Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neopl... von Trimble, Cornelia L, Prof, Morrow, Matthew P, PhD, Kraynyak, Kimberly A, PhD, Shen, Xuefei, PhD, Dallas, Michael, PhD, Yan, Jian, PhD, Edwards, Lance, MD, Parker, R Lamar, MD, Denny, Lynette, MD, Giffear, Mary, BS, Brown, Ami Shah, PhD, Marcozzi-Pierce, Kathleen, MA, Shah, Divya, MS, Slager, Anna M, MS, Sylvester, Albert J, MS, Khan, Amir, PhD, Broderick, Kate E, PhD, Juba, Robert J, MSCEP, Herring, Timothy A, MPH, Boyer, Jean, PhD, Lee, Jessica, MPH, Sardesai, Niranjan Y, PhD, Weiner, David B, Prof, Bagarazzi, Mark L, MD

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Immunotherapy Targeting HPV16/18 Generates Potent Immune Responses in HPV-Associated Head and Neck Cancer von Aggarwal, Charu, Cohen, Roger B, Morrow, Matthew P, Kraynyak, Kimberly A, Sylvester, Albert J, Knoblock, Dawson M, Bauml, Joshua M, Weinstein, Gregory S, Lin, Alexander, Boyer, Jean, Sakata, Lindsay, Tan, Sophie, Anton, Aubrey, Dickerson, Kelsie, Mangrolia, Drishty, Vang, Russell, Dallas, Michael, Oyola, Sandra, Duff, Susan, Esser, Mark, Kumar, Rakesh, Weiner, David, Csiki, Ildiko, Bagarazzi, Mark L

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Safety and immunogenicity of an anti-Middle East respiratory syndrome coronavirus DNA vaccine: a phase 1, open-label, single-arm, dose-escalation trial von Modjarrad, Kayvon, Roberts, Christine C, Mills, Kristin T, Castellano, Amy R, Paolino, Kristopher, Muthumani, Kar, Reuschel, Emma L, Robb, Merlin L, Racine, Trina, Oh, Myoung-don, Lamarre, Claude, Zaidi, Faraz I, Boyer, Jean, Kudchodkar, Sagar B, Jeong, Moonsup, Darden, Janice M, Park, Young K, Scott, Paul T, Remigio, Celine, Parikh, Ajay P, Wise, Megan C, Patel, Ami, Duperret, Elizabeth K, Kim, Kevin Y, Choi, Hyeree, White, Scott, Bagarazzi, Mark, May, Jeanine M, Kane, Deborah, Lee, Hyojin, Kobinger, Gary, Michael, Nelson L, Weiner, David B, Thomas, Stephen J, Maslow, Joel N

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Clinical and Immunologic Biomarkers for Histologic Regression of High-Grade Cervical Dysplasia and Clearance of HPV16 and HPV18 after Immunotherapy von Morrow, Matthew P, Kraynyak, Kimberly A, Sylvester, Albert J, Dallas, Michael, Knoblock, Dawson, Boyer, Jean D, Yan, Jian, Vang, Russell, Khan, Amir S, Humeau, Laurent, Sardesai, Niranjan Y, Kim, J Joseph, Plotkin, Stanley, Weiner, David B, Trimble, Cornelia L, Bagarazzi, Mark L

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CD8+ T Cells Impact Rising PSA in Biochemically Relapsed Cancer Patients Using Immunotherapy Targeting Tumor-Associated Antigens von Shore, Neal D., Morrow, Matthew P., McMullan, Trevor, Kraynyak, Kimberly A., Sylvester, Albert, Bhatt, Khamal, Cheung, Jocelyn, Boyer, Jean D., Liu, Li, Sacchetta, Brian, Rosencranz, Samantha, Heath, Elizabeth I., Nordquist, Luke, Cheng, Heather H., Tagawa, Scott T., Appleman, Leonard J., Tutrone, Ronald, Garcia, Jorge A., Whang, Young E., Kelly, W. Kevin, Weiner, David B., Bagarazzi, Mark L., Skolnik, Jeffrey M.

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Intramuscular and Intradermal Electroporation of HIV-1 PENNVAX-GP(R) DNA Vaccine and IL-12 Is Safe, Tolerable, Acceptable in Healthy Adults von Edupuganti, Srilatha, C. De Rosa, Stephen, Elizaga, Marnie, Lu, Yiwen, Han, Xue, Huang, Yunda, Swann, Edith, Polakowski, Laura, A. Kalams, Spyros, Keefer, Michael, Maenza, Janine, C. Wise, Megan, Yan, Jian, Morrow, Matthew P., Khan, Amir S., Boyer, Jean D., Humeau, Laurent, White, Scott, Sardesai, Niranjan Y., Bagarazzi, Mark L., Gilbert, Peter B., Kublin, James G., Corey, Lawrence, Weiner, David B.

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Tolerability of intramuscular and intradermal delivery by CELLECTRA® adaptive constant current electroporation device in healthy volunteers von Diehl, Malissa C, Lee, Jessica C, Daniels, Stephen E, Tebas, Pablo, Khan, Amir S, Giffear, Mary, Sardesai, Niranjan Y, Bagarazzi, Mark L

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Synthetic Consensus HIV-1 DNA Induces Potent Cellular Immune Responses and Synthesis of Granzyme B, Perforin in HIV Infected Individuals von Morrow, Matthew P, Tebas, Pablo, Yan, Jian, Ramirez, Lorenzo, Slager, Anna, Kraynyak, Kim, Diehl, Malissa, Shah, Divya, Khan, Amir, Lee, Jessica, Boyer, Jean, Kim, J Joseph, Sardesai, Niranjan Y, Weiner, David B, Bagarazzi, Mark L

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Robust antibody and cellular responses induced by DNA-only vaccination for HIV von Rosa, Stephen C. De, Edupuganti, Srilatha, Huang, Yunda, Han, Xue, Elizaga, Marnie, Swann, Edith, Polakowski, Laura, Kalams, Spyros A., Keefer, Michael C., Maenza, Janine, Lu, Yiwen, Wise, Megan C., Yan, Jian, Morrow, Matthew P., Khan, Amir S., Boyer, Jean D., Humeau, Laurent, White, Scott, Pensiero, Michael, Sardesai, Niranjan Y., Bagarazzi, Mark L., Weiner, David B., Ferrari, Guido, Tomaras, Georgia D., Montefiori, David C., Corey, Lawrence, McElrath, M. Juliana

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Rethinking the Regulatory Infrastructure for Human Gene Transfer Clinical Trials von Jenkins, Christopher L, Bagarazzi, Mark L, Kiem, Hans-Peter, Levine, Arnold J, Ando, Dale, June, Carl H, Reid, Tony, Emery, David W

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Augmentation of cellular and humoral immune responses to HPV16 and HPV18 E6 and E7 antigens by VGX-3100 von Morrow, Matthew P, Kraynyak, Kimberly A, Sylvester, Albert J, Shen, Xuefei, Amante, Dinah, Sakata, Lindsay, Parker, Lamar, Yan, Jian, Boyer, Jean, Roh, Christian, Humeau, Laurent, Khan, Amir S, Broderick, Kate, Marcozzi-Pierce, Kathleen, Giffear, Mary, Lee, Jessica, Trimble, Cornelia L, Kim, J Joseph, Sardesai, Niranjan Y, Weiner, David B, Bagarazzi, Mark L

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Protection of chimpanzees from high-dose heterologous HIV-1 challenge by DNA vaccination von Boyer, Jean D, Ugen, Kenneth E, Wang, Bin, Agadjanyan, Michael, Gilbert, Lori, Bagarazzi, Mark L, Chattergoon, Michael, Frost, Patrice, Javadian, Ali, Williams, Williams V, Refaeli, Yosef, Ciccarelli, Richard B, Mccallus, Daniel, coney, Leslie, Weiner, David B

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Vaccination of Seronegative Volunteers with a Human Immunodeficiency Virus Type 1 env/rev DNA Vaccine Induces Antigen-Specific Proliferation and Lymphocyte Production of β-Chemokin... von Boyer, Jean D., Cohen, Adam D., Vogt, Suzanne, Schumann, Kristen, Nath, Brett, Ahn, Lois, Lacy, Kim, Bagarazzi, Mark L., Higgins, Terry J., Baine, Yaela, Ciccarelli, Richard B., Ginsberg, Richard S., MacGregor, Rob Roy, Weiner, David B.

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Safety and Immunogenicity of an Anti–Zika Virus DNA Vaccine von Tebas, Pablo, Roberts, Christine C, Muthumani, Kar, Reuschel, Emma L, Kudchodkar, Sagar B, Zaidi, Faraz I, White, Scott, Khan, Amir S, Racine, Trina, Choi, Hyeree, Boyer, Jean, Park, Young K, Trottier, Sylvie, Remigio, Celine, Krieger, Diane, Spruill, Susan E, Bagarazzi, Mark, Kobinger, Gary P, Weiner, David B, Maslow, Joel N

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Safety, bioavailability, and pharmacokinetics of VGX-1027-A novel oral anti-inflammatory drug in healthy human subjects von Lee, Jessica C., Menacherry, Stanley, Diehl, Malissa C., Giffear, Mary D., White, C. Jo, Juba, Rob, Bagarazzi, Mark L., Muthumani, Karuppiah, Boyer, Jean, Agarwal, Vipin, Nicoletti, Ferdinando, Bart, Stephen, Kim, J. Joseph, Weiner, David B., Sardesai, Niranjan Y.

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Intradermal SynCon® Ebola GP DNA Vaccine Is Temperature Stable and Safely Demonstrates Cellular and Humoral Immunogenicity Advantages in Healthy Volunteers von Tebas, Pablo, Kraynyak, Kimberly A, Patel, Ami, Maslow, Joel N, Morrow, Matthew P, Sylvester, Albert J, Knoblock, Dawson, Gillespie, Elisabeth, Amante, Dinah, Racine, Trina, McMullan, Trevor, Jeong, Moonsup, Roberts, Christine C, Park, Young K, Boyer, Jean, Broderick, Kate E, Kobinger, Gary P, Bagarazzi, Mark, Weiner, David B, Sardesai, Niranjan Y, White, Scott M

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A Phase 1 Trial Assessing the Safety and Tolerability of a Therapeutic DNA Vaccination Against HPV16 and HPV18 E6/E7 Oncogenes After Chemoradiation for Cervical Cancer von Hasan, Yasmin, Furtado, Larissa, Tergas, Ana, Lee, Nita, Brooks, Rebecca, McCall, Anne, Golden, Daniel, Jolly, Shruti, Fleming, Gini, Morrow, Matthew, Kraynyak, Kimberly, Sylvester, Albert, Arif, Fauzia, Levin, Matt, Schwartz, David, Boyer, Jean, Skolnik, Jeffrey, Esser, Mark, Kumar, Rakesh, Bagarazzi, Mark, Weichselbaum, Ralph, Spiotto, Michael

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Engineering of in vivo immune responses to DNA immunization via codelivery of costimulatory molecule genes von Kirn, Jong J, Bagarazzi, Mark L, Trivedi, Neil, Hu, Yin, Kazahaya, Ken, Wilson, Darren M, Ciccarelli, Richard, Chattergoon, Michael A, Dang, Kesan, Mahalingam, Sundarasamy, Chalian, Ara A, Agadjanyan, Michael G, Boyer, Jean D, Wang, Bin, Weiner, David B

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Systemic and Mucosal Immunity Is Elicited after Both Intramuscular and Intravaginal Delivery of Human Immunodeficiency Virus Type 1 DNA Plasmid Vaccines to Pregnant Chimpanzees von Bagarazzi, Mark L., Boyer, Jean D., Javadian, M. Ali, Chattergoon, Michael A., Shah, Ami R., Cohen, Adam D., Bennett, Mosi K., Ciccarelli, Richard B., Ugen, Kenneth E., Weiner, David B.

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First Human Trial of a DNA-Based Vaccine for Treatment of Human Immunodeficiency Virus Type 1 Infection: Safety and Host Response von MacGregor, Rob Roy, Boyer, Jean D., Ugen, Kenneth E., Lacy, Kim E., Gluckman, Stephen J., Bagarazzi, Mark L., Chattergoon, Michael A., Baine, Yaela, Higgins, Terry J., Ciccarelli, Richard B., Coney, Leslie R., Ginsberg, Richard S., Weiner, David B.

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