The Role of Alcohol Dehydrogenase in Drug Metabolism: Beyond Ethanol Oxidation von Di, Li, Balesano, Amanda, Jordan, Samantha, Shi, Sophia M.

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Defining the Selectivity of Chemical Inhibitors Used for Cytochrome P450 Reaction Phenotyping: Overcoming Selectivity Limitations with a Six-Parameter Inhibition Curve-Fitting Appr... von Doran, Angela C, Burchett, Woodrow, Landers, Connor, Gualtieri, Gabrielle M, Balesano, Amanda, Eng, Heather, Dantonio, Alyssa L, Goosen, Theunis C, Obach, R Scott

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An improved method for cytochrome p450 reaction phenotyping using a sequential qualitative-then-quantitative approach von Doran, Angela C, Dantonio, Alyssa L, Gualtieri, Gabrielle M, Balesano, Amanda, Landers, Connor, Burchett, Woodrow, Goosen, Theunis C, Obach, R Scott

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The Comparison of Machine Learning and Mechanistic In Vitro–In Vivo Extrapolation Models for the Prediction of Human Intrinsic Clearance von Keefer, Christopher E., Chang, George, Di, Li, Woody, Nathaniel A., Tess, David A., Osgood, Sarah M., Kapinos, Brendon, Racich, Jill, Carlo, Anthony A., Balesano, Amanda, Ferguson, Nicholas, Orozco, Christine, Zueva, Larisa, Luo, Lina

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Discovery of First Branched-Chain Ketoacid Dehydrogenase Kinase (BDK) Inhibitor Clinical Candidate PF-07328948 von Filipski, Kevin J., Martinez-Alsina, Luis A., Reese, Matthew R., Evrard, Edelweiss, Buzon, Leanne M., Cameron, Kimberly O., Zhang, Yuan, Coffman, Karen J., Bradow, James, Kormos, Bethany L., Liu, Shenping, Knafels, John D., Sahasrabudhe, Parag V., Chen, Jie, Kalgutkar, Amit S., Bessire, Andrew J., Orozco, Christine C., Balesano, Amanda, Cerny, Matthew A., Bollinger, Eliza, Reyes, Allan R., Laforest, Brigitte, Rosado, Amy, Williams, George, Marshall, Mackenzie, Tam Neale, Kelly, Chen, Xian, Hirenallur-Shanthappa, Dinesh, Stansfield, John C., Groarke, John, Qiu, Ruolun, Karas, Spinel, Roth Flach, Rachel J., Esler, William P.

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Discovery of SARS-CoV-2 papain-like protease (PL pro ) inhibitors with efficacy in a murine infection model von Garnsey, Michelle R, Robinson, Matthew C, Nguyen, Luong T, Cardin, Rhonda, Tillotson, Joseph, Mashalidis, Ellene, Yu, Aijia, Aschenbrenner, Lisa, Balesano, Amanda, Behzadi, Amin, Boras, Britton, Chang, Jeanne S, Eng, Heather, Ephron, Andrew, Foley, Tim, Ford, Kristen K, Frick, James M, Gibson, Scott, Hao, Li, Hurst, Brett, Kalgutkar, Amit S, Korczynska, Magdalena, Lengyel-Zhand, Zsofia, Gao, Liping, Meredith, Hannah R, Patel, Nandini C, Polivkova, Jana, Rai, Devendra, Rose, Colin R, Rothan, Hussin, Sakata, Sylvie K, Vargo, Thomas R, Qi, Wenying, Wu, Huixian, Liu, Yiping, Yurgelonis, Irina, Zhang, Jinzhi, Zhu, Yuao, Zhang, Lei, Lee, Alpha A

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