Mechanisms of resistance to immune checkpoint inhibitors von Jenkins, Russell W, Barbie, David A, Flaherty, Keith T

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3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade von Aref, Amir R, Campisi, Marco, Ivanova, Elena, Portell, Andrew, Larios, Dalia, Piel, Brandon P, Mathur, Natasha, Zhou, Chensheng, Coakley, Raven Vlahos, Bartels, Alan, Bowden, Michaela, Herbert, Zach, Hill, Sarah, Gilhooley, Sean, Carter, Jacob, Cañadas, Israel, Thai, Tran C, Kitajima, Shunsuke, Chiono, Valeria, Paweletz, Cloud P, Barbie, David A, Kamm, Roger D, Jenkins, Russell W

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Targeting Transcriptional Addictions in Small Cell Lung Cancer with a Covalent CDK7 Inhibitor von Christensen, Camilla L., Kwiatkowski, Nicholas, Abraham, Brian J., Carretero, Julian, Al-Shahrour, Fatima, Zhang, Tinghu, Chipumuro, Edmond, Herter-Sprie, Grit S., Akbay, Esra A., Altabef, Abigail, Zhang, Jianming, Shimamura, Takeshi, Capelletti, Marzia, Reibel, Jakob B., Cavanaugh, Jillian D., Gao, Peng, Liu, Yan, Michaelsen, Signe R., Poulsen, Hans S., Aref, Amir R., Barbie, David A., Bradner, James E., George, Rani E., Gray, Nathanael S., Young, Richard A., Wong, Kwok-Kin

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Retinoblastoma Inactivation Induces a Protumoral Microenvironment via Enhanced CCL2 Secretion von Li, Fengkai, Kitajima, Shunsuke, Kohno, Susumu, Yoshida, Akiyo, Tange, Shoichiro, Sasaki, Soichiro, Okada, Nobuhiro, Nishimoto, Yuuki, Muranaka, Hayato, Nagatani, Naoko, Suzuki, Misa, Masuda, Sayuri, Thai, Tran C, Nishiuchi, Takumi, Tanaka, Tomoaki, Barbie, David A, Mukaida, Naofumi, Takahashi, Chiaki

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Combination Olaparib and Temozolomide in Relapsed Small-Cell Lung Cancer von Farago, Anna F, Yeap, Beow Y, Stanzione, Marcello, Hung, Yin P, Heist, Rebecca S, Marcoux, J Paul, Zhong, Jun, Rangachari, Deepa, Barbie, David A, Phat, Sarah, Myers, David T, Morris, Robert, Kem, Marina, Dubash, Taronish D, Kennedy, Elizabeth A, Digumarthy, Subba R, Sequist, Lecia V, Hata, Aaron N, Maheswaran, Shyamala, Haber, Daniel A, Lawrence, Michael S, Shaw, Alice T, Mino-Kenudson, Mari, Dyson, Nicholas J, Drapkin, Benjamin J

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Targeting an IKBKE cytokine network impairs triple-negative breast cancer growth von Barbie, Thanh U, Alexe, Gabriela, Aref, Amir R, Li, Shunqiang, Zhu, Zehua, Zhang, Xiuli, Imamura, Yu, Thai, Tran C, Huang, Ying, Bowden, Michaela, Herndon, John, Cohoon, Travis J, Fleming, Timothy, Tamayo, Pablo, Mesirov, Jill P, Ogino, Shuji, Wong, Kwok-Kin, Ellis, Matthew J, Hahn, William C, Barbie, David A, Gillanders, William E

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Use of Ex Vivo Patient-Derived Tumor Organotypic Spheroids to Identify Combination Therapies for HER2 Mutant Non-Small Cell Lung Cancer von Ivanova, Elena, Kuraguchi, Mari, Xu, Man, Portell, Andrew J., Taus, Luke, Diala, Irmina, Lalani, Alshad S., Choi, Jihyun, Chambers, Emily S., Li, Shuai, Liu, Shengwu, Chen, Ting, Barbie, Thanh U., Oxnard, Geoffrey R., Haworth, Jacob J., Wong, Kwok-Kin, Dahlberg, Suzanne E., Aref, Amir A., Barbie, David A., Bahcall, Magda, Paweletz, Cloud P., Janne, Pasi A.

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Molecular and Genomic Determinants of Response to Immune Checkpoint Inhibition in Cancer von Jenkins, Russell W, Thummalapalli, Rohit, Carter, Jacob, Cañadas, Israel, Barbie, David A

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Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors von Tan, Li, Wang, Jun, Tanizaki, Junko, Huang, Zhifeng, Aref, Amir R, Rusan, Maria, Zhu, Su-Jie, Zhang, Yiyun, Ercan, Dalia, Liao, Rachel G, Capelletti, Marzia, Zhou, Wenjun, Hur, Wooyoung, Kim, NamDoo, Sim, Taebo, Gaudet, Suzanne, Barbie, David A, Yeh, Jing-Ruey Joanna, Yun, Cai-Hong, Hammerman, Peter S, Mohammadi, Moosa, Jänne, Pasi A, Gray, Nathanael S

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Engineering approaches for studying immune-tumor cell interactions and immunotherapy von Shelton, Sarah E., Nguyen, Huu Tuan, Barbie, David A., Kamm, Roger D.

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ER Stress Signaling Promotes the Survival of Cancer "Persister Cells" Tolerant to EGFR Tyrosine Kinase Inhibitors von Terai, Hideki, Kitajima, Shunsuke, Potter, Danielle S, Matsui, Yusuke, Quiceno, Laura Gutierrez, Chen, Ting, Kim, Tae-Jung, Rusan, Maria, Thai, Tran C, Piccioni, Federica, Donovan, Katherine A, Kwiatkowski, Nicholas, Hinohara, Kunihiko, Wei, Guo, Gray, Nathanael S, Fischer, Eric S, Wong, Kwok-Kin, Shimamura, Teppei, Letai, Anthony, Hammerman, Peter S, Barbie, David A

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Structure and Ubiquitination-Dependent Activation of TANK-Binding Kinase 1 von Tu, Daqi, Zhu, Zehua, Zhou, Alicia Y., Yun, Cai-hong, Lee, Kyung-Eun, Toms, Angela V., Li, Yiqun, Dunn, Gavin P., Chan, Edmond, Thai, Tran, Yang, Shenghong, Ficarro, Scott B., Marto, Jarrod A., Jeon, Hyesung, Hahn, William C., Barbie, David A., Eck, Michael J.

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Requirement for CDK6 in MLL-rearranged acute myeloid leukemia von Placke, Theresa, Faber, Katrin, Nonami, Atsushi, Putwain, Sarah L., Salih, Helmut R., Heidel, Florian H., Krämer, Alwin, Root, David E., Barbie, David A., Krivtsov, Andrei V., Armstrong, Scott A., Hahn, William C., Huntly, Brian J., Sykes, Stephen M., Milsom, Michael D., Scholl, Claudia, Fröhling, Stefan

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Synthetic Lethal Interaction between Oncogenic KRAS Dependency and STK33 Suppression in Human Cancer Cells von Scholl, Claudia, Fröhling, Stefan, Dunn, Ian F., Schinzel, Anna C., Barbie, David A., Kim, So Young, Silver, Serena J., Tamayo, Pablo, Wadlow, Raymond C., Ramaswamy, Sridhar, Döhner, Konstanze, Bullinger, Lars, Sandy, Peter, Boehm, Jesse S., Root, David E., Jacks, Tyler, Hahn, William C., Gilliland, D. Gary

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Highly parallel identification of essential genes in cancer cells von Luo, Biao, Cheung, Hiu Wing, Subramanian, Aravind, Sharifnia, Tanaz, Okamoto, Michael, Yang, Xiaoping, Hinkle, Greg, Boehm, Jesse S, Beroukhim, Rameen, Weir, Barbara A, Mermel, Craig, Barbie, David A, Awad, Tarif, Zhou, Xiaochuan, Nguyen, Tuyen, Piqani, Bruno, Li, Cheng, Golub, Todd R, Meyerson, Matthew, Hacohen, Nir, Hahn, William C, Lander, Eric S, Sabatini, David M, Root, David E

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Inactivation of Fbxw7 Impairs dsRNA Sensing and Confers Resistance to PD-1 Blockade von Gstalder, Cecile, Liu, David, Miao, Diana, Lutterbach, Bart, DeVine, Alexander L., Lin, Chenyu, Shettigar, Megha, Pancholi, Priya, Buchbinder, Elizabeth, Carter, Scott L., Manos, Michael P., Rojas-Rudilla, Vanesa, Brennick, Ryan, Gjini, Evisa, Chen, Pei-Hsuan, Lako, Ana, Rodig, Scott, Yoon, Charles H., Freeman, Gordon J., Barbie, David A., Hodi, F. Stephen, Miles, Wayne, Van Allen, Eliezer M., Haq, Rizwan

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Cotargeting a MYC/eIF4A-survival axis improves the efficacy of KRAS inhibitors in lung cancer von Nardi, Francesca, Perurena, Naiara, Schade, Amy E, Li, Ze-Hua, Ngo, Kenneth, Ivanova, Elena V, Saldanha, Aisha, Li, Chendi, Gokhale, Prafulla C, Hata, Aaron N, Barbie, David A, Paweletz, Cloud P, Jänne, Pasi A, Cichowski, Karen

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MET-Induced CD73 Restrains STING-Mediated Immunogenicity of EGFR-Mutant Lung Cancer von Yoshida, Ryohei, Saigi, Maria, Tani, Tetsuo, Springer, Benjamin F, Shibata, Hirofumi, Kitajima, Shunsuke, Mahadevan, Navin R, Campisi, Marco, Kim, William, Kobayashi, Yoshihisa, Thai, Tran C, Haratani, Koji, Yamamoto, Yurie, Sundararaman, Shriram K, Knelson, Erik H, Vajdi, Amir, Canadas, Israel, Uppaluri, Ravindra, Paweletz, Cloud P, Miret, Juan J, Lizotte, Patrick H, Gokhale, Prafulla C, Jänne, Pasi A, Barbie, David A

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Overcoming Resistance to Dual Innate Immune and MEK Inhibition Downstream of KRAS von Kitajima, Shunsuke, Asahina, Hajime, Chen, Ting, Guo, Sujuan, Quiceno, Laura Gutierrez, Cavanaugh, Jillian D., Merlino, Ashley A., Tange, Shoichiro, Terai, Hideki, Kim, Jong Wook, Wang, Xiaoen, Zhou, Shan, Xu, Man, Wang, Stephen, Zhu, Zehua, Thai, Tran C., Takahashi, Chiaki, Wang, Yujin, Neve, Richard, Stinson, Susanna, Tamayo, Pablo, Watanabe, Hideo, Kirschmeier, Paul T., Wong, Kwok-Kin, Barbie, David A.

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Priming a vascular-selective cytokine response permits CD8+ T-cell entry into tumors von Kim, Dae Joong, Anandh, Swetha, Null, Jamie L., Przanowski, Piotr, Bhatnagar, Sanchita, Kumar, Pankaj, Shelton, Sarah E., Grundy, Erin E., Chiappinelli, Katherine B., Kamm, Roger D., Barbie, David A., Dudley, Andrew C.

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