In Vitro and In Vivo Assessment of the Potential of Supersaturation to Enhance the Absorption of Poorly Soluble Basic Drugs von Li, Jibin, Bukhtiyarov, Yuri, Spivey, Nicole, Force, Christopher, Hidalgo, Carlos, Huang, Yuehua, Owen, Albert J., Hidalgo, Ismael J.

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Cloning, Characterization and Site-Directed Mutagenesis of Canine Renin von Bukhtiyarov, Yuri, Zecher, Marianne, Panemangalore, Reshma, Wu, Zhongren, Bruno, Joseph G, Yuan, Jing, Xu, Zhenrong, Dillard, Lawrence W, McGeehan, Gerard M, Harrison, Richard K, Scott, Boyd B

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Purification and characterization of recombinant human renin for X-ray crystallization studies von Wu, Zhongren, Cappiello, Maria G, Scott, Boyd B, Bukhtiyarov, Yuri, McGeehan, Gerard M

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Identification of spirooxindole and dibenzoxazepine motifs as potent mineralocorticoid receptor antagonists von Lotesta, Stephen D., Marcus, Andrew P., Zheng, Yajun, Leftheris, Katerina, Noto, Paul B., Meng, Shi, Kandpal, Geeta, Chen, Guozhou, Zhou, Jing, McKeever, Brian, Bukhtiyarov, Yuri, Zhao, Yi, Lala, Deepak S., Singh, Suresh B., McGeehan, Gerard M.

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Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR) β Agonist von Zheng, Yajun, Zhuang, Linghang, Fan, Kristi Yi, Tice, Colin M, Zhao, Wei, Dong, Chengguo, Lotesta, Stephen D, Leftheris, Katerina, Lindblom, Peter R, Liu, Zhijie, Shimada, Jun, Noto, Paul B, Meng, Shi, Hardy, Andrew, Howard, Lamont, Krosky, Paula, Guo, Joan, Lipinski, Kerri, Kandpal, Geeta, Bukhtiyarov, Yuri, Zhao, Yi, Lala, Deepak, Van Orden, Rebecca, Zhou, Jing, Chen, Guozhou, Wu, Zhongren, McKeever, Brian M, McGeehan, Gerard M, Gregg, Richard E, Claremon, David A, Singh, Suresh B

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Regulation of Sphingomyelin Phosphodiesterase Acid-Like 3A Gene (SMPDL3A) by Liver X Receptors von Noto, Paul B., Bukhtiyarov, Yuri, Shi, Meng, McKeever, Brian M., McGeehan, Gerard M., Lala, Deepak S.

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Morphological Measures of Pacific Walruses Collected in the Chukchi and Bering Seas 1972-1991 von Yuri Bukhtiyarov

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Discovery of BI 135585, an in vivo efficacious oxazinanone-based 11β hydroxysteroid dehydrogenase type 1 inhibitor von Zhuang, Linghang, Tice, Colin M., Xu, Zhenrong, Zhao, Wei, Cacatian, Salvacion, Ye, Yuan-Jie, Singh, Suresh B., Lindblom, Peter, McKeever, Brian M., Krosky, Paula M., Zhao, Yi, Lala, Deepak, Kruk, Barbara A., Meng, Shi, Howard, Lamont, Johnson, Judith A., Bukhtiyarov, Yuri, Panemangalore, Reshma, Guo, Joan, Guo, Rong, Himmelsbach, Frank, Hamilton, Bradford, Schuler-Metz, Annette, Schauerte, Heike, Gregg, Richard, McGeehan, Gerard M., Leftheris, Katerina, Claremon, David A.

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The potent, selective RORγt blocker, VTP-43742, suppresses Th17 production in vivo and provides greater benefit than IL-17 blockade in the EAE model of autoimmunity (THER3P.968) von Zhao, Yi, Meng, Shi, Noto, Paul, Bukhtiyarov, Yuri, Stadanlick, Jason, Zhuang, Linghang, Dillard, Lawrence, Claremon, David, Gregg, Richard, McGeehan, Gerard, Lala, Deepak

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Abstract 334: The LXRβ Selective Agonist, VTP-38443, Significantly Decreases Plaque Cholesterol Ester Content and Inflammation in a Murine Model of Accelerated Atherosclerosis von McGeehan, Gerard M, Lala, Deepak S, Zhao, Yi, Noto, Paul B, Zhuang, Linghang, Claremon, David A, Meng, Shi, Bukhtiyarov, Yuri, Gregg, Richard R

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Safety, tolerability, pharmacokinetics and pharmacodynamics of VTP-43742, a RORγt inhibitor, in normal healthy volunteers von McGeehan, Gerard M, Palmer, Sally A, Bryson, Catherine C, Zhao, Yi, Shi, Meng, Lipinski, Kerri K, Bukhtiyarov, Yuri, Guo, Joan, Claremon, David A, Lala, Deepak S, Gregg, Richard E

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P4‐217: EFFECTS OF BACE1 INHIBITION ON ABETA IN RATS AND TG2576 von Dorner‐Ciossek, Cornelia, Hobson, Scott, Lenter, Martin, Bukhtiyarov, Yuri, Lala, Deepak

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EFFECTS OF BACE1 INHIBITION ON ABETA IN RATS AND TG2576 von Dorner-Ciossek, Cornelia, Hobson, Scott, Lenter, Martin, Bukhtiyarov, Yuri, Lala, Deepak

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Identification of spirooxindole and dibenzoxazepine motifs as potent mineralocorticoid receptor antagonists von Lotesta, Stephen D., Marcus, Andrew P., Zheng, Yajun, Leftheris, Katerina, Noto, Paul B., Meng, Shi, Kandpal, Geeta, Chen, Guozhou, Zhou, Jing, McKeever, Brian, Bukhtiyarov, Yuri, Zhao, Yi, Lala, Deepak S., Singh, Suresh B., McGeehan, Gerard M.

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Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core von Tice, Colin M., Noto, Paul B., Fan, Kristi Yi, Zhao, Wei, Lotesta, Stephen D., Dong, Chengguo, Marcus, Andrew P., Zheng, Ya-Jun, Chen, Guozhou, Wu, Zhongren, Van Orden, Rebecca, Zhou, Jing, Bukhtiyarov, Yuri, Zhao, Yi, Lipinski, Kerri, Howard, Lamont, Guo, Joan, Kandpal, Geeta, Meng, Shi, Hardy, Andrew, Krosky, Paula, Gregg, Richard E., Leftheris, Katerina, McKeever, Brian M., Singh, Suresh B., Lala, Deepak, McGeehan, Gerard M., Zhuang, Linghang, Claremon, David A.

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Structure-Based Design and Synthesis of 1,3-Oxazinan-2-one Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 von Xu, Zhenrong, Tice, Colin M, Zhao, Wei, Cacatian, Salvacion, Ye, Yuan-Jie, Singh, Suresh B, Lindblom, Peter, McKeever, Brian M, Krosky, Paula M, Kruk, Barbara A, Berbaum, Jennifer, Harrison, Richard K, Johnson, Judith A, Bukhtiyarov, Yuri, Panemangalore, Reshma, Scott, Boyd B, Zhao, Yi, Bruno, Joseph G, Togias, Jennifer, Guo, Joan, Guo, Rong, Carroll, Patrick J, McGeehan, Gerard M, Zhuang, Linghang, He, Wei, Claremon, David A

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VTP-43742 is a potent and selective RORγt blocker that demonstrates oral efficacy in a mouse model of autoimmunity through suppression of IL-17A production (THER7P.945) von McGeehan, Gerard, Bukhtiyarov, Yuri, Zhao, Yi, Meng, Shi, Noto, Paul, Stadanlick, Jason, Kruk, Barbara, Hardy, Andrew, Lipinski, Kerri, Kandpal, Geeta, Algayer, Bethany, Guo, Joan, Guo, Rong, Marcus, Andrew, Lotesta, Stephen, Dong, Chengguo, Fan, Kristi, Jia, Lanqi, Yuan, Jing, Zheng, Yajun, Zhuang, Linghang, Dillard, Lawrence, Claremon, David, Gregg, Richard, Lala, Deepak

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Photoreactive Analogues of Prenyl Diphosphates as Inhibitors and Probes of Human Protein Farnesyltransferase and Geranylgeranyltransferase Type I von Bukhtiyarov, Yuri E., Omer, Charles A., Allen, Charles M.

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P1‐314: Pharmacological characterization of the new bace1 inhibitor bi 1181181 von Dorner-Ciossek, Cornelia, Hobson, Scott, Fuchs, Klaus, Sauer, Achim, Bauer, Margit, Morales-Ramos, Angel, Venkatraman, Shankar, Dillard, Lawrence W., Kruk, Barbara, Howard, Lamont, Bukhtiyarov, Yuri, Zhao, Yi, Lala, Deepak S.

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Pharmacological characterization of the new bace1 inhibitor bi 1181181 von Dorner-Ciossek, Cornelia, Hobson, Scott, Fuchs, Klaus, Sauer, Achim, Bauer, Margit, Morales-Ramos, Angel, Venkatraman, Shankar, Dillard, Lawrence W, Kruk, Barbara, Howard, Lamont, Bukhtiyarov, Yuri, Zhao, Yi, Lala, Deepak S

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