Small Molecules Drive Big Improvements in Immuno‐Oncology Therapies von Huck, Bayard R., Kötzner, Lisa, Urbahns, Klaus

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Recent progress towards clinically relevant ATP-competitive Akt inhibitors von Huck, Bayard R., Mochalkin, Igor

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Rules were made to be broken von Hartung, Ingo V., Huck, Bayard R., Crespo, Alejandro

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Discovery of Evobrutinib: An Oral, Potent, and Highly Selective, Covalent Bruton’s Tyrosine Kinase (BTK) Inhibitor for the Treatment of Immunological Diseases von Caldwell, Richard D, Qiu, Hui, Askew, Ben C, Bender, Andrew T, Brugger, Nadia, Camps, Montserrat, Dhanabal, Mohanraj, Dutt, Vikram, Eichhorn, Thomas, Gardberg, Anna S, Goutopoulos, Andreas, Grenningloh, Roland, Head, Jared, Healey, Brian, Hodous, Brian L, Huck, Bayard R, Johnson, Theresa L, Jones, Christopher, Jones, Reinaldo C, Mochalkin, Igor, Morandi, Federica, Nguyen, Ngan, Meyring, Michael, Potnick, Justin R, Santos, Dusica Cvetinovic, Schmidt, Ralf, Sherer, Brian, Shutes, Adam, Urbahns, Klaus, Follis, Ariele Viacava, Wegener, Ansgar A, Zimmerli, Simone C, Liu-Bujalski, Lesley

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Corrigendum to “Discovery of 4-aminopyrimidine analogs as highly potent dual P70S6K/Akt inhibitors” [Bioorgan. Med. Chem. Lett. 50 (2021) 128352] von Xiao, Yufang, Huck, Bayard R., Lan, Ruoxi, DeSelm, Lizbeth, Chen, Xiaoling, Qiu, Hui, Neagu, Constantin, Johnson, Theresa, Mochalkin, Igor, Gardberg, Anna, Jiang, Xuliang, Tian, Hui, Dutt, Vikram, Santos, Dusica, Head, Jared, Jackson, Jennifer, Syed, Sakeena, Lin, Jing, Wilker, Erik, Ma, Jianguo, Clark, Anderson, Machl, Andreas, Bankston, Donald, Jones, Christopher C.V., Goutopoulos, Andreas, Sherer, Brian

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Discovery of 4-aminopyrimidine analogs as highly potent dual P70S6K/Akt inhibitors von Xiao, Yufang, Huck, Bayard R., Lan, Ruoxi, DeSelm, Lizbeth, Chen, Xiaoling, Qiu, Hui, Neagu, Constantin, Johnson, Theresa, Mochalkin, Igor, Gardberg, Anna, Jiang, Xuliang, Tian, Hui, Dutt, Vikram, Santos, Dusica, Head, Jared, Jackson, Jennifer, Syed, Sakeena, Lin, Jing, Wilker, Erik, Ma, Jianguo, Clark, Anderson, Machl, Andreas, Bankston, Donald, Jones, Christopher C.V., Goutopoulos, Andreas, Sherer, Brian

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Protein prosthesis: β‐peptides as reverse‐turn surrogates von Arnold, Ulrich, Huck, Bayard R., Gellman, Samuel H., Raines, Ronald T.

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M2698 is a potent dual-inhibitor of p70S6K and Akt that affects tumor growth in mouse models of cancer and crosses the blood-brain barrier von Machl, Andreas, Wilker, Erik W, Tian, Hui, Liu, Xiaohong, Schroeder, Patricia, Clark, Anderson, Huck, Bayard R

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Protein Prosthesis:  A Semisynthetic Enzyme with a β-Peptide Reverse Turn von Arnold, Ulrich, Hinderaker, Matthew P, Nilsson, Bradley L, Huck, Bayard R, Gellman, Samuel H, Raines, Ronald T

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Synthesis of 2,2-Disubstituted Pyrrolidine-4-carboxylic Acid Derivatives and Their Incorporation into β-Peptide Oligomers von Huck, Bayard R, Gellman, Samuel H

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Design of Non-Cysteine-Containing Antimicrobial β-Hairpins:  Structure−Activity Relationship Studies with Linear Protegrin-1 Analogues von Lai, Jonathan R, Huck, Bayard R, Weisblum, Bernard, Gellman, Samuel H

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Stereochemical Control of Hairpin Formation in β-Peptides Containing Dinipecotic Acid Reverse Turn Segments von Chung, Yong Jun, Huck, Bayard R, Christianson, Laurie A, Stanger, Heather E, Krauthäuser, Susanne, Powell, Douglas R, Gellman, Samuel H

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Kleine Moleküle, ganz groß: niedermolekulare immunonkologische Kombinationstherapien von Huck, Bayard R., Kötzner, Lisa, Urbahns, Klaus

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Secondary Structural Preferences of 2,2-Disubstituted Pyrrolidine-4-carboxylic Acid Oligomers:  β-Peptide Foldamers that Cannot Form Internal Hydrogen Bonds von Huck, Bayard R, Fisk, John D, Guzei, Ilia A, Carlson, Heather A, Gellman, Samuel H

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Promotion of Sheet Formation in α-Peptide Strands by a β-Peptide Reverse Turn von Huck, Bayard R, Fisk, John D, Gellman, Samuel H

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Non-Hydrogen-Bonded Secondary Structure in β-Peptides:  Evidence from Circular Dichroism of (S)-Pyrrolidine-3- carboxylic Acid Oligomers and (S)-Nipecotic Acid Oligomers von Huck, Bayard R, Langenhan, Joseph M, Gellman, Samuel H

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The design and synthesis of a tricyclic single-nitrogen scaffold that serves as a 5-HT2C receptor agonist von HUCK, Bayard R, LLAMAS, Luis, BENNANI, Youssef L, ROBARGE, Michael J, DENT, Thomas C, JIANPING SONG, HODNICK, William F, CRUMRINE, Chris, STRICKER-KRONGRAD, Alain, HARRINGTON, John, BRUNDEN, Kurt R

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The identification of pyrimidine-diazabicyclo[3.3.0]octane derivatives as 5-HT2C receptor agonists von HUCK, Bayard R, LLAMAS, Luis, BENNANI, Youssef L, ROBARGE, Michael J, DENT, Thomas C, JIANPING SONG, HODNICK, William F, CRUMRINE, Chris, STRICKER-KRONGRAD, Alain, HARRINGTON, John, BRUNDEN, Kurt R

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Abstract 4516: Evaluation of p70S6K/Akt inhibitor MSC2363318A in patient derived xenograft (PDX) models of breast cancer von Huck, Bayard R., Tian, H, Syed, Sakeena, Lin, Jing, Ma, Jianguo, Clark, Anderson, Kaleta, Remiguisz, Machl, Andreas, Wilker, Erik, Lecomte, Marc

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Protein prosthesis: [beta]-peptides as reverse-turn surrogates von Arnold, Ulrich, Huck, Bayard R, Gellman, Samuel H, Raines, Ronald T

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