Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool von Sannerud, Ragna, Esselens, Cary, Ejsmont, Paulina, Mattera, Rafael, Rochin, Leila, Tharkeshwar, Arun Kumar, De Baets, Greet, De Wever, Veerle, Habets, Roger, Baert, Veerle, Vermeire, Wendy, Michiels, Christine, Groot, Arjan J., Wouters, Rosanne, Dillen, Katleen, Vints, Katlijn, Baatsen, Pieter, Munck, Sebastian, Derua, Rita, Waelkens, Etienne, Basi, Guriqbal S., Mercken, Mark, Vooijs, Marc, Bollen, Mathieu, Schymkowitz, Joost, Rousseau, Frederic, Bonifacino, Juan S., Van Niel, Guillaume, De Strooper, Bart, Annaert, Wim

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Treatment strategies targeting amyloid β-protein von Schenk, Dale, Basi, Guriqbal S, Pangalos, Menelas N

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Polo-like Kinase 2 (PLK2) Phosphorylates α-Synuclein at Serine 129 in Central Nervous System von Inglis, Kelly J., Chereau, David, Brigham, Elizabeth F., Chiou, San-San, Schöbel, Susanne, Frigon, Normand L., Yu, Mei, Caccavello, Russell J., Nelson, Seth, Motter, Ruth, Wright, Sarah, Chian, David, Santiago, Pamela, Soriano, Ferdie, Ramos, Carla, Powell, Kyle, Goldstein, Jason M., Babcock, Michael, Yednock, Ted, Bard, Frederique, Basi, Guriqbal S., Sham, Hing, Chilcote, Tamie J., McConlogue, Lisa, Griswold-Prenner, Irene, Anderson, John P.

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Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and... von Kukar, Thomas L, Ladd, Thomas B, Robertson, Paul, Pintchovski, Sean A, Moore, Brenda, Bann, Maralyssa A, Ren, Zhao, Jansen-West, Karen, Malphrus, Kim, Eggert, Simone, Maruyama, Hiroko, Cottrell, Barbara A, Das, Pritam, Basi, Guriqbal S, Koo, Edward H, Golde, Todd E

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Amyloid β-Protein Precursor Juxtamembrane Domain Regulates Specificity of γ-Secretase-dependent Cleavages von Ren, Zhao, Schenk, Dale, Basi, Guriqbal S., Shapiro, I. Paul

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Accelerating drug discovery for Alzheimer's disease: best practices for preclinical animal studies von Shineman, Diana W, Basi, Guriqbal S, Bizon, Jennifer L, Colton, Carol A, Greenberg, Barry D, Hollister, Beth A, Lincecum, John, Leblanc, Gabrielle G, Lee, Linda Bobbi H, Luo, Feng, Morgan, Dave, Morse, Iva, Refolo, Lorenzo M, Riddell, David R, Scearce-Levie, Kimberly, Sweeney, Patrick, Yrjänheikki, Juha, Fillit, Howard M

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Purification and cloning of amyloid precursor protein β-secretase from human brain von Sinha, Sukanto, Anderson, John P, Barbour, Robin, Basi, Guriqbal S, Caccavello, Russell, Davis, David, Doan, Minhtam, Dovey, Harry F, Frigon, Normand, Hong, Jin, Jacobson-Croak, Kirsten, Jewett, Nancy, Keim, Pamela, Knops, Jeroen, Lieberburg, Ivan, Power, Michael, Tan, Hua, Tatsuno, Gwen, Tung, Jay, Schenk, Dale, Seubert, Peter, Suomensaari, Susanna M, Wang, Shuwen, Walker, Donald, Zhao, Jun, McConlogue, Lisa, John, Varghese

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Crystal structure reveals conservation of amyloid-β conformation recognized by 3D6 following humanization to bapineuzumab von Feinberg, Hadar, Saldanha, José W, Diep, Linnea, Goel, Amita, Widom, Angela, Veldman, Geertruida M, Weis, William I, Schenk, Dale, Basi, Guriqbal S

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Discovery of (R)‑4-Cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro‑1H‑pyrazolo[4,3‑c]quinoline (ELND006) and (R)‑4-Cyclopropyl-8-fluoro-5-(6-(trifluorome... von Probst, Gary, Aubele, Danielle L, Bowers, Simeon, Dressen, Darren, Garofalo, Albert W, Hom, Roy K, Konradi, Andrei W, Marugg, Jennifer L, Mattson, Matthew N, Neitzel, Martin L, Semko, Chris M, Sham, Hing L, Smith, Jenifer, Sun, Minghua, Truong, Anh P, Ye, Xiaocong M, Xu, Ying-zi, Dappen, Michael S, Jagodzinski, Jacek J, Keim, Pamela S, Peterson, Brian, Latimer, Lee H, Quincy, David, Wu, Jing, Goldbach, Erich, Ness, Daniel K, Quinn, Kevin P, Sauer, John-Michael, Wong, Karina, Zhang, Hongbin, Zmolek, Wes, Brigham, Elizabeth F, Kholodenko, Dora, Hu, Kang, Kwong, Grace T, Lee, Michael, Liao, Anna, Motter, Ruth N, Sacayon, Patricia, Santiago, Pamela, Willits, Christopher, Bard, Frédérique, Bova, Michael P, Hemphill, Susanna S, Nguyen, Lam, Ruslim, Lany, Tanaka, Kevin, Tanaka, Pearl, Wallace, William, Yednock, Ted A, Basi, Guriqbal S

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Structural Correlates of Antibodies Associated with Acute Reversal of Amyloid β-related Behavioral Deficits in a Mouse Model of Alzheimer Disease von Basi, Guriqbal S., Feinberg, Hadar, Oshidari, Farshid, Anderson, John, Barbour, Robin, Baker, Jeanne, Comery, Thomas A., Diep, Linnea, Gill, Davinder, Johnson-Wood, Kelly, Goel, Amita, Grantcharova, Katerina, Lee, Mike, Li, Jingzhi, Partridge, Anthony, Griswold-Prenner, Irene, Piot, Nicolas, Walker, Don, Widom, Angela, Pangalos, Menelas N., Seubert, Peter, Jacobsen, J. Steven, Schenk, Dale, Weis, William I.

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Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide-pyrazoles as potent, selective and efficacious γ-secretase inhibitors von Ye, Xiaocong M., Konradi, Andrei W., Sun, Minghua, Yuan, Shendong, Aubele, Danielle L., Dappen, Michael, Dressen, Darren, Garofalo, Albert W., Jagodzinski, Jacek J., Latimer, Lee, Probst, Gary D., Sham, Hing L., Wone, David, Xu, Ying-zi, Ness, Daniel, Brigham, Elizabeth, Kwong, Grace T., Willtis, Chris, Tonn, George, Goldbach, Erich, Quinn, Kevin P., Zhang, Hongbin H., Sauer, John-Michael, Bova, Michael, Basi, Guriqbal S.

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Discovery of sulfonamide–pyrazole γ-secretase inhibitors von Mattson, Matthew N., Neitzel, Martin L., Quincy, David A., Semko, Christopher M., Garofalo, Albert W., Keim, Pamela S., Konradi, Andrei W., Pleiss, Michael A., Sham, Hing L., Brigham, Elizabeth F., Goldbach, Erich G., Zhang, Hongbin, Sauer, John-Michael, Basi, Guriqbal S.

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Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and Efficacious γ-Secretase Inhibitors von Ye, Xiaocong M., Konradi, Andrei W., Smith, Jenifer, Xu, Ying-Zi, Dressen, Darren, Garofalo, Albert W., Marugg, Jennifer, Sham, Hing L., Truong, Anh P., Jagodzinski, Jacek, Pleiss, Michael, Zhang, Hongbin, Goldbach, Erich, Sauer, John-Michael, Brigham, Elizabeth, Bova, Michael, Basi, Guriqbal S.

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Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and efficacious γ-secretase inhibitors (Part II) von Ye, Xiaocong M., Konradi, Andrei W., Smith, Jenifer, Aubele, Danielle L., Garofalo, Albert W., Marugg, Jennifer, Neitzel, Marty L., Semko, Chris M., Sham, Hing L., Sun, Minghua, Truong, Anh P., Wu, Jing, Zhang, Hongbin, Goldbach, Erich, Sauer, John-Michael, Brigham, Elizabeth F., Bova, Michael, Basi, Guriqbal S.

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N-Bridged bicyclic sulfonamides as inhibitors of γ-secretase von Bowers, Simeon, Probst, Gary D., Truong, Anh P., Hom, Roy K., Konradi, Andrei W., Sham, Hing L., Garofalo, Albert W., Wong, Karina, Goldbach, Erich, Quinn, Kevin P., Sauer, John-Michael, Wallace, William, Nguyen, Lan, Hemphill, Susanna S., Bova, Michael P., Basi, Guriqbal S.

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Caspase-mediated Cleavage of DNA Topoisomerase I at Unconventional Sites during Apoptosis von Samejima, K, Svingen, P A, Basi, G S, Kottke, T, Mesner, Jr, P W, Stewart, L, Durrieu, F, Poirier, G G, Alnemri, E S, Champoux, J J, Kaufmann, S H, Earnshaw, W C

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Pharmacokinetic and pharmacodynamic analysis of a novel gamma secretase inhibitor in a non-transgenic A-beta mouse efficacy model von Quinn, Kevin P, Kuwabara-Wagg, Jonathan, Brigham, Elizabeth, Cabrera, Cristian, Goldbach, Erich, Dreyer, Mark, Hu, Kang, Lee, Mike, Green, Michelle, Ness, Daniel, Santiago, Pamela, Samant, Bhushan, Soriano, Ferdie, Webb, Steve, Basi, Guriqbal S, Sauer, John-Michael

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Pharmacokinetic and pharmacodynamic analysis of a novel gamma secretase inhibitor in a nontransgenic A-beta mouse efficacy model von Quinn, Kevin P, Kuwabara-Wagg, Jonathan, Brigham, Elizabeth, Cabrera, Cristian, Goldbach, Erich, Dreyer, Mark, Hu, Kang, Lee, Mike, Green, Michelle, Ness, Daniel, Santiago, Pamela, Samant, Bhushan, Soriano, Ferdie, Webb, Steve, Basi, Guriqbal S, Sauer, John-Michael

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Discovery of ( R )-4-Cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1 H -pyrazolo[4,3- c ]quinoline (ELND006) and ( R )-4-Cyclopropyl-8-fluoro-5-(6-(tri... von Probst, Gary, Aubele, Danielle L., Bowers, Simeon, Dressen, Darren, Garofalo, Albert W., Hom, Roy K., Konradi, Andrei W., Marugg, Jennifer L., Mattson, Matthew N., Neitzel, Martin L., Semko, Chris M., Sham, Hing L., Smith, Jenifer, Sun, Minghua, Truong, Anh P., Ye, Xiaocong M., Xu, Ying-zi, Dappen, Michael S., Jagodzinski, Jacek J., Keim, Pamela S., Peterson, Brian, Latimer, Lee H., Quincy, David, Wu, Jing, Goldbach, Erich, Ness, Daniel K., Quinn, Kevin P., Sauer, John-Michael, Wong, Karina, Zhang, Hongbin, Zmolek, Wes, Brigham, Elizabeth F., Kholodenko, Dora, Hu, Kang, Kwong, Grace T., Lee, Michael, Liao, Anna, Motter, Ruth N., Sacayon, Patricia, Santiago, Pamela, Willits, Christopher, Bard, Frédérique, Bova, Michael P., Hemphill, Susanna S., Nguyen, Lam, Ruslim, Lany, Tanaka, Kevin, Tanaka, Pearl, Wallace, William, Yednock, Ted A., Basi, Guriqbal S.

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Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool von Sannerud, Ragna, Esselens, Cary, Ejsmont, Paulina, Mattera, Rafael, Rochin, Leila, Tharkeshwar Raghunath, Arun Kumar, De Baets, Greet, De Wever, Veerle, Habets, Roger, Baert, Veerle, Vermeire, Wendy, Michiels, Christine, Groot, Arjan J, Wouters, Rosanne, Dillen, Katleen, Vints, Katlijn, Baatsen, Pieter, Munck, Sebastian, Derua, Rita, Waelkens, Etienne, Basi, Guriqbal S, Mercken, Mark, Vooijs, Marc, Bollen, Mathieu, Schymkowitz, Joost, Rousseau, Frederic, Bonifacino, Juan S, Van Niel, Guillaume, De Strooper, Bart, Annaert, Wim

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