CD25-targeted antibody–drug conjugate depletes regulatory T cells and eliminates established syngeneic tumors via antitumor immunity von Zammarchi, Francesca, Havenith, Karin, Bertelli, Francois, Vijayakrishnan, Balakumar, Chivers, Simon, van Berkel, Patrick H

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TR1801‐ADC: a highly potent cMet antibody–drug conjugate with high activity in patient‐derived xenograft models of solid tumors von Gymnopoulos, Marco, Betancourt, Oscar, Blot, Vincent, Fujita, Ryo, Galvan, Diana, Lieuw, Vincent, Nguyen, Sophie, Snedden, Jeanette, Stewart, Christine, Villicana, Jose, Wojciak, Jon, Wong, Eley, Pardo, Raul, Patel, Neki, D’Hooge, Francois, Vijayakrishnan, Balakumar, Barry, Conor, Hartley, John A., Howard, Philip W., Newman, Roland, Coronella, Julia

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Rationally Designed Short Polyisoprenol-Linked PglB Substrates for Engineered Polypeptide and Protein N‑Glycosylation von Liu, Feng, Vijayakrishnan, Balakumar, Faridmoayer, Amirreza, Taylor, Thomas A, Parsons, Thomas B, Bernardes, Gonçalo J.L, Kowarik, Michael, Davis, Benjamin G

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Chain-growth polyglycosylation: synthesis of linker-equipped mannosyl oligomers von Schuster, Heiko J., Vijayakrishnan, Balakumar, Davis, Benjamin G.

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An antibacterial vaccination strategy based on a glycoconjugate containing the core lipopolysaccharide tetrasaccharide Hep2Kdo2 von Kong, Lingbing, Vijayakrishnan, Balakumar, Kowarik, Michael, Park, Jin, Zakharova, Alexandra N., Neiwert, Larissa, Faridmoayer, Amirreza, Davis, Benjamin G.

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Analysis of the dispersity in carbohydrate loading of synthetic glycoproteins using MALDI-TOF mass spectrometry von Patel, Mitul K, Vijayakrishnan, Balakumar, Koeppe, Julia R, Chalker, Justin M, Doores, Katie J, Davis, Benjamin G

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Extensive Biotransformation Profiling of AZD8205, an Anti-B7-H4 Antibody-Drug Conjugate, Elucidates Pathways Underlying Its Stability In Vivo von Huang, Yue, Tan, Hui Yin, Yuan, Jiaqi, Mu, Ruipeng, Yang, Junyan, Ball, Kathryn, Vijayakrishnan, Balakumar, Masterson, Luke, Kinneer, Krista, Luheshi, Nadia, Liang, Meina, Rosenbaum, Anton I.

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Thiyl Glycosylation of Olefinic Proteins: S-Linked Glycoconjugate Synthesis von Floyd, Nicola, Vijayakrishnan, Balakumar, Koeppe, Julia R, Davis, Benjamin G

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Design and Preclinical Evaluation of a Novel B7-H4-Directed Antibody-Drug Conjugate, AZD8205, Alone and in Combination with the PARP1-Selective Inhibitor AZD5305 von Kinneer, Krista, Wortmann, Philipp, Cooper, Zachary A, Dickinson, Niall J, Masterson, Luke, Cailleau, Thais, Hutchinson, Ian, Vijayakrishnan, Balakumar, McFarlane, Mary, Ball, Kathryn, Davies, Michael, Lewis, Arthur, Huang, Yue, Rosenbaum, Anton I, Yuan, Jiaqi, Chesebrough, Jon, Anderton, Judith, Monks, Noel, Novick, Steven, Wang, Jixin, Dimasi, Nazzareno, Christie, R James, Sabol, Darrin, Tosto, Frances Anne, Wallez, Yann, Leo, Elisabetta, Albertella, Mark R, Staniszewska, Anna D, Tice, David A, Howard, Philip W, Luheshi, Nadia, Sapra, Puja

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Simultaneous monitoring of multiple attributes of pyrrolobenzodiazepine antibody-drug conjugates by size exclusion chromatography – high resolution mass spectrometry von Füssl, Florian, Barry, Conor S., Pugh, Kathryn M., Chooi, K. Phin, Vijayakrishnan, Balakumar, Kang, Gyoung-Dong, von Bulow, Christina, Howard, Philip W., Bones, Jonathan

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Comparison of pyrrolobenzodiazepine dimer bis-imine versus mono-imine: DNA interstrand cross-linking, cytotoxicity, and antibody-drug conjugate efficacy and toxicity von Tiberghien, Arnaud C, Vijayakrishnan, Balakumar, Esfandiari, Arman, Ahmed, Mahammad, Pardo, Raul, Bingham, John, Adams, Lauren, Santos, Kathleen, Kang, Gyoung-Dong, Pugh, Kathryn M, Afif-Rider, Shameen, Vashisht, Kapil, Haque, Kemal, Tammali, Ravinder, Rosfjord, Edward, Savoca, Adriana, Hartley, John A, Howard, Philip W

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Comparison of Pyrrolobenzodiazepine Dimer Bis-imine versus Mono-imine: DNA Interstrand Cross-linking, Cytotoxicity, Antibody-Drug Conjugate Efficacy and Toxicity von Tiberghien, Arnaud C, Vijayakrishnan, Balakumar, Esfandiari, Arman, Ahmed, Mahammad, Pardo, Raul, Bingham, John, Adams, Lauren, Santos, Kathleen, Kang, Gyoung-Dong, Pugh, Kathryn M, Afif-Rider, Shameen, Vashisht, Kapil, Haque, Kemal, Tammali, Ravinder, Rosfjord, Edward, Savoca, Adriana, Hartley, John A, Howard, Philip W

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Efficacy, Tolerability, and Pharmacokinetic Studies of Antibody–Drug Conjugates Containing a Low-Potency Pyrrolobenzodiazepine Dimer von Gregson, Stephen J., Pugh, Kathryn, Patel, Neki, Afif-Rider, Shameen, Vijayakrishnan, Balakumar, Santos, Kathleen, Riedl, Jitka, Hutchinson, Ian, Kang, Gyoung-Dong, Chooi, K. Phin, Beard, Rhiannon, Adams, Lauren, Barry, Conor S., Ball, Kathryn, Masterson, Luke A., McFarlane, Mary, Hartley, John A., Howard, Philip W.

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Improved Physical Stability of an Antibody–Drug Conjugate Using Host–Guest Chemistry von Sonzini, Silvia, Greco, Maria Laura, Cailleau, Thais, Adams, Lauren, Masterson, Luke, Vijayakrishnan, Balakumar, Barry, Conor, Howard, Phillip, Ravn, Peter, van der Walle, Christopher F

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Improved Inhibition of Tumor Growth by Diabody-Drug Conjugates via Half-Life Extension von Li, Qing, Barrett, Allison, Vijayakrishnan, Balakumar, Tiberghien, Arnaud, Beard, Rhiannon, Rickert, Keith W, Allen, Kevin L, Christie, R. Jim, Marelli, Marcello, Harper, Jay, Howard, Philip, Wu, Herren, Dall’Acqua, William F, Tsui, Ping, Gao, Changshou, Borrok, M. Jack

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A Reactive Antibody Platform for One-Step Production of Antibody–Drug Conjugates through a Diels–Alder Reaction with Maleimide von St. Amant, Andre H, Huang, Fengying, Lin, Jia, Lemen, Daniel, Chakiath, Chacko, Mao, Shenlan, Fazenbaker, Christine, Zhong, Haihong, Harper, Jay, Xu, Wenshu, Patel, Neki, Adams, Lauren, Vijayakrishnan, Balakumar, Howard, Philip W, Marelli, Marcello, Wu, Herren, Gao, Changshou, Read de Alaniz, Javier, Christie, R. James

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Strategies in the Design and Use of Synthetic "Internal Glycan" Vaccines von Lakshminarayanan, Abirami, Vijayakrishnan, Balakumar, Bayley, Hagan, Davis, Benjamin G

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Synthesis and evaluation of pyrrolobenzodiazepine dimer antibody-drug conjugates with dual β-glucuronide and dipeptide triggers von Gregson, Stephen J., Barrett, Allison M., Patel, Neki V., Kang, Gyoung-Dong, Schiavone, Davide, Sult, Erin, Barry, Conor S., Vijayakrishnan, Balakumar, Adams, Lauren R., Masterson, Luke A., D'Hooge, Francois, Snaith, Mike, Harper, Jay, Hartley, John A., Howard, Philip W.

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Abstract 225: TR1801-ADC, an optimized anti cMet PBD ADC with high efficacy in solid tumors of the GI tract and head & neck cancer von Gymnopoulos, Marco, Betancourt, Oscar, Blot, Vincent, Fujita, Ryo, Ly, Diana, Nguyen, Sophie, Snedden, Jeanette, Villicana, Jose, Wojciak, Jon, Wong, Eley, Patel, Neki, D'Hooge, Francois, Vijayakrishnan, Balakumar, Barry, Conor, Hartley, John A., Howard, Phil W., Newman, Roland, Coronella, Julia

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An antibacterial vaccination strategy based on a glycoconjugate containing the core lipopolysaccharide tetrasaccharide Hep sub(2)Kdo sub(2) von Kong, Lingbing, Vijayakrishnan, Balakumar, Kowarik, Michael, Park, Jin, Zakharova, Alexandra N, Neiwert, Larissa, Faridmoayer, Amirreza, Davis, Benjamin G

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