Identification of apilimod as a first-in-class PIKfyve kinase inhibitor for treatment of B-cell non-Hodgkin lymphoma von Gayle, Sophia, Landrette, Sean, Beeharry, Neil, Conrad, Chris, Hernandez, Marylens, Beckett, Paul, Ferguson, Shawn M., Mandelkern, Talya, Zheng, Meiling, Xu, Tian, Rothberg, Jonathan, Lichenstein, Henri

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Thymine DNA glycosylase as a novel target for melanoma von Mancuso, Pietro, Tricarico, Rossella, Bhattacharjee, Vikram, Cosentino, Laura, Kadariya, Yuwaraj, Jelinek, Jaroslav, Nicolas, Emmanuelle, Einarson, Margret, Beeharry, Neil, Devarajan, Karthik, Katz, Richard A., Dorjsuren, Dorjbal G., Sun, Hongmao, Simeonov, Anton, Giordano, Antonio, Testa, Joseph R., Davidson, Guillaume, Davidson, Irwin, Larue, Lionel, Sobol, Robert W., Yen, Timothy J., Bellacosa, Alfonso

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HuR Posttranscriptionally Regulates WEE1: Implications for the DNA Damage Response in Pancreatic Cancer Cells von LAI, Shruti, BURKHART, Richard A, SAWICKI, Janet A, WINTER, Jordan M, RIGOUTSOS, Isidore, YEN, Timothy J, BRODY, Jonathan R, BEEHARRY, Neil, BHATTACHARJEE, Vikram, LONDIN, Eric R, COZZITORTO, Joseph A, ROMEO, Carmella, JIMBO, Masaya, NORRIS, Zoë A, YEO, Charles J

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A modified HSP70 inhibitor shows broad activity as an anticancer agent von Balaburski, Gregor M, Leu, Julia I-Ju, Beeharry, Neil, Hayik, Seth, Andrake, Mark D, Zhang, Gao, Herlyn, Meenhard, Villanueva, Jessie, Dunbrack, Jr, Roland L, Yen, Tim, George, Donna L, Murphy, Maureen E

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Comparison of the activity of three different HSP70 inhibitors on apoptosis, cell cycle arrest, autophagy inhibition, and HSP90 inhibition von Budina-Kolomets, Anna, Balaburski, Gregor M, Bondar, Anastasia, Beeharry, Neil, Yen, Tim, Murphy, Maureen E

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Oncogenic Ras Regulates BRIP1 Expression to Induce Dissociation of BRCA1 from Chromatin, Inhibit DNA Repair, and Promote Senescence von Tu, Zhigang, Aird, Katherine M., Bitler, Benjamin G., Nicodemus, Jasmine P., Beeharry, Neil, Xia, Bing, Yen, Tim J., Zhang, Rugang

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Targeting WEE1 to enhance conventional therapies for acute lymphoblastic leukemia von Ghelli Luserna Di Rorà, Andrea, Beeharry, Neil, Imbrogno, Enrica, Ferrari, Anna, Robustelli, Valentina, Righi, Simona, Sabattini, Elena, Verga Falzacappa, Maria Vittoria, Ronchini, Chiara, Testoni, Nicoletta, Baldazzi, Carmen, Papayannidis, Cristina, Abbenante, Maria Chiara, Marconi, Giovanni, Paolini, Stefania, Parisi, Sarah, Sartor, Chiara, Fontana, Maria Chiara, De Matteis, Serena, Iacobucci, Ilaria, Pelicci, Pier Giuseppe, Cavo, Michele, Yen, Timothy J, Martinelli, Giovanni

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Leukemia-associated RhoGEF (LARG) is a novel RhoGEF in cytokinesis and required for the proper completion of abscission von Martz, Matthew K, Grabocka, Elda, Beeharry, Neil, Yen, Timothy J, Wedegaertner, Philip B

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Dose dependent effects on cell cycle checkpoints and DNA repair by bendamustine von Beeharry, Neil, Rattner, Jerome B, Bellacosa, Alfonso, Smith, Mitchell R, Yen, Timothy J

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Network modeling of kinase inhibitor polypharmacology reveals pathways targeted in chemical screens von Ursu, Oana, Gosline, Sara J C, Beeharry, Neil, Fink, Lauren, Bhattacharjee, Vikram, Huang, Shao-Shan Carol, Zhou, Yan, Yen, Tim, Fraenkel, Ernest

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G Protein-coupled Receptor Kinase 5 Is Localized to Centrosomes and Regulates Cell Cycle Progression von Michal, Allison M., So, Christopher H., Beeharry, Neil, Shankar, Haripriya, Mashayekhi, Rouzbeh, Yen, Timothy J., Benovic, Jeffrey L.

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LAM-003, a new drug for treatment of tyrosine kinase inhibitor–resistant FLT3-ITD–positive AML von Beeharry, Neil, Landrette, Sean, Gayle, Sophia, Hernandez, Marylens, Grotzke, Jeff E., Young, Peter R., Beckett, Paul, Zhang, Xuan, Carter, Bing Z., Andreeff, Michael, Halene, Stephanie, Xu, Tian, Rothberg, Jonathan, Lichenstein, Henri

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p53-dependent apoptosis in response to spindle damage is linked to loss of Bub1 von Beeharry, Neil, Yen, Tim

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DNA double-strand breaks with 5' adducts are efficiently channeled to the DNA2-mediated resection pathway von Tammaro, Margaret, Liao, Shuren, Beeharry, Neil, Yan, Hong

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SunRISe-1: Phase 2b study of TAR-200 plus cetrelimab, TAR-200 alone, or cetrelimab alone in participants with high-risk nonmuscle-invasive bladder cancer unresponsive to Bacillus C... von Van Der Heijden, Michiel Simon, Cutie, Christopher, Hampras, Shalaka, Indoria, Charu, Stewart, Rachel, Acharya, Milin, Stromberg, Katherine, Li, Xiang, Beeharry, Neil, Maffeo, John, Jacob, Joseph M

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Safety and efficacy of the erdafitinib (erda) intravesical delivery system, TAR-210, in patients (pts) with non–muscle-invasive bladder cancer (NMIBC) or muscle-invasive bladder ca... von Vilaseca, Antoni, Guerrero, Félix, Zainfeld, Daniel, Shore, Neal D., Rodriguez Faba, Oscar, Meijer, Richard P., Witjes, Alfred Alfred, McRee, Autumn Jackson, Kalota, Anna, Stone, Nicole L., Lauring, Josh David, Zhu, Wei, Beeharry, Neil, O'Dondi, Lang A, Jayram, Gautam

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SunRISe-4: TAR-200 plus cetrelimab or cetrelimab alone as neoadjuvant therapy in patients with muscle-invasive bladder cancer (MIBC) who are ineligible for or refuse neoadjuvant pl... von Psutka, Sarah P., Cutie, Christopher, Bhanvadia, Sumeet Kaur, Keegan, Kirk A., Crist, Wendy, Tian, Shaozhou Ken, Maffeo, John, Raybold, Bradley, Kashmer, Marietta, Hasan, Mohamad, Li, Xiang, Beeharry, Neil, Thomas, Shibu, Tian, Hui, Powles, Thomas

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A phase 3, multicenter, randomized study evaluating the efficacy of TAR-200 in combination with cetrelimab versus concurrent chemoradiotherapy in participants with muscle-invasive... von Williams, Stephen B., Cutie, Christopher, Keegan, Kirk A, Raybold, Bradley, Acharya, Milin, Zhu, Wei, Li, Xiang, O'Dondi, Lang A, Beeharry, Neil, Spratt, Daniel Eidelberg

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Urine-based testing for patient selection and genomic characterization of patients with FGFR alteration-positive non–muscle-invasive bladder cancer (NMIBC) treated with TAR-210 von Li, Roger, Ku, Ja Hyeon, Vilaseca Cabo, Antoni, Guerrero-Ramos, Félix, Meeks, Joshua J, Beeharry, Neil, Quiroz, Michelle, Zhang, Jiarui, Smirnov, Denis, Rajpurohit, Yashoda Rani, Brunton, Bethany, Martinez, Gabriela, Cost, Carrye Rudolph, Kalota, Anna, Lauring, Josh David, Stone, Nicole L., Thomas, Shibu, Jia, Shidong, Kim, Il-Jin, Du, Pan

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Evaluating technical feasibility of a urine cell-free DNA (cfDNA) NGS assay for identifying biomarkers in bladder cancer von Kim, Il-Jin, Quiroz, Michelle, Zhao, Zhixin, Mo, Wei, Zheng, Tiantian, Wang, Amy, Singh, Usha, Beeharry, Neil, Smirnov, Denis, Wang, Songbai, Tate, Renee, Zhang, Tom, Liu, Fang, Hanumanthe, Seema, Xiang, Binggang, Luo, Shujun, Kuklin, Alexander, Wirtz, Ralph M., Du, Pan, Jia, Shidong

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