Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA von Liu, M.C., Klein, E.A., Swanton, C., Seiden, M.V., Klein, Eric A., Yeatman, Timothy J., Cohn, Allen L., Lapham, Rosanna, Parker, Alexander S., McIntyre, Kristi, Sekeres, Mikkael A., Siegel, Robert, Wang, Xuezhong, Cosgrove, David P., Trent, Jonathan, Thiel, David D., Garbo, Lawrence E., Giguere, Jeffrey K., Michels, Ross M., Harris, Ronald P., Richey, Stephen L., McCarthy, Timothy A., Couch, Fergus J., Wilks, Sharon T., Krie, Amy K., Balaraman, Rama, Rieger-Christ, Kimberly, Sullivan, Travis, Greenwald, Daniel R., Oh, William, Tsao, Che-Kai, Kennecke, Hagen F., Manhas, Atisha P., Ulrich, Brian K., Kovoor, Philip A., Stokoe, Christopher, Courtright, Jay G., Larson, Timothy G., Seiden, Michael V., Cummings, Steven R., Absalan, Farnaz, Alexander, Gregory, Allen, Brian, Aravanis, Alexander M., Beausang, John F., Berman, Jennifer, Bredno, Joerg, Calef, Robert, Cann, Gordon, Carter, Jeremy, Chen, Xiaoji, Chien, Tom C., Davydov, Konstantin, Demas, Vasiliki, Fields, Alexander P., Freese, Peter, Gnerre, Sante, Gross, Samuel, Hall, Megan P., Hartman, Anne-Renee, Hou, Chenlu, Hubbell, Earl, Jiang, Roger, Kim, TaeHyung, Klausner, Richard D., Kurtzman, Kathryn N., Lee, Mark, Lin, Wendy, Lipson, Jafi, Maddala, Tara, Maher, M. Cyrus, Melton, Collin, Mich, Andrea, Newman, Joshua, Nicula, Virgil, Nikolic, Ongjen, Patel, Shilpen, Rava, Richard, Schellenberger, Jan, Scott, Eric, Sehnert, Amy J., Shaknovich, Rita, Shanmugam, Avinash, Shashidhar, K.C., Shenoy, Archana, Shojaee, Seyedmehdi, Tang, Susan, Valouev, Anton, Venn, Oliver, Williams, Richard T., Wu, Tony, Yakym, Christopher, Yang, Xiao, Yecies, Jessica, Yip, Alexander S., Yue, Jeanne, Zhang, Lily, Zhang, Lori (Quan), Curtis, Christina, Berry, Donald A.

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Abstract LB-343: Development of plasma cell-free DNA (cfDNA) assays for early cancer detection: first insights from the Circulating Cell-Free Genome Atlas Study (CCGA) von Aravanis, Alexander A., Oxnard, Geoffrey R., Maddala, Tara, Hubbell, Earl, Venn, Oliver, Jamshidi, Arash, Shen, Ling, Amini, Hamed, Beausang, John A., Betts, Craig, Civello, Daniel, Davydov, Konstantin, Fazullina, Saniya, Filippova, Darya, Gnerre, Sante, Gross, Samuel, Hou, Chenlu, Jiang, Roger, Jung, Byoungsok, Kurtzman, Kathryn, Melton, Collin, Nautiyal, Shivani, Newman, Jonathan, Newman, Joshua, Nicolaou, Cosmos, Rava, Richard, Sakarya, Onur, Satya, Ravi Vijaya, Shojaee, Seyedmehdi, Steffen, Kristan, Valouev, Anton, Xu, Hui, Yue, Jeanne, Zhang, Nan, Baselga, Jose, Lapham, Rosanna, Davis, Daron G., Smith, David, Richards, Donald, Seiden, Michael V., Swanton, Charles, Yeatman, Timothy J., Tibshirani, Robert, Curtis, Christina, Plevritis, Sylvia K., Williams, Richard, Klein, Eric, Hartman, Anne-Renee, Liu, Minetta C.

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Single-Cell Analysis of Human Pancreas Reveals Transcriptional Signatures of Aging and Somatic Mutation Patterns von Enge, Martin, Arda, H. Efsun, Mignardi, Marco, Beausang, John, Bottino, Rita, Kim, Seung K., Quake, Stephen R.

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Tilting and Wobble of Myosin V by High-Speed Single-Molecule Polarized Fluorescence Microscopy von Beausang, John F., Shroder, Deborah Y., Nelson, Philip C., Goldman, Yale E.

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The promise and challenge of high-throughput sequencing of the antibody repertoire von Georgiou, George, Ippolito, Gregory C, Beausang, John, Busse, Christian E, Wardemann, Hedda, Quake, Stephen R

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Evaluation of cell-free DNA approaches for multi-cancer early detection von Jamshidi, Arash, Liu, Minetta C., Klein, Eric A., Venn, Oliver, Hubbell, Earl, Beausang, John F., Gross, Samuel, Melton, Collin, Fields, Alexander P., Liu, Qinwen, Zhang, Nan, Fung, Eric T., Kurtzman, Kathryn N., Amini, Hamed, Betts, Craig, Civello, Daniel, Freese, Peter, Calef, Robert, Davydov, Konstantin, Fayzullina, Saniya, Hou, Chenlu, Jiang, Roger, Jung, Byoungsok, Tang, Susan, Demas, Vasiliki, Newman, Joshua, Sakarya, Onur, Scott, Eric, Shenoy, Archana, Shojaee, Seyedmehdi, Steffen, Kristan K., Nicula, Virgil, Chien, Tom C., Bagaria, Siddhartha, Hunkapiller, Nathan, Desai, Mohini, Dong, Zhao, Richards, Donald A., Yeatman, Timothy J., Cohn, Allen L., Thiel, David D., Berry, Donald A., Tummala, Mohan K., McIntyre, Kristi, Sekeres, Mikkael A., Bryce, Alan, Aravanis, Alexander M., Seiden, Michael V., Swanton, Charles

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Antigen Identification for Orphan T Cell Receptors Expressed on Tumor-Infiltrating Lymphocytes von Gee, Marvin H., Han, Arnold, Lofgren, Shane M., Beausang, John F., Mendoza, Juan L., Birnbaum, Michael E., Bethune, Michael T., Fischer, Suzanne, Yang, Xinbo, Gomez-Eerland, Raquel, Bingham, David B., Sibener, Leah V., Fernandes, Ricardo A., Velasco, Andrew, Baltimore, David, Schumacher, Ton N., Khatri, Purvesh, Quake, Stephen R., Davis, Mark M., Garcia, K. Christopher

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Elongation factor G initiates translocation through a power stroke von Chen, Chunlai, Cui, Xiaonan, Beausang, John F., Zhang, Haibo, Farrell, Ian, Cooperman, Barry S., Goldman, Yale E.

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Concentration and length dependence of DNA looping in transcriptional regulation von Han, Lin, Garcia, Hernan G, Blumberg, Seth, Towles, Kevin B, Beausang, John F, Nelson, Philip C, Phillips, Rob

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Quaternary InGaAsSb Thermophotovoltaic Diodes von Dashiell, Michael W., Beausang, John F., Ehsani, Hassan, Nichols, G. J., Depoy, David M., Danielson, Lee R., Talamo, Phil, Rahner, Kevin D., Brown, Edward J., Burger, Steven R., Fourspring, Patrick M., Topper, William F., Baldasaro, P. F., Wang, Christine A., Huang, Robin K., Connors, Michael K., Turner, George W., Shellenbarger, Zane A., Taylor, Gordon, Li, Jizhong, Martinelli, Ramon, Donetski, Dmitry, Anikeev, Sergei, Belenky, Gregory L., Luryi, Serge

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T cell receptor sequencing of early-stage breast cancer tumors identifies altered clonal structure of the T cell repertoire von Beausang, John F., Wheeler, Amanda J., Chan, Natalie H., Hanft, Violet R., Dirbas, Frederick M., Jeffrey, Stefanie S., Quake, Stephen R.

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A Randomized Controlled Trial Comparing Adductor Canal Catheter and Intraarticular Catheter After Primary Total Knee Arthroplasty von Beausang, David H., MD, Pozek, John-Paul J., MD, Chen, Antonia F., MD, MBA, Hozack, William J., MD, Kaufmann, Marc W., DO, Torjman, Marc C., PhD, Baratta, Jaime L., MD

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Twirling of Actin by Myosins II and V Observed via Polarized TIRF in a Modified Gliding Assay von Beausang, John F., Schroeder, Harry W., Nelson, Philip C., Goldman, Yale E.

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Tethered Particle Motion as a Diagnostic of DNA Tether Length von Nelson, Philip C, Zurla, Chiara, Brogioli, Doriano, Beausang, John F, Finzi, Laura, Dunlap, David

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Early real-world (RW) experience with a multi-cancer early detection (MCED) test von Westgate, Candace, Kingsbury, Dallas, Poliak, Martin, Lipton, Jordan, McMillin, Matthew, Malinow, Louis B., Matrana, Marc Ryan, Beausang, John F., Stanley, Geoff, Shaknovich, Rita, Venstrom, Jeffrey M., Kurtzman, Kathryn, Shukla, Vershalee

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B cell repertoires in HLA-sensitized kidney transplant candidates undergoing desensitization therapy von Beausang, John F, Fan, H Christina, Sit, Rene, Hutchins, Maria U, Jirage, Kshama, Curtis, Rachael, Hutchins, Edward, Quake, Stephen R, Yabu, Julie M

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Abstract 2114: HPV-driven cancers show distinct methylation signatures in cell-free DNA (cfDNA) von Calef, Robert, Venn, Oliver, Maher, M. Cyrus, Beausang, John F., Hubbell, Earl, Patel, Aman, Fields, Alexander P., Bredno, Joerg, Jamshidi, Arash, Aravanis, Alexander M.

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Myosin VI Walks “Wiggly” on Actin with Large and Variable Tilting von Sun, Yujie, Schroeder, Harry W., Beausang, John F., Homma, Kazuaki, Ikebe, Mitsuo, Goldman, Yale E.

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Abstract C139: The robustness of a targeted methylation-based multi-cancer early detection (MCED) test to population differences in self-reported ethnicity von Venn, Oliver, Bredno, Joerg, Thornton, Alexis, Hubbell, Earl, Kurtzman, Kathryn, Beausang, John, Swanton, Charles

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Genome-wide sequencing for early stage lung cancer detection from plasma cell-free DNA (cfDNA): The Circulating Cancer Genome Atlas (CCGA) study von Oxnard, Geoffrey R., Maddala, Tara, Hubbell, Earl, Aravanis, Alex, Zhang, Nan, Venn, Oliver, Valouev, Anton, Shen, Ling, Patel, Shilpen, Jamshidi, Arash, Jagadeesh, Karthik, Gross, Samuel, Filippova, Darya, Beausang, John F., Liu, Minetta C., Richards, Donald A., Plevritis, Sylvia, Williams, Richard Thomas, Hartman, Anne-Renee, Swanton, Charles

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