On the Discovery and Development of Pimavanserin: A Novel Drug Candidate for Parkinson’s Psychosis von Hacksell, Uli, Burstein, Ethan S., McFarland, Krista, Mills, Roger G., Williams, Hilde

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Inverse agonists of the 5-HT2A receptor reduce nicotine withdrawal signs in rats von Malin, David, Henceroth, Mallori, Rao, Gadam Srinivas, Campbell, Joseph, Ma, Jian-Nong, Tsai, Ping-Hsun, Kishbaugh, Jordan C., Burstein, Ethan S.

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Relevance of 5-HT2A Receptor Modulation of Pyramidal Cell Excitability for Dementia-Related Psychosis: Implications for Pharmacotherapy von Burstein, Ethan S.

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The impact of pimavanserin on psychotic phenotypes and tau phosphorylation in the P301L/COMT– and rTg(P301L)4510 mouse models of Alzheimer's disease von Jimenez, Heidy, Adrien, Leslie, Wolin, Adam, Eun, John, Chang, Eric H., Burstein, Ethan S., Gomar, Jesus, Davies, Peter, Koppel, Jeremy

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Ligand Dependent Switch from RXR Homo- to RXR-NURR1 Heterodimerization von Scheepstra, Marcel, Andrei, Sebastian A, de Vries, Rens M. J. M, Meijer, Femke A, Ma, Jian-Nong, Burstein, Ethan S, Olsson, Roger, Ottmann, Christian, Milroy, Lech-Gustav, Brunsveld, Luc

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Should inverse agonists be defined by pharmacological mechanism or clinical effect? von Burstein, Ethan S.

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Structural Requirements of Transmembrane Domain 3 for Activation by the M1 Muscarinic Receptor Agonists AC-42, AC-260584, Clozapine, and N-Desmethylclozapine: Evidence for Three Di... von Spalding, Tracy A, Ma, Jian-Nong, Ott, Thomas R, Friberg, Mikael, Bajpai, Abhishek, Bradley, Stefania Risso, Davis, Robert E, Brann, Mark R, Burstein, Ethan S

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Preclinical PET Neuroimaging of [11C]Bexarotene von Rotstein, Benjamin H., Placzek, Michael S., Krishnan, Hema S., Pekošak, Aleksandra, Collier, Thomas Lee, Wang, Changning, Liang, Steven H., Burstein, Ethan S., Hooker, Jacob M., Vasdev, Neil

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Imaging the 5-HT2C receptor with PET: Evaluation of 5-HT2C and 5-HT2A affinity of pimavanserin in the primate brain von Ridler, Khanum, Rizzo, Gaia, Burstein, Ethan S, sberg Morén, Anton, Stepanov, Vladimir, Halldin, Christer, Rabiner, Eugenii A

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Functional enhancement of AT1R potency in the presence of the TPαR is revealed by a comprehensive 7TM receptor co-expression screen von Hansen, Jonas Tind, Lyngsø, Christina, Speerschneider, Tobias, Hansen, Pernille B L, Galés, Céline, Weiner, David M, Sheikh, Søren P, Burstein, Ethan S, Hansen, Jakob Lerche

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Characterization of the Mas‐related gene family: structural and functional conservation of human and rhesus MrgX receptors von Burstein, Ethan S, Ott, Thomas R, Feddock, Michele, Ma, Jian‐Nong, Fuhs, Steve, Wong, Steven, Schiffer, Hans H, Brann, Mark R, Nash, Norman R

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Low Dose Bexarotene Treatment Rescues Dopamine Neurons and Restores Behavioral Function in Models of Parkinson’s Disease von McFarland, Krista, Spalding, Tracy A, Hubbard, David, Ma, Jian-Nong, Olsson, Roger, Burstein, Ethan S

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Pimavanserin reverses multiple measures of anxiety in a rodent model of post-traumatic stress disorder von Malin, David H., Tsai, Ping-Hsun, Campbell, Joseph R., Moreno, Georgina L., Chapman, Holly L., Suzaki, Aoi, Keivan, Mehrshad S., Gibbons, Kaitlyn M., Morales, Erica R., Burstein, Ethan S., Ward, Christopher P.

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Pimavanserin, a 5HT2A receptor inverse agonist, rapidly suppresses Aβ production and related pathology in a mouse model of Alzheimer’s disease von Yuede, Carla M., Wallace, Clare E., Davis, Todd A., Gardiner, Woodrow D., Hettinger, Jane C., Edwards, Hannah M., Hendrix, Rachel D., Doherty, Brookelyn M., Yuede, Kayla M., Burstein, Ethan S., Cirrito, John R.

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Pimavanserin Promotes Trophic Factor Release and Protects Cultured Primary Dopaminergic Neurons Exposed to MPP+ in a GDNF-Dependent Manner von Lavigne, Elodie Gras, Buttigieg, Dorothée, Steinschneider, Rémy, Burstein, Ethan S

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Optimization of isochromanone based urotensin II receptor agonists von Lehmann, Fredrik, Currier, Erika A., Olsson, Roger, Ma, Jian-Nong, Burstein, Ethan S., Hacksell, Uli, Luthman, Kristina

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Pimavanserin, a 5HT 2A receptor inverse agonist, rapidly suppresses Aβ production and related pathology in a mouse model of Alzheimer's disease von Yuede, Carla M, Wallace, Clare E, Davis, Todd A, Gardiner, Woodrow D, Hettinger, Jane C, Edwards, Hannah M, Hendrix, Rachel D, Doherty, Brookelyn M, Yuede, Kayla M, Burstein, Ethan S, Cirrito, John R

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Estrogen Receptor Beta Selective Agonists as Agents to Treat Chemotherapeutic-Induced Neuropathic Pain von Ma, Jian-Nong, McFarland, Krista, Olsson, Roger, Burstein, Ethan S

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Bexarotene prodrugs: targeting through cleavage by NQO1 (DT-diaphorase) von Schäfer, Anja, Burstein, Ethan S, Olsson, Roger

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The protease activated receptor 2 (PAR2) polymorphic variant F240S constitutively activates PAR2 receptors and potentiates responses to small-molecule PAR2 agonists von Ma, Jian-Nong, Burstein, Ethan S

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