Cellular senescence drives age-dependent hepatic steatosis von Ogrodnik, Mikolaj, Miwa, Satomi, Tchkonia, Tamar, Tiniakos, Dina, Wilson, Caroline L., Lahat, Albert, Day, Christoper P., Burt, Alastair, Palmer, Allyson, Anstee, Quentin M., Grellscheid, Sushma Nagaraja, Hoeijmakers, Jan H J., Barnhoorn, Sander, Mann, Derek A., Bird, Thomas G., Vermeij, Wilbert P., Kirkland, James L., Passos, João F., von Zglinicki, Thomas, Jurk, Diana

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DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering von Milanese, Chiara, Bombardieri, Cíntia R., Sepe, Sara, Barnhoorn, Sander, Payán-Goméz, César, Caruso, Donatella, Audano, Matteo, Pedretti, Silvia, Vermeij, Wilbert P., Brandt, Renata M. C., Gyenis, Akos, Wamelink, Mirjam M., de Wit, Annelieke S., Janssens, Roel C., Leen, René, van Kuilenburg, André B. P., Mitro, Nico, Hoeijmakers, Jan H. J., Mastroberardino, Pier G.

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Gender biased neuroprotective effect of Transferrin Receptor 2 deletion in multiple models of Parkinson’s disease von Milanese, Chiara, Gabriels, Sylvia, Barnhoorn, Sander, Cerri, Silvia, Ulusoy, Ayse, Gornati, S. V., Wallace, Daniel F., Blandini, Fabio, Di Monte, Donato A., Subramaniam, V. Nathan, Mastroberardino, Pier G.

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Orthogonal analysis of mitochondrial function in Parkinson’s disease patients von Barnhoorn, Sander, Milanese, Chiara, Li, Tracy, Dons, Lieke, Ghazvini, Mehrnaz, Sette, Martina, Farina, Stefania, Sproviero, Daisy, Payan-Gomez, Cesar, Mastroberardino, Pier G.

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Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair‐deficient mice von Birkisdóttir, María B., Jaarsma, Dick, Brandt, Renata M. C., Barnhoorn, Sander, Vliet, Nicole, Imholz, Sandra, Oostrom, Conny T., Nagarajah, Bhawani, Portilla Fernández, Eliana, Roks, Anton J. M., Elgersma, Ype, Steeg, Harry, Ferreira, José A., Pennings, Jeroen L. A., Hoeijmakers, Jan H. J., Vermeij, Wilbert P., Dollé, Martijn E. T.

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Cell-autonomous progeroid changes in conditional mouse models for repair endonuclease XPG deficiency von Barnhoorn, Sander, Uittenboogaard, Lieneke M, Jaarsma, Dick, Vermeij, Wilbert P, Tresini, Maria, Weymaere, Michael, Menoni, Hervé, Brandt, Renata M C, de Waard, Monique C, Botter, Sander M, Sarker, Altaf H, Jaspers, Nicolaas G J, van der Horst, Gijsbertus T J, Cooper, Priscilla K, Hoeijmakers, Jan H J, van der Pluijm, Ingrid

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Frontline Science: Tryptophan restriction arrests B cell development and enhances microbial diversity in WT and prematurely aging Ercc1−/Δ7 mice von Beek, Adriaan A., Hugenholtz, Floor, Meijer, Ben, Sovran, Bruno, Perdijk, Olaf, Vermeij, Wilbert P., Brandt, Renata M. C., Barnhoorn, Sander, Hoeijmakers, Jan H. J., Vos, Paul, Leenen, Pieter J. M., Hendriks, Rudi W., Savelkoul, Huub F. J.

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Purkinje-cell-specific DNA repair-deficient mice reveal that dietary restriction protects neurons by cell-intrinsic preservation of genomic health von Birkisdóttir, María Björk, Van't Sant, Lisanne J, Brandt, Renata M C, Barnhoorn, Sander, Hoeijmakers, Jan H J, Vermeij, Wilbert P, Jaarsma, Dick

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Metabolomic analysis of dietary‐restriction‐induced attenuation of sarcopenia in prematurely aging DNA repair‐deficient mice von He, Yupeng, Yang, Wei, Huang, Luojiao, Mever, Marlien Admiraal‐van, Ramautar, Rawi, Harms, Amy, Rijksen, Yvonne, Brandt, Renata M.C., Barnhoorn, Sander, Smit, Kimberly, Jaarsma, Dick, Lindenburg, Peter, Hoeijmakers, Jan H. J., Vermeij, Wilbert P., Hankemeier, Thomas

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Compression of morbidity in a progeroid mouse model through the attenuation of myostatin/activin signalling von Alyodawi, Khalid, Vermeij, Wilbert P., Omairi, Saleh, Kretz, Oliver, Hopkinson, Mark, Solagna, Francesca, Joch, Barbara, Brandt, Renata M.C., Barnhoorn, Sander, Vliet, Nicole, Ridwan, Yanto, Essers, Jeroen, Mitchell, Robert, Morash, Taryn, Pasternack, Arja, Ritvos, Olli, Matsakas, Antonios, Collins‐Hooper, Henry, Huber, Tobias B., Hoeijmakers, Jan H.J., Patel, Ketan

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Decreased hepatic thyroid hormone signaling in systemic and liver-specific but not brain-specific accelerated aging due to DNA repair deficiency in mice von Barnhoorn, Sander, Meima, Marcel E, Peeters, Robin P, Darras, Veerle M, Leeuwenburgh, Selmar, Hoeijmakers, Jan H J, Vermeij, Wilbert P, Visser, W Edward

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The use of progeroid DNA repair-deficient mice for assessing anti-aging compounds, illustrating the benefits of nicotinamide riboside von Birkisdóttir, María B, van Galen, Ivar, Brandt, Renata M C, Barnhoorn, Sander, van Vliet, Nicole, van Dijk, Claire, Nagarajah, Bhawani, Imholz, Sandra, van Oostrom, Conny T, Reiling, Erwin, Gyenis, Ákos, Mastroberardino, Pier G, Jaarsma, Dick, van Steeg, Harry, Hoeijmakers, Jan H J, Dollé, Martijn E T, Vermeij, Wilbert P

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Functional Evolution of the Photolyase/Cryptochrome Protein Family: Importance of the C Terminus of Mammalian CRY1 for Circadian Core Oscillator Performance von Chaves, Inês, Yagita, Kazuhiro, Barnhoorn, Sander, Okamura, Hitoshi, van der Horst, Gijsbertus T. J., Tamanini, Filippo

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Corrigendum: The use of progeroid DNA repair-deficient mice for assessing anti-aging compounds, illustrating the benefits of nicotinamide riboside von Birkisdóttir, María B, van Galen, Ivar, Brandt, Renata M C, Barnhoorn, Sander, van Vliet, Nicole, van Dijk, Claire, Nagarajah, Bhawani, Imholz, Sandra, van Oostrom, Conny T, Reiling, Erwin, Gyenis, Ákos, Mastroberardino, Pier G, Jaarsma, Dick, van Steeg, Harry, Hoeijmakers, Jan H J, Dollé, Martijn E T, Vermeij, Wilbert P

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Development of an IPSC Derived In Vitro Model to Study Vascular ageing von van der Linden, Janette, van Vuuren, Laura, Brandt, Renata, Barnhoorn, Sander, Danser, Jan, Cheng, Caroline, Roks, Anton, van der Pluijm, Ingrid

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Genome-wide RNA polymerase stalling shapes the transcriptome during aging von Gyenis, Akos, Chang, Jiang, Demmers, Joris J. P. G., Bruens, Serena T., Barnhoorn, Sander, Brandt, Renata M. C., Baar, Marjolein P., Raseta, Marko, Derks, Kasper W. J., Hoeijmakers, Jan H. J., Pothof, Joris

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Genome-wide RNA polymerase stalling shapes the transcriptome during aging von Gyenis, Akos, Chang, Jiang, Demmers, Joris J.P.G, Bruens, Serena T, Barnhoorn, Sander, Brandt, Renata M.C, Baar, Marjolein P, Raseta, Marko, Derks, Kasper W.J, Hoeijmakers, Jan H.J, Pothof, Joris

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Slc2a10 knock-out mice deficient in ascorbic acid synthesis recapitulate aspects of arterial tortuosity syndrome and display mitochondrial respiration defects von Boel, Annekatrien, Burger, Joyce, Vanhomwegen, Marine, Beyens, Aude, Renard, Marjolijn, Barnhoorn, Sander, Casteleyn, Christophe, Reinhardt, Dieter P, Descamps, Benedicte, Vanhove, Christian, van der Pluijm, Ingrid, Coucke, Paul, Willaert, Andy, Essers, Jeroen, Callewaert, Bert

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Decreased hepatic thyroid hormone signaling in systemic and liver-specific but not brain-specific accelerated aging due to DNA repair deficiency in mice von Barnhoorn, Sander, Meima, Marcel, Peeters, Robin, Darras, Veerle, Leeuwenburgh, Selmar, Hoeijmakers, Jan, Vermeij, Wilbert, Visser, W. Edward

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DNA repair in cardiomyocytes is critical for maintaining cardiac function in mice von Boer, Martine, Lintel Hekkert, Maaike, Chang, Jiang, Thiel, Bibi S., Martens, Leonie, Bos, Maxime M., Kleijnen, Marion G. J., Ridwan, Yanto, Octavia, Yanti, Deel, Elza D., Blonden, Lau A., Brandt, Renata M. C., Barnhoorn, Sander, Bautista‐Niño, Paula K., Krabbendam‐Peters, Ilona, Wolswinkel, Rianne, Arshi, Banafsheh, Ghanbari, Mohsen, Kupatt, Christian, Windt, Leon J., Danser, A. H. Jan, Pluijm, Ingrid, Remme, Carol Ann, Stoll, Monika, Pothof, Joris, Roks, Anton J. M., Kavousi, Maryam, Essers, Jeroen, Velden, Jolanda, Hoeijmakers, Jan H. J., Duncker, Dirk J.

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