Selective FLT3 inhibition of FLT3-ITD+ acute myeloid leukaemia resulting in secondary D835Y mutation: a model for emerging clinical resistance patterns von Moore, A S, Faisal, A, de Castro, D Gonzalez, Bavetsias, V, Sun, C, Atrash, B, Valenti, M, de Haven Brandon, A, Avery, S, Mair, D, Mirabella, F, Swansbury, J, Pearson, A D J, Workman, P, Blagg, J, Raynaud, F I, Eccles, S A, Linardopoulos, S

Volltext

Design and Synthesis of Cyclopenta[g]quinazoline-Based Antifolates as Inhibitors of Thymidylate Synthase and Potential Antitumor Agents von Bavetsias, Vassilios, Marriott, Jonathan H, Melin, Camille, Kimbell, Rosemary, Matusiak, Zbigniew S, Boyle, F. Thomas, Jackman, Ann L

Volltext

The Design and Synthesis of Water-Soluble Analogues of CB30865, a Quinazolin-4-one-Based Antitumor Agent von Bavetsias, V, Skelton, L. A, Yafai, F, Mitchell, F, Wilson, S. C, Allan, B, Jackman, A. L

Volltext

Cyclopenta[ g]quinazoline-based antifolates: the effect of the chirality at the 6-position on the inhibition of thymidylate synthase (TS) von Bavetsias, V., Marriott, J.H., Theti, D.S., Melin, J.C., Wilson, S.C., Jackman, A.L.

Volltext

Crystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: insights into selectivity and drug design von Dodson, C.A., Kosmopoulou, M., Richards, M.W., Atrash, B., Bavetsias, V., Blagg, J., Bayliss, R.

Volltext

Selective FLT3 inhibition of [FLT3-ITD.sup.+] acute myeloid leukaemia resulting in secondary D835Y mutation: a model for emerging clinical resistance patterns von Moore, A.S, Faisal, A, de Castro, D. Gonzalez, Bavetsias, V, Sun, C, Atrash, B, Valenti, M, Brandon, A. de Haven, Avery, S, Mair, D, Mirabella, F, Swansbury, J, Pearson, A.D.J, Workman, P, Blagg, J, Raynaud, F.I, Eccles, S.A, Linardopoulos, S

Volltext

A Facile Route to Quinazolin-4(3H)-ones Functionalised at the 2-Position von Bavetsias, V.

Volltext

Selective FLT3 inhibition of FLT3-ITD super(+) acute myeloid leukaemia resulting in secondary D835Y mutation: a model for emerging clinical resistance patterns von Moore, A S, Faisal, A, de Castro, D Gonzalez, Bavetsias, V, Sun, C, Atrash, B, Valenti, M, de Haven Brandon, A, Avery, S, Mair, D, Mirabella, F, Swansbury, J, Pearson, A D J, Workman, P, Blagg, J, Raynaud, F I, Eccles, S A, Linardopoulos, S

Volltext

2-Pivalamido-3 H -pyrimidin-4-one derivatives: convenient pivalamide hydrolysis using Fe(NO 3 ) 3 in MeOH von Bavetsias, V., Henderson, E.A., McDonald, E.

Volltext

Synthesis of N-substituted derivatives of tert-butyl 4-aminobenzoate via a palladium-catalysed reaction von Bavetsias, V., Henderson, E.A.

Volltext

Synthesis and profiling of a 3-aminopyridin-2-one-based kinase targeted fragment library: Identification of 3-amino-5-(pyridin-4-yl)pyridin-2(1H)-one scaffold for monopolar spindle... von Fearon, D, Westwood, IM, Van Montfort, RLM, Bayliss, R, Jones, K, Bavetsias, V

Volltext bestellen

Folate-Based Inhibitors of Thymidylate Synthase:  Synthesis and Antitumor Activity of γ-Linked Sterically Hindered Dipeptide Analogues of 2-Desamino-2-methyl-N10-propargyl-5,8-dide... von BAVETSIAS, Vassilios, JACKMAN, Ann L., MARRIOTT, Jonathan H., KIMBELL, Rosemary, GIBSON, William, BOYLE, F. Thomas, BISSET, Graham M. F.

Volltext

ChemInform Abstract: Heterocyclic Templates and Nonpolyglutamatable Inhibitors of Thymidylate Synthase as Potential Antitumor Agents: A Chemical Perspective von Bavetsias, V.

Volltext

ChemInform Abstract: A Facile Route to Quinazolin-4(3H)-ones Functionalized at the 2-Position von Bavetsias, V.

Volltext

Convenient Preparation of α-Tert-Butyl N-Blocked Glutamates Through γ-Allyl Ester Protection von Bavetsias, V., Bisset, G. M. F., Jarman, M.

Volltext

Quinazoline Antifolate Thymidylate Synthase Inhibitors:  γ-Linked l-d, d-d, and d-l Dipeptide Analogues of 2-Desamino-2-methyl-N10-propargyl-5,8-dideazafolic Acid (ICI 198583) von BAVETSIAS, Vassilios, JACKMAN, Ann L., KIMBELL, Rosemary, GIBSON, William, BOYLE, F. Thomas, BISSET, Graham M. F.

Volltext

2-Pivalamido-3H-pyrimidin-4-one Derivatives: Convenient Pivalamide Hydrolysis Using Fe(NO3)3 in MeOH von Bavetsias, V., Henderson, E. A., McDonald, E.

Volltext

ChemInform Abstract: Synthesis of N-Substituted Derivatives of tert-Butyl 4-Aminobenzoate via a Palladium-Catalyzed Reaction von Bavetsias, V., Henderson, E. A.

Volltext

The Synthesis and Thymidylate Synthase Inhibitory Activity of L-.gamma.-L-Linked Dipeptide and L-.gamma.-Amide Analogs of 2-Desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (I... von Bisset, Graham M. F, Bavetsias, Vassilios, Thornton, Timothy J, Pawelczak, Krzysztof, Calvert, A. Hilary, Hughes, Leslie R, Jackman, Ann L

Volltext

ChemInform Abstract: Nonpolyglutamatable Antifolates as Inhibitors of Thymidylate Synthase (TS) and Potential Antitumor Agents von BAVETSIAS, V., JACKMAN, A. L.

Volltext