Ibrutinib plus lenalidomide and rituximab has promising activity in relapsed/refractory non–germinal center B-cell–like DLBCL von Goy, Andre, Ramchandren, Radhakrishnan, Ghosh, Nilanjan, Munoz, Javier, Morgan, David S., Dang, Nam H., Knapp, Mark, Delioukina, Maria, Kingsley, Edwin, Ping, Jerry, Beaupre, Darrin M., Neuenburg, Jutta K., Ruan, Jia

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Combination of Ibrutinib and ABT-199 in Diffuse Large B-Cell Lymphoma and Follicular Lymphoma von Kuo, Hsu-Ping, Ezell, Scott A, Schweighofer, Karl J, Cheung, Leo W K, Hsieh, Sidney, Apatira, Mutiah, Sirisawad, Mint, Eckert, Karl, Hsu, Ssucheng J, Chen, Chun-Te, Beaupre, Darrin M, Versele, Matthias, Chang, Betty Y

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Safety, Pharmacokinetics, and Pharmacodynamics of AMG 102, a Fully Human Hepatocyte Growth Factor–Neutralizing Monoclonal Antibody, in a First-in-Human Study of Patients with Advan... von Gordon, Michael S, Sweeney, Christopher S, Mendelson, David S, Eckhardt, S Gail, Anderson, Abraham, Beaupre, Darrin M, Branstetter, Daniel, Burgess, Teresa L, Coxon, Angela, Deng, Hongjie, Kaplan-Lefko, Paula, Leitch, Ian M, Oliner, Kelly S, Yan, Lucy, Zhu, Min, Gore, Lia

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Ibrutinib‐associated lymphocytosis corresponds to bone marrow involvement in mantle cell lymphoma von Furtado, Michelle, Wang, Michael L., Munneke, Brian, McGreivy, Jesse, Beaupre, Darrin M., Rule, Simon

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Targeting Bruton tyrosine kinase with ibrutinib in relapsed/refractory marginal zone lymphoma von Noy, Ariela, de Vos, Sven, Thieblemont, Catherine, Martin, Peter, Flowers, Christopher R., Morschhauser, Franck, Collins, Graham P., Ma, Shuo, Coleman, Morton, Peles, Shachar, Smith, Stephen, Barrientos, Jacqueline C., Smith, Alina, Munneke, Brian, Dimery, Isaiah, Beaupre, Darrin M., Chen, Robert

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Targeting B cell receptor signaling with ibrutinib in diffuse large B cell lymphoma von Wilson, Wyndham H, Young, Ryan M, Schmitz, Roland, Yang, Yandan, Pittaluga, Stefania, Wright, George, Lih, Chih-Jian, Williams, P Mickey, Shaffer, Arthur L, Gerecitano, John, de Vos, Sven, Goy, Andre, Kenkre, Vaishalee P, Barr, Paul M, Blum, Kristie A, Shustov, Andrei, Advani, Ranjana, Fowler, Nathan H, Vose, Julie M, Elstrom, Rebecca L, Habermann, Thomas M, Barrientos, Jacqueline C, McGreivy, Jesse, Fardis, Maria, Chang, Betty Y, Clow, Fong, Munneke, Brian, Moussa, Davina, Beaupre, Darrin M, Staudt, Louis M

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Tipifarnib-induced apoptosis in acute myeloid leukemia and multiple myeloma cells depends on Ca2+ influx through plasma membrane Ca2+ channels von Yanamandra, Niranjan, Buzzeo, Robert W, Gabriel, Mark, Hazlehurst, Lori A, Mari, Yelenis, Beaupre, Darrin M, Cuevas, Javier

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Long-term follow-up of MCL patients treated with single-agent ibrutinib: updated safety and efficacy results von Wang, Michael L., Blum, Kristie A., Martin, Peter, Goy, Andre, Auer, Rebecca, Kahl, Brad S., Jurczak, Wojciech, Advani, Ranjana H., Romaguera, Jorge E., Williams, Michael E., Barrientos, Jacqueline C., Chmielowska, Ewa, Radford, John, Stilgenbauer, Stephan, Dreyling, Martin, Jedrzejczak, Wieslaw Wiktor, Johnson, Peter, Spurgeon, Stephen E., Zhang, Liang, Baher, Linda, Cheng, Mei, Lee, Dana, Beaupre, Darrin M., Rule, Simon

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Targeting BTK with Ibrutinib in Relapsed or Refractory Mantle-Cell Lymphoma von Wang, Michael L, Rule, Simon, Martin, Peter, Goy, Andre, Auer, Rebecca, Kahl, Brad S, Jurczak, Wojciech, Advani, Ranjana H, Romaguera, Jorge E, Williams, Michael E, Barrientos, Jacqueline C, Chmielowska, Ewa, Radford, John, Stilgenbauer, Stephan, Dreyling, Martin, Jedrzejczak, Wieslaw Wiktor, Johnson, Peter, Spurgeon, Stephen E, Li, Lei, Zhang, Liang, Newberry, Kate, Ou, Zhishuo, Cheng, Nancy, Fang, Bingliang, McGreivy, Jesse, Clow, Fong, Buggy, Joseph J, Chang, Betty Y, Beaupre, Darrin M, Kunkel, Lori A, Blum, Kristie A

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Tipifarnib and Bortezomib Are Synergistic and Overcome Cell Adhesion–Mediated Drug Resistance in Multiple Myeloma and Acute Myeloid Leukemia von YANAMANDRA, Niranjan, COLACO, Nandita M, PARQUET, Nancy A, BUZZER, Robert W, BOULWARE, David, WRIGHT, Gabriela, PEREZ, Lia E, DALTON, William S, BEAUPRE, Darrin M

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Modulation of RNA splicing enhances response to BCL2 inhibition in leukemia von Wang, Eric, Pineda, Jose Mario Bello, Kim, Won Jun, Chen, Sisi, Bourcier, Jessie, Stahl, Maximilian, Hogg, Simon J., Bewersdorf, Jan Phillipp, Han, Cuijuan, Singer, Michael E., Cui, Daniel, Erickson, Caroline E., Tittley, Steven M., Penson, Alexander V., Knorr, Katherine, Stanley, Robert F., Rahman, Jahan, Krishnamoorthy, Gnana, Fagin, James A., Creger, Emily, McMillan, Elizabeth, Mak, Chi-Ching, Jarvis, Matthew, Bossard, Carine, Beaupre, Darrin M., Bradley, Robert K., Abdel-Wahab, Omar

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The combination of ibrutinib and rituximab demonstrates activity in first‐line follicular lymphoma von Fowler, Nathan H., Nastoupil, Loretta, De Vos, Sven, Knapp, Mark, Flinn, Ian W., Chen, Robert, Advani, Ranjana H., Bhatia, Sumeet, Martin, Peter, Mena, Raul, Davis, Richard Eric, Neelapu, Sattva S., Eckert, Karl, Ping, Jerry, Co, Melannie, Beaupre, Darrin M., Neuenburg, Jutta K., Palomba, M. Lia

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Characterization of a R115777-Resistant Human Multiple Myeloma Cell Line with Cross-Resistance to PS-341 von BUZZEO, Robert, ENKEMANN, Steven, NIMMANAPALLI, Rama, ALSINA, Melissa, LICHTENHELD, Mathias G, DALTON, William S, BEAUPRE, Darrin M

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A Phase Ib Study of AMG 102 in Combination with Bevacizumab or Motesanib in Patients with Advanced Solid Tumors von ROSEN, Peter J, SWEENEY, Christopher J, YEE, Lorrin K, PARK, Dorothy J, BEAUPRE, Darrin M, HONGJIE DENG, LEITCH, Ian M, SHUBHAKAR, Poornima, MIN ZHU, OLINER, Kelly S, ANDERSON, Abraham

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A first-in-human study of AMG 208, an oral MET inhibitor, in adult patients with advanced solid tumors von Hong, David S, Rosen, Peter, Lockhart, A Craig, Fu, Siqing, Janku, Filip, Kurzrock, Razelle, Khan, Rabia, Amore, Benny, Caudillo, Isaac, Deng, Hongjie, Hwang, Yuying C, Loberg, Robert, Ngarmchamnanrith, Gataree, Beaupre, Darrin M, Lee, Peter

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RAS and Leukemia: From Basic Mechanisms to Gene-Directed Therapy von BEAUPRE, D. M, KURZROCK, R

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Starting dose selection and dose escalation for oncology small molecule first-in-patient trials: Learnings from a survey of approved drugs von Mittapalli, Rajendar K, Yin, Donghua, Beaupre, Darrin M., Palaparthy, Rameshraja

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Farnesyltransferase inhibitor R115777 (Zarnestra, Tipifarnib) synergizes with paclitaxel to induce apoptosis and mitotic arrest and to inhibit tumor growth of multiple myeloma cell... von Zhu, Kuichun, Gerbino, Elvira, Beaupre, Darrin M., Mackley, Paul A., Muro-Cacho, Carlos, Beam, Craig, Hamilton, Andrew D., Lichtenheld, Mathias G., Kerr, William G., Dalton, William, Alsina, Melissa, Sebti, Saïd M.

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R115777 induces Ras-independent apoptosis of myeloma cells via multiple intrinsic pathways von Beaupre, Darrin M, Cepero, Enrique, Obeng, Esther A, Boise, Lawrence H, Lichtenheld, Mathias G

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The Pan-Clk/Dyrk Inhibitor Cirtuvivint (SM08502) Exposes Mechanistic Underpinnings of Alternative Splicing As a Therapeutic Vulnerability in Heme Malignancies von Bossard, Carine, McMillan, Elizabeth A., Creger, Emily, Eastman, Brian, Mak, Chi-Ching, Beaupre, Darrin M., White, Michael A.

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