Advances in mixed cell deconvolution enable quantification of cell types in spatial transcriptomic data von Danaher, Patrick, Kim, Youngmi, Nelson, Brenn, Griswold, Maddy, Yang, Zhi, Piazza, Erin, Beechem, Joseph M.

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High-Plex Predictive Marker Discovery for Melanoma Immunotherapy-Treated Patients Using Digital Spatial Profiling von Toki, Maria I, Merritt, Christopher R, Wong, Pok Fai, Smithy, James W, Kluger, Harriet M, Syrigos, Konstantinos N, Ong, Giang T, Warren, Sarah E, Beechem, Joseph M, Rimm, David L

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High-Plex Spatially Resolved RNA and Protein Detection Using Digital Spatial Profiling: A Technology Designed for Immuno-oncology Biomarker Discovery and Translational Research von Beechem, Joseph M.

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CTLA-4 blockade and interferon-α induce proinflammatory transcriptional changes in the tumor immune landscape that correlate with pathologic response in melanoma von Khunger, Arjun, Piazza, Erin, Warren, Sarah, Smith, Thomas H, Ren, Xing, White, Andrew, Elliott, Nathan, Cesano, Alessandra, Beechem, Joseph M, Kirkwood, John M, Tarhini, Ahmad A

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Multiplex digital spatial profiling of proteins and RNA in fixed tissue von Merritt, Christopher R., Ong, Giang T., Church, Sarah E., Barker, Kristi, Danaher, Patrick, Geiss, Gary, Hoang, Margaret, Jung, Jaemyeong, Liang, Yan, McKay-Fleisch, Jill, Nguyen, Karen, Norgaard, Zach, Sorg, Kristina, Sprague, Isaac, Warren, Charles, Warren, Sarah, Webster, Philippa J., Zhou, Zoey, Zollinger, Daniel R., Dunaway, Dwayne L., Mills, Gordon B., Beechem, Joseph M.

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Analysis of Steady-state Protein Phosphorylation in Mitochondria Using a Novel Fluorescent Phosphosensor Dye von Schulenberg, Birte, Aggeler, Robert, Beechem, Joseph M., Capaldi, Roderick A., Patton, Wayne F.

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Global quantitative phosphoprotein analysis using Multiplexed Proteomics technology von Steinberg, Thomas H., Agnew, Brian J., Gee, Kyle R., Leung, Wai-Yee, Goodman, Terrie, Schulenberg, Birte, Hendrickson, Jill, Beechem, Joseph M., Haugland, Richard P., Patton, Wayne F.

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GeoMx™ RNA Assay: High Multiplex, Digital, Spatial Analysis of RNA in FFPE Tissue von Zollinger, Daniel R., Lingle, Stan E., Sorg, Kristina, Beechem, Joseph M., Merritt, Christopher R.

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High-plex imaging of RNA and proteins at subcellular resolution in fixed tissue by spatial molecular imaging von He, Shanshan, Bhatt, Ruchir, Brown, Carl, Brown, Emily A., Buhr, Derek L., Chantranuvatana, Kan, Danaher, Patrick, Dunaway, Dwayne, Garrison, Ryan G., Geiss, Gary, Gregory, Mark T., Hoang, Margaret L., Khafizov, Rustem, Killingbeck, Emily E., Kim, Dae, Kim, Tae Kyung, Kim, Youngmi, Klock, Andrew, Korukonda, Mithra, Kutchma, Alecksandr, Lewis, Zachary R., Liang, Yan, Nelson, Jeffrey S., Ong, Giang T., Perillo, Evan P., Phan, Joseph C., Phan-Everson, Tien, Piazza, Erin, Rane, Tushar, Reitz, Zachary, Rhodes, Michael, Rosenbloom, Alyssa, Ross, David, Sato, Hiromi, Wardhani, Aster W., Williams-Wietzikoski, Corey A., Wu, Lidan, Beechem, Joseph M.

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1277-P: Spatial Whole Transcriptome Profiling of the Human Pancreas Uncovers Unique Insights into Histological Structures von YANG, WEI, HOGAN, MEGHAN F., LIANG, YAN, BEECHEM, JOSEPH M.

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Quantitative analysis of protein phosphorylation status and protein kinase activity on microarrays using a novel fluorescent phosphorylation sensor dye von Martin, Karen, Steinberg, Thomas H., Cooley, Laurie A., Gee, Kyle R., Beechem, Joseph M., Patton, Wayne F.

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Easily reversible desthiobiotin binding to streptavidin, avidin, and other biotin-binding proteins: uses for protein labeling, detection, and isolation von Hirsch, James D, Eslamizar, Leila, Filanoski, Brian J, Malekzadeh, Nabi, Haugland, Rosaria P, Beechem, Joseph M, Haugland, Richard P

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Spatially resolved whole transcriptome profiling in human and mouse tissue using Digital Spatial Profiling von Zimmerman, Stephanie M., Fropf, Robin, Kulasekara, Bridget R., Griswold, Maddy, Appelbe, Oliver, Bahrami, Arya, Boykin, Rich, Buhr, Derek L., Fuhrman, Kit, Hoang, Margaret L., Huynh, Quoc, Isgur, Lesley, Klock, Andrew, Kutchma, Alecksandr, Lasley, Alexa E., Liang, Yan, McKay-Fleisch, Jill, Nelson, Jeffrey S., Nguyen, Karen, Piazza, Erin, Rininger, Aric, Zollinger, Daniel R., Rhodes, Michael, Beechem, Joseph M.

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Highly Multiplexed Spatially Resolved Proteomic and Transcriptional Profiling of the Glioblastoma Microenvironment Using Archived Formalin-Fixed Paraffin-Embedded Specimens von Kim, Youngmi, Danaher, Patrick, Cimino, Patrick J, Hurth, Kyle, Warren, Sarah, Glod, John, Beechem, Joseph M, Zada, Gabriel, McEachron, Troy A

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Quantitative Comparison of Long-wavelength Alexa Fluor Dyes to Cy Dyes: Fluorescence of the Dyes and Their Bioconjugates von Berlier, Judith E, Rothe, Anca, Buller, Gayle, Bradford, Jolene, Gray, Diane R, Filanoski, Brian J, Telford, William G, Yue, Stephen, Liu, Jixiang, Cheung, Ching-Ying, Chang, Wesley, Hirsch, James D, Beechem, Joseph M, Haugland, Rosaria P, Haugland, Richard P

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Distinct actions of cis and trans ATP within the double ring of the chaperonin GroEL von RYE, H. S, BURSTON, S. G, FENTON, W. A, BEECHEM, J. M, XU, Z, SIGLER, P. B, HORWICH, A. L

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CTLA-4 blockade and interferon-[alpha] induce proinflammatory transcriptional changes in the tumor immune landscape that correlate with pathologic response in melanoma von Khunger, Arjun, Piazza, Erin, Warren, Sarah, Smith, Thomas H, Ren, Xing, White, Andrew, Elliott, Nathan, Cesano, Alessandra, Beechem, Joseph M, Kirkwood, John M, Tarhini, Ahmad A

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Characterization of the Active Intermediate of a GroEL–GroES-Mediated Protein Folding Reaction von Weissman, Jonathan S, Rye, Hays S, Fenton, Wayne A, Beechem, Joseph M, Horwich, Arthur L

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Spatially resolved analysis of pancreatic cancer identifies therapy-associated remodeling of the tumor microenvironment von Shiau, Carina, Cao, Jingyi, Gong, Dennis, Gregory, Mark T., Caldwell, Nicholas J., Yin, Xunqin, Cho, Jae-Won, Wang, Peter L., Su, Jennifer, Wang, Steven, Reeves, Jason W., Kim, Tae Kyung, Kim, Youngmi, Guo, Jimmy A., Lester, Nicole A., Bae, Jung Woo, Zhao, Ryan, Schurman, Nathan, Barth, Jamie L., Ganci, Maria L., Weissleder, Ralph, Jacks, Tyler, Qadan, Motaz, Hong, Theodore S., Wo, Jennifer Y., Roberts, Hannah, Beechem, Joseph M., Castillo, Carlos Fernandez-del, Mino-Kenudson, Mari, Ting, David T., Hemberg, Martin, Hwang, William L.

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Multiplatform Analysis of Intratumoral PTEN Heterogeneity in Melanoma von Chagani, Sharmeen, De Macedo, Mariana P., Carapeto, Fernando, Wang, Feng, Marzese, Diego M., Wani, Khalida, Haydu, Lauren E., Peng, Weiyi, Ong, Giang T., Warren, Sarah E., Beechem, Joseph M., Hoon, Dave S.B., Mills, Gordon B., Tetzlaff, Michael T., Lazar, Alexander J., Kwong, Lawrence N., Davies, Michael A.

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