Advantages of crystallographic fragment screening: Functional and mechanistic insights from a powerful platform for efficient drug discovery von Patel, Disha, Bauman, Joseph D., Arnold, Eddy

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High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: Strategic flexibility explains potency against resistance mutations von Das, Kalyan, Bauman, Joseph D, Clark, Arthur D. Jr, Frenkel, Yulia V, Lewi, Paul J, Shatkin, Aaron J, Hughes, Stephen H, Arnold, Eddy

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Snapshot of the equilibrium dynamics of a drug bound to HIV-1 reverse transcriptase von Kuroda, Daniel G., Bauman, Joseph D., Challa, J. Reddy, Patel, Disha, Troxler, Thomas, Das, Kalyan, Arnold, Eddy, Hochstrasser, Robin M.

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Targeting HIV-1 Reverse Transcriptase Using a Fragment-Based Approach von Mansouri, Mahta, Rumrill, Shawn, Dawson, Shane, Johnson, Adam, Pinson, Jo-Anne, Gunzburg, Menachem J, Latham, Catherine F, Barlow, Nicholas, Mbogo, George W, Ellenberg, Paula, Headey, Stephen J, Sluis-Cremer, Nicolas, Tyssen, David, Bauman, Joseph D, Ruiz, Francesc X, Arnold, Eddy, Chalmers, David K, Tachedjian, Gilda

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Two-dimensional infrared spectra reveal relaxation of the nonnucleoside inhibitor TMC278 complexed with HIV-1 reverse transcriptase von Fang, Chong, Bauman, Joseph D, Das, Kalyan, Remorino, Amanda, Arnold, Eddy, Hochstrasser, Robin M

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Structural basis of HIV-1 resistance to AZT by excision von Arnold, Eddy, Tu, Xiongying, Das, Kalyan, Han, Qianwei, Bauman, Joseph D, Clark, Arthur D, Hou, Xiaorong, Frenkel, Yulia V, Gaffney, Barbara L, Jones, Roger A, Boyer, Paul L, Hughes, Stephen H, Sarafianos, Stefan G

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Crystallographic Fragment Screening and Structure-Based Optimization Yields a New Class of Influenza Endonuclease Inhibitors von Bauman, Joseph D, Patel, Disha, Baker, Steven F, Vijayan, R. S. K, Xiang, Amy, Parhi, Ajit K, Martínez-Sobrido, Luis, LaVoie, Edmond J, Das, Kalyan, Arnold, Eddy

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Crystal Structure of a Retroviral Polyprotein: Prototype Foamy Virus Protease-Reverse Transcriptase (PR-RT) von Harrison, Jerry Joe E. K., Tuske, Steve, Das, Kalyan, Ruiz, Francesc X., Bauman, Joseph D., Boyer, Paul L., DeStefano, Jeffrey J., Hughes, Stephen H., Arnold, Eddy

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Halo Library, a Tool for Rapid Identification of Ligand Binding Sites on Proteins Using Crystallographic Fragment Screening von Chopra, Ashima, Bauman, Joseph D., Ruiz, Francesc X., Arnold, Eddy

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Structure of the guanylyltransferase domain of human mRNA capping enzyme von Chu, Chun, Das, Kalyan, Tyminski, James R, Bauman, Joseph D, Guan, Rongjin, Qiu, Weihua, Montelione, Gaetano T, Arnold, Eddy, Shatkin, Aaron J

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HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism von Das, Kalyan, Martinez, Sergio E, Bauman, Joseph D, Arnold, Eddy

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Identification of Alternative Binding Sites for Inhibitors of HIV-1 Ribonuclease H Through Comparative Analysis of Virtual Enrichment Studies von Felts, Anthony K, LaBarge, Krystal, Bauman, Joseph D, Patel, Dishaben V, Himmel, Daniel M, Arnold, Eddy, Parniak, Michael A, Levy, Ronald M

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Rapid experimental SAD phasing and hot-spot identification with halogenated fragments von Bauman, Joseph D, Harrison, Jerry Joe E K, Arnold, Eddy

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A comparison of the ability of rilpivirine (TMC278) and selected analogues to inhibit clinically relevant HIV-1 reverse transcriptase mutants von Johnson, Barry C, Pauly, Gary T, Rai, Ganesha, Patel, Disha, Bauman, Joseph D, Baker, Heather L, Das, Kalyan, Schneider, Joel P, Maloney, David J, Arnold, Eddy, Thomas, Craig J, Hughes, Stephen H

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Integrative structural biology studies of HIV-1 reverse transcriptase binding to a high-affinity DNA aptamer von Tuske, Steve, Zheng, Jie, Olson, Erik D., Ruiz, Francesc X., Pascal, Bruce D., Hoang, Anthony, Bauman, Joseph D., Das, Kalyan, DeStefano, Jeffrey J., Musier-Forsyth, Karin, Griffin, Patrick R., Arnold, Eddy

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Phenyl Substituted 4‑Hydroxypyridazin-3(2H)‑ones and 5‑Hydroxypyrimidin-4(3H)‑ones: Inhibitors of Influenza A Endonuclease von Sagong, Hye Yeon, Bauman, Joseph D, Patel, Disha, Das, Kalyan, Arnold, Eddy, LaVoie, Edmond J

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Structure of HIV‐1 reverse transcriptase/d4TTP complex: Novel DNA cross‐linking site and pH‐dependent conformational changes von Martinez, Sergio E., Bauman, Joseph D., Das, Kalyan, Arnold, Eddy

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Detecting Allosteric Sites of HIV‑1 Reverse Transcriptase by X‑ray Crystallographic Fragment Screening von Bauman, Joseph D, Patel, Disha, Dharia, Chhaya, Fromer, Marc W, Ahmed, Sameer, Frenkel, Yulia, Vijayan, R. S. K, Eck, J. Thomas, Ho, William C, Das, Kalyan, Shatkin, Aaron J, Arnold, Eddy

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Structure of HIV-1 Reverse Transcriptase with the Inhibitor β-Thujaplicinol Bound at the RNase H Active Site von Himmel, Daniel M., Maegley, Karen A., Pauly, Tom A., Bauman, Joseph D., Das, Kalyan, Dharia, Chhaya, Clark, Arthur D., Ryan, Kevin, Hickey, Michael J., Love, Robert A., Hughes, Stephen H., Bergqvist, Simon, Arnold, Eddy

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Crystal Structure of tert-Butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in Complex with HIV-1 Reverse Transcriptase (RT) Redefines the Elastic Limits of the Non-nu... von Das, Kalyan, Bauman, Joseph D, Rim, Angela S, Dharia, Chhaya, Clark, Arthur D, Camarasa, María-José, Balzarini, Jan, Arnold, Eddy

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