Targeting class I histone deacetylases by the novel small molecule inhibitor 4SC‐202 blocks oncogenic hedgehog‐GLI signaling and overcomes smoothened inhibitor resistance von Gruber, Wolfgang, Peer, Elisabeth, Elmer, Dominik P., Sternberg, Christina, Tesanovic, Suzana, del Burgo, Pedro, Coni, Sonia, Canettieri, Gianluca, Neureiter, Daniel, Bartz, René, Kohlhof, Hella, Vitt, Daniel, Aberger, Fritz

Volltext

lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology von Szymanski, Kimberly M, Binns, Derk, Bartz, René, Grishin, Nick V, Li, Wei-Ping, Agarwal, Anil K, Garg, Abhimanyu, Anderson, Richard G.W, Goodman, Joel M

Volltext

Elucidating the mechanism of action of domatinostat (4SC-202) in cutaneous T cell lymphoma cells von Wobser, Marion, Weber, Alexandra, Glunz, Amelie, Tauch, Saskia, Seitz, Kristina, Butelmann, Tobias, Hesbacher, Sonja, Goebeler, Matthias, Bartz, René, Kohlhof, Hella, Schrama, David, Houben, Roland

Volltext

Targeting sequences of UBXD8 and AAM-B reveal that the ER has a direct role in the emergence and regression of lipid droplets von Zehmer, John K, Bartz, René, Bisel, Blaine, Liu, Pingsheng, Seemann, Joachim, Anderson, Richard G.W

Volltext

Dynamic Activity of Lipid Droplets:  Protein Phosphorylation and GTP-Mediated Protein Translocation von Bartz, René, Zehmer, John K, Zhu, Meifang, Chen, Yue, Serrero, Ginette, Zhao, Yingming, Liu, Pingsheng

Volltext

Identification of a novel N-terminal hydrophobic sequence that targets proteins to lipid droplets von Zehmer, John K, Bartz, René, Liu, Pingsheng, Anderson, Richard G.W

Volltext

Computational Design and Experimental Characterization of Peptides Intended for pH-Dependent Membrane Insertion and Pore Formation von Zhang, Yao, Bartz, René, Grigoryan, Gevorg, Bryant, Michael, Aaronson, Jeff, Beck, Stephen, Innocent, Nathalie, Klein, Lee, Procopio, William, Tucker, Tom, Jadhav, Vasant, Tellers, David M, DeGrado, William F

Volltext

Quantitative evaluation of siRNA delivery in vivo von Pei, Yi, Hancock, Paula J, Zhang, Hangchun, Bartz, René, Cherrin, Craig, Innocent, Nathalie, Pomerantz, Colin J, Seitzer, Jessica, Koser, Martin L, Abrams, Marc T, Xu, Yan, Kuklin, Nelly A, Burke, Paul A, Sachs, Alan B, Sepp-Lorenzino, Laura, Barnett, Stanley F

Volltext

Effective siRNA delivery and target mRNA degradation using an amphipathic peptide to facilitate pH-dependent endosomal escape von Bartz, René, Fan, Haihong, Zhang, Jingtao, Innocent, Nathalie, Cherrin, Craig, Beck, Stephen C, Pei, Yi, Momose, Aaron, Jadhav, Vasant, Tellers, David M, Meng, Fanyu, Crocker, Louis S, Sepp-Lorenzino, Laura, Barnett, Stanley F

Volltext

Domatinostat favors the immunotherapy response by modulating the tumor immune microenvironment (TIME) von Bretz, Anne Catherine, Parnitzke, Ulrike, Kronthaler, Kerstin, Dreker, Tobias, Bartz, René, Hermann, Frank, Ammendola, Astrid, Wulff, Tanja, Hamm, Svetlana

Volltext

Fibroblast growth factor 23 directly targets hepatocytes to promote inflammation in chronic kidney disease von Singh, Saurav, Grabner, Alexander, Yanucil, Christopher, Schramm, Karla, Czaya, Brian, Krick, Stefanie, Czaja, Mark J., Bartz, Rene, Abraham, Reimar, Di Marco, Giovana S., Brand, Marcus, Wolf, Myles, Faul, Christian

Volltext

Phase I study of domatinostat (4SC‐202), a class I histone deacetylase inhibitor in patients with advanced hematological malignancies von Tresckow, Bastian, Sayehli, Cyrus, Aulitzky, Walter E., Goebeler, Maria‐Elisabeth, Schwab, Matthias, Braz, Eunice, Krauss, Babett, Krauss, Rolf, Hermann, Frank, Bartz, René, Engert, Andreas

Volltext

Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid traffic von Bartz, René, Li, Wen-Hong, Venables, Barney, Zehmer, John K, Roth, Mary R, Welti, Ruth, Anderson, Richard G.W, Liu, Pingsheng, Chapman, Kent D

Volltext

Preclinical Development of U3-1784, a Novel FGFR4 Antibody Against Cancer, and Avoidance of Its On-target Toxicity von Bartz, René, Fukuchi, Keisuke, Ohtsuka, Toshiaki, Lange, Tanja, Gruner, Katrin, Watanabe, Ichiro, Hayashi, Shinko, Oda, Yoko, Kawaida, Reimi, Komori, Hironobu, Kashimoto, Yoshinori, Wirtz, Peter, Mayer, Jan-Peter A, Redondo-Müller, Mauricio, Saito, Shuntaro, Takahashi, Mizuki, Hanzawa, Hiroyuki, Imai, Emi, Martinez, Alberto, Hanai, Masaharu, Häussinger, Dieter, Chapman, Roger W, Agatsuma, Toshinori, Bange, Johannes, Abraham, Reimar

Volltext

Rab-regulated interaction of early endosomes with lipid droplets von Liu, Pingsheng, Bartz, René, Zehmer, John K., Ying, Yun-shu, Zhu, Meifang, Serrero, Ginette, Anderson, Richard G.W.

Volltext

Mathematical Modeling: A Tool for Optimization of Lipid Nanoparticle-Mediated Delivery of siRNA von Mihaila, Radu, Ruhela, Dipali, Keough, Edward, Cherkaev, Elena, Chang, Silvia, Galinski, Beverly, Bartz, René, Brown, Duncan, Howell, Bonnie, Cunningham, James J.

Volltext

Mitotic regulation of SREBP and ATF6 by separation of the Golgi and ER von Bartz, René, Seemann, Joachim

Volltext

Abstract 4722: 4SC-202 increases immunogenicity of tumor cells, induces infiltration of tumor microenvironment with cytotoxic T cells, and primes tumors for combinations with diffe... von Hamm, Svetlana, Wulff, Tanja, Kronthaler, Kerstin, Schrepfer, Sabine, Parnitzke, Ulrike, Bretz, Anne Catherine, Bartz, René

Volltext

Spatial separation of Golgi and ER during mitosis protects SREBP from unregulated activation von Bartz, René, Sun, Li-Ping, Bisel, Blaine, Wei, Jen-Hsuan, Seemann, Joachim

Volltext

Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid traffic1,s von Bartz, René, Li, Wen-Hong, Venables, Barney, Zehmer, John K., Roth, Mary R., Welti, Ruth, Anderson, Richard G.W., Liu, Pingsheng, Chapman, Kent D.

Volltext