Evaluation of novel synthetic TLR7/8 agonists as vaccine adjuvants von Smith, Alyson J, Li, Yufeng, Bazin, Hélène G, St-Jean, Julien R, Larocque, Daniel, Evans, Jay T, Baldridge, Jory R

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Novel Lipidated Imidazoquinoline TLR7/8 Adjuvants Elicit Influenza-Specific Th1 Immune Responses and Protect Against Heterologous H3N2 Influenza Challenge in Mice von Miller, Shannon M., Cybulski, Van, Whitacre, Margaret, Bess, Laura S., Livesay, Mark T., Walsh, Lois, Burkhart, David, Bazin, Helene G., Evans, Jay T.

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Diamino Allose Phosphates: Novel, Potent, and Highly Stable Toll-like Receptor 4 Agonists von Khalaf, Juhienah K., Bess, Laura S., Walsh, Lois M., Ward, Janine M., Johnson, Craig L., Livesay, Mark T., Jackson, Konner J., Evans, Jay T., Ryter, Kendal T., Bazin-Lee, Hélène G.

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Intranasal administration of a synthetic TLR4 agonist INI-2004 significantly reduces allergy symptoms following therapeutic administration in a murine model of allergic sensitizati... von Jackson, Konner J, Buhl, Cassandra, Miller, Shannon M, Khalaf, Juhienah K, Ward, Janine, Sands, Cherrokee, Walsh, Lois, Whitacre, Margaret, Burkhart, David J, Bazin-Lee, Hélène G, Evans, Jay T

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Optimization of 8-oxoadenines with toll-like-receptor 7 and 8 activity von Bazin, Hélène G., Bess, Laura S., Livesay, Mark T., Li, Yufeng, Cybulski, Van, Miller, Shannon M., Johnson, David A., Evans, Jay T.

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Structural requirements for TLR7-selective signaling by 9-(4-piperidinylalkyl)-8-oxoadenine derivatives von Bazin, Hélène G., Li, Yufeng, Khalaf, Juhienah K., Mwakwari, Sandra, Livesay, Mark T., Evans, Jay T., Johnson, David A.

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A lipidated TLR7/8 adjuvant enhances the efficacy of a vaccine against fentanyl in mice von Miller, Shannon M., Crouse, Bethany, Hicks, Linda, Amin, Hardik, Cole, Shelby, Bazin, Helene G., Burkhart, David J., Pravetoni, Marco, Evans, Jay T.

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Characterization of TRIF selectivity in the AGP class of lipid A mimetics: Role of secondary lipid chains von Khalaf, Juhienah K., Bowen, William S., Bazin, Hélène G., Ryter, Kendal T., Livesay, Mark T., Ward, Jon R., Evans, Jay T., Johnson, David A.

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Development of a TLR7/8 agonist adjuvant formulation to overcome early life hyporesponsiveness to DTaP vaccination von Dowling, David J., Barman, Soumik, Smith, Alyson J., Borriello, Francesco, Chaney, Danielle, Brightman, Spencer E., Melhem, Gandolina, Brook, Byron, Menon, Manisha, Soni, Dheeraj, Schüller, Simone, Siram, Karthik, Nanishi, Etsuro, Bazin, Hélène G., Burkhart, David J., Levy, Ofer, Evans, Jay T.

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Co-Delivery of a Novel Lipidated TLR7/8 Agonist and Hemagglutinin-Based Influenza Antigen Using Silica Nanoparticles Promotes Enhanced Immune Responses von Abdelwahab, Walid M, Auclair, Sarah, Borgogna, Timothy, Siram, Karthik, Riffey, Alexander, Bazin, Hélène G, Cottam, Howard B, Hayashi, Tomoko, Evans, Jay T, Burkhart, David J

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Synthetic Toll-like Receptors 7 and 8 Agonists: Structure–Activity Relationship in the Oxoadenine Series von Evans, Jay T, Bess, Laura S, Mwakwari, Sandra C, Livesay, Mark T, Li, Yufeng, Cybulski, Van, Johnson, David A, Bazin, Hélène G

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Efficient tin-mediated synthesis of lysophospholipid conjugates of a TLR7/8-active imidazoquinoline von Mwakwari, Sandra C., Bess, Laura S., Bazin, Hélène G., Johnson, David A.

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Phospholipidation of TLR7/8-active imidazoquinolines using a tandem phosphoramidite method von Bazin, Hélène G., Bess, Laura S., Livesay, Mark T., Mwakwari, Sandra C., Johnson, David A.

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The ‘Ethereal’ nature of TLR4 agonism and antagonism in the AGP class of lipid A mimetics von Bazin, Hélène G., Murray, Tim J., Bowen, William S., Mozaffarian, Afsaneh, Fling, Steven P., Bess, Laura S., Livesay, Mark T., Arnold, Jeffrey S., Johnson, Craig L., Ryter, Kendal T., Cluff, Christopher W., Evans, Jay T., Johnson, David A.

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Intranasal administration of a novel synthetic TLR4 agonist suppresses allergen-specific Th2 responses in mice von Miller, Shannon M, Buhl, Cassandra, Whitacre, Margaret, Ward, Janine, Jackson, Konner, Khalaf, Juhienah K, Bazin, Helene G, Evans, Jay T

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Pre-treatment with a novel synthetic TLR4 agonist prior to challenge with mouse-adapted H1N1 and H2N3 influenza strains reduced morbidity and mortality in BALB/c mice von Whitacre, Margaret, Ward, Janine, Jackson, Konner, Bess, Laura, Jayah, Rachel, Sands, Cherrokee, Arayangkul, Hathaipat, Khalaf, Juhienah K, Miller, Shannon M, Evans, Jay T, Bazin, Helene G

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A novel, synthetic TLR7/8 agonist demonstrates monotherapy efficacy and synergy with anti-PD-1 in syngeneic mouse tumor models von Beyer, Caleb A., Lussier, Danielle, Jackson, Konner, Whitacre, Margaret, Ward, Janine, Schoener, Roman, Bazin, Helene G, Burkhart, David, Miller, Shannon M

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Synthesis of a Versatile Neuraminic Acid “C”-Disaccharide Precursor for the Synthesis of C-Glycoside Analogues of Gangliosides von Bazin, Hélène G, Du, Yuguo, Polat, Tülay, Linhardt, Robert J

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Inhibition of Apolipoprotein E-Related Neurotoxicity by Glycosaminoglycans and Their Oligosaccharides von Bazin, Hélène G, Marques, Marcos A, Owens, Albert P, Linhardt, Robert J, Crutcher, Keith A

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Regio- and Stereoselective Synthesis of beta-D-Gluco-, alpha-L-Ido-, and alpha-L-Altropyranosiduronic Acids from Delta(4)-Uronates von Bazin, Hélène G., Wolff, Michael W., Linhardt, Robert J.

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