Applications of chemogenomic library screening in drug discovery von Jones, Lyn H., Bunnage, Mark E.

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Discovery and Optimization of Small-Molecule Ligands for the CBP/p300 Bromodomains von Hay, Duncan A, Fedorov, Oleg, Martin, Sarah, Singleton, Dean C, Tallant, Cynthia, Wells, Christopher, Picaud, Sarah, Philpott, Martin, Monteiro, Octovia P, Rogers, Catherine M, Conway, Stuart J, Rooney, Timothy P. C, Tumber, Anthony, Yapp, Clarence, Filippakopoulos, Panagis, Bunnage, Mark E, Müller, Susanne, Knapp, Stefan, Schofield, Christopher J, Brennan, Paul E

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PFI-1, a Highly Selective Protein Interaction Inhibitor, Targeting BET Bromodomains von PICAUD, Sarah, DA COSTA, David, BRADNER, James E, TANIERE, Philippe, O'SULLIVAN, Brendan, MÜLLER, Susanne, SCHWALLER, Juerg, STANKOVIC, Tatjana, KNAPP, Stefan, THANASOPOULOU, Angeliki, FILIPPAKOPOULOS, Panagis, FISH, Paul V, PHILPOTT, Martin, FEDOROV, Oleg, BRENNAN, Paul, BUNNAGE, Mark E, OWEN, Dafydd R

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Getting pharmaceutical R&D back on target von Bunnage, Mark E

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(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells von Barsyte-Lovejoy, Dalia, Li, Fengling, Oudhoff, Menno J., Tatlock, John H., Dong, Aiping, Zeng, Hong, Wu, Hong, Freeman, Spencer A., Schapira, Matthieu, Senisterra, Guillermo A., Kuznetsova, Ekaterina, Marcellus, Richard, Allali-Hassani, Abdellah, Kennedy, Steven, Lambert, Jean-Philippe, Couzens, Amber L., Aman, Ahmed, Gingras, Anne-Claude, Al-Awar, Rima, Fish, Paul V., Gerstenberger, Brian S., Roberts, Lee, Benn, Caroline L., Grimley, Rachel L., Braam, Mitchell J. S., Rossi, Fabio M. V., Sudol, Marius, Brown, Peter J., Bunnage, Mark E., Owen, Dafydd R., Zaph, Colby, Vedadi, Masoud, Arrowsmith, Cheryl H.

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Identification of a Chemical Probe for Bromo and Extra C‑Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit von Fish, Paul V, Filippakopoulos, Panagis, Bish, Gerwyn, Brennan, Paul E, Bunnage, Mark E, Cook, Andrew S, Federov, Oleg, Gerstenberger, Brian S, Jones, Hannah, Knapp, Stefan, Marsden, Brian, Nocka, Karl, Owen, Dafydd R, Philpott, Martin, Picaud, Sarah, Primiano, Michael J, Ralph, Michael J, Sciammetta, Nunzio, Trzupek, John D

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Identification of a Chemical Probe for Family VIII Bromodomains through Optimization of a Fragment Hit von Gerstenberger, Brian S, Trzupek, John D, Tallant, Cynthia, Fedorov, Oleg, Filippakopoulos, Panagis, Brennan, Paul E, Fedele, Vita, Martin, Sarah, Picaud, Sarah, Rogers, Catherine, Parikh, Mihir, Taylor, Alexandria, Samas, Brian, O’Mahony, Alison, Berg, Ellen, Pallares, Gabriel, Torrey, Adam D, Treiber, Daniel K, Samardjiev, Ivan J, Nasipak, Brian T, Padilla-Benavides, Teresita, Wu, Qiong, Imbalzano, Anthony N, Nickerson, Jeffrey A, Bunnage, Mark E, Müller, Susanne, Knapp, Stefan, Owen, Dafydd R

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Target validation using chemical probes von Bunnage, Mark E, Chekler, Eugene L Piatnitski, Jones, Lyn H

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Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance von Fedorov, Oleg, Castex, Josefina, Tallant, Cynthia, Owen, Dafydd R, Martin, Sarah, Aldeghi, Matteo, Monteiro, Octovia, Filippakopoulos, Panagis, Picaud, Sarah, Trzupek, John D, Gerstenberger, Brian S, Bountra, Chas, Willmann, Dominica, Wells, Christopher, Philpott, Martin, Rogers, Catherine, Biggin, Philip C, Brennan, Paul E, Bunnage, Mark E, Schüle, Roland, Günther, Thomas, Knapp, Stefan, Müller, Susanne

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Inaxaplin for Proteinuric Kidney Disease in Persons with Two APOL1 Variants von Egbuna, Ogo, Zimmerman, Brandon, Manos, George, Fortier, Anne, Chirieac, Madalina C., Dakin, Leslie A., Friedman, David J., Bramham, Kate, Campbell, Kirk, Knebelmann, Bertrand, Barisoni, Laura, Falk, Ronald J., Gipson, Debbie S., Lipkowitz, Michael S., Ojo, Akinlolu, Bunnage, Mark E., Pollak, Martin R., Altshuler, David, Chertow, Glenn M.

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Know your target, know your molecule von Bunnage, Mark E, Gilbert, Adam M, Jones, Lyn H, Hett, Erik C

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Fluorine in Drug Design: A Case Study with Fluoroanisoles von Xing, Li, Blakemore, David C., Narayanan, Arjun, Unwalla, Ray, Lovering, Frank, Denny, R. Aldrin, Zhou, Huanyu, Bunnage, Mark E.

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Acidic triazoles as soluble guanylate cyclase stimulators von Roberts, Lee R., Bradley, Paul A., Bunnage, Mark E., England, Katherine S., Fairman, David, Fobian, Yvette M., Fox, David N.A., Gymer, Geoff E., Heasley, Steven E., Molette, Jerome, Smith, Graham L., Schmidt, Michelle A., Tones, Michael A., Dack, Kevin N.

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Discovery of Novel, Orally Bioavailable Pyrimidine Ether-Based Inhibitors of ELOVL1 von Boyd, Michael J, Collier, Philip N, Clark, Michael P, Deng, Hongbo, Kesavan, Sarathy, Ronkin, Steven M, Waal, Nathan, Wang, Jian, Cao, Jingrong, Li, Pan, Come, Jon, Davies, Ioana, Duffy, John P, Cochran, John E, Court, John J, Chandupatla, Kishan, Jackson, Katrina L, Maltais, Francois, O’Dowd, Hardwin, Boucher, Christina, Considine, Tony, Taylor, William P, Gao, Hong, Chakilam, Ananthisrinivas, Engtrakul, Juntyma, Crawford, Dan, Doyle, Elizabeth, Phillips, Jonathan, Kemper, Raymond, Swett, Rebecca, Empfield, James, Bunnage, Mark E, Charifson, Paul S, Magavi, Sanjay Shivayogi

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Discovery and Optimization of Pyrazole Amides as Inhibitors of ELOVL1 von Come, Jon H, Senter, Timothy J, Clark, Michael P, Court, John J, Gale-Day, Zachary, Gu, Wenxin, Krueger, Elaine, Liang, Jianglin, Morris, Mark, Nanthakumar, Suganthini, O’Dowd, Hardwin, Maltais, Francois, Iyer, Ganesh, Andreassi, John, Boucher, Christina, Considine, Tony, Moody, Cameron S, Taylor, William, Mohanty, Arun K, Huang, Yulin, Zuccola, Harmon, Coll, Joyce, Bonanno, Kenneth C, Gagnon, Kevin J, Gan, Lu, Lu, Fan, Gao, Hong, Chakilam, Ananthisrinivas, Engtrakul, Juntyma, Song, Bin, Crawford, Dan, Doyle, Elisabeth, Kramer, Tal, Vought, Bryan, Phillips, Jonathan, Kemper, Raymond, Sanders, Martin, Swett, Rebecca, Furey, Brinley, Winquist, Ray, Bunnage, Mark E, Jackson, Katrina L, Charifson, Paul S, Magavi, Sanjay S

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Small molecule modulation of stem cells in regenerative medicine: recent applications and future direction von Allsopp, Timothy E, Bunnage, Mark E, Fish, Paul V

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Design and Synthesis of Inhaled p38 Inhibitors for the Treatment of Chronic Obstructive Pulmonary Disease von Millan, David S, Bunnage, Mark E, Burrows, Jane L, Butcher, Kenneth J, Dodd, Peter G, Evans, Timothy J, Fairman, David A, Hughes, Samantha J, Kilty, Iain C, Lemaitre, Arnaud, Lewthwaite, Russell A, Mahnke, Axel, Mathias, John P, Philip, James, Smith, Robert T, Stefaniak, Mark H, Yeadon, Michael, Phillips, Christopher

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Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists von Liu, Shenping, Dakin, Leslie A., Xing, Li, Withka, Jane M., Sahasrabudhe, Parag V., Li, Wei, Banker, Mary Ellen, Balbo, Paul, Shanker, Suman, Chrunyk, Boris A., Guo, Zuojun, Chen, Jinshan M., Young, Jennifer A., Bai, Guoyun, Starr, Jeremy T., Wright, Stephen W., Bussenius, Joerg, Tan, Sheng, Gopalsamy, Ariamala, Lefker, Bruce A., Vincent, Fabien, Jones, Lyn H., Xu, Hua, Hoth, Lise R., Geoghegan, Kieran F., Qiu, Xiayang, Bunnage, Mark E., Thorarensen, Atli

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Asymmetric synthesis of the cis- and trans-stereoisomers of 4-aminopyrrolidine-3-carboxylic acid and 4-aminotetrahydrofuran-3-carboxylic acid von Bunnage, Mark E, Davies, Stephen G, Roberts, Paul M, Smith, Andrew D, Withey, Jonathan M

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Kinetic resolution of tert-butyl (RS)-3-alkylcyclopentene-1-carboxylates for the synthesis of homochiral 3-alkyl-cispentacin and 3-alkyl-transpentacin derivatives von Bunnage, Mark E, Davies, Stephen G, Parkin, Richard M, Roberts, Paul M, Smith, Andrew D, Withey, Jonathan M

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