Synthesis of Heterobifunctional Protein Fusions Using Copper-Free Click Chemistry and the Aldehyde Tag von Hudak, Jason E., Barfield, Robyn M., de Hart, Gregory W., Grob, Patricia, Nogales, Eva, Bertozzi, Carolyn R., Rabuka, David

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Leveraging Formylglycine-Generating Enzyme for Production of Site-Specifically Modified Bioconjugates von Barfield, Robyn M., Rabuka, David

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Tandem-Cleavage Linkers Improve the In Vivo Stability and Tolerability of Antibody–Drug Conjugates von Chuprakov, Stepan, Ogunkoya, Ayodele O, Barfield, Robyn M, Bauzon, Maxine, Hickle, Colin, Kim, Yun Cheol, Yeo, Dominick, Zhang, Fangjiu, Rabuka, David, Drake, Penelope M

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Aldehyde Tag Coupled with HIPS Chemistry Enables the Production of ADCs Conjugated Site-Specifically to Different Antibody Regions with Distinct in Vivo Efficacy and PK Outcomes von Drake, Penelope M, Albers, Aaron E, Baker, Jeanne, Banas, Stefanie, Barfield, Robyn M, Bhat, Abhijit S, de Hart, Gregory W, Garofalo, Albert W, Holder, Patrick, Jones, Lesley C, Kudirka, Romas, McFarland, Jesse, Zmolek, Wes, Rabuka, David

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Site-Specific Bioconjugation Using SMARTag® Technology: A Practical and Effective Chemoenzymatic Approach to Generate Antibody–Drug Conjugates von Liu, Junjie, Barfield, Robyn M., Rabuka, David

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CRISPR-Cas9 screens identify regulators of antibody–drug conjugate toxicity von Tsui, C. Kimberly, Barfield, Robyn M., Fischer, Curt R., Morgens, David W., Li, Amy, Smith, Benjamin A. H., Gray, Melissa Anne, Bertozzi, Carolyn R., Rabuka, David, Bassik, Michael C.

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Hydrazino-Pictet-Spengler Ligation as a Biocompatible Method for the Generation of Stable Protein Conjugates von Agarwal, Paresh, Kudirka, Romas, Albers, Aaron E, Barfield, Robyn M, de Hart, Gregory W, Drake, Penelope M, Jones, Lesley C, Rabuka, David

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Maytansine-bearing antibody-drug conjugates induce in vitro hallmarks of immunogenic cell death selectively in antigen-positive target cells von Bauzon, Maxine, Drake, Penelope M, Barfield, Robyn M, Cornali, Brandon M, Rupniewski, Igor, Rabuka, David

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Reconstitution of Formylglycine-generating Enzyme with Copper(II) for Aldehyde Tag Conversion von Holder, Patrick G., Jones, Lesley C., Drake, Penelope M., Barfield, Robyn M., Bañas, Stefanie, de Hart, Gregory W., Baker, Jeanne, Rabuka, David

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A Novel HER2-targeted Antibody–drug Conjugate Offers the Possibility of Clinical Dosing at Trastuzumab-equivalent Exposure Levels von Barfield, Robyn M., Kim, Yun Cheol, Chuprakov, Stepan, Zhang, Fangjiu, Bauzon, Maxine, Ogunkoya, Ayodele O., Yeo, Dominick, Hickle, Colin, Pegram, Mark D., Rabuka, David, Drake, Penelope M.

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Hydrophilic Sequence-Defined Cross-Linkers for Antibody–Drug Conjugates von Walker, Joshua A, Sorkin, Michelle R, Ledesma, Francis, Kabaria, Sneha R, Barfield, Robyn M, Rabuka, David, Alabi, Christopher A

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The exomer coat complex transports Fus1p to the plasma membrane via a novel plasma membrane sorting signal in yeast von Barfield, Robyn M, Fromme, J Christopher, Schekman, Randy

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A simple LC/MRM–MS-based method to quantify free linker-payload in antibody-drug conjugate preparations von Zmolek, Wesley, Bañas, Stefanie, Barfield, Robyn M., Rabuka, David, Drake, Penelope M.

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CAT-02-106, a Site-Specifically Conjugated Anti-CD22 Antibody Bearing an MDR1-Resistant Maytansine Payload Yields Excellent Efficacy and Safety in Preclinical Models von Drake, Penelope M, Carlson, Adam, McFarland, Jesse M, Bañas, Stefanie, Barfield, Robyn M, Zmolek, Wesley, Kim, Yun Cheol, Huang, Betty C B, Kudirka, Romas, Rabuka, David

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Exploring the effects of linker composition on site-specifically modified antibody–drug conjugates von Albers, Aaron E., Garofalo, Albert W., Drake, Penelope M., Kudirka, Romas, de Hart, Gregory W., Barfield, Robyn M., Baker, Jeanne, Banas, Stefanie, Rabuka, David

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Generating aldehyde-tagged antibodies with high titers and high formylglycine yields by supplementing culture media with copper(II) von York, Dona, Baker, Jeanne, Holder, Patrick G, Jones, Lesley C, Drake, Penelope M, Barfield, Robyn M, Bleck, Gregory T, Rabuka, David

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Site-Specific Tandem Knoevenagel Condensation–Michael Addition To Generate Antibody–Drug Conjugates von Kudirka, Romas A, Barfield, Robyn M, McFarland, Jesse M, Drake, Penelope M, Carlson, Adam, Bañas, Stefanie, Zmolek, Wes, Garofalo, Albert W, Rabuka, David

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Antibody-drug conjugate library prepared by scanning insertion of the aldehyde tag into IgG1 constant regions von Huang, Betty C B, Kim, Yun Cheol, Bañas, Stefanie, Barfield, Robyn M, Drake, Penelope M, Rupniewski, Igor, Haskins, William E, Rabuka, David

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Phosphorylation of Chs2p regulates interaction with COPII von Jakobsen, Mia Kyed, Cheng, Zhiliang, Lam, Sheung Kwan, Roth-Johnson, Elizabeth, Barfield, Robyn M, Schekman, Randy

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Antibody-Drug Conjugates Targeting the Urokinase Receptor (uPAR) as a Possible Treatment of Aggressive Breast Cancer von Harel, Efrat T, Drake, Penelope M, Barfield, Robyn M, Lui, Irene, Farr-Jones, Shauna, Van't Veer, Laura, Gartner, Zev J, Green, Evan M, Lourenço, André Luiz, Cheng, Yifan, Hann, Byron C, Rabuka, David, Craik, Charles S

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