Cholinergic deficits selectively boost cortical intratelencephalic control of striatum in male Huntington’s disease model mice von Pancani, Tristano, Day, Michelle, Tkatch, Tatiana, Wokosin, David L., González-Rodríguez, Patricia, Kondapalli, Jyothisri, Xie, Zhong, Chen, Yu, Beaumont, Vahri, Surmeier, D. James

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Characterization of neurophysiological and behavioral changes, MRI brain volumetry and 1H MRS in zQ175 knock-in mouse model of Huntington's disease von Heikkinen, Taneli, Lehtimäki, Kimmo, Vartiainen, Nina, Puoliväli, Jukka, Hendricks, Susan J, Glaser, Jack R, Bradaia, Amyaouch, Wadel, Kristian, Touller, Chrystelle, Kontkanen, Outi, Yrjänheikki, Juha M, Buisson, Bruno, Howland, David, Beaumont, Vahri, Munoz-Sanjuan, Ignacio, Park, Larry C

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HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration von Mielcarek, Michal, Landles, Christian, Weiss, Andreas, Bradaia, Amyaouch, Seredenina, Tamara, Inuabasi, Linda, Osborne, Georgina F, Wadel, Kristian, Touller, Chrystelle, Butler, Rachel, Robertson, Janette, Franklin, Sophie A, Smith, Donna L, Park, Larry, Marks, Paul A, Wanker, Erich E, Olson, Eric N, Luthi-Carter, Ruth, van der Putten, Herman, Beaumont, Vahri, Bates, Gillian P

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Design, Synthesis, and Biological Evaluation of Potent and Selective Class IIa Histone Deacetylase (HDAC) Inhibitors as a Potential Therapy for Huntington’s Disease von Bürli, Roland W, Luckhurst, Christopher A, Aziz, Omar, Matthews, Kim L, Yates, Dawn, Lyons, Kathy. A, Beconi, Maria, McAllister, George, Breccia, Perla, Stott, Andrew J, Penrose, Stephen D, Wall, Michael, Lamers, Marieke, Leonard, Philip, Müller, Ilka, Richardson, Christine M, Jarvis, Rebecca, Stones, Liz, Hughes, Samantha, Wishart, Grant, Haughan, Alan F, O’Connell, Catherine, Mead, Tania, McNeil, Hannah, Vann, Julie, Mangette, John, Maillard, Michel, Beaumont, Vahri, Munoz-Sanjuan, Ignacio, Dominguez, Celia

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Age- and sex-related changes in cortical and striatal nitric oxide synthase in the Q175 mouse model of Huntington's disease von Padovan-Neto, Fernando E., Jurkowski, Lauren, Murray, Conor, Stutzmann, Grace E., Kwan, Mei, Ghavami, Afshin, Beaumont, Vahri, Park, Larry C., West, Anthony R.

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Striatal Pre- and Postsynaptic Profile of Adenosine A2A Receptor Antagonists von Orru, Marco, Bakešová, Jana, Brugarolas, Marc, Quiroz, César, Beaumont, Vahri, Goldberg, Steven R., Lluís, Carme, Cortés, Antoni, Franco, Rafael, Casadó, Vicent, Canela, Enric I., Ferré, Sergi

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Behavioral and Neurochemical Alterations in Mice Deficient in Anaplastic Lymphoma Kinase Suggest Therapeutic Potential for Psychiatric Indications von BILSLAND, James G, WHEELDON, Alan, WHITING, Paul, MCALLISTER, George, MUNOZ-SANJUAN, Ignacio, MEAD, Andrew, ZNAMENSKIY, Petr, ALMOND, Sarah, WATERS, Kerry A, THAKUR, Matthew, BEAUMONT, Vahri, BONNERT, Timothy P, HEAVENS, Robert

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Phosphodiesterase 9A Inhibition Facilitates Corticostriatal Transmission in Wild-Type and Transgenic Rats That Model Huntington's Disease von Chakroborty, Shreaya, Manfredsson, Fredric P., Dec, Alexander M., Campbell, Peter W., Stutzmann, Grace E., Beaumont, Vahri, West, Anthony R.

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Efficacy of selective PDE4D negative allosteric modulators in the object retrieval task in female cynomolgus monkeys (Macaca fascicularis) von Sutcliffe, Jane S, Beaumont, Vahri, Watson, James M, Chew, Chang Sing, Beconi, Maria, Hutcheson, Daniel M, Dominguez, Celia, Munoz-Sanjuan, Ignacio

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Evaluation of 5‑(Trifluoromethyl)-1,2,4-oxadiazole-Based Class IIa HDAC Inhibitors for Huntington’s Disease von Stott, Andrew J, Maillard, Michel C, Beaumont, Vahri, Allcock, David, Aziz, Omar, Borchers, Alexander H, Blackaby, Wesley, Breccia, Perla, Creighton-Gutteridge, Gillian, Haughan, Alan F, Jarvis, Rebecca E, Luckhurst, Christopher A, Matthews, Kim L, McAllister, George, Pollack, Scott, Saville-Stones, Elizabeth, Van de Poël, Amanda J, Vater, Huw D, Vann, Julie, Williams, Rachel, Yates, Dawn, Muñoz-Sanjuán, Ignacio, Dominguez, Celia

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HDAC4 does not act as a protein deacetylase in the postnatal murine brain in vivo von Mielcarek, Michal, Seredenina, Tamara, Stokes, Matthew P, Osborne, Georgina F, Landles, Christian, Inuabasi, Linda, Franklin, Sophie A, Silva, Jeffrey C, Luthi-Carter, Ruth, Beaumont, Vahri, Bates, Gillian P

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Oral administration of the pimelic diphenylamide HDAC inhibitor HDACi 4b is unsuitable for chronic inhibition of HDAC activity in the CNS in vivo von Beconi, Maria, Aziz, Omar, Matthews, Kim, Moumné, Lara, O'Connell, Catherine, Yates, Dawn, Clifton, Steven, Pett, Hannah, Vann, Julie, Crowley, Lynsey, Haughan, Alan F, Smith, Donna L, Woodman, Ben, Bates, Gillian P, Brookfield, Fred, Bürli, Roland W, McAllister, George, Dominguez, Celia, Munoz-Sanjuan, Ignacio, Beaumont, Vahri

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Expansion of Calcium Microdomains Regulates Fast Exocytosis at a Ribbon Synapse von Beaumont, Vahri, Llobet, Artur, Lagnado, Leon, Stevens, Charles F.

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Real-Time Measurement of Exocytosis and Endocytosis Using Interference of Light von Llobet, Artur, Beaumont, Vahri, Lagnado, Leon

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Unravelling and Exploiting Astrocyte Dysfunction in Huntington’s Disease von Khakh, Baljit S, Beaumont, Vahri, Cachope, Roger, Munoz-Sanjuan, Ignacio, Goldman, Steven A, Grantyn, Rosemarie

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Phosphorylation and Local Presynaptic Protein Synthesis in Calcium- and Calcineurin-Dependent Induction of Crayfish Long-Term Facilitation von Beaumont, Vahri, Zhong, Ning, Fletcher, Russell, Froemke, Robert C, Zucker, Robert S

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Roles for Mitochondrial and Reverse Mode Na+/Ca2+ Exchange and the Plasmalemma Ca2+ ATPase in Post-Tetanic Potentiation at Crayfish Neuromuscular Junctions von Zhong, Ning, Beaumont, Vahri, Zucker, Robert S

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Developing HDAC4-Selective Protein Degraders To Investigate the Role of HDAC4 in Huntington’s Disease Pathology von Macabuag, Natsuko, Esmieu, William, Breccia, Perla, Jarvis, Rebecca, Blackaby, Wesley, Lazari, Ovadia, Urbonas, Liudvikas, Eznarriaga, Maria, Williams, Rachel, Strijbosch, Annelieke, Van de Bospoort, Rhea, Matthews, Kim, Clissold, Cole, Ladduwahetty, Tammy, Vater, Huw, Heaphy, Patrick, Stafford, Douglas G., Wang, Hong-Jun, Mangette, John E., McAllister, George, Beaumont, Vahri, Vogt, Thomas F., Wilkinson, Hilary A., Doherty, Elizabeth M., Dominguez, Celia

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Enhanced striatopallidal gamma‐aminobutyric acid (GABA)A receptor transmission in mouse models of huntington's disease von Perez‐Rosello, Tamara, Gelman, Simon, Tombaugh, Geoffrey, Cachope, Roger, Beaumont, Vahri, Surmeier, D. James

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Phosphodiesterase 10A Inhibition Improves Cortico-Basal Ganglia Function in Huntington’s Disease Models von Beaumont, Vahri, Zhong, Sheng, Lin, Hai, Xu, WenJin, Bradaia, Amyaouch, Steidl, Esther, Gleyzes, Melanie, Wadel, Kristian, Buisson, Bruno, Padovan-Neto, Fernando E., Chakroborty, Shreaya, Ward, Karen M., Harms, John F., Beltran, Jose, Kwan, Mei, Ghavami, Afshin, Häggkvist, Jenny, Tóth, Miklós, Halldin, Christer, Varrone, Andrea, Schaab, Christoph, Dybowski, J. Nikolaj, Elschenbroich, Sarah, Lehtimäki, Kimmo, Heikkinen, Taneli, Park, Larry, Rosinski, James, Mrzljak, Ladislav, Lavery, Daniel, West, Anthony R., Schmidt, Christopher J., Zaleska, Margaret M., Munoz-Sanjuan, Ignacio

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