Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY-876 von Siebeneicher, Holger, Cleve, Arwed, Rehwinkel, Hartmut, Neuhaus, Roland, Heisler, Iring, Müller, Thomas, Bauser, Marcus, Buchmann, Bernd

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Preclinical Efficacy of the Novel Monocarboxylate Transporter 1 Inhibitor BAY-8002 and Associated Markers of Resistance von Quanz, Maria, Bender, Eckhard, Kopitz, Charlotte, Grünewald, Sylvia, Schlicker, Andreas, Schwede, Wolfgang, Eheim, Ashley, Toschi, Luisella, Neuhaus, Roland, Richter, Carmen, Toedling, Joern, Merz, Claudia, Lesche, Ralf, Kamburov, Atanas, Siebeneicher, Holger, Bauser, Marcus, Hägebarth, Andrea

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Sequential Nitration/Hydrogenation Protocol for the Synthesis of Triaminophloroglucinol: Safe Generation and Use of an Explosive Intermediate under Continuous-Flow Conditions von Cantillo, David, Damm, Markus, Dallinger, Doris, Bauser, Marcus, Berger, Markus, Kappe, C. Oliver

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The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies von Christian, Sven, Merz, Claudia, Evans, Laura, Gradl, Stefan, Seidel, Henrik, Friberg, Anders, Eheim, Ashley, Lejeune, Pascale, Brzezinka, Krzysztof, Zimmermann, Katja, Ferrara, Steven, Meyer, Hanna, Lesche, Ralf, Stoeckigt, Detlef, Bauser, Marcus, Haegebarth, Andrea, Sykes, David B, Scadden, David T, Losman, Julie-Aurore, Janzer, Andreas

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Creation of a Novel Class of Potent and Selective MutT Homologue 1 (MTH1) Inhibitors Using Fragment-Based Screening and Structure-Based Drug Design von Rahm, Fredrik, Viklund, Jenny, Trésaugues, Lionel, Ellermann, Manuel, Giese, Anja, Ericsson, Ulrika, Forsblom, Rickard, Ginman, Tobias, Günther, Judith, Hallberg, Kenth, Lindström, Johan, Persson, Lars Boukharta, Silvander, Camilla, Talagas, Antoine, Díaz-Sáez, Laura, Fedorov, Oleg, Huber, Kilian V. M, Panagakou, Ioanna, Siejka, Paulina, Gorjánácz, Mátyás, Bauser, Marcus, Andersson, Martin

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Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target von Ellermann, Manuel, Eheim, Ashley, Rahm, Fredrik, Viklund, Jenny, Guenther, Judith, Andersson, Martin, Ericsson, Ulrika, Forsblom, Rickard, Ginman, Tobias, Lindström, Johan, Silvander, Camilla, Trésaugues, Lionel, Giese, Anja, Bunse, Stefanie, Neuhaus, Roland, Weiske, Jörg, Quanz, Maria, Glasauer, Andrea, Nowak-Reppel, Katrin, Bader, Benjamin, Irlbacher, Horst, Meyer, Hanna, Queisser, Nina, Bauser, Marcus, Haegebarth, Andrea, Gorjánácz, Mátyás

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Identification of the Highly Active, Species Cross-Reactive Complex I Inhibitor BAY-179 von Mowat, Jeffrey, Ehrmann, Alexander H. M, Christian, Sven, Sperl, Carolyn, Menz, Stephan, Günther, Judith, Hillig, Roman C, Bauser, Marcus, Schwede, Wolfgang

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The potent AMPK inhibitor BAY-3827 shows strong efficacy in androgen-dependent prostate cancer models von Lemos, Clara, Schulze, Volker K., Baumgart, Simon J., Nevedomskaya, Ekaterina, Heinrich, Tobias, Lefranc, Julien, Bader, Benjamin, Christ, Clara D., Briem, Hans, Kuhnke, Lara P., Holton, Simon J., Bömer, Ulf, Lienau, Philip, von Nussbaum, Franz, Nising, Carl F., Bauser, Marcus, Hägebarth, Andrea, Mumberg, Dominik, Haendler, Bernard

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Gene expression levels of matrix metalloproteinases in human atherosclerotic plaques and evaluation of radiolabeled inhibitors as imaging agents for plaque vulnerability von Müller, Adrienne, Krämer, Stefanie D, Meletta, Romana, Beck, Katharina, Selivanova, Svetlana V, Rancic, Zoran, Kaufmann, Philipp A, Vos, Bernhard, Meding, Jörg, Stellfeld, Timo, Heinrich, Tobias K, Bauser, Marcus, Hütter, Joachim, Dinkelborg, Ludger M, Schibli, Roger, Ametamey, Simon M

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New Class of Bacterial Phenylalanyl-tRNA Synthetase Inhibitors with High Potency and Broad-Spectrum Activity von Beyer, Dieter, Kroll, Hein-Peter, Endermann, Rainer, Schiffer, Guido, Siegel, Stephan, Bauser, Marcus, Pohlmann, Jens, Brands, Michael, Ziegelbauer, Karl, Haebich, Dieter, Eymann, Christine, Brötz-Oesterhelt, Heike

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Hafnium-Based Contrast Agents for X‑ray Computed Tomography von Berger, Markus, Bauser, Marcus, Frenzel, Thomas, Hilger, Christoph Stephan, Jost, Gregor, Lauria, Silvia, Morgenstern, Bernd, Neis, Christian, Pietsch, Hubertus, Sülzle, Detlev, Hegetschweiler, Kaspar

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Abstract 3790: Targeting the one-carbon metabolism protein MTHFD2 for cancer therapy: Exploiting the unique redox status of cancer cells von Glasauer, Andrea, Steckel, Michael, Haegebarth, Andrea, Bauser, Marcus, Toschi, Luisella

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Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-yl)pyrido[3,2‑d]pyrimidine Based in Vitro Probe BAY-885 for the Kinase ERK5 von Nguyen, Duy, Lemos, Clara, Wortmann, Lars, Eis, Knut, Holton, Simon J, Boemer, Ulf, Moosmayer, Dieter, Eberspaecher, Uwe, Weiske, Joerg, Lechner, Christian, Prechtl, Stefan, Suelzle, Detlev, Siegel, Franziska, Prinz, Florian, Lesche, Ralf, Nicke, Barbara, Nowak-Reppel, Katrin, Himmel, Herbert, Mumberg, Dominik, von Nussbaum, Franz, Nising, Carl F, Bauser, Marcus, Haegebarth, Andrea

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Discovery of an Oral, Beyond-Rule-of-Five Mcl‑1 Protein–Protein Interaction Modulator with the Potential of Treating Hematological Malignancies von Romanov-Michailidis, Fedor, Hsiao, Chien-Chi, Urner, Lorenz M., Jerhaoui, Soufyan, Surkyn, Michel, Miller, Bradley, Vos, Ann, Dominguez Blanco, Maria, Bueters, Ruud, Vinken, Petra, Bekkers, Mariette, Walker, David, Pietrak, Beth, Eyckmans, Werner, Dores-Sousa, José Luís, Joo Koo, Seong, Lento, William, Bauser, Marcus, Philippar, Ulrike, Rombouts, Frederik J. R.

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Discovery and Characterization of the Potent and Highly Selective 1,7-Naphthyridine-Based Inhibitors BAY-091 and BAY-297 of the Kinase PIP4K2A von Wortmann, Lars, Bräuer, Nico, Holton, Simon J, Irlbacher, Horst, Weiske, Jörg, Lechner, Christian, Meier, Robin, Karén, Jakob, Siöberg, Catrine Berthold, Pütter, Vera, Christ, Clara D, ter Laak, Antonius, Lienau, Philip, Lesche, Ralf, Nicke, Barbara, Cheung, Shing-Hu, Bauser, Marcus, Haegebarth, Andrea, von Nussbaum, Franz, Mumberg, Dominik, Lemos, Clara

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Identification of novel GLUT inhibitors von Siebeneicher, Holger, Bauser, Marcus, Buchmann, Bernd, Heisler, Iring, Müller, Thomas, Neuhaus, Roland, Rehwinkel, Hartmut, Telser, Joachim, Zorn, Ludwig

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Computationally Empowered Workflow Identifies Novel Covalent Allosteric Binders for KRAS(G12C) von Mortier, Jeremie, Friberg, Anders, Badock, Volker, Moosmayer, Dieter, Schroeder, Jens, Steigemann, Patrick, Siegel, Franziska, Gradl, Stefan, Bauser, Marcus, Hillig, Roman C., Briem, Hans, Eis, Knut, Bader, Benjamin, Nguyen, Duy, Christ, Clara D.

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Abstract 3599: BAY 2402234: Preclinical evaluation of a novel, selective dihydroorotate dehydrogenase (DHODH) inhibitor for the treatment of colorectal carcinomas von Merz, Claudia, Christian, Sven, Eheim, Ashley, Seidel, Henrik, Lesche, Ralf, Eversloh, Merlin Luetke, Meyer, Hanna, Ferrara, Steven, Bauser, Marcus, Haegebarth, Andrea, Gradl, Stefan, Janzer, Andreas

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Abstract 3597: BAY 2402234: Preclinical evaluation of a novel, selective dihydroorotate dehydrogenase (DHODH) inhibitor for the treatment of diffuse large B-cell lymphoma (DLBCL) von Eheim, Ashley, Christian, Sven, Meyer, Hanna, Stoeckigt, Detlef, Merz, Claudia, Zimmermann, Katja, Bauser, Marcus, Haegebarth, Andrea, Ferrara, Steven, Sykes, David B., Scadden, David T., Gradl, Stefan, Janzer, Andreas

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Abstract 1049: Pharmacological characterization of a novel potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with robust in vivo efficacy and increased therapeutic in... von Quanz, Maria, Merz, Claudia, Bernthaler, Andreas, Kaulfuss, Stefan, Richter, Anja, Bauser, Marcus, Haegebarth, Andrea

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