Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases von Park, Sung-Jun, Ahmad, Faiyaz, Philp, Andrew, Baar, Keith, Williams, Tishan, Luo, Haibin, Ke, Hengming, Rehmann, Holger, Taussig, Ronald, Brown, Alexandra L., Kim, Myung K., Beaven, Michael A., Burgin, Alex B., Manganiello, Vincent, Chung, Jay H.

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Structural basis for the design of selective phosphodiesterase 4B inhibitors von Fox, David, Burgin, Alex B., Gurney, Mark E.

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The Mechanism of Topoisomerase I Poisoning by a Camptothecin Analog von Staker, Bart L., Hjerrild, Kathryn, Feese, Michael D., Behnke, Craig A., Burgin, Alex B., Stewart, Lance

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Phenotypic Characterization of a Comprehensive Set of MAPK1/ERK2 Missense Mutants von Brenan, Lisa, Andreev, Aleksandr, Cohen, Ofir, Pantel, Sasha, Kamburov, Atanas, Cacchiarelli, Davide, Persky, Nicole S., Zhu, Cong, Bagul, Mukta, Goetz, Eva M., Burgin, Alex B., Garraway, Levi A., Getz, Gad, Mikkelsen, Tarjei S., Piccioni, Federica, Root, David E., Johannessen, Cory M.

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Artificial neural networks trained to detect viral and phage structural proteins von Seguritan, Victor, Alves, Jr, Nelson, Arnoult, Michael, Raymond, Amy, Lorimer, Don, Burgin, Jr, Alex B, Salamon, Peter, Segall, Anca M

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Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets von Davies, Douglas R, Gelinas, Amy D, Zhang, Chi, Rohloff, John C, Carter, Jeffrey D, O’Connell, Daniel, Waugh, Sheela M, Wolk, Steven K, Mayfield, Wesley S, Burgin, Alex B, Edwards, Thomas E, Stewart, Lance J, Gold, Larry, Janjic, Nebojsa, Jarvis, Thale C

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Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer von O’Connell, James, Porter, John, Kroeplien, Boris, Norman, Tim, Rapecki, Stephen, Davis, Rachel, McMillan, David, Arakaki, Tracy, Burgin, Alex, Fox III, David, Ceska, Tom, Lecomte, Fabien, Maloney, Alison, Vugler, Alex, Carrington, Bruce, Cossins, Benjamin P, Bourne, Tim, Lawson, Alastair

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A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases von Deweese, Joseph E, Osheroff, Neil, Berger, James M, Schmidt, Bryan H, Burgin, Alex B

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Structures of Three Classes of Anticancer Agents Bound to the Human Topoisomerase I−DNA Covalent Complex von Staker, Bart L, Feese, Michael D, Cushman, Mark, Pommier, Yves, Zembower, David, Stewart, Lance, Burgin, Alex B

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Phosphodiesterase-4 (PDE4) Molecular Pharmacology and Alzheimer’s Disease von Gurney, Mark E., D’Amato, Emily C., Burgin, Alex B.

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Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety von Burgin, Alex B, Gurney, Mark E, Magnusson, Olafur T, Singh, Jasbir, Witte, Pam, Staker, Bart L, Bjornsson, Jon M, Thorsteinsdottir, Margret, Hrafnsdottir, Sigrun, Hagen, Timothy, Kiselyov, Alex S, Stewart, Lance J

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Structural model of the dimeric Parkinson’s protein LRRK2 reveals a compact architecture involving distant interdomain contacts von Guaitoli, Giambattista, Raimondi, Francesco, Gilsbach, Bernd K., Gómez-Llorente, Yacob, Deyaert, Egon, Renzi, Fabiana, Li, Xianting, Schaffner, Adam, Jagtap, Pravin Kumar Ankush, Boldt, Karsten, von Zweydorf, Felix, Gotthardt, Katja, Lorimer, Donald D., Yue, Zhenyu, Burgin, Alex, Janjic, Nebojsa, Sattler, Michael, Versées, Wim, Ueffing, Marius, Ubarretxena-Belandia, Iban, Kortholt, Arjan, Gloeckner, Christian Johannes

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A Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1 von Clifton, Matthew C, Dranow, David M, Leed, Alison, Fulroth, Ben, Fairman, James W, Abendroth, Jan, Atkins, Kateri A, Wallace, Ellen, Fan, Dazhong, Xu, Guoping, Ni, Z J, Daniels, Doug, Van Drie, John, Wei, Guo, Burgin, Alex B, Golub, Todd R, Hubbard, Brian K, Serrano-Wu, Michael H

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Non-helical DNA Triplex Forms a Unique Aptamer Scaffold for High Affinity Recognition of Nerve Growth Factor von Jarvis, Thale C., Davies, Douglas R., Hisaminato, Akihiko, Resnicow, Daniel I., Gupta, Shashi, Waugh, Sheela M., Nagabukuro, Akira, Wadatsu, Takashi, Hishigaki, Haretsugu, Gawande, Bharat, Zhang, Chi, Wolk, Steven K., Mayfield, Wesley S., Nakaishi, Yuichiro, Burgin, Alex B., Stewart, Lance J., Edwards, Thomas E., Gelinas, Amy D., Schneider, Daniel J., Janjic, Nebojsa

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Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics von de Waal, Luc, Lewis, Timothy A, Rees, Matthew G, Tsherniak, Aviad, Wu, Xiaoyun, Choi, Peter S, Gechijian, Lara, Hartigan, Christina, Faloon, Patrick W, Hickey, Mark J, Tolliday, Nicola, Carr, Steven A, Clemons, Paul A, Munoz, Benito, Wagner, Bridget K, Shamji, Alykhan F, Koehler, Angela N, Schenone, Monica, Burgin, Alex B, Schreiber, Stuart L, Greulich, Heidi, Meyerson, Matthew

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Structure and function of a cyanophage-encoded peptide deformylase von Frank, Jeremy A, Lorimer, Don, Youle, Merry, Witte, Pam, Craig, Tim, Abendroth, Jan, Rohwer, Forest, Edwards, Robert A, Segall, Anca M, Burgin, Alex B

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Mechanisms of Camptothecin Resistance by Human Topoisomerase I Mutations von Chrencik, Jill E, Staker, Bart L, Burgin, Alex B, Pourquier, Philippe, Pommier, Yves, Stewart, Lance, Redinbo, Matthew R

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A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex von Marchand, Christophe, Antony, Smitha, Kohn, Kurt W, Cushman, Mark, Ioanoviciu, Alexandra, Staker, Bart L, Burgin, Alex B, Stewart, Lance, Pommier, Yves

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Substrate Specificity of Tyrosyl-DNA Phosphodiesterase I (Tdp1) von Raymond, Amy C., Staker, Bart L., Burgin, Alex B.

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Discovery of triazines as selective PDE4B versus PDE4D inhibitors von Hagen, Timothy J., Mo, Xuesheng, Burgin, Alex B., Fox, David, Zhang, Zheng, Gurney, Mark E.

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