P363 The AMETHIST phase 3 trial of venglustat in patients with GM2 gangliosidoses and related diseases: baseline characteristics von Zheng, R., Tifft, C., Minini, P., Batsu, I.

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P.75 GM2 Gangliosidoses patient journey: Results from interviews with Late-Onset GM2 patients and frontline treaters von Lopshire, M., Flores, A., Burns, J., Gould, R., Batsu, I.

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Longitudinal analyses reveal immunological misfiring in severe COVID-19 von Lucas, Carolina, Wong, Patrick, Klein, Jon, Castro, Tiago B. R., Silva, Julio, Sundaram, Maria, Ellingson, Mallory K., Mao, Tianyang, Oh, Ji Eun, Israelow, Benjamin, Takahashi, Takehiro, Tokuyama, Maria, Lu, Peiwen, Venkataraman, Arvind, Park, Annsea, Mohanty, Subhasis, Wang, Haowei, Wyllie, Anne L., Vogels, Chantal B. F., Earnest, Rebecca, Lapidus, Sarah, Ott, Isabel M., Moore, Adam J., Muenker, M. Catherine, Fournier, John B., Campbell, Melissa, Odio, Camila D., Casanovas-Massana, Arnau, Herbst, Roy, Shaw, Albert C., Medzhitov, Ruslan, Schulz, Wade L., Grubaugh, Nathan D., Dela Cruz, Charles, Farhadian, Shelli, Ko, Albert I., Omer, Saad B., Iwasaki, Akiko

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Sex differences in immune responses that underlie COVID-19 disease outcomes von Takahashi, Takehiro, Ellingson, Mallory K., Wong, Patrick, Israelow, Benjamin, Lucas, Carolina, Klein, Jon, Silva, Julio, Mao, Tianyang, Oh, Ji Eun, Tokuyama, Maria, Lu, Peiwen, Venkataraman, Arvind, Park, Annsea, Liu, Feimei, Meir, Amit, Sun, Jonathan, Wang, Eric Y., Casanovas-Massana, Arnau, Wyllie, Anne L., Vogels, Chantal B. F., Earnest, Rebecca, Lapidus, Sarah, Ott, Isabel M., Moore, Adam J., Shaw, Albert, Fournier, John B., Odio, Camila D., Farhadian, Shelli, Dela Cruz, Charles, Grubaugh, Nathan D., Schulz, Wade L., Ring, Aaron M., Ko, Albert I., Omer, Saad B., Iwasaki, Akiko

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Diverse functional autoantibodies in patients with COVID-19 von Wang, Eric Y., Mao, Tianyang, Klein, Jon, Dai, Yile, Huck, John D., Jaycox, Jillian R., Liu, Feimei, Zhou, Ting, Israelow, Benjamin, Wong, Patrick, Coppi, Andreas, Lucas, Carolina, Silva, Julio, Oh, Ji Eun, Song, Eric, Perotti, Emily S., Zheng, Neil S., Fischer, Suzanne, Campbell, Melissa, Fournier, John B., Wyllie, Anne L., Vogels, Chantal B. F., Ott, Isabel M., Kalinich, Chaney C., Petrone, Mary E., Watkins, Anne E., Dela Cruz, Charles, Farhadian, Shelli F., Schulz, Wade L., Ma, Shuangge, Grubaugh, Nathan D., Ko, Albert I., Iwasaki, Akiko, Ring, Aaron M.

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OTHER NMDs von Petrovic, M., Zheng, R., Canabarro, C., Minini, P., Batsu, I.

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OTHER NMDs: EP.352 Venglustat, a novel brain-penetrant glucosylceramide synthase inhibitor, for GM2 gangliosidosis and related diseases: Phase 3 AMETHIST trial design von Petrovic, M., Zheng, R., Canabarro, C., Minini, P., Batsu, I.

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Delayed production of neutralizing antibodies correlates with fatal COVID-19 von Lucas, Carolina, Klein, Jon, Sundaram, Maria E., Liu, Feimei, Wong, Patrick, Silva, Julio, Mao, Tianyang, Oh, Ji Eun, Mohanty, Subhasis, Huang, Jiefang, Tokuyama, Maria, Lu, Peiwen, Venkataraman, Arvind, Park, Annsea, Israelow, Benjamin, Vogels, Chantal B. F., Muenker, M. Catherine, Chang, C-Hong, Casanovas-Massana, Arnau, Moore, Adam J., Zell, Joseph, Fournier, John B., Wyllie, Anne L., Campbell, Melissa, Lee, Alfred I., Chun, Hyung J., Grubaugh, Nathan D., Schulz, Wade L., Farhadian, Shelli, Dela Cruz, Charles, Ring, Aaron M., Shaw, Albert C., Wisnewski, Adam V., Yildirim, Inci, Ko, Albert I., Omer, Saad B., Iwasaki, Akiko

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Gut microbiome dysbiosis in antibiotic-treated COVID-19 patients is associated with microbial translocation and bacteremia von Bernard-Raichon, Lucie, Venzon, Mericien, Klein, Jon, Axelrad, Jordan E., Zhang, Chenzhen, Sullivan, Alexis P., Hussey, Grant A., Casanovas-Massana, Arnau, Noval, Maria G., Valero-Jimenez, Ana M., Gago, Juan, Putzel, Gregory, Pironti, Alejandro, Wilder, Evan, Thorpe, Lorna E., Littman, Dan R., Dittmann, Meike, Stapleford, Kenneth A., Shopsin, Bo, Torres, Victor J., Ko, Albert I., Iwasaki, Akiko, Cadwell, Ken, Schluter, Jonas

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SalivaDirect: A simplified and flexible platform to enhance SARS-CoV-2 testing capacity von Vogels, Chantal B.F., Watkins, Anne E., Harden, Christina A., Brackney, Doug E., Shafer, Jared, Wang, Jianhui, Caraballo, César, Kalinich, Chaney C., Ott, Isabel M., Fauver, Joseph R., Kudo, Eriko, Lu, Peiwen, Venkataraman, Arvind, Tokuyama, Maria, Moore, Adam J., Muenker, M. Catherine, Casanovas-Massana, Arnau, Fournier, John, Bermejo, Santos, Campbell, Melissa, Datta, Rupak, Nelson, Allison, Anastasio, Kelly, Askenase, Michael H., Batsu, Maria, Bickerton, Sean, Brower, Kristina, Bucklin, Molly L., Cahill, Staci, Cao, Yiyun, Courchaine, Edward, DeIuliis, Giuseppe, Earnest, Rebecca, Geng, Bertie, Goldman-Israelow, Benjamin, Handoko, Ryan, Khoury-Hanold, William, Kim, Daniel, Knaggs, Lynda, Kuang, Maxine, Lapidus, Sarah, Lim, Joseph, Linehan, Melissa, Lu-Culligan, Alice, Martin, Anjelica, Matos, Irene, McDonald, David, Minasyan, Maksym, Nakahata, Maura, Naushad, Nida, Nouws, Jessica, Obaid, Abeer, Odio, Camila, Oh, Ji Eun, Omer, Saad, Park, Annsea, Park, Hong-Jai, Peng, Xiaohua, Petrone, Mary, Prophet, Sarah, Rice, Tyler, Rose, Kadi-Ann, Sewanan, Lorenzo, Sharma, Lokesh, Shaw, Albert C., Shepard, Denise, Smolgovsky, Mikhail, Sonnert, Nicole, Strong, Yvette, Todeasa, Codruta, Valdez, Jordan, Velazquez, Sofia, Vijayakumar, Pavithra, White, Elizabeth B., Yang, Yexin, Dela Cruz, Charles S., Ko, Albert I., Iwasaki, Akiko, Krumholz, Harlan M., Matheus, J.D., Hui, Pei, Liu, Chen, Farhadian, Shelli F., Sikka, Robby, Wyllie, Anne L., Grubaugh, Nathan D.

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EPH85 Clinical Burden of GM2 Gangliosidoses in the United States (US): A Retrospective Observational Cohort Study Using Electronic Health Records (EHR) von Rodriguez, M.B., Petruski-Ivleva, N., Pulikottil-Jacob, R., Batsu, I., Flores, A.L., Fournier, M., Kissell, J., Zheng, R., Madziva, D., Umarje, S., Tifft, C.J.

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Multiscale PHATE identifies multimodal signatures of COVID-19 von Kuchroo, Manik, Huang, Jessie, Wong, Patrick, Grenier, Jean-Christophe, Shung, Dennis, Tong, Alexander, Lucas, Carolina, Klein, Jon, Burkhardt, Daniel B., Gigante, Scott, Godavarthi, Abhinav, Rieck, Bastian, Israelow, Benjamin, Simonov, Michael, Mao, Tianyang, Oh, Ji Eun, Silva, Julio, Takahashi, Takehiro, Odio, Camila D., Casanovas-Massana, Arnau, Fournier, John, Farhadian, Shelli, Dela Cruz, Charles S., Ko, Albert I., Hirn, Matthew J., Wilson, F. Perry, Hussin, Julie G., Wolf, Guy, Iwasaki, Akiko, Krishnaswamy, Smita

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Lack of association between pandemic chilblains and SARS-CoV-2 infection von Gehlhausen, Jeff R, Little, Alicia J, Ko, Christine J, Emmenegger, Marc, Lucas, Carolina, Wong, Patrick, Klein, Jon, Lu, Peiwen, Mao, Tianyang, Jaycox, Jillian, Wang, Eric, Ugwu, Nelson, Muenker, Cate, Mekael, Dilgash, Klein, Rhonda Q, Patrignelli, Robert, Antaya, Richard, McNiff, Jennifer, Damsky, William, Kamath, Kathy, Shon, John, Ring, Aaron M, Yildirim, Inci, Omer, Saad, Ko, Albert I, Aguzzi, Adriano, Iwasaki, Akiko

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Author Correction: Delayed production of neutralizing antibodies correlates with fatal COVID-19 von Lucas, Carolina, Klein, Jon, Sundaram, Maria E., Liu, Feimei, Wong, Patrick, Silva, Julio, Mao, Tianyang, Oh, Ji Eun, Mohanty, Subhasis, Huang, Jiefang, Tokuyama, Maria, Lu, Peiwen, Venkataraman, Arvind, Park, Annsea, Israelow, Benjamin, Vogels, Chantal B. F., Muenker, M. Catherine, Chang, C-Hong, Casanovas-Massana, Arnau, Moore, Adam J., Zell, Joseph, Fournier, John B., Wyllie, Anne L., Campbell, Melissa, Lee, Alfred I., Chun, Hyung J., Grubaugh, Nathan D., Schulz, Wade L., Farhadian, Shelli, Dela Cruz, Charles, Ring, Aaron M., Shaw, Albert C., Wisnewski, Adam V., Yildirim, Inci, Ko, Albert I., Omer, Saad B., Iwasaki, Akiko

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High-resolution epitope mapping and characterization of SARS-CoV-2 antibodies in large cohorts of subjects with COVID-19 von Haynes, Winston A., Kamath, Kathy, Bozekowski, Joel, Baum-Jones, Elisabeth, Campbell, Melissa, Casanovas-Massana, Arnau, Daugherty, Patrick S., Dela Cruz, Charles S., Dhal, Abhilash, Farhadian, Shelli F., Fitzgibbons, Lynn, Fournier, John, Jhatro, Michael, Jordan, Gregory, Klein, Jon, Lucas, Carolina, Kessler, Debra, Luchsinger, Larry L., Martinez, Brian, Catherine Muenker, M., Pischel, Lauren, Reifert, Jack, Sawyer, Jaymie R., Waitz, Rebecca, Wunder, Elsio A., Zhang, Minlu, Iwasaki, Akiko, Ko, Albert, Shon, John C.

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An AI-powered patient triage platform for future viral outbreaks using COVID-19 as a disease model von Charkoftaki, Georgia, Aalizadeh, Reza, Santos-Neto, Alvaro, Tan, Wan Ying, Davidson, Emily A, Nikolopoulou, Varvara, Wang, Yewei, Thompson, Brian, Furnary, Tristan, Chen, Ying, Wunder, Elsio A, Coppi, Andreas, Schulz, Wade, Iwasaki, Akiko, Pierce, Richard W, Cruz, Charles S Dela, Desir, Gary V, Kaminski, Naftali, Farhadian, Shelli, Veselkov, Kirill, Datta, Rupak, Campbell, Melissa, Thomaidis, Nikolaos S, Ko, Albert I, Thompson, David C, Vasiliou, Vasilis

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G-Protein-Coupled Receptors as Signaling Targets for Antiplatelet Therapy von SMYTH, Susan S, WOULFE, Donna S, STEINHUBL, Steven R, BECKER, Richard C, WEITZ, Jeffrey I, GACHET, Christian, CONLEY, Pamela B, GOODMAN, Shaun G, ROE, Matthew T, KULIOPULOS, Athan, MOLITEMO, David J, FRENCH, Patricia A

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Standardized reporting of bleeding complications for clinical investigations in acute coronary syndromes: A proposal from the Academic Bleeding Consensus (ABC) Multidisciplinary Wo... von Rao, Sunil V., MD, Eikelboom, John, MBBS, MSc, Steg, Ph. Gabriel, MD, Lincoff, A. Michael, MD, Weintraub, William S., MD, Bassand, Jean-Pierre, MD, Rao, A. Koneti, MD, Gibson, C. Michael, MD, Petersen, John L., MD, Mehran, Roxana, MD, Manoukian, Steven V., MD, Charnigo, Richard, PhD, Lee, Kerry L., PhD, Moscucci, Mauro, MD, Harrington, Robert A., MD

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One-year results of a clinical trial of olipudase alfa enzyme replacement therapy in pediatric patients with acid sphingomyelinase deficiency von Diaz, George A., Jones, Simon A., Scarpa, Maurizio, Mengel, Karl Eugen, Giugliani, Roberto, Guffon, Nathalie, Batsu, Isabela, Fraser, Patricia A., Li, Jing, Zhang, Qi, Ortemann-Renon, Catherine

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AMETHIST: Baseline characteristics from a phase 3 trial of venglustat, a novel brain-penetrant glucosylceramide synthase inhibitor, in GM2-gangliosidoses and related diseases von Tifft, Cynthia J., Batsu, Isabela, Zheng, Riliang, Minini, Pascal

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