard S.

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The 7p15.3 (rs4487645) association for multiple myeloma shows strong allele-specific regulation of the MYC-interacting gene CDCA7L in malignant plasma cells von Weinhold, Niels, Meissner, Tobias, Johnson, David C, Seckinger, Anja, Moreaux, Jérôme, Försti, Asta, Chen, Bowang, Nickel, Jolanta, Chubb, Daniel, Rawstron, Andrew C, Doughty, Chi, Dahir, Nasrin B, Begum, Dil B, Young, Kwee, Walker, Brian A, Hoffmann, Per, Nöthen, Marcus M, Davies, Faith E, Klein, Bernard, Goldschmidt, Hartmut, Morgan, Gareth J, Houlston, Richard S, Hose, Dirk, Hemminki, Kari

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A molecular diagnostic approach able to detect the recurrent genetic prognostic factors typical of presenting myeloma von Boyle, Eileen M., Proszek, Paula Z., Kaiser, Martin F., Begum, Dil, Dahir, Nasrin, Savola, Suvi, Wardell, Christopher P., Leleu, Xavier, Ross, Fiona M., Chiecchio, Laura, Cook, Gordon, Drayson, Mark T., Owen, Richard G., Ashcroft, John M., Jackson, Graham H., Anthony Child, James, Davies, Faith E., Walker, Brian A., Morgan, Gareth J.

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MYC Translocations In Multiple Myeloma Involve Recruitment Of Enhancer Elements Resulting In Over-Expression and Decreased Overall Survival von Walker, Brian A, Wardell, Christopher P, Begum, Dil, Dahir, Nasrin, Johnson, David C, Davies, Faith E, Morgan, Gareth J

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DNA Methylation Profiling of Myeloma Trial Patients Reveals Specific Epigenetic Changes Associated with Outcome von Johnson, David C, Begum, Dil B, Ellis, Sidra, Sherborne, Amy L, Price, Amy, Smith, Charlotte, Mirabella, Fabio, Menezes, Karen, Kimber, Scott, Jones, John R, Pawlyn, Charlotte, Jenner, Matthew W, Houlston, Richard S, Cook, Gordon, Russell, Nigel H., Striha, Alina, Collett, Corinne, Waterhouse, Anna, Gregory, Walter M, Cairns, David A, Drayson, Mark T, Owen, Roger G, Davies, Faith E, Morgan, Gareth J, Jackson, Graham H, Kaiser, Martin F

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The Impact of Maintenance Lenalidomide on the Mutational Status of the Myeloma Clone at Relapse in the NCRI Myeloma XI Trial for Newly Diagnosed Multiple Myeloma Patients (NDMM) von Jones, John R, Weinhold, Niels, Chavan, Shweta S., Pawlyn, Charlotte, Melchor, Lorenzo, Cairns, David A, Begum, Dil B, Smith, Charlotte, Ellis, Sidra, Price, Amy, Sherborne, Amy L, Walker, Brian A, Wardell, Christopher P, Cook, Gordon, Jenner, Matthew W, Russell, Nigel H, Drayson, Mark T, Owen, Roger G, Davies, Faith E, Kaiser, Martin F, Jackson, Graham H, Gregory, Walter M, Greaves, Mel, Morgan, Gareth J

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Identifying Ultra-High Risk Myeloma By Integrated Molecular Genetic and Gene Expression Profiling von Sherborne, Amy L, Begum, Dil B, Price, Amy, Johnson, David C, Ellis, Sidra, Smith, Charlotte, Mirabella, Fabio, Menezes, Karen, Kimber, Scott, Jones, John R, Pawlyn, Charlotte, Houlston, Richard S, Russell, Nigel H., Jenner, Matthew W, Cook, Gordon, Striha, Alina, Collett, Corinne, Waterhouse, Anna, Gregory, Walter M, Cairns, David A, Drayson, Mark T, Owen, Roger G, Davies, Faith E, Morgan, Gareth J, Jackson, Graham H, Kaiser, Martin F

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Rapid, Robust and Accessible Molecular Profiling of Biologically and Clinically Relevant Copy Number Alterations in Multiple Myeloma from Small Amounts of Tumor DNA von Kaiser, Martin F, Proszek, Paula, Begum, Dil, Dahir, Nasrin, Walker, Brian A, Savola, Suvi, Boyle, Eileen M, Johnson, David C, Cairns, David A, Gregory, Walter, Jackson, Graham, Owen, Roger G, Cook, Gordon, Drayson, Mark T, Davies, Faith E, Morgan, Gareth J

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Specific Identification of High Risk Disease Using Molecular Profiling By Mymap (Myeloma MLPA and translocation PCR) of 1,036 Cases von Kaiser, Martin F, Boyle, Eileen Mary, Walker, Brian A, Begum, Dil B, Proszek, Paula, Johnson, David C, Pawlyn, Charlotte, Jones, John R, Savola, Suvi, Owen, Roger G, Drayson, Mark T, Cairns, David A, Cook, Gordon, Gregory, Walter M, Houlston, Richard S, Davies, Faith E, Jackson, Graham H, Morgan, Gareth J

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Spatiotemporal Analysis of Intraclonal Heterogeneity in Multiple Myeloma: Unravelling the Impact of Treatment and the Propagating Capacity of Subclones Using Whole Exome Sequencing von Melchor, Lorenzo, Jones, John R, Lenive, Oleg, Peterson, Erich Allen, Brioli, Annamaria, Murison, Alex, Wardell, Christopher P, Kaiser, Martin F, Proszek, Paula, Boyle, Eileen Mary, Begum, Dil B, Pawlyn, Charlotte, Johnson, David C, Rapado, Inmaculada, Cairns, David A, Gregory, Walter M, Owen, Roger G, Jackson, Graham H, Drayson, Mark T, Davies, Faith E, Martínez-López, Joaquín, Houlston, Richard S, Greaves, Mel, Walker, Brian A, Morgan, Gareth J

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Molecular Subgroups of Hyperdiploidy and Their Prognostic Relevance - an Analysis of 1,036 Myeloma Trial Patients von Kaiser, Martin F, Boyle, Eileen Mary, Walker, Brian A, Begum, Dil B, Proszek, Paula, Johnson, David C, Pawlyn, Charlotte, Jones, John R, Savola, Suvi, Owen, Roger G, Drayson, Mark T, Cairns, David A, Cook, Gordon, Gregory, Walter M, Houlston, Richard S, Davies, Faith E, Jackson, Graham H, Morgan, Gareth J

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Base-Pair Resolution Mapping of IGH Translocations in Multiple Myeloma Using Targeted Capture and Massively Parallel Sequencing von Walker, Brian A, Wardell, Christopher P, Begum, Dil B, Dahir, Nasrin B, Ross, Fiona M, Davies, Faith E., Gonzalez, David, Morgan, Gareth J.

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