Roles of Angiotensin Peptides and Recombinant Human ACE2 in Heart Failure von Basu, Ratnadeep, MD, PhD, Poglitsch, Marko, PhD, Yogasundaram, Haran, MD, Thomas, Jissy, MN, Rowe, Brian H., MD, Oudit, Gavin Y., MD, PhD

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ACE2 Deficiency Worsens Epicardial Adipose Tissue Inflammation and Cardiac Dysfunction in Response to Diet-Induced Obesity von Patel, Vaibhav B, Mori, Jun, McLean, Brent A, Basu, Ratnadeep, Das, Subhash K, Ramprasath, Tharmarajan, Parajuli, Nirmal, Penninger, Josef M, Grant, Maria B, Lopaschuk, Gary D, Oudit, Gavin Y

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Angiotensin II induced proteolytic cleavage of myocardial ACE2 is mediated by TACE/ADAM-17: A positive feedback mechanism in the RAS von Patel, Vaibhav B, Clarke, Nicola, Wang, Zuocheng, Fan, Dong, Parajuli, Nirmal, Basu, Ratnadeep, Putko, Brendan, Kassiri, Zamaneh, Turner, Anthony J, Oudit, Gavin Y

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Angiotensin-Converting Enzyme 2 Suppresses Pathological Hypertrophy, Myocardial Fibrosis, and Cardiac Dysfunction von JIUCHANG ZHONG, BASU, Ratnadeep, OUDIT, Gavin Y, GUO, Danny, CHOW, Fung L, BYRNS, Simon, SCHUSTER, Manfred, LOIBNER, Hans, WANG, Xiu-Hua, PENNINGER, Josef M, KASSIRI, Zamaneh

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Divergent roles of matrix metalloproteinase 2 in pathogenesis of thoracic aortic aneurysm von Shen, Mengcheng, Lee, Jiwon, Basu, Ratnadeep, Sakamuri, Siva S V P, Wang, Xiuhua, Fan, Dong, Kassiri, Zamaneh

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Tissue inhibitor of metalloproteinases (TIMPs) in heart failure von Moore, Linn, Fan, Dong, Basu, Ratnadeep, Kandalam, Vijay, Kassiri, Zamaneh

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PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease von Patel, Vaibhav B., Zhabyeyev, Pavel, Chen, Xueyi, Wang, Faqi, Paul, Manish, Fan, Dong, McLean, Brent A., Basu, Ratnadeep, Zhang, Pu, Shah, Saumya, Dawson, John F., Pyle, W. Glen, Hazra, Mousumi, Kassiri, Zamaneh, Hazra, Saugata, Vanhaesebroeck, Bart, McCulloch, Christopher A., Oudit, Gavin Y.

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Iron-overload injury and cardiomyopathy in acquired and genetic models is attenuated by resveratrol therapy von Das, Subhash K., Wang, Wang, Zhabyeyev, Pavel, Basu, Ratnadeep, McLean, Brent, Fan, Dong, Parajuli, Nirmal, DesAulniers, Jessica, Patel, Vaibhav B., Hajjar, Roger J., Dyck, Jason R. B., Kassiri, Zamaneh, Oudit, Gavin Y.

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Human Recombinant ACE2 Reduces the Progression of Diabetic Nephropathy von OUDIT, Gavin Y, LIU, George C, HERZENBERG, Andrew M, KASSIRI, Zamaneh, SCHOLEY, James W, JIUCHANG ZHONG, BASU, Ratnadeep, CHOW, Fung L, ZHOU, Joyce, LOIBNER, Hans, JANZEK, Evelyne, SCHUSTER, Manfred, PENNINGER, Josef M

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ACE2/Ang 1-7 axis: A critical regulator of epicardial adipose tissue inflammation and cardiac dysfunction in obesity von Patel, Vaibhav B., Basu, Ratnadeep, Oudit, Gavin Y.

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A Disintegrin and Metalloprotease-17 Regulates Pressure Overload–Induced Myocardial Hypertrophy and Dysfunction Through Proteolytic Processing of Integrin β1 von Fan, Dong, Takawale, Abhijit, Shen, Mengcheng, Samokhvalov, Victor, Basu, Ratnadeep, Patel, Vaibhav, Wang, Xiuhua, Fernandez-Patron, Carlos, Seubert, John M, Oudit, Gavin Y, Kassiri, Zamaneh

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Cardioprotective Effects Mediated by Angiotensin II Type 1 Receptor Blockade and Enhancing Angiotensin 1-7 in Experimental Heart Failure in Angiotensin-Converting Enzyme 2–Null Mic... von Patel, Vaibhav B, Bodiga, Sreedhar, Fan, Dong, Das, Subhash K, Wang, Zuocheng, Wang, Wang, Basu, Ratnadeep, Zhong, JiuChang, Kassiri, Zamaneh, Oudit, Gavin Y

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TIMP2 Deficiency Accelerates Adverse Post–Myocardial Infarction Remodeling Because of Enhanced MT1-MMP Activity Despite Lack of MMP2 Activation von Kandalam, Vijay, Basu, Ratnadeep, Abraham, Thomas, Wang, Xiuhua, Soloway, Paul D, Jaworski, Diane M, Oudit, Gavin Y, Kassiri, Zamaneh

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Transcriptomic Signatures of End-Stage Human Dilated Cardiomyopathy Hearts with and without Left Ventricular Assist Device Support von Parikh, Mihir, Shah, Saumya, Basu, Ratnadeep, Famulski, Konrad S, Kim, Daniel, Mullen, John C, Halloran, Philip F, Oudit, Gavin Y

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Lack of Tissue Inhibitor of Metalloproteinases 2 Leads to Exacerbated Left Ventricular Dysfunction and Adverse Extracellular Matrix Remodeling in Response to Biomechanical Stress von KANDALAM, Vijay, BASU, Ratnadeep, MOORE, Linn, DONG FAN, XIUHUA WANG, JAWORSKI, Diane M, OUDIT, Gavin Y, KASSIRI, Zamaneh

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Loss of Timp3 Gene Leads to Abdominal Aortic Aneurysm Formation in Response to Angiotensin II von Basu, Ratnadeep, Fan, Dong, Kandalam, Vijay, Lee, Jiwon, Das, Subhash K., Wang, Xiuhua, Baldwin, Troy A., Oudit, Gavin Y., Kassiri, Zamaneh

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Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction von Kassiri, Zamaneh, Zhong, Jiuchang, Guo, Danny, Basu, Ratnadeep, Wang, Xiuhua, Liu, Peter P, Scholey, James W, Penninger, Josef M, Oudit, Gavin Y

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Myocardial recovery from ischemia-reperfusion is compromised in the absence of tissue inhibitor of metalloproteinase 4 von Takawale, Abhijit, Fan, Dong, Basu, Ratnadeep, Shen, Mengcheng, Parajuli, Nirmal, Wang, Wang, Wang, Xiuhua, Oudit, Gavin Y, Kassiri, Zamaneh

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Females Are Protected From Iron‐Overload Cardiomyopathy Independent of Iron Metabolism: Key Role of Oxidative Stress von Das, Subhash K., Patel, Vaibhav B., Basu, Ratnadeep, Wang, Wang, DesAulniers, Jessica, Kassiri, Zamaneh, Oudit, Gavin Y.

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Heterozygote loss of ACE2 is sufficient to increase the susceptibility to heart disease von Wang, Wang, Patel, Vaibhav B., Parajuli, Nirmal, Fan, Dong, Basu, Ratnadeep, Wang, Zuocheng, Ramprasath, Tharmarajan, Kassiri, Zamaneh, Penninger, Josef M., Oudit, Gavin Y.

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