Comparison of the cancer gene targeting and biochemical selectivities of all targeted kinase inhibitors approved for clinical use von Uitdehaag, Joost C M, de Roos, Jeroen A D M, van Doornmalen, Antoon M, Prinsen, Martine B W, de Man, Jos, Tanizawa, Yoshinori, Kawase, Yusuke, Yoshino, Kohichiro, Buijsman, Rogier C, Zaman, Guido J R

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IL-7 Receptor Mutations and Steroid Resistance in Pediatric T cell Acute Lymphoblastic Leukemia: A Genome Sequencing Study von Li, Yunlei, Buijs-Gladdines, Jessica G C A M, Canté-Barrett, Kirsten, Stubbs, Andrew P, Vroegindeweij, Eric M, Smits, Willem K, van Marion, Ronald, Dinjens, Winand N M, Horstmann, Martin, Kuiper, Roland P, Buijsman, Rogier C, Zaman, Guido J R, van der Spek, Peter J, Pieters, Rob, Meijerink, Jules P P

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Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation von van der Goot, Annemieke T, Zhu, Wentao, Vázquez-Manrique, Rafael P, Seinstra, Renée I, Dettmer, Katja, Michels, Helen, Farina, Francesca, Krijnen, Jasper, Melki, Ronald, Buijsman, Rogier C, Ruiz Silva, Mariana, Thijssen, Karen L, Kema, Ido P, Neri, Christian, Oefner, Peter J, Nollen, Ellen A. A

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Pharmacological validation of TDO as a target for Parkinson’s disease von Perez‐Pardo, Paula, Grobben, Yvonne, Willemsen‐Seegers, Nicole, Hartog, Mitch, Tutone, Michaela, Muller, Michelle, Adolfs, Youri, Pasterkamp, Ronald Jeroen, Vu‐Pham, Diep, Doornmalen, Antoon M., Cauter, Freek, Wit, Joeri, Gerard Sterrenburg, Jan, Uitdehaag, Joost C.M., Man, Jos, Buijsman, Rogier C., Zaman, Guido J.R., Kraneveld, Aletta D.

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A guide to picking the most selective kinase inhibitor tool compounds for pharmacological validation of drug targets von Uitdehaag, Joost CM, Verkaar, Folkert, Alwan, Husam, de Man, Jos, Buijsman, Rogier C, Zaman, Guido JR

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Dual TTK/PLK1 inhibition has potent anticancer activity in TNBC as monotherapy and in combination von Zanini, Elisa, Forster-Gross, Nicole, Bachmann, Felix, Brüngger, Adrian, McSheehy, Paul, Litherland, Karine, Burger, Karin, Groner, Anna C, Roceri, Mila, Bury, Luc, Stieger, Martin, Willemsen-Seegers, Nicole, de Man, Jos, Vu-Pham, Diep, van Riel, Helma W E, Zaman, Guido J R, Buijsman, Rogier C, Kellenberger, Laurenz, Lane, Heidi A

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Structural insights into human Arginase-1 pH dependence and its inhibition by the small molecule inhibitor CB-1158 von Grobben, Yvonne, Uitdehaag, Joost C.M., Willemsen-Seegers, Nicole, Tabak, Werner W.A., de Man, Jos, Buijsman, Rogier C., Zaman, Guido J.R.

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Targeting Indoleamine 2,3-Dioxygenase in Cancer Models Using the Novel Small Molecule Inhibitor NTRC 3883-0 von Grobben, Yvonne, de Man, Jos, van Doornmalen, Antoon M, Muller, Michelle, Willemsen-Seegers, Nicole, Vu-Pham, Diep, Mulder, Winfried R, Prinsen, Martine B W, de Wit, Joeri, Sterrenburg, Jan Gerard, van Cauter, Freek, den Ouden, Judith E, van Altena, Anne M, Massuger, Leon F, Uitdehaag, Joost C M, Buijsman, Rogier C, Zaman, Guido J R

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Selective Targeting of CTNBB1-, KRAS- or MYC-Driven Cell Growth by Combinations of Existing Drugs von Uitdehaag, Joost C M, de Roos, Jeroen A D M, van Doornmalen, Antoon M, Prinsen, Martine B W, Spijkers-Hagelstein, Jill A P, de Vetter, Judith R F, de Man, Jos, Buijsman, Rogier C, Zaman, Guido J R

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Ruthenium-Catalyzed Olefin Metathesis in Ionic Liquids von Buijsman, Rogier C, van Vuuren, Elizabeth, Sterrenburg, Jan Gerard

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LCK inhibition downregulates YAP activity and is therapeutic in patient-derived models of cholangiocarcinoma von Conboy, Caitlin B., Yonkus, Jennifer A., Buckarma, EeeLN H., Mun, Dong-Gi, Werneburg, Nathan W., Watkins, Ryan D., Alva-Ruiz, Roberto, Tomlinson, Jennifer L., Guo, Yi, Wang, Juan, O’Brien, Daniel, McCabe, Chantal E., Jessen, Erik, Graham, Rondell P., Buijsman, Rogier C., Vu, Diep, de Man, Jos, Ilyas, Sumera I., Truty, Mark J., Borad, Mitesh, Pandey, Akhilesh, Gores, Gregory J., Smoot, Rory L.

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Compound Selectivity and Target Residence Time of Kinase Inhibitors Studied with Surface Plasmon Resonance von Willemsen-Seegers, Nicole, Uitdehaag, Joost C.M., Prinsen, Martine B.W., de Vetter, Judith R.F., de Man, Jos, Sawa, Masaaki, Kawase, Yusuke, Buijsman, Rogier C., Zaman, Guido J.R.

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Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity von Uitdehaag, Joost C.M., de Man, Jos, Willemsen-Seegers, Nicole, Prinsen, Martine B.W., Libouban, Marion A.A., Sterrenburg, Jan Gerard, de Wit, Joeri J.P., de Vetter, Judith R.F., de Roos, Jeroen A.D.M., Buijsman, Rogier C., Zaman, Guido J.R.

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TTK Inhibitors as a Targeted Therapy for CTNNB1 ( β -catenin) Mutant Cancers von Zaman, Guido J R, de Roos, Jeroen A D M, Libouban, Marion A A, Prinsen, Martine B W, de Man, Jos, Buijsman, Rogier C, Uitdehaag, Joost C M

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Mapping Arginase Expression with 18 F-Fluorinated Late-Generation Arginase Inhibitors Derived from Quaternary α-Amino Acids von Clemente, Gonçalo S, Antunes, Inês F, Kurhade, Santosh, van den Berg, Mariska P M, Sijbesma, Jürgen W A, van Waarde, Aren, Buijsman, Rogier C, Willemsen-Seegers, Nicole, Gosens, Reinoud, Meurs, Herman, Dömling, Alexander, Elsinga, Philip H

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Optimized Target Residence Time: Type I1/2 Inhibitors for p38α MAP Kinase with Improved Binding Kinetics through Direct Interaction with the R‐Spine von Wentsch, Heike K., Walter, Niklas M., Bührmann, Mike, Mayer‐Wrangowski, Svenja, Rauh, Daniel, Zaman, Guido J. R., Willemsen‐Seegers, Nicole, Buijsman, Rogier C., Henning, Melanie, Dauch, Daniel, Zender, Lars, Laufer, Stefan

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Combined Cellular and Biochemical Profiling to Identify Predictive Drug Response Biomarkers for Kinase Inhibitors Approved for Clinical Use between 2013 and 2017 von Uitdehaag, Joost C M, Kooijman, Jeffrey J, de Roos, Jeroen A D M, Prinsen, Martine B W, Dylus, Jelle, Willemsen-Seegers, Nicole, Kawase, Yusuke, Sawa, Masaaki, de Man, Jos, van Gerwen, Suzanne J C, Buijsman, Rogier C, Zaman, Guido J R

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Chemotherapy sensitivity testing on ovarian cancer cells isolated from malignant ascites von den Ouden, Judith E, Zaman, Guido J R, Dylus, Jelle, van Doornmalen, Antoon M, Mulder, Winfried R, Grobben, Yvonne, van Riel, Wilhelmina E, de Hullu, Joanne A, Buijsman, Rogier C, van Altena, Anne M

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Screening of predicted synergistic multi-target therapies in glioblastoma identifies new treatment strategies von Houweling, Megan, Giczewska, Anna, Abdul, Kulsoom, Nieuwenhuis, Ninke, Küçükosmanoglu, Asli, Pastuszak, Krzysztof, Buijsman, Rogier C, Wesseling, Pieter, Wedekind, Laurine, Noske, David, Supernat, Anna, Bailey, David, Watts, Colin, Wurdinger, Thomas, Westerman, Bart A

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Selective Targeting of CTNNB1-, KRAS- or MYC-Driven Cell Growth by Combinations of Existing Drugs von Uitdehaag, Joost C. M., de Roos, Jeroen A. D. M., van Doornmalen, Antoon M., Prinsen, Martine B. W., Spijkers-Hagelstein, Jill A. P., de Vetter, Judith R. F., de Man, Jos, Buijsman, Rogier C., Zaman, Guido J. R.

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