Capivasertib Plus Paclitaxel Versus Placebo Plus Paclitaxel As First-Line Therapy for Metastatic Triple-Negative Breast Cancer: The PAKT Trial von Schmid, Peter, Abraham, Jacinta, Chan, Stephen, Wheatley, Duncan, Brunt, Adrian Murray, Nemsadze, Gia, Baird, Richard D., Park, Yeon Hee, Hall, Peter S., Perren, Timothy, Stein, Robert C., Mangel, Laszlo, Ferrero, Jean-Marc, Phillips, Melissa, Conibear, John, Cortes, Javier, Foxley, Andrew, de Bruin, Elza C., McEwen, Robert, Stetson, Daniel, Dougherty, Brian, Sarker, Shah-Jalal, Prendergast, Aaron, McLaughlin-Callan, Max, Burgess, Matthew, Lawrence, Cheryl, Cartwright, Hayley, Mousa, Kelly, Turner, Nicholas C.

Volltext

Genetic heterogeneity in breast cancer: the road to personalized medicine? von Baird, Richard D, Caldas, Carlos

Volltext

The poly(ADP-ribose) polymerase inhibitor niraparib (MK4827) in BRCA mutation carriers and patients with sporadic cancer: a phase 1 dose-escalation trial von Sandhu, Shahneen K, MD, Schelman, William R, MD, Wilding, George, MD, Moreno, Victor, MD, Baird, Richard D, PhD, Miranda, Susana, BSc, Hylands, Lucy, BSc, Riisnaes, Ruth, FIBMS, Forster, Martin, PhD, Omlin, Aurelius, MD, Kreischer, Nathan, MSc, Thway, Khin, MD, Gevensleben, Heidrun, MD, Sun, Linda, PhD, Loughney, John, PhD, Chatterjee, Manash, PhD, Toniatti, Carlo, PhD, Carpenter, Christopher L, MD, Iannone, Robert, MD, Kaye, Stan B, Prof, de Bono, Johann S, Prof, Wenham, Robert M

Volltext

Genomic profile of advanced breast cancer in circulating tumour DNA von Kingston, Belinda, Cutts, Rosalind J., Bye, Hannah, Beaney, Matthew, Walsh-Crestani, Giselle, Hrebien, Sarah, Swift, Claire, Kilburn, Lucy S., Kernaghan, Sarah, Moretti, Laura, Wilkinson, Katie, Wardley, Andrew M., Macpherson, Iain R., Baird, Richard D., Roylance, Rebecca, Reis-Filho, Jorge S., Hubank, Michael, Faull, Iris, Banks, Kimberly C., Lanman, Richard B., Garcia-Murillas, Isaac, Bliss, Judith M., Ring, Alistair, Turner, Nicholas C.

Volltext

Circulating tumour DNA analysis to direct therapy in advanced breast cancer (plasmaMATCH): a multicentre, multicohort, phase 2a, platform trial von Turner, Nicholas C, Kingston, Belinda, Kilburn, Lucy S, Kernaghan, Sarah, Wardley, Andrew M, Macpherson, Iain R, Baird, Richard D, Roylance, Rebecca, Stephens, Peter, Oikonomidou, Olga, Braybrooke, Jeremy P, Tuthill, Mark, Abraham, Jacinta, Winter, Matthew C, Bye, Hannah, Hubank, Michael, Gevensleben, Heidrun, Cutts, Ros, Snowdon, Claire, Rea, Daniel, Cameron, David, Shaaban, Abeer, Randle, Katrina, Martin, Sue, Wilkinson, Katie, Moretti, Laura, Bliss, Judith M, Ring, Alistair

Volltext

First-in-Man Clinical Trial of the Oral Pan-AKT Inhibitor MK-2206 in Patients With Advanced Solid Tumors von YAP, Timothy A, LI YAN, RIISNAES, Ruth, POPE, Lorna L, HEATON, Simon P, THOMAS, George, GARRETT, Michelle D, SULLIVAN, Daniel M, DE BONO, Johann S, TOLCHER, Anthony W, PATNAIK, Amita, FEAREN, Ivy, OLMOS, David, PAPADOPOULOS, Kyriakos, BAIRD, Richard D, DELGADO, Liliana, TAYLOR, Adekemi, LUPINACCI, Lisa

Volltext

Adaptive enrichment trial designs using joint modelling of longitudinal and time-to-event data von Burdon, Abigail J, Baird, Richard D, Jaki, Thomas

Volltext

Characteristics, origin, and potential for cancer diagnostics of ultrashort plasma cell-free DNA von Hudecova, Irena, Smith, Christopher G, Hänsel-Hertsch, Robert, Chilamakuri, Chandra S, Morris, James A, Vijayaraghavan, Aadhitthya, Heider, Katrin, Chandrananda, Dineika, Cooper, Wendy N, Gale, Davina, Garcia-Corbacho, Javier, Pacey, Simon, Baird, Richard D, Rosenfeld, Nitzan, Mouliere, Florent

Volltext

Dose escalation and expansion cohorts in patients with advanced breast cancer in a Phase I study of the CDK7-inhibitor samuraciclib von Coombes, R. C., Howell, Sacha, Lord, Simon R., Kenny, Laura, Mansi, Janine, Mitri, Zahi, Palmieri, Carlo, Chap, Linnea I., Richards, Paul, Gradishar, William, Sardesai, Sagar, Melear, Jason, O’Shaughnessy, Joyce, Ward, Patrick, Chalasani, Pavani, Arkenau, Tobias, Baird, Richard D., Jeselsohn, Rinath, Ali, Simak, Clack, Glen, Bahl, Ashwani, McIntosh, Stuart, Krebs, Matthew G.

Volltext

Antitumor activity in RAS-driven tumors by blocking AKT and MEK von Tolcher, Anthony W, Khan, Khurum, Ong, Michael, Banerji, Udai, Papadimitrakopoulou, Vassiliki, Gandara, David R, Patnaik, Amita, Baird, Richard D, Olmos, David, Garrett, Christopher R, Skolnik, Jeffrey M, Rubin, Eric H, Smith, Paul D, Huang, Pearl, Learoyd, Maria, Shannon, Keith A, Morosky, Anne, Tetteh, Ernestina, Jou, Ying-Ming, Papadopoulos, Kyriakos P, Moreno, Victor, Kaiser, Brianne, Yap, Timothy A, Yan, Li, de Bono, Johann S

Volltext

NMR-based metabolomics of plasma from dairy calves infected with two primary causal agents of bovine respiratory disease (BRD) von Santos-Rivera, Mariana, Fitzkee, Nicholas C., Hill, Rebecca A., Baird, Richard E., Blair, Ellianna, Thoresen, Merrilee, Woolums, Amelia R., Meyer, Florencia, Vance, Carrie K.

Volltext

Eight-year blight (Cryphonectria parasitica) resistance of backcross-generation American chestnuts (Castanea dentata) planted in the southeastern United States von Clark, Stacy L., Schlarbaum, Scott E., Saxton, Arnold M., Baird, Richard

Volltext

A phase I/II study of epertinib plus trastuzumab with or without chemotherapy in patients with HER2-positive metastatic breast cancer von Macpherson, Iain R, Spiliopoulou, Pavlina, Rafii, Saeed, Saggese, Matilde, Baird, Richard D, Garcia-Corbacho, Javier, Italiano, Antoine, Bonneterre, Jacques, Campone, Mario, Cresti, Nicola, Posner, John, Takeda, Yousuke, Arimura, Akinori, Spicer, James

Volltext

A First-in-Human Study of the New Oral Selective Estrogen Receptor Degrader AZD9496 for ER + /HER2 - Advanced Breast Cancer von Hamilton, Erika P, Patel, Manish R, Armstrong, Anne C, Baird, Richard D, Jhaveri, Komal, Hoch, Matthias, Klinowska, Teresa, Lindemann, Justin P O, Morgan, Shethah R, Schiavon, Gaia, Weir, Hazel M, Im, Seock-Ah

Volltext

PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer von Glaviano, Antonino, Foo, Aaron S C, Lam, Hiu Y, Yap, Kenneth C H, Jacot, William, Jones, Robert H, Eng, Huiyan, Nair, Madhumathy G, Makvandi, Pooyan, Geoerger, Birgit, Kulke, Matthew H, Baird, Richard D, Prabhu, Jyothi S, Carbone, Daniela, Pecoraro, Camilla, Teh, Daniel B L, Sethi, Gautam, Cavalieri, Vincenzo, Lin, Kevin H, Javidi-Sharifi, Nathalie R, Toska, Eneda, Davids, Matthew S, Brown, Jennifer R, Diana, Patrizia, Stebbing, Justin, Fruman, David A, Kumar, Alan P

Volltext

Metabolic Imaging Detects Resistance to PI3Kα Inhibition Mediated by Persistent FOXM1 Expression in ER+ Breast Cancer von Ros, Susana, Wright, Alan J., D'Santos, Paula, Hu, De-en, Hesketh, Richard L., Lubling, Yaniv, Georgopoulou, Dimitra, Lerda, Giulia, Couturier, Dominique-Laurent, Razavi, Pedram, Pelossof, Rapahel, Batra, Ankita S., Mannion, Elizabeth, Lewis, David Y., Martin, Alistair, Baird, Richard D., Oliveira, Mafalda, de Boo, Leonora W., Linn, Sabine C., Scaltriti, Maurizio, Rueda, Oscar M., Bruna, Alejandra, Caldas, Carlos, Brindle, Kevin M.

Volltext

A Road Map for Designing Phase I Clinical Trials of Radiotherapy-Novel Agent Combinations von Brown, Sarah R, Hinsley, Samantha, Hall, Emma, Hurt, Chris, Baird, Richard D, Forster, Martin, Scarsbrook, Andrew F, Adams, Richard A

Volltext

Clinical Development of Novel Drug-Radiotherapy Combinations von Ahmad, Saif S, Crittenden, Marka R, Tran, Phuoc T, Kluetz, Paul G, Blumenthal, Gideon M, Bulbeck, Helen, Baird, Richard D, Williams, Kaye J, Illidge, Tim, Hahn, Stephen M, Lawrence, Theodore S, Spears, Patricia A, Walker, Amanda J, Sharma, Ricky A

Volltext

Author Correction: Dose escalation and expansion cohorts in patients with advanced breast cancer in a Phase I study of the CDK7-inhibitor samuraciclib von Coombes, R. C., Howell, Sacha, Lord, Simon R., Kenny, Laura, Mansi, Janine, Mitri, Zahi, Palmieri, Carlo, Chap, Linnea I., Richards, Paul, Gradishar, William, Sardesai, Sagar, Melear, Jason, O’Shaughnessy, Joyce, Ward, Patrick, Chalasani, Pavani, Arkenau, Tobias, Baird, Richard D., Jeselsohn, Rinath, Ali, Simak, Clack, Glen, Bahl, Ashwani, McIntosh, Stuart, Krebs, Matthew G.

Volltext

The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology von Tamborero, David, Dienstmann, Rodrigo, Rachid, Maan Haj, Boekel, Jorrit, Lopez-Fernandez, Adria, Jonsson, Markus, Razzak, Ali, Braña, Irene, De Petris, Luigi, Yachnin, Jeffrey, Baird, Richard D, Loriot, Yohann, Massard, Christophe, Martin-Romano, Patricia, Opdam, Frans, Schlenk, Richard F, Vernieri, Claudio, Masucci, Michele, Villalobos, Xenia, Chavarria, Elena, Balmaña, Judith, Apolone, Giovanni, Caldas, Carlos, Bergh, Jonas, Ernberg, Ingemar, Fröhling, Stefan, Garralda, Elena, Karlsson, Claes, Tabernero, Josep, Voest, Emile, Rodon, Jordi, Lehtiö, Janne

Volltext