Phosphorylation of ΔNp63α via a novel TGFβ/ALK5 signaling mechanism mediates the anti-clonogenic effects of TGFβ von Cherukuri, Pratima, DeCastro, Andrew J, Balboni, Amanda L, Downey, Sondra L, Liu, Jennifer Y, Hutchinson, Justine A, DiRenzo, James

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p53 and ΔNp63α Coregulate the Transcriptional and Cellular Response to TGFβ and BMP Signals von Balboni, Amanda L, Cherukuri, Pratima, Ung, Matthew, DeCastro, Andrew J, Cheng, Chao, DiRenzo, James

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ΔNp63α-Mediated Activation of Bone Morphogenetic Protein Signaling Governs Stem Cell Activity and Plasticity in Normal and Malignant Mammary Epithelial Cells von BALBONI, Amanda L, HUTCHINSON, Justine A, DIRENZO, James, DECASTRO, Andrew J, CHERUKURI, Pratima, LIBY, Karen, SPORN, Michael B, SCHWARTZ, Gary N, WELLS, Wendy A, SEMPERE, Lorenzo F, YU, Paul B

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Phosphorylation of [DELTA]Np63[alpha] via a Novel TGF[beta]/ALK5 Signaling Mechanism Mediates the Anti-Clonogenic Effects of TGF[beta] von Cherukuri, Pratima, DeCastro, Andrew J, Balboni, Amanda L, Downey, Sondra L, Liu, Jennifer Y, Hutchinson, Justine A, DiRenzo, James

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Oncogenic transformation of mammary epithelial cells by transforming growth factor beta independent of mammary stem cell regulation von Dunphy, Karen A, Seo, Jae-Hong, Kim, Daniel J, Roberts, Amy L, Tao, Luwei, DiRenzo, James, Balboni, Amanda L, Crisi, Giovanna M, Hagen, Mary J, Chandrasekaran, Thiruppavai, Gauger, Kelly J, Schneider, Sallie Smith, Jerry, D Joseph

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p53 and ΔNp63α Co-regulate the Transcriptional and Cellular Response to TGFβ and BMP Signals von Balboni, Amanda L., Cherukuri, Pratima, Ung, Matthew, DeCastro, Andrew J., Cheng, Chao, DiRenzo, James

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Abstract 1118: Synthetic lethality of CDK12 inhibition in tumors with EWS/FLI rearrangements von Balboni, Amanda L., Stolte, Bjorn, Conway, Amy Saur, Alexe, Gabriela, Wang, Emily Jue, Kwiatkowski, Nicholas, Zhang, Tinghu, Abraham, Brian J., Kalev, Peter, Chowdhury, Dipanjan, Benes, Cyril H., Young, Richard A., Gray, Nathanael S., Stegmaier, Kimberly

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EWS–FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma von Gorthi, Aparna, Romero, July Carolina, Loranc, Eva, Cao, Lin, Lawrence, Liesl A., Goodale, Elicia, Iniguez, Amanda Balboni, Bernard, Xavier, Masamsetti, V. Pragathi, Roston, Sydney, Lawlor, Elizabeth R., Toretsky, Jeffrey A., Stegmaier, Kimberly, Lessnick, Stephen L., Chen, Yidong, Bishop, Alexander J. R.

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Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in TP53 wild-type Ewing sarcoma von Stolte, Björn, Iniguez, Amanda Balboni, Dharia, Neekesh V, Robichaud, Amanda L, Conway, Amy Saur, Morgan, Ann M, Alexe, Gabriela, Schauer, Nathan J, Liu, Xiaoxi, Bird, Gregory H, Tsherniak, Aviad, Vazquez, Francisca, Buhrlage, Sara J, Walensky, Loren D, Stegmaier, Kimberly

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STAG2 loss rewires oncogenic and developmental programs to promote metastasis in Ewing sarcoma von Adane, Biniam, Alexe, Gabriela, Seong, Bo Kyung A., Lu, Diana, Hwang, Elizabeth E., Hnisz, Denes, Lareau, Caleb A., Ross, Linda, Lin, Shan, Dela Cruz, Filemon S., Richardson, Melissa, Weintraub, Abraham S., Wang, Sarah, Iniguez, Amanda Balboni, Dharia, Neekesh V., Conway, Amy Saur, Robichaud, Amanda L., Tanenbaum, Benjamin, Krill-Burger, John M., Vazquez, Francisca, Schenone, Monica, Berman, Jason N., Kung, Andrew L., Carr, Steven A., Aryee, Martin J., Young, Richard A., Crompton, Brian D., Stegmaier, Kimberly

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Resistance to Epigenetic-Targeted Therapy Engenders Tumor Cell Vulnerabilities Associated with Enhancer Remodeling von Iniguez, Amanda Balboni, Alexe, Gabriela, Wang, Emily Jue, Roti, Giovanni, Patel, Sarvagna, Chen, Liying, Kitara, Samuel, Conway, Amy, Robichaud, Amanda L., Stolte, Björn, Bandopadhayay, Pratiti, Goodale, Amy, Pantel, Sasha, Lee, Yenarae, Cheff, Dorian M., Hall, Matthew D., Guha, Rajarshi, Davis, Mindy I., Menard, Marie, Nasholm, Nicole, Weiss, William A., Qi, Jun, Beroukhim, Rameen, Piccioni, Federica, Johannessen, Cory, Stegmaier, Kimberly

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STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells von Kim, Jong Wook, Berrios, Christian, Kim, Miju, Schade, Amy E, Adelmant, Guillaume, Yeerna, Huwate, Damato, Emily, Iniguez, Amanda Balboni, Florens, Laurence, Washburn, Michael P, Stegmaier, Kim, Gray, Nathanael S, Tamayo, Pablo, Gjoerup, Ole, Marto, Jarrod A, DeCaprio, James, Hahn, William C

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Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma von Bandopadhayay, Pratiti, Piccioni, Federica, O’Rourke, Ryan, Ho, Patricia, Gonzalez, Elizabeth M., Buchan, Graham, Qian, Kenin, Gionet, Gabrielle, Girard, Emily, Coxon, Margo, Rees, Matthew G., Brenan, Lisa, Dubois, Frank, Shapira, Ofer, Greenwald, Noah F., Pages, Melanie, Balboni Iniguez, Amanda, Paolella, Brenton R., Meng, Alice, Sinai, Claire, Roti, Giovanni, Dharia, Neekesh V., Creech, Amanda, Tanenbaum, Benjamin, Khadka, Prasidda, Tracy, Adam, Tiv, Hong L., Hong, Andrew L., Coy, Shannon, Rashid, Rumana, Lin, Jia-Ren, Cowley, Glenn S., Lam, Fred C., Goodale, Amy, Lee, Yenarae, Schoolcraft, Kathleen, Vazquez, Francisca, Hahn, William C., Tsherniak, Aviad, Bradner, James E., Yaffe, Michael B., Milde, Till, Pfister, Stefan M., Qi, Jun, Schenone, Monica, Carr, Steven A., Ligon, Keith L., Kieran, Mark W., Santagata, Sandro, Olson, James M., Gokhale, Prafulla C., Jaffe, Jacob D., Root, David E., Stegmaier, Kimberly, Johannessen, Cory M., Beroukhim, Rameen

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Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry von Durbin, Adam D., Zimmerman, Mark W., Dharia, Neekesh V., Abraham, Brian J., Iniguez, Amanda Balboni, Weichert-Leahey, Nina, He, Shuning, Krill-Burger, John M., Root, David E., Vazquez, Francisca, Tsherniak, Aviad, Hahn, William C., Golub, Todd R., Young, Richard A., Look, A. Thomas, Stegmaier, Kimberly

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The synergy of BET inhibitors with aurora A kinase inhibitors in MYCN-amplified neuroblastoma is heightened with functional TP53 von Yi, Joanna S., Sias-Garcia, Oscar, Nasholm, Nicole, Hu, Xiaoyu, Iniguez, Amanda Balboni, Hall, Matthew D., Davis, Mindy, Guha, Rajarshi, Moreno-Smith, Myrthala, Barbieri, Eveline, Duong, Kevin, Koach, Jessica, Qi, Jun, Bradner, James E., Stegmaier, Kimberly, Weiss, William A., Gustafson, W. Clay

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CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2 von Chen, Liying, Alexe, Gabriela, Dharia, Neekesh V, Ross, Linda, Iniguez, Amanda Balboni, Conway, Amy Saur, Wang, Emily Jue, Veschi, Veronica, Lam, Norris, Qi, Jun, Gustafson, W Clay, Nasholm, Nicole, Vazquez, Francisca, Weir, Barbara A, Cowley, Glenn S, Ali, Levi D, Pantel, Sasha, Jiang, Guozhi, Harrington, William F, Lee, Yenarae, Goodale, Amy, Lubonja, Rakela, Krill-Burger, John M, Meyers, Robin M, Tsherniak, Aviad, Root, David E, Bradner, James E, Golub, Todd R, Roberts, Charles Wm, Hahn, William C, Weiss, William A, Thiele, Carol J, Stegmaier, Kimberly

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EWSFLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma von Gorthi, Aparna, Romero, July Carolina, Loranc, Eva, Cao, Lin, Lawrence, Liesl A, Goodale, Elicia, Iniguez, Amanda Balboni, Bernard, Xavier, Masamsetti, V. Pragathi, Roston, Sydney, Lawlor, Elizabeth R, Toretsky, Jeffrey A, Stegmaier, Kimberly, Lessnick, Stephen L, Chen, Yidong, Bishop, Alexander J. R

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Author Correction: EWS–FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma von Gorthi, Aparna, Romero, July Carolina, Loranc, Eva, Cao, Lin, Lawrence, Liesl A., Goodale, Elicia, Iniguez, Amanda Balboni, Bernard, Xavier, Masamsetti, V. Pragathi, Roston, Sydney, Lawlor, Elizabeth R., Toretsky, Jeffrey A., Stegmaier, Kimberly, Lessnick, Stephen L., Chen, Yidong, Bishop, Alexander J. R.

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ΔNp63α promotes cellular quiescence via induction and activation of Notch3 von Kent, Sierra, Hutchinson, Justine, Balboni, Amanda, DeCastro, Andrew, Cherukuri, Pratima, DiRenzo, James

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CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2 von Chen, Liying, Alexe, Gabriela, Dharia, Neekesh V, Ross, Linda, Iniguez, Amanda Balboni, Conway, Amy Saur, Wang, Emily Jue, Veschi, Veronica, Lam, Norris, Qi, Jun, Gustafson, W. Clay, Nasholm, Nicole, Vazquez, Francisca, Weir, Barbara A, Cowley, Glenn S, Ali, Levi D, Pantel, Sasha, Jiang, Guozhi, Harrington, William F, Lee, Yenarae, Goodale, Amy, Lubonja, Rakela, Krill-Burger, John M, Meyers, Robin M, Tsherniak, Aviad, Root, David E, Bradner, James E, Golub, Todd R, Roberts, Charles W.M, Hahn, William C, Weiss, William A, Thiele, Carol J, Stegmaier, Kimberly

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