Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors von Holzer, Philipp, Masuya, Keiichi, Furet, Pascal, Kallen, Joerg, Valat-Stachyra, Therese, Ferretti, Stéphane, Berghausen, Joerg, Bouisset-Leonard, Michèle, Buschmann, Nicole, Pissot-Soldermann, Carole, Rynn, Caroline, Ruetz, Stephan, Stutz, Stefan, Chène, Patrick, Jeay, Sébastien, Gessier, Francois

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2‑Formylpyridyl Ureas as Highly Selective Reversible-Covalent Inhibitors of Fibroblast Growth Factor Receptor 4 von Knoepfel, Thomas, Furet, Pascal, Mah, Robert, Buschmann, Nicole, Leblanc, Catherine, Ripoche, Sebastien, Graus-Porta, Diana, Wartmann, Markus, Galuba, Inga, Fairhurst, Robin A

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A New Approach to (−)-Swainsonine by Ruthenium-Catalyzed Ring Rearrangement von Buschmann, Nicole, Rückert, Anke, Blechert, Siegfried

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Studies on Oxidopyrylium [5 + 2] Cycloadditions:  Toward a General Synthetic Route to the C12-Hydroxy Daphnetoxins von Wender, Paul A, Bi, F. Christopher, Buschmann, Nicole, Gosselin, Francis, Kan, Cindy, Kee, Jung-Min, Ohmura, Hirofumi

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Abstract 5079: Immuno-competent 3d in vitro tumor models as novel platform to assess combinatorial biologics therapy von Agarkova, Irina, Buschmann, Nicole, Strebel, Silvan, Wolf, Armin, Chiovaro, Francesca

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Abstract 57: Development of an in vitro 3D model system for testing PD-1/ PDL-1 immune checkpoint inhibitors von Buschmann, Nicole, Strebel, Silvan, Chiovaro, Francesca, Guye, Patrick, Agarkova, Irina

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Abstract 1684: PDX-derived 3D InSightTM immune-competent tumor microtissues as ex-vivo human model for evaluating therapeutic responses von Wardwell, Judi, Chiovaro, Francesca, Buschmann, Nicole, Strebel, Silvan, Wolf, Armin, Agarkova, Irina

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Discovery of Roblitinib (FGF401) as a Reversible-Covalent Inhibitor of the Kinase Activity of Fibroblast Growth Factor Receptor 4 von Fairhurst, Robin A, Knoepfel, Thomas, Buschmann, Nicole, Leblanc, Catherine, Mah, Robert, Todorov, Milen, Nimsgern, Pierre, Ripoche, Sebastien, Niklaus, Michel, Warin, Nicolas, Luu, Van Huy, Madoerin, Mario, Wirth, Jasmin, Graus-Porta, Diana, Weiss, Andreas, Kiffe, Michael, Wartmann, Markus, Kinyamu-Akunda, Jacqueline, Sterker, Dario, Stamm, Christelle, Adler, Flavia, Buhles, Alexandra, Schadt, Heiko, Couttet, Philippe, Blank, Jutta, Galuba, Inga, Trappe, Jörg, Voshol, Johannes, Ostermann, Nils, Zou, Chao, Berghausen, Jörg, Del Rio Espinola, Alberto, Jahnke, Wolfgang, Furet, Pascal

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FGF401, A First-In-Class Highly Selective and Potent FGFR4 Inhibitor for the Treatment of FGF19-Driven Hepatocellular Cancer von Weiss, Andreas, Adler, Flavia, Buhles, Alexandra, Stamm, Christelle, Fairhurst, Robin A, Kiffe, Michael, Sterker, Dario, Centeleghe, Mario, Wartmann, Markus, Kinyamu-Akunda, Jacqueline, Schadt, Heiko S, Couttet, Philippe, Wolf, Armin, Wang, Youzhen, Barzaghi-Rinaudo, Patrizia, Murakami, Masato, Kauffmann, Audrey, Knoepfel, Thomas, Buschmann, Nicole, Leblanc, Catherine, Mah, Robert, Furet, Pascal, Blank, Jutta, Hofmann, Francesco, Sellers, William R, Graus Porta, Diana

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Abstract 52: PDX-derived 3D InSightTM tumor microtissues as ex-vivo human experimental models for evaluating therapeutic responses von Chiovaro, Francesca, Agarkova, Irina, Buschmann, Nicole, Pichon, Chloe', Langova, Teresa, Maier, Armin, Schueler, Julia, Guye, Patrick

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Discovery of Potent, Highly Selective, and In Vivo Efficacious, Allosteric MALT1 Inhibitors by Iterative Scaffold Morphing von Pissot Soldermann, Carole, Simic, Oliver, Renatus, Martin, Erbel, Paulus, Melkko, Samu, Wartmann, Markus, Bigaud, Marc, Weiss, Andreas, McSheehy, Paul, Endres, Ralf, Santos, Paulo, Blank, Jutta, Schuffenhauer, Ansgar, Bold, Guido, Buschmann, Nicole, Zoller, Thomas, Altmann, Eva, Manley, Paul W, Dix, Ina, Buchdunger, Elisabeth, Scesa, Julien, Quancard, Jean, Schlapbach, Achim, Bornancin, Frédéric, Radimerski, Thomas, Régnier, Catherine H

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NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo von Namoto, Kenji, Baader, Clara, Orsini, Vanessa, Landshammer, Alexandro, Breuer, Eva, Dinh, Kieu Trinh, Ungricht, Rosemarie, Pikiolek, Monika, Laurent, Stephane, Lu, Bo, Aebi, Alexandra, Schönberger, Katharina, Vangrevelinghe, Eric, Evrova, Olivera, Sun, Tianliang, Annunziato, Stefano, Lachal, Julie, Redmond, Emily, Wang, Louis, Wetzel, Kristie, Capodieci, Paola, Turner, Jonathan, Schutzius, Gabi, Unterreiner, Vincent, Trunzer, Markus, Buschmann, Nicole, Behnke, Dirk, Machauer, Rainer, Scheufler, Clemens, Parker, Christian N., Ferro, Magali, Grevot, Armelle, Beyerbach, Armin, Lu, Wei-Yu, Forbes, Stuart J., Wagner, Jürgen, Bouwmeester, Tewis, Liu, Jun, Sohal, Bindi, Sahambi, Sukhdeep, Greenbaum, Linda E., Lohmann, Felix, Hoppe, Philipp, Cong, Feng, Sailer, Andreas W., Ruffner, Heinz, Glatthar, Ralf, Humar, Bostjan, Clavien, Pierre-Alain, Dill, Michael T., George, Elizabeth, Maibaum, Jürgen, Liberali, Prisca, Tchorz, Jan S.

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Bioorthogonal Probes for the Study of MDM2-p53 Inhibitors in Cells and Development of High-Content Screening Assays for Drug Discovery von D'Alessandro, Pier Luca, Buschmann, Nicole, Kaufmann, Markus, Furet, Pascal, Baysang, Frederic, Brunner, Reto, Marzinzik, Andreas, Vorherr, Thomas, Stachyra, Therese-Marie, Ottl, Johannes, Lizos, Dimitrios E., Cobos-Correa, Amanda

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Approaches to selective fibroblast growth factor receptor 4 inhibition through targeting the ATP-pocket middle-hinge region von Fairhurst, Robin A, Knoepfel, Thomas, Leblanc, Catherine, Buschmann, Nicole, Gaul, Christoph, Blank, Jutta, Galuba, Inga, Trappe, Jörg, Zou, Chao, Voshol, Johannes, Genick, Christine, Brunet-Lefeuvre, Peggy, Bitsch, Francis, Graus-Porta, Diana, Furet, Pascal

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Correction to “2-Formylpyridyl Ureas as Highly Selective Reversible-Covalent Inhibitors of Fibroblast Growth Factor Receptor 4” von Knoepfel, Thomas, Furet, Pascal, Mah, Robert, Buschmann, Nicole, Leblanc, Catherine, Ripoche, Sebastien, Graus-Porta, Diana, Wartmann, Markus, Galuba, Inga, Fairhurst, Robin A

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A Framework for Optimizing High-Content Imaging of 3D Models for Drug Discovery von Wardwell-Swanson, Judith, Suzuki, Mahomi, Dowell, Karen G., Bieri, Manuela, Thoma, Eva C., Agarkova, Irina, Chiovaro, Francesca, Strebel, Silvan, Buschmann, Nicole, Greve, Frauke, Frey, Olivier

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Ruthenium olefin metathesis catalysts with modified styrene ethers: influence of steric and electronic effects von Zaja, Mirko, Connon, Stephen J, Dunne, Aideen M, Rivard, Michael, Buschmann, Nicole, Jiricek, Jan, Blechert, Siegfried

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Synthesis and Application of a Permanently Immobilized Olefin-Metathesis Catalyst von Schürer, Stephan C., Gessler, Simon, Buschmann, Nicole, Blechert, Siegfried

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Hydroboration and Suzuki–Miyaura Coupling Reactions with the Electronically Modulated Variant of an Ynamine: The Synthesis of ( E)-β-Arylenamides von Witulski, Bernhard, Buschmann, Nicole, Bergsträßer, Uwe

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Abstract 1798: Mechanistic study of NVP-CGM097: a potent, selective and species specific inhibitor of p53-Mdm2 von Valat, Thérèse, Masuya, Keiichi, Baysang, Frédéric, Albrecht, Geneviève, Buschmann, Nicole, Erdmann, Dirk, Furet, Pascal, Gabriel, Tobias, Gessier, François, Hofmann, Francesco, Holzer, Philipp, Kallen, Joerg, Pissot-Solderman, Carole, Stutz, Stefan, Chène, Patrick, Jeay, Sébastien

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