Binding Mode and Structure-Activity Relationships around Direct Inhibitors of the Nrf2-Keap1 Complex von Jnoff, Eric, Albrecht, Claudia, Barker, John J., Barker, Oliver, Beaumont, Edward, Bromidge, Steven, Brookfield, Frederick, Brooks, Mark, Bubert, Christian, Ceska, Tom, Corden, Vincent, Dawson, Graham, Duclos, Stephanie, Fryatt, Tara, Genicot, Christophe, Jigorel, Emilie, Kwong, Jason, Maghames, Rosemary, Mushi, Innocent, Pike, Richard, Sands, Zara A., Smith, Myron A., Stimson, Christopher C., Courade, Jean-Philippe

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Structural insights into selective small molecule activation of PKG1α von Metwally, Essam, Mak, Victor, Soriano, Aileen, Zebisch, Matthias, Silvestre, H. Leonardo, McEwan, Paul A., Ermakov, Grigori, Beaumont, Maribel, Tawa, Paul, Barker, John J., Yen, Rose, Patel, Akash, Lim, Yeon-Hee, Healy, David, Hanisak, Jennifer, Cheng, Alan C., Greshock, Tom, Fischmann, Thierry O.

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The multiple roles of computational chemistry in fragment-based drug design von Law, Richard, Barker, Oliver, Barker, John J., Hesterkamp, Thomas, Godemann, Robert, Andersen, Ole, Fryatt, Tara, Courtney, Steve, Hallett, Dave, Whittaker, Mark

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Structural and biochemical studies of a moderately thermophilic exonuclease I from Methylocaldum szegediense von Fei, Li, Tian, SiSi, Moysey, Ruth, Misca, Mihaela, Barker, John J, Smith, Myron A, McEwan, Paul A, Pilka, Ewa S, Crawley, Lauren, Evans, Tom, Sun, Dapeng

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Antibacterial drug discovery and structure-based design von Barker, John J.

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Function from structure? The crystal structure of human phosphatidylethanolamine-binding protein suggests a role in membrane signal transduction von Banfield, Mark J, Barker, John J, Perry, Anthony CF, Brady, R Leo

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Fragment‐based Identification of Hsp90 Inhibitors von Barker, John J., Barker, Oliver, Boggio, Roberto, Chauhan, Viddhata, Cheng, Robert K. Y., Corden, Vincent, Courtney, Stephen M., Edwards, Neil, Falque, Virginie M., Fusar, Fulvia, Gardiner, Mihaly, Hamelin, Estelle M. N., Hesterkamp, Thomas, Ichihara, Osamu, Jones, Richard S., Mather, Owen, Mercurio, Ciro, Minucci, Saverio, Montalbetti, Christian A. G. N., Müller, Annett, Patel, Deepti, Phillips, Banu G., Varasi, Mario, Whittaker, Mark, Winkler, Dirk, Yarnold, Christopher J.

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Development of a robust crystallization platform for immune receptor TREM2 using a crystallization chaperone strategy von Byrne, Noel J., Lee, Amy C., Kostas, James, Reid, John C., Partridge, Andrea T., So, Sung-Sau, Cowan, Joseph E., Abeywickrema, Pravien, Huang, Hua, Zebisch, Matthias, Barker, John J., Soisson, Stephen M., Brooun, Alexei, Su, Hua-Poo

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Tetrahydroindazoles as Interleukin‑2 Inducible T‑Cell Kinase Inhibitors. Part II. Second-Generation Analogues with Enhanced Potency, Selectivity, and Pharmacodynamic Modulation in... von Burch, Jason D, Barrett, Kathy, Chen, Yuan, DeVoss, Jason, Eigenbrot, Charles, Goldsmith, Richard, Ismaili, M. Hicham A, Lau, Kevin, Lin, Zhonghua, Ortwine, Daniel F, Zarrin, Ali A, McEwan, Paul A, Barker, John J, Ellebrandt, Claire, Kordt, Daniel, Stein, Daniel B, Wang, Xiaolu, Chen, Yong, Hu, Baihua, Xu, Xiaofeng, Yuen, Po-Wai, Zhang, Yamin, Pei, Zhonghua

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High-Throughput Production of Proteins in E. coli for Structural Studies von Black, Charikleia, Barker, John J., Hitchman, Richard B., Kwong, Hok Sau, Festenstein, Sam, Acton, Thomas B.

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Property- and Structure-Guided Discovery of a Tetrahydroindazole Series of Interleukin‑2 Inducible T‑Cell Kinase Inhibitors von Burch, Jason D, Lau, Kevin, Barker, John J, Brookfield, Fred, Chen, Yong, Chen, Yuan, Eigenbrot, Charles, Ellebrandt, Claire, Ismaili, M. Hicham A, Johnson, Adam, Kordt, Daniel, MacKinnon, Colin H, McEwan, Paul A, Ortwine, Daniel F, Stein, Daniel B, Wang, Xiaolu, Winkler, Dirk, Yuen, Po-Wai, Zhang, Yamin, Zarrin, Ali A, Pei, Zhonghua

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Discovery and Structure–Activity Relationship of Potent and Selective Covalent Inhibitors of Transglutaminase 2 for Huntington’s Disease von Prime, Michael E, Andersen, Ole A, Barker, John J, Brooks, Mark A, Cheng, Robert K. Y, Toogood-Johnson, Ian, Courtney, Stephen M, Brookfield, Frederick A, Yarnold, Christopher J, Marston, Richard W, Johnson, Peter D, Johnsen, Siw F, Palfrey, Jordan J, Vaidya, Darshan, Erfan, Sayeh, Ichihara, Osamu, Felicetti, Brunella, Palan, Shilpa, Pedret-Dunn, Anna, Schaertl, Sabine, Sternberger, Ina, Ebneth, Andreas, Scheel, Andreas, Winkler, Dirk, Toledo-Sherman, Leticia, Beconi, Maria, Macdonald, Douglas, Muñoz-Sanjuan, Ignacio, Dominguez, Celia, Wityak, John

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Discovery of a Novel Hsp90 Inhibitor by Fragment Linking von Barker, John J., Barker, Oliver, Courtney, Stephen M., Gardiner, Mihaly, Hesterkamp, Thomas, Ichihara, Osamu, Mather, Owen, Montalbetti, Christian A. G. N., Müller, Annett, Varasi, Mario, Whittaker, Mark, Yarnold, Christopher J.

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Design, synthesis and structure-activity relationships of a novel class of sulfonylpyridine inhibitors of Interleukin-2 inducible T-cell kinase (ITK) von Trani, Giancarlo, Barker, John J, Bromidge, Steven M, Brookfield, Frederick A, Burch, Jason D, Chen, Yuan, Eigenbrot, Charles, Heifetz, Alexander, Ismaili, M Hicham A, Johnson, Adam, Krülle, Thomas M, MacKinnon, Colin H, Maghames, Rosemary, McEwan, Paul A, Montalbetti, Christian A G N, Ortwine, Daniel F, Pérez-Fuertes, Yolanda, Vaidya, Darshan G, Wang, Xiaolu, Zarrin, Ali A, Pei, Zhonghua

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Inside Cover: Binding Mode and Structure-Activity Relationships around Direct Inhibitors of the Nrf2-Keap1 Complex (ChemMedChem 4/2014) von Jnoff, Eric, Albrecht, Claudia, Barker, John J., Barker, Oliver, Beaumont, Edward, Bromidge, Steven, Brookfield, Frederick, Brooks, Mark, Bubert, Christian, Ceska, Tom, Corden, Vincent, Dawson, Graham, Duclos, Stephanie, Fryatt, Tara, Genicot, Christophe, Jigorel, Emilie, Kwong, Jason, Maghames, Rosemary, Mushi, Innocent, Pike, Richard, Sands, Zara A., Smith, Myron A., Stimson, Christopher C., Courade, Jean-Philippe

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HCV NS5B polymerase inhibitors 2: Synthesis and in vitro activity of (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives von Wang, Guangyi, Lei, Huoxing, Wang, Xiaofang, Das, Debasis, Hong, Jian, Mackinnon, Colin H., Coulter, Thomas S., Montalbetti, Christian A.G.N., Mears, Richard, Gai, Xinjie, Bailey, Sarah E., Ruhrmund, Donald, Hooi, Lisa, Misialek, Shawn, Rajagopalan, P.T. Ravi, Cheng, Robert K.Y., Barker, John J., Felicetti, Brunella, Schönfeld, Dorian L., Stoycheva, Antitsa, Buckman, Brad O., Kossen, Karl, Seiwert, Scott D., Beigelman, Leonid

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Inhibitors of phosphopantetheine adenylyltransferase von Zhao, Lihua, Allanson, Nigel M., Thomson, Samantha P., Maclean, John K.F., Barker, John J., Primrose, William U., Tyler, Paul D., Lewendon, Ann

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The structure of lactate dehydrogenase from Plasmodium falciparum reveals a new target for anti-malarial design von Dunn, Cameron R, Banfield, Mark J, Barker, John J, Higham, Christopher W, Moreton, Kathleen M, Turgut-Balik, Dilek, Brady, R. Leo, Holbrook, J. John

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Absolute Binding Free Energy Calculations of Bromodomain Inhibitors von Aldeghi, Matteo, Knapp, Stefan, Heifetz, Alexander, Barker, John J., Bodkin, Michael J., Law, Richard J., Biggin, Philip C.

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Engineering an intertwined form of CD2 for stability and assembly von Brady, R. Leo, Murray, Alison J, Head, Jared G, Barker, John J

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