Expression Analysis of BACE2 in Brain and Peripheral Tissues von Bennett, Brian D., Babu-Khan, Safura, Loeloff, Richard, Louis, Jean-Claude, Curran, Eileen, Citron, Martin, Vassar, Robert

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Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease von Yan, Qiao, Zhang, Jianhua, Liu, Hantao, Babu-Khan, Safura, Vassar, Robert, Biere, Anja Leona, Citron, Martin, Landreth, Gary

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Cloning of a mineral phosphate-solubilizing gene from Pseudomonas cepacia von Babu-Khan, S. (Beckman Research Institute, Duarte, CA.), Yeo, T.C, Martin, W.L, Duron, M.R, Rogers, R.D, Goldstein, A.H

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Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation von Vassar, Robert, Luo, Yi, Bolon, Brad, Kahn, Steve, Bennett, Brian D, Babu-Khan, Safura, Denis, Paul, Fan, Wei, Kha, Hue, Zhang, Jianhua, Gong, Yunhua, Martin, Laura, Louis, Jean-Claude, Yan, Qiao, Richards, William G, Citron, Martin

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β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE von Vassar, Robert, Bennett, Brian D., Babu-Khan, Safura, Kahn, Steve, Mendiaz, Elizabeth A., Denis, Paul, Teplow, David B., Ross, Sandra, Amarante, Patricia, Loeloff, Richard, Luo, Yi, Fisher, Seth, Fuller, Janis, Edenson, Steven, Lile, Jackson, Jarosinski, Mark A., Biere, Anja Leona, Curran, Eileen, Burgess, Teresa, Louis, Jean-Claude, Collins, Frank, Treanor, James, Rogers, Gary, Citron, Martin

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Design and Preparation of a Potent Series of Hydroxyethylamine Containing β-Secretase Inhibitors That Demonstrate Robust Reduction of Central β-Amyloid von Weiss, Matthew M, Williamson, Toni, Babu-Khan, Safura, Bartberger, Michael D, Brown, James, Chen, Kui, Cheng, Yuan, Citron, Martin, Croghan, Michael D, Dineen, Thomas A, Esmay, Joel, Graceffa, Russell F, Harried, Scott S, Hickman, Dean, Hitchcock, Stephen A, Horne, Daniel B, Huang, Hongbing, Imbeah-Ampiah, Ronke, Judd, Ted, Kaller, Matthew R, Kreiman, Charles R, La, Daniel S, Li, Vivian, Lopez, Patricia, Louie, Steven, Monenschein, Holger, Nguyen, Thomas T, Pennington, Lewis D, Rattan, Claire, San Miguel, Tisha, Sickmier, E.Allen, Wahl, Robert C, Wen, Paul H, Wood, Stephen, Xue, Qiufen, Yang, Bryant H, Patel, Vinod F, Zhong, Wenge

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Design and Synthesis of Potent, Orally Efficacious Hydroxyethylamine Derived β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors von Dineen, Thomas A, Weiss, Matthew M, Williamson, Toni, Acton, Paul, Babu-Khan, Safura, Bartberger, Michael D, Brown, James, Chen, Kui, Cheng, Yuan, Citron, Martin, Croghan, Michael D, Dunn, Robert T, Esmay, Joel, Graceffa, Russell F, Harried, Scott S, Hickman, Dean, Hitchcock, Stephen A, Horne, Daniel B, Huang, Hongbing, Imbeah-Ampiah, Ronke, Judd, Ted, Kaller, Matthew R, Kreiman, Charles R, La, Daniel S, Li, Vivian, Lopez, Patricia, Louie, Steven, Monenschein, Holger, Nguyen, Thomas T, Pennington, Lewis D, San Miguel, Tisha, Sickmier, E. Allen, Vargas, Hugo M, Wahl, Robert C, Wen, Paul H, Whittington, Douglas A, Wood, Stephen, Xue, Qiufen, Yang, Bryant H, Patel, Vinod F, Zhong, Wenge

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Discovery of 2-methylpyridine-based biaryl amides as γ-secretase modulators for the treatment of Alzheimer’s disease von Chen, Jian Jeffrey, Qian, Wenyuan, Biswas, Kaustav, Yuan, Chester, Amegadzie, Albert, Liu, Qingyian, Nixey, Thomas, Zhu, Joe, Ncube, Mqhele, Rzasa, Robert M., Chavez, Frank, Chen, Ning, DeMorin, Frenel, Rumfelt, Shannon, Tegley, Christopher M., Allen, Jennifer R., Hitchcock, Stephen, Hungate, Randy, Bartberger, Michael D., Zalameda, Leeanne, Liu, Yichin, McCarter, John D., Zhang, Jianhua, Zhu, Li, Babu-Khan, Safura, Luo, Yi, Bradley, Jodi, Wen, Paul H., Reid, Darren L., Koegler, Frank, Dean, Charles, Hickman, Dean, Correll, Tiffany L., Williamson, Toni, Wood, Stephen

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Establishing the relationship between in vitro potency, pharmacokinetic, and pharmacodynamic parameters in a series of orally available, hydroxyethylamine-derived β-secretase inhib... von Wood, Stephen, Wen, Paul H, Zhang, Jianhua, Zhu, Li, Luo, Yi, Babu-Khan, Safura, Chen, Kui, Pham, Roger, Esmay, Joel, Dineen, Thomas A, Kaller, Matthew R, Weiss, Matthew M, Hitchcock, Stephen A, Citron, Martin, Zhong, Wenge, Hickman, Dean, Williamson, Toni

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A Potent and Orally Efficacious, Hydroxyethylamine-Based Inhibitor of β-Secretase von Kaller, Matthew R, Harried, Scott S, Albrecht, Brian, Amarante, Patricia, Babu-Khan, Safura, Bartberger, Michael D, Brown, James, Brown, Ryan, Chen, Kui, Cheng, Yuan, Citron, Martin, Croghan, Michael D, Graceffa, Russell, Hickman, Dean, Judd, Ted, Kriemen, Chuck, La, Daniel, Li, Vivian, Lopez, Patricia, Luo, Yi, Masse, Craig, Monenschein, Holger, Nguyen, Thomas, Pennington, Lewis D, Miguel, Tisha San, Sickmier, E. Allen, Wahl, Robert C, Weiss, Matthew M, Wen, Paul H, Williamson, Toni, Wood, Stephen, Xue, May, Yang, Bryant, Zhang, Jianhua, Patel, Vinod, Zhong, Wenge, Hitchcock, Stephen

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Pharmacokinetic and pharmacodynamic evaluation of orally available hydroxyethylamine-derived beta-secretase inhibitors in Sprague Dawley rats von Wood, Stephen, Wen, Paul, Amarante, Patricia, Acton, Paul, Bradley, Jodi, Babu-Khan, Safura, Chen, Kui, Zhang, Jan, Zhu, Li, Cheng, Yuan, Dineen, Tom, Esmay, Joel, Graceffa, Russell, Horne, Daniel, Huang, Hongbing, Judd, Ted, Kaller, Mathew, Lopez, Patricia, Luo, Yi, Louie, Steven, Wahl, Robert, Weiss, Matt, Yang, Bryant, Zhong, Wenge, Hickman, Dean, Williamson, Toni

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P1‐243: Pharmacokinetic and pharmacodynamic evaluation of orally available hydroxyethylamine‐derived beta‐secretase inhibitors in Sprague Dawley rats von Wood, Stephen, Wen, Paul, Amarante, Patricia, Acton, Paul, Bradley, Jodi, Babu‐Khan, Safura, Chen, Kui, Zhang, Jan, Zhu, Li, Cheng, Yuan, Dineen, Tom, Esmay, Joel, Graceffa, Russell, Horne, Daniel, Huang, Hongbing, Judd, Ted, Kaller, Mathew, Lopez, Patricia, Luo, Yi, Louie, Steven, Wahl, Robert, Weiss, Matt, Yang, Bryant, Zhong, Wenge, Hickman, Dean, Williamson, Toni

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(Beta-secretase) cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE von Vassar, Robert, Bennett, Brian D, Babu-Khan, Safura, Kahn, Steve

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BACE and BACE2 define a novel subfamily of trans-membrane aspartic proteases von Bennett, Brian D., Babu-Khan, Safura, Loeloff, Richard, Louis, Jean-Claude, Curran, Eileen, Citron, Martin, Vassar, Robert

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Mice deficient in BACE1, the Alzheimer's b-secretase, have normal phenotype and abolished b-amyloid generation von Luo, Yi, Bolon, Brad, Kahn, Steve, Bennett, Brian D, Babu-Khan, Safura, Denis, Paul, Fan, Wei, Kha, Hue, Zhang, Jianhua, Gong, Yunhua, Martin, Laura, Louis, Jean-Claude, Yan, Qiao, Richards, William G, Citron, Martin, Vassar, Robert

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Mice deficient in BACE1, the Alzheimer's [beta]-secretase, have normal phenotype and abolished [beta]-amyloid generation von Luo, Yi, Bolon, Brad, Kahn, Steve, Bennett, Brian D, Babu-Khan, Safura, Denis, Paul, Fan, Wei, Kha, Hue, Zhang, Jianhua, Gong, Yunhua, Martin, Laura, Louis, Jean-Claude, Qiao, Yan, Richards, William G, Citron, Martin, Vassar, Robert

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[Beta]-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE von Vassar, Robert, Bennett, Brian D, Babu-Khan, Safura, Kahn, Steve, Mendiaz, Elizabeth A, Denis, Paul, Teplow, David B, Ross, Sandra, Amarante, Patricia, Loeloff, Richard, Luo, Yi, Fisher, Seth, Fuller, Janis, Edenson, Steven, Lile, Jackson, Jarosinski, Mark A, Biere, Anja Leona, Curran, Eileen, Burgess, Teresa, Louis, Jean-Claude, Collins, Frank, Treanor, James, Rogers, Gary, Citron, Martin

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Anti-Inflammatory Drug Therapy Alters {beta}-Amyloid Processing and Deposition in an Animal Model of Alzheimer's Disease von Yan, Qiao, Zhang, Jianhua, Liu, Hantao, Babu-Khan, Safura, Vassar, Robert, Biere, Anja Leona, Citron, Martin, Landreth, Gary

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Characterization of Alzheimer's β‐Secretase Protein BACE: Processing and Other Post‐translational Modifications von Haniu, Mitsuru, Bennett, Brian D, Denis, Paul, Young, Yunjen, Mendiaz, Elizabeth A, Fuller, Janis, Hui, John O, Kahn, Steven, Babu‐Khan, Safura, Ross, Sandra, Burgess, Teresa, Katta, Viswanatham, Nicolson, Margery, Lull, Jonathan, Wang, Shue‐Yuan, Rogers, Gary, Vassar, Robert, Citron, Martin

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