Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1‑f][triazin-4-amino] Adenine C‑Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses von Siegel, Dustin, Hui, Hon C, Doerffler, Edward, Clarke, Michael O, Chun, Kwon, Zhang, Lijun, Neville, Sean, Carra, Ernest, Lew, Willard, Ross, Bruce, Wang, Queenie, Wolfe, Lydia, Jordan, Robert, Soloveva, Veronica, Knox, John, Perry, Jason, Perron, Michel, Stray, Kirsten M, Barauskas, Ona, Feng, Joy Y, Xu, Yili, Lee, Gary, Rheingold, Arnold L, Ray, Adrian S, Bannister, Roy, Strickley, Robert, Swaminathan, Swami, Lee, William A, Bavari, Sina, Cihlar, Tomas, Lo, Michael K, Warren, Travis K, Mackman, Richard L

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The DHODH inhibitor PTC299 arrests SARS-CoV-2 replication and suppresses induction of inflammatory cytokines von Luban, Jeremy, Sattler, Rachel A., Mühlberger, Elke, Graci, Jason D., Cao, Liangxian, Weetall, Marla, Trotta, Christopher, Colacino, Joseph M., Bavari, Sina, Strambio-De-Castillia, Caterina, Suder, Ellen L., Wang, Yetao, Soloveva, Veronica, Cintron-Lue, Katherine, Naryshkin, Nikolai A., Pykett, Mark, Welch, Ellen M., O’Keefe, Kylie, Kong, Ronald, Goodwin, Elizabeth, Jacobson, Allan, Paessler, Slobodan, Peltz, Stuart W.

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BCX4430 – A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease von Taylor, Raymond, Kotian, Pravin, Warren, Travis, Panchal, Rekha, Bavari, Sina, Julander, Justin, Dobo, Sylvia, Rose, Angela, El-Kattan, Yahya, Taubenheim, Brian, Babu, Yarlagadda, Sheridan, William P

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Deubiquitinating enzyme VCIP135 dictates the duration of botulinum neurotoxin type A intoxication von Tsai, Yien Che, Kotiya, Archana, Kiris, Erkan, Yang, Mei, Bavari, Sina, Tessarollo, Lino, Oyler, George A., Weissman, Allan M.

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Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus von Huang, I-Chueh, Bailey, Charles C, Weyer, Jessica L, Radoshitzky, Sheli R, Becker, Michelle M, Chiang, Jessica J, Brass, Abraham L, Ahmed, Asim A, Chi, Xiaoli, Dong, Lian, Longobardi, Lindsay E, Boltz, Dutch, Kuhn, Jens H, Elledge, Stephen J, Bavari, Sina, Denison, Mark R, Choe, Hyeryun, Farzan, Michael

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Neuropathogenesis of Zika Virus in a Highly Susceptible Immunocompetent Mouse Model after Antibody Blockade of Type I Interferon von Smith, Darci R, Hollidge, Bradley, Daye, Sharon, Zeng, Xiankun, Blancett, Candace, Kuszpit, Kyle, Bocan, Thomas, Koehler, Jeff W, Coyne, Susan, Minogue, Tim, Kenny, Tara, Chi, Xiaoli, Yim, Soojin, Miller, Lynn, Schmaljohn, Connie, Bavari, Sina, Golden, Joseph W

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The FDA-Approved Oral Drug Nitazoxanide Amplifies Host Antiviral Responses and Inhibits Ebola Virus von Jasenosky, Luke D., Cadena, Cristhian, Mire, Chad E., Borisevich, Viktoriya, Haridas, Viraga, Ranjbar, Shahin, Nambu, Aya, Bavari, Sina, Soloveva, Veronica, Sadukhan, Supriya, Cassell, Gail H., Geisbert, Thomas W., Hur, Sun, Goldfeld, Anne E.

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A systematic screen of FDA-approved drugs for inhibitors of biological threat agents von Madrid, Peter B, Chopra, Sidharth, Manger, Ian D, Gilfillan, Lynne, Keepers, Tiffany R, Shurtleff, Amy C, Green, Carol E, Iyer, Lalitha V, Dilks, Holli Hutcheson, Davey, Robert A, Kolokoltsov, Andrey A, Carrion, Jr, Ricardo, Patterson, Jean L, Bavari, Sina, Panchal, Rekha G, Warren, Travis K, Wells, Jay B, Moos, Walter H, Burke, Raelyn L, Tanga, Mary J

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Sorafenib Impedes Rift Valley Fever Virus Egress by Inhibiting Valosin-Containing Protein Function in the Cellular Secretory Pathway von Brahms, Ashwini, Mudhasani, Rajini, Pinkham, Chelsea, Kota, Krishna, Nasar, Farooq, Zamani, Rouzbeh, Bavari, Sina, Kehn-Hall, Kylene

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HSPA5 is an essential host factor for Ebola virus infection von Patrick Reid, St, Shurtleff, Amy C., Costantino, Julie A., Tritsch, Sarah R., Retterer, Cary, Spurgers, Kevin B., Bavari, Sina

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IFITM-2 and IFITM-3 but Not IFITM-1 Restrict Rift Valley Fever Virus von Mudhasani, Rajini, Tran, Julie P, Retterer, Cary, Radoshitzky, Sheli R, Kota, Krishna P, Altamura, Louis A, Smith, Jeffrey M, Packard, Beverly Z, Kuhn, Jens H, Costantino, Julie, Garrison, Aura R, Schmaljohn, Connie S, Huang, I-Chueh, Farzan, Michael, Bavari, Sina

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High Infection Rates for Adult Macaques after Intravaginal or Intrarectal Inoculation with Zika Virus von Haddow, Andrew D, Nalca, Aysegul, Rossi, Franco D, Miller, Lynn J, Wiley, Michael R, Perez-Sautu, Unai, Washington, Samuel C, Norris, Sarah L, Wollen-Roberts, Suzanne E, Shamblin, Joshua D, Kimmel, Adrienne E, Bloomfield, Holly A, Valdez, Stephanie M, Sprague, Thomas R, Principe, Lucia M, Bellanca, Stephanie A, Cinkovich, Stephanie S, Lugo-Roman, Luis, Cazares, Lisa H, Pratt, William D, Palacios, Gustavo F, Bavari, Sina, Pitt, M Louise, Nasar, Farooq

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Ebola virus uses clathrin-mediated endocytosis as an entry pathway von Bhattacharyya, Suchita, Warfield, Kelly L, Ruthel, Gordon, Bavari, Sina, Aman, M. Javad, Hope, Thomas J

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Ebolavirus Glycoprotein Fc Fusion Protein Protects Guinea Pigs against Lethal Challenge von Konduru, Krishnamurthy, Shurtleff, Amy C, Bradfute, Steven B, Nakamura, Siham, Bavari, Sina, Kaplan, Gerardo

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Advanced antisense therapies for postexposure protection against lethal filovirus infections von Iversen, Patrick L, Bavari, Sina, Warren, Travis K, Warfield, Kelly L, Wells, Jay, Swenson, Dana L, Donner, Kelly S, Van Tongeren, Sean A, Garza, Nicole L, Dong, Lian, Mourich, Dan V, Crumley, Stacy, Nichols, Donald K

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Lactobacilli Activate Human Dendritic Cells That Skew T Cells toward T Helper 1 Polarization von Mohamadzadeh, Mansour, Olson, Scott, Kalina, Warren V., Ruthel, Gordon, Demmin, Gretchen L., Warfield, Kelly L., Bavari, Sina, Klaenhammer, Todd R.

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African and Asian Zika Virus Isolates Display Phenotypic Differences Both In Vitro and In Vivo von Smith, Darci R, Sprague, Thomas R, Hollidge, Bradley S, Valdez, Stephanie M, Padilla, Susana L, Bellanca, Stephanie A, Golden, Joseph W, Coyne, Susan R, Kulesh, David A, Miller, Lynn Jean, Haddow, Andrew D, Koehler, Jeff W, Gromowski, Gregory D, Jarman, Richard G, Alera, Maria Theresa P, Yoon, In-Kyu, Buathong, Rome, Lowen, Robert G, Kane, Christopher D, Minogue, Timothy D, Bavari, Sina, Tesh, Robert B, Weaver, Scott C, Linthicum, Kenneth J, Pitt, Margaret L, Nasar, Farooq

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AVI-7288 for Marburg Virus in Nonhuman Primates and Humans von Heald, Alison E, Charleston, Jay S, Iversen, Patrick L, Warren, Travis K, Saoud, Jay B, Al-Ibrahim, Mohamed, Wells, Jay, Warfield, Kelly L, Swenson, Dana L, Welch, Lisa S, Sazani, Peter, Wong, Michael, Berry, Diane, Kaye, Edward M, Bavari, Sina

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3D visualization of HIV transfer at the virological synapse between dendritic cells and T cells von Felts, Richard L., Narayan, Kedar, Estes, Jacob D., Shi, Dan, Trubey, Charles M., Fu, Jing, Hartnell, Lisa M., Ruthel, Gordon T., Schneider, Douglas K., Nagashima, Kunio, Bess, Julian W., Bavari, Sina, Lowekamp, Bradley C., Bliss, Donald, Lifson, Jeffrey D., Subramaniam, Sriram, Moss, Bernard

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Remdesivir is efficacious in rhesus monkeys exposed to aerosolized Ebola virus von Warren, Travis K., Kane, Christopher D., Wells, Jay, Stuthman, Kelly S., Van Tongeren, Sean A., Garza, Nicole L., Donnelly, Ginger, Steffens, Jesse, Gomba, Laura, Weidner, Jessica M., Norris, Sarah, Zeng, Xiankun, Bannister, Roy, Cihlar, Tomas, Bavari, Sina, Porter, Danielle P., Iversen, Patrick L.

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